Mu-conopeptides

ABSTRACT

The present invention is to μ-conopeptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated sodium channels. Thus, the μ-conopeptides or derivatives are useful as neuromuscular blocking agents, local anesthetic agents, analgesic agents and neuroprotective agents. The μ-conopeptides are also useful for treating neuromuscular disorders. The invention is further directed to nucleic acid sequences encoding the μ-conopeptides and encoding propeptides, as well as the propeptides.

CROSS-REFERENCE TO RELATED APPLICATIONS

The present application claims benefit under 35 USC §119(e) to U.S. provisional patent applications Ser. No. 60/219,619 filed on Jul. 21, 2000, Ser. No. 60/245,157 filed on Nov. 3, 2000, Ser. No. 60/264,319 filed on Jan. 29, 2001 and Ser. No. 60/277,270 filed on Mar. 21, 2001. Each of these applications is incorporated herein by reference.

This invention was made with Government support under Grant No. PO1 GM48677 awarded by the National Institute of General Medical Sciences, National Institutes of Health, Bethesda, Md. The United States Government has certain rights in the invention.

BACKGROUND OF THE INVENTION

The present invention is to μ-conopeptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated sodium channels. Thus, the μ-conopeptides or derivatives are useful as neuromuscular blocking agents, local anesthetic agents, analgesic agents and neuroprotective agents. The μ-conopeptides are also useful for treating neuromuscular disorders. The invention is further directed to nucleic acid sequences encoding the μ-conopeptides and encoding propeptides, as well as the propeptides.

The publications and other materials used herein to illuminate the background of the invention, and in particular, cases to provide additional details respecting the practice, are incorporated by reference, and for convenience are referenced in the following text by author and date and are listed alphabetically by author in the appended bibliography.

Conus is a genus of predatory marine gastropods (snails) which envenomate their prey. Venomous cone snails use a highly developed projectile apparatus to deliver their cocktail of toxic conotoxins into their prey. In fish-eating species such as Conus magus the cone detects the presence of the fish using chemosensors in its siphon and when close enough extends its proboscis and fires a hollow harpoon-like tooth containing venom into the fish. This immobilizes the fish and enables the cone snail to wind it into its mouth via an attached filament. Prey capture is accomplished through a sophisticated arsenal of peptides which target specific ion channel and receptor subtypes. Each Conus species venom appears to contain a unique set of 50-200 peptides. The composition of the venom differs greatly between species and between individual snails within each species, each optimally evolved to paralyse it's prey. The active components of the venom are small peptides toxins, typically 10-40 amino acid residues in length and are typically highly constrained peptides due to their high density of disulphide bonds.

The venoms consist of a large number of different peptide components that when separated exhibit a range of biological activities: when injected into mice they elicit a range of physiological responses from shaking to depression. The paralytic components of the venom that have been the focus of recent investigation are the α-, ω- and μ-conotoxins. All of these conotoxins act by preventing neuronal communication, but each targets a different aspect of the process to achieve this. The α-conotoxins target nicotinic ligand gated channels, the μ-conotoxins target the voltage-gated sodium channels and the ω-conotoxins target the voltage-gated calcium channels (Olivera et al., 1985; Olivera et al., 1990). For example a linkage has been established between α-, αA- & ψ-conotoxins and the nicotinic ligand-gated ion channel; ω-conotoxins and the voltage-gated calcium channel; μ-conotoxins and the voltage-gated sodium channel; δ-conotoxins and the voltage-gated sodium channel; ν-conotoxins and the voltage-gated potassium channel; conantokins and the ligand-gated glutamate (NMDA) channel.

However, the structure and function of only a small minority of these peptides have been determined to date. For peptides where function has been determined, three classes of targets have been elucidated: voltage-gated ion channels; ligand-gated ion channels, and G-protein-linked receptors.

Conus peptides which target voltage-gated ion channels include those that delay the inactivation of sodium channels, as well as blockers specific for sodium channels, calcium channels and potassium channels. Peptides that target ligand-gated ion channels include antagonists of NMDA and serotonin receptors, as well as competitive and noncompetitive nicotinic receptor antagonists. Peptides which act on G-protein receptors include neurotensin and vasopressin receptor agonists. The unprecedented pharmaceutical selectivity of conotoxins is at least in part defined by a specific disulfide bond frameworks combined with hypervariable amino acids within disulfide loops (for a review see McIntosh et al., 1998).

There are drugs used in the treatment of pain, which are known in the literature and to the skilled artisan. See, for example, Merck Manual, 16th Ed. (1992). However, there is a demand for more active analgesic agents with diminished side effects and toxicity and which are non-addictive. The ideal analgesic would reduce the awareness of pain, produce analgesia over a wide range of pain types, act satisfactorily whether given orally or parenterally, produce minimal or no side effects, be free from tendency to produce tolerance and drug dependence.

Due to the high potency and exquisite selectivity of the conopeptides, several are in various stages of clinical development for treatment of human disorders. For example, two Conus peptides are being developed for the treatment of pain. The most advanced is ω-conotoxin MVIIA (ziconotide), an N-type calcium channel blocker (see Heading, C., 1999; U.S. Pat. No. 5,859,186). ω-Conotoxin MVIIA, isolated from Conus magus, is approximately 1000 times more potent than morphine, yet does not produce the tolerance or addictive properties of opiates. ω-Conotoxin MVIIA has completed Phase III (final stages) of human clinical trials and has been approved as a therapeutic agent. ω-Conotoxin MVIIA is introduced into human patients by means of an implantable, programmable pump with a catheter threaded into the intrathecal space. Preclinical testing for use in post-surgical pain is being carried out on another Conus peptide, contulakin-G, isolated from Conus geographus (Craig et al. 1999). Contulakin-G is a 16 amino acid O-linked glycopeptide whose C-terminus resembles neurotensin. It is an agonist of neurotensin receptors, but appears significantly more potent than neurotensin in inhibiting pain in in vivo assays.

In view of a large number of biologically active substances in Conus species it is desirable to further characterize them and to identify peptides capable of treating disorders involving voltage gated ion channels, such as stroke and pain. Surprisingly, and in accordance with this invention, Applicants have discovered novel conotoxins that can be useful for the treatment of disorders involving voltage gated ion channels and could address a long felt need for a safe and effective treatment.

SUMMARY OF THE INVENTION

The present invention is to μ-conopeptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated sodium channels. Thus, the μ-conopeptides or derivatives are useful as neuromuscular blocking agents, local anesthetic agents, analgesic agents and neuroprotective agents. The μ-conopeptides are also useful for treating neuromuscular disorders. The invention is further directed to nucleic acid sequences encoding the μ-conopeptides and encoding propeptides, as well as the propeptides.

More specifically, the present invention is directed to μ-conopeptides, having the amino acid sequences set forth in Tables 1 and 2 below.

The present invention is also directed to derivatives or pharmaceutically acceptable salts of the μ-conopeptides or the derivatives. Examples of derivatives include peptides in which the Arg residues may be substituted by Lys, ornithine, homoargine, nor-Lys, N-methyl-Lys, N,N-dimethyl-Lys, N,N,N-trimethyl-Lys or any synthetic basic amino acid; the Lys residues may be substituted by Arg, ornithine, homoargine, nor-Lys, or any synthetic basic amino acid; the Tyr residues may be substituted with meta-Tyr, ortho-Tyr, nor-Tyr, mono-halo-Tyr, di-halo-Tyr, O-sulpho-Tyr, O-phospho-Tyr, nitro-Tyr or any synthetic hydroxy containing amino acid; the Ser residues may be substituted with Thr or any synthetic hydroxylated amino acid; the Thr residues may be substituted with Ser or any synthetic hydroxylated amino acid; the Phe residues may be substituted with any synthetic aromatic amino acid; the Trp residues may be substituted with Trp (D), neo-Trp, halo-Trp (D or L) or any aromatic synthetic amino acid; and the Asn, Ser, Thr or Hyp residues may be glycosylated. The halogen may be iodo, chloro, fluoro or bromo; preferably iodo for halogen substituted-Tyr and bromo for halogen-substituted Trp. The Tyr residues may also be substituted with the 3-hydroxyl or 2-hydroxyl isomers (meta-Tyr or ortho-Tyr, respectively) and corresponding O-sulpho- and O-phospho-derivatives. The acidic amino acid residues may be substituted with any synthetic acidic amino acid, e.g., tetrazolyl derivatives of Gly and Ala. The aliphatic amino acids may be substituted by synthetic derivatives bearing non-natural aliphatic branched or linear side chains C_(n)H_(2n+2) up to and including n=8. The Met residues may be substituted by norleucine (Nle). The Cys residues may be in D or L configuration and may optionally be substituted with homocysteine (D or L).

Examples of synthetic aromatic amino acid include, but are not limited to, nitro-Phe, 4-substituted-Phe wherein the substituent is C₁-C₃ alkyl, carboxyl, hyrdroxymethyl, sulphomethyl, halo, phenyl, —CHO, —CN, —SO₃H and —NHAc. Examples of synthetic hydroxy containing amino acid, include, but are not limited to, such as 4-hydroxymethyl-Phe, 4-hydroxyphenyl-Gly, 2,6-dimethyl-Tyr and 5-amino-Tyr. Examples of synthetic basic amino acids include, but are not limited to, N-1-(2-pyrazolinyl)-Arg, 2-(4-piperinyl)-Gly, 2-(4-piperinyl)-Ala, 2-[3-(2S)pyrrolininyl)-Gly and 2-[3-(2S)pyrrolininyl)-Ala. These and other synthetic basic amino acids, synthetic hydroxy containing amino acids or synthetic aromatic amino acids are described in Building Block Index, Version 3.0(1999 Catalog, pages 4-47 for hydroxy containing amino acids and aromatic amino acids and pages 66-87 for basic amino acids incorporated herein by reference, by and available from RSP Amino Acid Analogues, Inc., Worcester, Mass. Examples of synthetic acid amino acids include those derivatives bearing acidic functionality, including carboxyl, phosphate, sulfonate and synthetic tetrazolyl derivatives such as described by Ornstein et al. (1993) and in U.S. Pat. No. 5,331,001, each incorporated herein by reference.

Optionally, in the μ-conopeptides of the present invention, the Asn residues may be modified to contain an N-glycan and the Ser, Thr and Hyp residues may be modified to contain an O-glycan (e.g., g-N, g-S, g-T and g-Hyp). In accordance with the present invention, a glycan shall mean any N-, S- or O-linked mono-, di-, tri-, poly- or oligosaccharide that can be attached to any hydroxy, amino or thiol group of natural or modified amino acids by synthetic or enzymatic methodologies known in the art. The monosaccharides making up the glycan can include D-allose, D-altrose, D-glucose, D-mannose, D-gulose, D-idose, D-galactose, D-talose, D-galactosamine, D-glucosamine, D-N-acetyl-glucosamine (GlcNAc), D-N-acetyl-galactosamine (GalNAc), D-fucose or D-arabinose. These saccharides may be structurally modified, e.g., with one or more O-sulfate, O-phosphate, O-acetyl or acidic groups, such as sialic acid, including combinations thereof. The gylcan may also include similar polyhydroxy groups, such as D-penicillamine 2,5 and halogenated derivatives thereof or polypropylene glycol derivatives. The glycosidic linkage is beta and 1-4 or 1-3, preferably 1-3. The linkage between the glycan and the amino acid may be alpha or beta, preferably alpha and is 1-.

Core O-glycans have been described by Van de Steen et al. (1998), incorporated herein by reference. Mucin type O-linked oligosaccharides are attached to Ser or Thr (or other hydroxylated residues of the present peptides) by a GalNAc residue. The monosaccharide building blocks and the linkage attached to this first GalNAc residue define the “core glycans,” of which eight have been identified. The type of glycosidic linkage (orientation and connectivities) are defined for each core glycan. Suitable glycans and glycan analogs are described further in U.S. Ser. No. 09/420,797 filed Oct. 19, 1999 and in PCT Application No. PCT/US99/24380 filed Oct. 19, 1999 (PCT Published Application No. WO 00/23092), each incorporated herein by reference. A preferred glycan is Gal(β1→3)GalNAc(α1→).

Optionally, in the μ-conopeptides described above, pairs of Cys residues may be replaced pairwise with isoteric lactam or ester-thioether replacements, such as Ser/(Glu or Asp), Lys/(Glu or Asp), Cys/(Glu or Asp) or Cys/Ala combinations. Sequential coupling by known methods (Barnay et al., 2000; Hruby et al., 1994; Bitan et al., 1997) allows replacement of native Cys bridges with lactam bridges. Thioether analogs may be readily synthesized using halo-Ala residues commercially available from RSP Amino Acid Analogues.

The present invention is further directed to derivatives of the above peptides and peptide derivatives which are acylic permutations in which the cyclic permutants retain the native bridging pattern of native toxin. See, for example, Craik et al. (2001).

The present invention is further directed to a method of treating disorders associated with voltage gated ion channel disorders in a subject comprising administering to the subject an effective amount of the pharmaceutical composition comprising a therapeutically effective amount of a μ-conopeptide described herein or a pharmaceutically acceptable salt or solvate thereof. The present invention is also directed to a pharmaceutical composition comprising a therapeutically effective amount of a μ-conopeptide described herein or a pharmaceutically acceptable salt or solvate thereof and a pharmaceutically acceptable carrier.

More specifically, the present invention is further directed to uses of these peptides or nucleic acids as described herein as neuromuscular blocking agents, local anesthetic agents, analgesic agents and neuroprotective agents. The μ-conopeptides are also useful for treating neuromuscular disorders.

The present invention is directed to the use of μ-conopeptides as a local anesthetic for treating pain. The μ-conopeptides have long lasting anesthetic activity and are particularly useful for spinal anesthesia, either administered acutely for post-operative pain or via an intrathecal pump for severe chronic pain situations. The μ-conopeptides are also useful as analgesics in chronic and neuropathic pain states, such as trigeminal neuralgia, diabetic neuropathy, post-herpetic neuralgia, neuroma pain and phantom limb pain. The μ-conopeptides are also useful for treating burn pain and as ocular anesthetics.

The present invention is directed to the use of μ-conopeptides as neuroprotectants. The μ-conopeptides are useful for the treatment and alleviation of epilepsy and as a general anticonvulsant agent. The μ-conopeptides are also useful for treating neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS). The μ-conopeptides are further useful as cerebroprotectants, such as for reducing neurotoxic injury associated with conditions of hypoxia, anoxia or ischemia which typically follows stroke, cerebrovascular accident, brain or spinal cord trauma, myocardial infarct, physical trauma, drowning, suffocation, perinatal asphyxia, or hypoglycemic events.

The present invention is directed to the use of μ-conopeptides as neuromuscular blockers and for treating neuromuscular disorders. As such, the μ-conopeptides are useful for providing relaxation of muscle, for treating benign essential blepharospasm and other forms of focal dystonia and for anti-wrinkle use.

More specifically, the present invention is also directed to nucleic acids which encode μ-conopeptides of the present invention or which encodes precursor peptides for these μ-conopeptides, as well as the precursor peptide. The nucleic acid sequences encoding the precursor peptides of other μ-conopeptides of the present invention are set forth in Table 1. Table 1 also sets forth the amino acid sequences of these precursor peptides.

The present invention is further directed to the use of selectively radioiodinated or radiotritiated μ-conopeptides for characterizing pore occlusion sites on different sodium channel subtypes or for use in screening assays.

The present invention is also directed to the use of μ-conopeptides for screening small molecule libraries to identify small molecules that are selective blocking agents at specific sodium channel subtypes expressed in mammalian systems. In one embodiment, the blocking activity of a small molecule at a particular sodium channel subtype is compared to the blocking activity of a μ-conopeptide at the same sodium channel subtype. In a second embodiment, the ability of a small molecule to displace a μ-conopeptide from a sodium channel subtype is determined. In a third emdiment, the binding affinity of a small molecule for a sodium channel subtype is compared to the binding affinity of a μ-conopeptide for the same sodium channel subtype.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

The present invention is to μ-conopeptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated sodium channels. Thus, the μ-conopeptides or derivatives are useful as neuromuscular blocking agents, local anesthetic agents, analgesic agents and neuroprotective agents. The μ-conopeptides are also useful for treating neuromuscular disorders. The invention is further directed to nucleic acid sequences encoding the μ-conopeptides and encoding propeptides, as well as the propeptides.

The present invention, in another aspect, relates to a pharmaceutical composition comprising an effective amount of an μ-conopeptides, a mutein thereof, an analog thereof, an active fragment thereof or pharmaceutically acceptable salts or solvates. Such a pharmaceutical composition has the capability of acting at voltage gated ion channels, and are thus useful for treating a disorder or disease of a living animal body, including a human, which disorder or disease is responsive to the partial or complete blockade of voltage gated ion channels of the central nervous system comprising the step of administering to such a living animal body, including a human, in need thereof a therapeutically effective amount of a pharmaceutical composition of the present invention.

The present invention is directed to the use of μ-conopeptides as neuromuscular blockers and for treating neuromuscular disorders. As such, the μ-conopeptides are useful for providing relaxation of muscle, for treating benign essential blepharospasm and other forms of focal dystonia and for anti-wrinkle use. Thus, in one aspect, the μ-conopeptides are useful as neurmuscular blocking agents in conjunction with surgery or for intubation of the trachea by conventional parenteral administration e.g., intramuscular or intravenous administration in solution. In a second aspect, the μ-conopeptides are useful as agents for treating neuromuscular disorders such as myofacial pain syndrome, chronic muscle spasm, dystonias and spasticity.

The primary factor detrimental to neurons in neurological disorders associated with deficient oxygen supply or mitochondrial dysfunction is insufficient ATP production relative to their requirement. As a large part of the energy consumed by brain cells is used for maintenance of the Na⁺gradient across the cellular membrane, reduction of energy demand by down-modulation of voltage-gated Na(+)-channels is one strategy for neuroprotection. In addition, preservation of the inward Na⁺gradient may be beneficial because it is an essential driving force for vital ion exchanges and transport mechanisms such as Ca²⁺homeostasis and neurotransmitter uptake. Thus, the μ-conopeptides of the present invention are useful as neuroprotectants.

Thus, the pharmaceutical compositions of the present invention are useful as neuroprotectants, especially cerebroprotectants, neuromuscular blockers, analgesics (both as a local anesthetic and for general analgesia use) or adjuvants to general anesthetics. A “neurological disorder or disease” is a disorder or disease of the nervous system including, but not limited to, global and focal ischemic and hemorrhagic stroke, head trauma, spinal cord injury, hypoxia-induced nerve cell damage as in cardiac arrest or neonatal distress or epilepsy. In addition, a “neurological disorder or disease” is a disease state and condition in which a neuroprotectant, anticonvulsant, analgesic and/or as an adjunct in general anesthesia may be indicated, useful, recommended or prescribed.

More specifically, the present invention is directed to the use of these compounds for reducing neurotoxic injury associated with conditions of hypoxia, anoxia or ischemia which typically follows stroke, cerebrovascular accident, brain or spinal cord trauma, myocardial infarct, physical trauma, drowning, suffocation, perinatal asphyxia, or hypoglycemic events. The present invention is further directed to the use of these compounds for treating pain, including acute and chronic pain, such migraine, nociceptive and neuropathic pain.

A “neuroprotectant” is a compound capable of preventing the neuronal death associated with a neurological disorder or disease. An “analgesic” is a compound capable of relieving pain by altering perception of nociceptive stimuli without producing anesthesia or loss it of consciousness. A “muscle relaxant” is a compound that reduces muscular tension. An “adjunct in general anesthesia” is a compound useful in conjunction with anesthetic agents in producing the loss of ability to perceive pain associated with the loss of consciousness.

The invention relates as well to methods useful for treatment of neurological disorders and diseases, including, but not limited to, global and focal ischemic and hemorrhagic stroke, head trauma, spinal cord injury, hypoxia-induced nerve cell damage such as in cardiac arrest or neonatal distress, epilepsy or other convulsive disorders without undesirable side effects.

Thus, in one embodiment, the invention provides a method of reducing/alleviating/ decreasing the perception of pain by a subject or for inducing analgesia in a subject comprising administering to the subject an effective amount of the pharmaceutical composition comprising a therapeutically effective amount of a μ-conopeptide described herein or a pharmaceutically acceptable salt or solvate thereof. The pain may be acute, persistent, inflammatory or neuropathic pain. The μ-conopeptides are useful as an analgesia for chronic and neuropathic pain states, such as trigeminal neuralgia, diabetic neuropathy, post-herpetic neuralgia, neuroma pain, phantom limb pain. These peptides are also useful for treating burn pain and as ocular anesthetics.

In a second embodiment, the invention provides a method of reducing/alleviating/decreasing the perception of pain by a subject or for inducing analgesia, particularly local analgesia, in a subject comprising administering to the subject an effective amount of the pharmaceutical composition comprising a therapeutically effective amount of a μ-conopeptide described herein or a pharmaceutically acceptable salt or solvate thereof. These peptides are also useful for treating burn pain and as ocular anesthetics.

In a third embodiment, the invention provides a method of treating stroke, head or spinal cord trauma or injury, anoxia, hypoxia-induced nerve cell damage, ischemia, migraine, psychosis, anxiety, schizophrenia, inflammation, movement disorder, epilepsy, any other convulsive disorder or in the prevention of the degenerative changes connected with the same in a subject comprising administering to the subject an effective amount of the pharmaceutical composition comprising a therapeutically effective amount of a μ-conopeptide described herein or a pharmaceutically acceptable salt or solvate thereof.

In a fourth embodiment, the invention provides a method for providing a neuromuscular block or for treating neuromuscular disorders, such as methods for providing relaxation of muscle, for treating benign essential blepharospasm and other forms of focal dystonia and for anti-wrinkle use. Thus, in one aspect, the μ-conopeptides are useful as neurmuscular blocking agents in conjunction with surgery or for intubation of the trachea by conventional parenteral administration e.g., intramuscular or intravenous administration in solution. In a second aspect, the μ-conopeptides are useful as agents for treating neuromuscular disorders such as myofacial pain syndrome, chronic muscle spasm, dystonias and spasticity.

The present invention is also directed to the use of μ-conopeptides for screening small molecule libraries to identify small molecules that are selective blocking agents at specific sodium channel subtypes expressed in mammalian systems. In one embodiment, the blocking activity of a small molecule at a particular sodium channel subtype is compared to the blocking activity of a μ-conopeptide at the same sodium channel subtype. In a second embodiment, the ability of a small molecule to displace a μ-conopeptide from a sodium channel subtype is determined. In a third emdiment, the binding affinity of a small molecule for a sodium channel subtype is compared to the binding affinity of a μ-conopeptide for the same sodium channel subtype.

The μ-conopeptides described herein are sufficiently small to be chemically synthesized. General chemical syntheses for preparing the foregoing ω-conotoxin peptides are described hereinafter. Various ones of the μ-conopeptides can also be obtained by isolation and purification from specific Conus species using the technique described in U.S. Pat. No. 4,447,356 (Olivera et al., 1984); U.S. Pat. Nos. 5,514,774; 5,719,264; and 5,591,821, as well as in PCT published application WO 98/03189, the disclosures of which are incorporated herein by reference.

Although the μ-conopeptides of the present invention can be obtained by purification from cone snails, because the amounts of μ-conopeptides obtainable from individual snails are very small, the desired substantially pure μ-conopeptides are best practically obtained in commercially valuable amounts by chemical synthesis using solid-phase strategy. For example, the yield from a single cone snail may be about 10 micrograms or less of μ-conopeptides peptide. By “substantially pure” is meant that the peptide is present in the substantial absence of other biological molecules of the same type; it is preferably present in an amount of at least about 85% purity and preferably at least about 95% purity. Chemical synthesis of biologically active μ-conopeptides peptides depends of course upon correct determination of the amino acid sequence.

The μ-conopeptides can also be produced by recombinant DNA techniques well known in the art. Such techniques are described by Sambrook et al. (1989). A gene of interest (i.e., a gene that encodes a suitable μ-conopeptides) can be inserted into a cloning site of a suitable expression vector by using standard techniques. These techniques are well known to those skilled in the art. The expression vector containing the gene of interest may then be used to transfect the desired cell line. Standard transfection techniques such as calcium phosphate co-precipitation, DEAE-dextran transfection or electroporation may be utilized. A wide variety of host/expression vector combinations may be used to express a gene encoding a conotoxin peptide of interest. Such combinations are well known to a skilled artisan. The peptides produced in this manner are isolated, reduced if necessary, and oxidized to form the correct disulfide bonds.

One method of forming disulfide bonds in the μ-conopeptides of the present invention is the air oxidation of the linear peptides for prolonged periods under cold room temperatures or at room temperature. This procedure results in the creation of a substantial amount of the bioactive, disulfide-linked peptides. The oxidized peptides are fractionated using reverse-phase high performance liquid chromatography (HPLC) or the like, to separate peptides having different linked configurations. Thereafter, either by comparing these fractions with the elution of the native material or by using a simple assay, the particular fraction having the correct linkage for maximum biological potency is easily determined. However, because of the dilution resulting from the presence of other fractions of less biopotency, a somewhat higher dosage may be required.

The peptides are synthesized by a suitable method, such as by exclusively solid-phase techniques, by partial solid-phase techniques, by fragment condensation or by classical solution couplings.

In conventional solution phase peptide synthesis, the peptide chain can be prepared by a series of coupling reactions in which constituent amino acids are added to the growing peptide chain in the desired sequence. Use of various coupling reagents, e.g., dicyclohexylcarbodiimide or diisopropylcarbonyldimidazole, various active esters, e.g., esters of N-hydroxyphthalimide or N-hydroxy-succinimide, and the various cleavage reagents, to carry out reaction in solution, with subsequent isolation and purification of intermediates, is well known classical peptide methodology. Classical solution synthesis is described in detail in the treatise, “Methoden der Organischen Chemie (Houben-Weyl): Synthese von Peptiden,” (1974). Techniques of exclusively solid-phase synthesis are set forth in the textbook, “Solid-Phase Peptide Synthesis,” (Stewart and Young, 1969), and are exemplified by the disclosure of U.S. Pat. No. 4,105,603 (Vale et al., 1978). The fragment condensation method of synthesis is exemplified in U.S. Pat. No. 3,972,859 (1976). Other available syntheses are exemplified by U.S. Pat. No. 3,842,067 (1974) and U.S. Pat. No. 3,862,925 (1975). The synthesis of peptides containing γ-carboxyglutamic acid residues is exemplified by Rivier et al. (1987), Nishiuchi et al. (1993) and Zhou et al. (1996).

Common to such chemical syntheses is the protection of the labile side chain groups of the various amino acid moieties with suitable protecting groups which will prevent a chemical reaction from occurring at that site until the group is ultimately removed. Usually also common is the protection of an α-amino group on an amino acid or a fragment while that entity reacts at the carboxyl group, followed by the selective removal of the α-amino protecting group to allow subsequent reaction to take place at that location. Accordingly, it is common that, as a step in such a synthesis, an intermediate compound is produced which includes each of the amino acid residues located in its desired sequence in the peptide chain with appropriate side-chain protecting groups linked to various ones of the residues having labile side chains.

As far as the selection of a side chain amino protecting group is concerned, generally one is chosen which is not removed during deprotection of the α-amino groups during the synthesis. However, for some amino acids, e.g., His, protection is not generally necessary. In selecting a particular side chain protecting group to be used in the synthesis of the peptides, the following general rules are followed: (a) the protecting group preferably retains its protecting properties and is not split off under coupling conditions, (b) the protecting group should be stable under the reaction conditions selected for removing the α-amino protecting group at each step of the synthesis, and (c) the side chain protecting group must be removable, upon the completion of the synthesis containing the desired amino acid sequence, under reaction conditions that will not undesirably alter the peptide chain.

It should be possible to prepare many, or even all, of these peptides using recombinant DNA technology. However, when peptides are not so prepared, they are preferably prepared using the Merrifield solid-phase synthesis, although other equivalent chemical syntheses known in the art can also be used as previously mentioned. Solid-phase synthesis is commenced from the C-terminus of the peptide by coupling a protected α-amino acid to a suitable resin. Such a starting material can be prepared by attaching an α-amino-protected amino acid by an ester linkage to a chloromethylated resin or a hydroxymethyl resin, or by an amide bond to a benzhydrylamine (BHA) resin or paramethylbenzhydrylamine (MBHA) resin. Preparation of the hydroxymethyl resin is described by Bodansky et al. (1966). Chloromethylated resins are commercially available from Bio Rad Laboratories (Richmond, Calif.) and from Lab. Systems, Inc. The preparation of such a resin is described by Stewart and Young (1969). BHA and MBHA resin supports are commercially available, and are generally used when the desired polypeptide being synthesized has an unsubstituted amide at the C-terminus. Thus, solid resin supports may be any of those known in the art, such as one having the formulae —O—CH₂-resin support, —NH—MBHA resin support, or —NH—MBHA resin support. When the unsubstituted amide is desired, use of a BHA or MBHA resin is preferred, because cleavage directly gives the amide. In case the N-methyl amide is desired, it can be generated from an N-methyl BHA resin. Should other substituted amides be desired, the teaching of U.S. Pat. No. 4,569,967 (Kornreich et al., 1986) can be used, or should still other groups than the free acid be desired at the C-terminus, it may be preferable to synthesize the peptide using classical methods as set forth in the Houben-Weyl text (1974).

The C-terminal amino acid, protected by Boc or Fmoc and by a side-chain protecting group, if appropriate, can be first coupled to a chloromethylated resin according to the procedure set forth in K. Horiki et al. (1978), using KF in DMF at about 60° C. for 24 hours with stirring, when a peptide having free acid at the C-terminus is to be synthesized. Following the coupling of the BOC-protected amino acid to the resin support, the α-amino protecting group is removed, as by using trifluoroacetic acid (TFA) in methylene chloride or TFA alone. The deprotection is carried out at a temperature between about 0° C. and room temperature. Other standard cleaving reagents, such as HCl in dioxane, and conditions for removal of specific α-amino protecting groups may be used as described in Schroder & Lubke (1965).

After removal of the α-amino-protecting group, the remaining α-amino- and side chain-protected amino acids are coupled step-wise in the desired order to obtain the intermediate compound defined hereinbefore, or as an alternative to adding each amino acid separately in the synthesis, some of them may be coupled to one another prior to addition to the solid phase reactor. Selection of an appropriate coupling reagent is within the skill of the art. Particularly suitable as a coupling reagent is N,N′-dicyclohexylcarbodiimide (DCC, DIC, HBTU, HATU, TBTU in the presence of HoBt or HoAt).

The activating reagents used in the solid phase synthesis of the peptides are well known in the peptide art. Examples of suitable activating reagents are carbodiimides, such as N,N′-diisopropylcarbodiimide and N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide. Other activating reagents and their use in peptide coupling are described by Schroder & Lubke (1965) and Kapoor (1970).

Each protected amino acid or amino acid sequence is introduced into the solid-phase reactor in about a twofold or more excess, and the coupling may be carried out in a medium of dimethylformamide (DMF):CH₂Cl₂ (1:1) or in DMF or CH₂Cl₂ alone. In cases where intermediate coupling occurs, the coupling procedure is repeated before removal of the α-amino protecting group prior to the coupling of the next amino acid. The success of the coupling reaction at each stage of the synthesis, if performed manually, is preferably monitored by the ninhydrin reaction, as described by Kaiser et al. (1970). Coupling reactions can be performed automatically, as on a Beckman 990 automatic synthesizer, using a program such as that reported in Rivier et al. (1978).

After the desired amino acid sequence has been completed, the intermediate peptide can be removed from the resin support by treatment with a reagent, such as liquid hydrogen fluoride or TFA (if using Fmoc chemistry), which not only cleaves the peptide from the resin but also cleaves all remaining side chain protecting groups and also the -amino protecting group at the N-terminus if it was not previously removed to obtain the peptide in the form of the free acid. If Met is present in the sequence, the Boc protecting group is preferably first removed using trifluoroacetic acid (TFA)/ethanedithiol prior to cleaving the peptide from the resin with HF to eliminate potential S-alkylation. When using hydrogen fluoride or TFA for cleaving, one or more scavengers such as anisole, cresol, dimethyl sulfide and methylethyl sulfide are included in the reaction vessel.

Cyclization of the linear peptide is preferably affected, as opposed to cyclizing the peptide while a part of the peptido-resin, to create bonds between Cys residues. To effect such a disulfide cyclizing linkage, fully protected peptide can be cleaved from a hydroxymethylated resin or a chloromethylated resin support by ammonolysis, as is well known in the art, to yield the fully protected amide intermediate, which is thereafter suitably cyclized and deprotected. Alternatively, deprotection, as well as cleavage of the peptide from the above resins or a benzhydrylamine (BHA) resin or a methylbenzhydrylamine (MBHA), can take place at 0° C. with hydrofluoric acid (HF) or TFA, followed by oxidation as described above.

The peptides are also synthesized using an automatic synthesizer. Amino acids are sequentially coupled to an MBHA Rink resin (typically 100 mg of resin) beginning at the C-terminus using an Advanced Chemtech 357 Automatic Peptide Synthesizer. Couplings are carried out using 1,3-diisopropylcarbodimide in N-methylpyrrolidinone (NMP) or by 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) and diethylisopropylethylamine (DIEA). The FMOC protecting group is removed by treatment with a 20% solution of piperidine in dimethylformamide(DMF). Resins are subsequently washed with DMF (twice), followed by methanol and NMP.

Muteins, analogs or active fragments, of the foregoing conotoxin peptides are also contemplated here. See, e.g., Hammerland et al. (1992). Derivative muteins, analogs or active fragments of the conotoxin peptides may be synthesized according to known techniques, including conservative amino acid substitutions, such as outlined in U.S. Pat. No. 5,545,723 (see particularly col. 2, line 50 —col. 3, line 8); U.S. Pat. No. 5,534,615 (see particularly col. 19, line 45—col. 22, line 33); and U.S. Pat. No. 5,364,769 (see particularly col. 4, line 55—col. 7, line 26), each herein incorporated by reference.

The μ-conopeptides of the present invention are also useful to reduce neurotoxic injury associated with conditions of hypoxia, anoxia or ischemia which typically follows stroke, cerebrovascular accident, brain or spinal chord trauma, myocardial infarct, physical trauma, drownings, suffocation, perinatal asphyxia, or hypoglycemic events. To reduce neurotoxic injury, an ω-conopeptide should be administered in a therapeutically effective amount to the patient within 24 hours of the onset of the hypoxic, anoxic or ischemic condition in order for the μ-conopeptide to effectively minimize the CNS damage which the patient will experience.

The μ-conopeptides of the present invention are further useful in controlling pain, e.g., as analgesic agents, and the treatment of migraine, acute pain or persistent pain. They can be used prophylactically or to relieve the symptoms associated with a migraine episode, or to treat acute or persistent pain. For these uses, an μ-conopeptide is administered in a therapeutically effective amount to overcome or to ease the pain.

The μ-conopeptides of the present invention are also useful as neuromuscular blockers and for treating neuromuscular disorders. They can be used for providing relaxation of muscle, for treating benign essential blepharospasm and other forms of focal dystonia and for anti-wrinkle use. Thus, in one aspect, the μ-conopeptides are used as neurmuscular blocking agents in conjunction with surgery or for intubation of the trachea by conventional parenteral administration e.g., intramuscular or intravenous administration in solution. In a second aspect, the μ-conopeptides are used as agents for treating neuromuscular disorders such as myofacial pain syndrome, chronic muscle spasm, dystonias and spasticity. For these uses, a μ-conopeptide is administered in a therapeutically effective amount to relax muscle or provide a neuromuscular block.

Pharmaceutical compositions containing a compound of the present invention as the active ingredient can be prepared according to conventional pharmaceutical compounding techniques. See, for example, Remington's Pharmaceutical Sciences, 18th Ed. (1990, Mack Publishing Co., Easton, Pa.). Typically, an antagonistic amount of active ingredient will be admixed with a pharmaceutically acceptable carrier. The carrier may take a wide variety of forms depending on the form of preparation desired for administration, e.g., intravenous, oral, parenteral or intrathecally. For examples of delivery methods see U.S. Pat. No. 5,844,077, incorporated herein by reference.

“Pharmaceutical composition” means physically discrete coherent portions suitable for medical administration. “Pharmaceutical composition in dosage unit form” means physically discrete coherent units suitable for medical administration, each containing a daily dose or a multiple (up to four times) or a sub-multiple (down to a fortieth) of a daily dose of the active compound in association with a carrier and/or enclosed within an envelope. Whether the composition contains a daily dose, or for example, a half, a third or a quarter of a daily dose, will depend on whether the pharmaceutical composition is to be administered once or, for example, twice, three times or four times a day, respectively.

The term “salt”, as used herein, denotes acidic and/or basic salts, formed with inorganic or organic acids and/or bases, preferably basic salts. While pharmaceutically acceptable salts are preferred, particularly when employing the compounds of the invention as medicaments, other salts find utility, for example, in processing these compounds, or where non-medicament-type uses are contemplated. Salts of these compounds may be prepared by art-recognized techniques.

Examples of such pharmaceutically acceptable salts include, but are not limited to, inorganic and organic addition salts, such as hydrochloride, sulphates, nitrates or phosphates and acetates, trifluoroacetates, propionates, succinates, benzoates, citrates, tartrates, fumarates, maleates, methane-sulfonates, isothionates, theophylline acetates, salicylates, respectively, or the like. Lower alkyl quaternary ammonium salts and the like are suitable, as well.

As used herein, the term “pharmaceutically acceptable” carrier means a non-toxic, inert solid, semi-solid liquid filler, diluent, encapsulating material, formulation auxiliary of any type, or simply a sterile aqueous medium, such as saline. Some examples of the materials that can serve as pharmaceutically acceptable carriers are sugars, such as lactose, glucose and sucrose, starches such as corn starch and potato starch, cellulose and its derivatives such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; powdered tragacanth; malt, gelatin, talc; excipients such as cocoa butter and suppository waxes; oils such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; glycols, such as propylene glycol, polyols such as glycerin, sorbitol, mannitol and polyethylene glycol; esters such as ethyl oleate and ethyl laurate, agar; buffering agents such as magnesium hydroxide and aluminum hydroxide; alginic acid; pyrogen-free water; isotonic saline, Ringer's solution; ethyl alcohol and phosphate buffer solutions, as well as other non-toxic compatible substances used in pharmaceutical formulations.

Wetting agents, emulsifiers and lubricants such as sodium lauryl sulfate and magnesium stearate, as well as coloring agents, releasing agents, coating agents, sweetening, flavoring and perfuming agents, preservatives and antioxidants can also be present in the composition, according to the judgment of the formulator. Examples of pharmaceutically acceptable antioxidants include, but are not limited to, water soluble antioxidants such as ascorbic acid, cysteine hydrochloride, sodium bisulfite, sodium metabisulfite, sodium sulfite, and the like; oil soluble antioxidants, such as ascorbyl palmitate, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), lecithin, propyl gallate, aloha-tocopherol and the like; and the metal chelating agents such as citric acid, ethylenediamine tetraacetic acid (EDTA), sorbitol, tartaric acid, phosphoric acid and the like.

For oral administration, the compounds can be formulated into solid or liquid preparations such as capsules, pills, tablets, lozenges, melts, powders, suspensions or emulsions. In preparing the compositions in oral dosage form, any of the usual pharmaceutical media may be employed, such as, for example, water, glycols, oils, alcohols, flavoring agents, preservatives, coloring agents, suspending agents, and the like in the case of oral liquid preparations (such as, for example, suspensions, elixirs and solutions); or carriers such as starches, sugars, diluents, granulating agents, lubricants, binders, disintegrating agents and the like in the case of oral solid preparations (such as, for example, powders, capsules and tablets). Because of their ease in administration, tablets and capsules represent the most advantageous oral dosage unit form, in which case solid pharmaceutical carriers are obviously employed. If desired, tablets may be sugar-coated or enteric-coated by standard techniques. The active agent can be encapsulated to make it stable to passage through the gastrointestinal tract while at the same time allowing for passage across the blood brain barrier. See for example, WO 96/11698.

For parenteral administration, the compound may be dissolved in a pharmaceutical carrier and administered as either a solution or a suspension. Illustrative of suitable carriers are water, saline, dextrose solutions, fructose solutions, ethanol, or oils of animal, vegetative or synthetic origin. The carrier may also contain other ingredients, for example, preservatives, suspending agents, solubilizing agents, buffers and the like. When the compounds are being administered intrathecally, they may also be dissolved in cerebrospinal fluid.

A variety of administration routes are available. The particular mode selected will depend of course, upon the particular drug selected, the severity of the disease state being treated and the dosage required for therapeutic efficacy. The methods of this invention, generally speaking, may be practiced using any mode of administration that is medically acceptable, meaning any mode that produces effective levels of the active compounds without causing clinically unacceptable adverse effects. Such modes of administration include oral, rectal, sublingual, topical, nasal, transdermal or parenteral routes. The term “parenteral” includes subcutaneous, intravenous, epidural, irrigation, intramuscular, release pumps, or infusion.

For example, administration of the active agent according to this invention may be achieved using any suitable delivery means, including:

(a) pump (see, e.g., Luer & Hatton (1993), Zimm et al. (1984) and Ettinger et al. (1978));

(b), microencapsulation (see, e.g., U.S. Pat. Nos. 4,352,883; 4,353,888; and 5,084,350);

(c) continuous release polymer implants (see, e.g., U.S. Pat. No. 4,883,666);

(d) macroencapsulation (see, e.g., U.S. Pat. Nos. 5,284,761, 5,158,881, 4,976,859 and 4,968,733 and published PCT patent applications W092/19195, WO 95/05452);

(e) naked or unencapsulated cell grafts to the CNS (see, e.g., U.S. Pat. Nos. 5,082,670 and 5,618,531);

(f) injection, either subcutaneously, intravenously, intra-arterially, intramuscularly, or to other suitable site; or

(g) oral administration, in capsule, liquid, tablet, pill, or prolonged release formulation.

In one embodiment of this invention, an active agent is delivered directly into the CNS, preferably to the brain ventricles, brain parenchyma, the intrathecal space or other suitable CNS location, most preferably intrathecally.

Alternatively, targeting therapies may be used to deliver the active agent more specifically to certain types of cell, by the use of targeting systems such as antibodies or cell specific ligands. Targeting may be desirable for a variety of reasons, e.g. if the agent is unacceptably toxic, or if it would otherwise require too high a dosage, or if it would not otherwise be able to enter the target cells.

The active agents, which are peptides, can also be administered in a cell based delivery system in which a DNA sequence encoding an active agent is introduced into cells designed for implantation in the body of the patient, especially in the spinal cord region. Suitable delivery systems are described in U.S. Pat. No. 5,550,050 and published PCT Application Nos. WO 92/19195, WO 94/25503, WO 95/01203, WO 95/05452, WO 96/02286, WO 96/02646, WO 96/40871, WO 96/40959 and WO 97/12635. Suitable DNA sequences can be prepared synthetically for each active agent on the basis of the developed sequences and the known genetic code.

Exemplary methods for administering such muscle relaxant compounds (e.g., so as to achieve sterile or aseptic conditions) will be apparent to the skilled artisan. Certain methods suitable for administering compounds useful according to the present invention are set forth in Goodman and Gilman's The Pharmacological Basis of Therapeutics, 7th Ed. (1985). The administration to the patient can be intermittent; or at a gradual, continuous, constant or controlled rate. Administration can be to a warm-blooded animal (e.g. a mammal, such as a mouse, rat, cat, rabbit, dog, pig, cow or monkey); but advantageously is administered to a human being. Administration occurs after general anesthesia is administered. The frequency of administration normally is determined by an anesthesiologist, and typically varies from patient to patient.

The active agent is preferably administered in an therapeutically effective amount. By a “therapeutically effective amount” or simply “effective amount” of an active compound is meant a sufficient amount of the compound to treat the desired condition at a reasonable benefit/risk ratio applicable to any medical treatment. The actual amount administered, and the rate and time-course of administration, will depend on the nature and severity of the condition being treated. Prescription of treatment, e.g. decisions on dosage, timing, etc., is within the responsibility of general practitioners or spealists, and typically takes account of the disorder to be treated, the condition of the individual patient, the site of delivery, the method of administration and other factors known to practitioners. Examples of techniques and protocols can be found in Remington's Parmaceutical Sciences.

Dosage may be adjusted appropriately to achieve desired drug levels, locally or systemically. Typically the active agents of the present invention exhibit their effect at a dosage range from about 0.001 mg/kg to about 250 mg/kg, preferably from about 0.01 mg/kg to about 100 mg/kg of the active ingredient, more preferably from about 0.05 mg/kg to about 75 mg/kg. A suitable dose can be administered in multiple sub-doses per day. Typically, a dose or sub-dose may contain from about 0.1 mg to about 500 mg of the active ingredient per unit dosage form. A more preferred dosage will contain from about 0.5 mg to about 100 mg of active ingredient per unit dosage form. Dosages are generally initiated at lower levels and increased until desired effects are achieved. In the event that the response in a subject is insufficient at such doses, even higher doses (or effective higher doses by a different, more localized delivery route) may be employed to the extent that patient tolerance permits. Continuous dosing over, for example 24 hours or multiple doses per day are contemplated to achieve appropriate systemic levels of compounds.

For the treatment of pain, if the route of administration is directly to the CNS, the dosage contemplated is from about 1 ng to about 100 mg per day, preferably from about 100 ng to about 10 mg per day, more preferably from about 1 μg to about 100 μg per day. If administered peripherally, the dosage contemplated is somewhat higher, from about 100 ng to about 1000 mg per day, preferably from about 10 μg to about 100 mg per day, more preferably from about 100 μg to about 10 mg per day. If the conopeptide is delivered by continuous infusion (e.g., by pump delivery, biodegradable polymer delivery or cell-based delivery), then a lower dosage is contemplated than for bolus delivery.

Advantageously, the compositions are formulated as dosage units, each unit being adapted to supply a fixed dose of active ingredients. Tablets, coated tablets, capsules, ampoules and suppositories are examples of dosage forms according to the invention.

It is only necessary that the active ingredient constitute an effective amount, i.e., such that a suitable effective dosage will be consistent with the dosage form employed in single or multiple unit doses. The exact individual dosages, as well as daily dosages, are determined according to standard medical principles under the direction of a physician or veterinarian for use humans or animals.

The pharmaceutical compositions will generally contain from about 0.0001 to 99 wt. %, preferably about 0.001 to 50 wt. %, more preferably about 0.01 to 10 wt. % of the active ingredient by weight of the total composition. In addition to the active agent, the pharmaceutical compositions and medicaments can also contain other pharmaceutically active compounds. Examples of other pharmaceutically active compounds include, but are not limited to, analgesic agents, cytokines and therapeutic agents in all of the major areas of clinical medicine. When used with other pharmaceutically active compounds, the conopeptides of the present invention may be delivered in the form of drug cocktails. A cocktail is a mixture of any one of the compounds useful with this invention with another drug or agent. In this embodiment, a common administration vehicle (e.g., pill, tablet, implant, pump, injectable solution, etc.) would contain both the instant composition in combination supplementary potentiating agent. The individual drugs of the cocktail are each administered in therapeutically effective amounts. A therapeutically effective amount will be determined by the parameters described above; but, in any event, is that amount which establishes a level of the drugs in the area of body where the drugs are required for a period of time which is effective in attaining the desired effects.

The practice of the present invention employs, unless otherwise indicated, conventional techniques of chemistry, molecular biology, microbiology, recombinant DNA, genetics, immunology, cell biology, cell culture and transgenic biology, which are within the skill of the art. See, e.g., Maniatis et al., 1982; Sambrook et al., 1989; Ausubel et al., 1992; Glover, 1985; Anand, 1992; Guthrie and Fink, 1991; Harlow and Lane, 1988; Jakoby and Pastan, 1979; Nucleic Acid Hybridization (B. D. Hames & S. J. Higgins eds. 1984); Transcription And Translation (B. D. Hames & S. J. Higgins eds. 1984); Culture Of Animal Cells (R. I. Freshney, Alan R. Liss, Inc., 1987); Immobilized Cells And Enzymes (IRL Press, 1986); B. Perbal, A Practical Guide To Molecular Cloning (1984); the treatise, Methods In Enzymology (Academic Press, Inc., N.Y.); Gene Transfer Vectors For Mammalian Cells (J. H. Miller and M. P. Calos eds., 1987, Cold Spring Harbor Laboratory); Methods In Enzymology, Vols. 154 and 155 (Wu et al. eds.), Immunochemical Methods In Cell And Molecular Biology (Mayer and Walker, eds., Academic Press, London, 1987); Handbook Of Experimental Immunology, Volumes I-IV (D. M. Weir and C. C. Blackwell, eds., 1986); Riott, Essential Immunology, 6th Edition, Blackwell Scientific Publications, Oxford, 1988; Hogan et al., Manipulating the Mouse Embryo, (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1986).

EXAMPLES

The present invention is described by reference to the following Examples, which are offered by way of illustration and are not intended to limit the invention in any manner. Standard techniques well known in the art or the techniques specifically described below were utilized.

Example 1 Isolation of μ-Conopeptides

Crude venom was extracted from venom ducts (Cruz et al., 1976), and the components were purified as previously described (Cartier et al., 1996). The crude extract from venom ducts was purified by reverse phase liquid chromatography (RPLC) using a Vydac C₁₈ semi-preparative column (10×250 mm). Further purification of bioactive peaks was done on a Vydac C₁₈ analytical column (4.6×220 mm). The effluents were monitored at 220 nm. Peaks were collected, and aliquots were assayed for activity. Throughout purification, HPLC fractions were assayed by means of intracerebral ventricular (i.c.v.) injection into mice (Clark et al., 1981).

The amino acid sequence of the purified peptides were determined by standard methods. The purified peptides were reduced and alkylated prior to sequencing by automated Edman degradation on an Applied Biosystems 477A Protein Sequencer with a 120A Analyzer (DNA/Peptide Facility, University of Utah) (Martinez et al., 1995; Shon et al., 1994).

In accordance with this method, the μ-conopeptides described as “isolated” in Table 1 were obtained. These μ-conopeptides, as well as the other μ-conopeptides and the μ-conopeptide precursors set forth in Table 1 are synthesized as described in U.S. Pat. No. 5,670,622.

Example 2 Isolation of DNA Encoding μ-Conopeptides

DNA coding for μ-conopeptides was isolated and cloned in accordance with conventional techniques using general procedures well known in the art, such as described in Olivera et al. (1996). Alternatively, cDNA libraries was prepared from Conus venom duct using conventional techniques. DNA from single clones was amplified by conventional techniques using primers which correspond approximately to the M13 universal priming site and the M13 reverse universal priming site. Clones having a size of approximately 300-500 nucleotides were sequenced and screened for similarity in sequence to known μ-conotoxins. The DNA sequences and encoded propeptide sequences are set forth in Table 1. DNA sequences coding for the mature toxin can also be prepared on the basis of the DNA sequences set forth in Table1. An alignment of the μ-conopeptides of the present invention is set forth in Table 2.

TABLE 1 DNA and Amino Acid Sequences of μ-Conopeptides and Precursors Name: Ar3.1 Species: arenatus Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTCTTGACCATCTG (SEQ ID NO:1) TATGCTTCTGTTTCCCCTTACTGCTCTTCCGCTGGATGGGGATCAACCTGCAGACCG ACCTGCAGAGCGTATGCAGGACGACTTTATAACTGAGCATCATCCCCTGTTTGATCC TGTCAAACGGTGTTGCGAGAGGCCATGCAACATAGGATGCGTACCTTGTTGTTAATG ACCAGCTTTGTCATCGCGGCCTCATCAAGCGAATAAGTAAAACGATTGCAGT Translation: MMSKIGVFLTICMLLFPLTALPLDGDQPADRPAERMQDDFITEHHPLFDPVKRCCERPC (SEQ ID NO:2) NIGCVPCC Toxin Sequence: Cys-Cys-Xaal-Arg-Xaa3-Cys-Asn-Ile-Gly-Cys-Val-Xaa3-Cys-Cys-{circumflex over ( )} (SEQ ID NO:3) Name: Ak3.1 Species: atlanticus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCAC (SEQ ID NO:4) TTACTGCTCTTCCGCTGGATGAAGATCAACCGGTACACCGACCTGCAGAGCGTATGC AGGACATTTCATCTGATCAACATCTCTTCTTTGATCTCATCAAACGGTGCTGCGAGT TGCCATGCGGGCCAGGCTTTTGCGTCCCTTGTTGCTGACATCAATAACGTGTTGATG ACCAACTTTCTCGAG Translation: GSMMSKLGVLLTICLLLFPLTALPLDEDQPVHRPAERMQDISSDQHLFFDLIKRCCELPC (SEQ ID NO:5) GPGFCVPCC Toxin Sequence: Cys-Cys-Xaal-Leu-Xaa3-Cys-Gly-Xaa3-Gly-Phe-Cys-Val-Xaa3-Cys-Cys-{circumflex over ( )} (SEQ ID NO:6) Name: A3.1 Species: aurisiacus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:7) TTTGCTTCTGTTTCCCCTTACTGCTCTTCCGATGGATGGAGATCAATCTGTAGACCGA CCTGAAGAGCGTATGCAGGACGACATTTCATCTGAGCAGCATCCCTTGTTTAATCAG AAAAGAATGTGTTGCGGCGAAGGCCGGAAATGCCCCAGCTATTTCAGAAACAGTCA GATTTGTCATTGTTGTTAAATGACAACGTGTCGATGACCAACTTCGTTATCACGACT AATGAATAAGTAAAACGATTGCAGT Translation: MMSKLGVLLTICLLLFPLTALPMDGDQSVDRPEERMQDDISSEQHPLFNQKRMCCGEG (SEQ ID NO:8) RKCPSYFRNSQICHCC Toxin Sequence: Met-Cys-Cys-Gly-Xaa1-Gly-Arg-Lys-Cys-Xaa3-Ser-Xaa5-Phe-Arg-Asn-Ser-Gln-Ile-Cys-His- (SEQ ID NO:9) Cys-Cys-{circumflex over ( )} Name: A3.2 Species: aurisiacus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTTTGCTTCTGTTTCCCC (SEQ ID NO:10) TTACTGCTCTTCCGATCGATGGAGATCAATCTGTAGACCGACCTGCAGAGCGTATGC AGGATGACATTTCATCTGAGCAGCATCGCTTGTTCAATCAGAAAAGAAGGTGCTGC CGGTGGCCATGCCCCCGACAAATCGACGGTGAATATTGTGGCTGTTGCCTTGGATGA TAACCGTGTTGATGACCAACTTTCTCGAG Translation: GSMMSKLGVLLTICLLLFPLTALPIDGDQSVDRPAERMQDDISSEQHRLFNQKRRCCRW (SEQ ID NO:11) PCPRQIDGEYCGCCLG Toxin Sequence: Cys-Cys-Arg-Xaa4-Xaa3-Cys-Xaa3-Arg-Gln-Ile-Asp-Gly-Xaa1-Xaa5-Cys-Gly-Cys-Cys-Leu-# (SEQ ID NO:12) Name: A3.3 Species: aurisiacus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTACTTCTGTTTCCCC (SEQ ID NO:13) TTACTGCTTTTCCGATGGATGGAGATCAACCTGCAGACCAACCTGCAGATCGTATGC AGGACGACATTTCATCTGAGCAGTATCCCTTGTTTGATAAGAGACAAAAGTGTTGCA CTGGGAAGAAGGGGTCATGCTCCGGCAAAGCATGCAAAAATCTCAAATGTTGCTCT GGACGATAACGTGTTGATGACCAACTTTCTCGAG Translation: GSMMSKLGVLLTICLLLFPLTAFPMDGDQPADQPADRMQDDISSEQYPLFDKRQKCCT (SEQ ID NO:14) GKKGSCSGKACKNLKCCSGR Toxin Sequence: Xaa2-Lys-Cys-Cys-Thr-Gly-Lys-Lys-Gly-Ser-Cys-Ser-Gly-Lys-Ala-Cys-Lys-Asn-Leu-Lys- (SEQ ID NO:15) Cys-Cys-Ser-# Name: A3.4 Species: aurisiacus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGCTGACCATCTGTCTGCTTCTGTTTCCAC (SEQ ID NO:16) TTACTGCTGTTCCGCTGGATGGAGATCAACCTCTAGACCGACACGCGGAGCGTATGC ATGATGGCATTTCACCTAAACGCCATCCCTGGTTTGATCCCGTCAAACGGTGTTGCA AGGTGCAATGCGAGTCTTGCACCCCTTGTTGCTAACGTGTTGATGACCAACTTTCTC GAG Translation: GSMMSKLGVLLTICLLLFPLTAVPLDGDQPLDRHAERMHDGISPKRHPWFDPVKRCCK (SEQ ID NO:17) VQCESCTPCC Toxin Sequence: Cys-Cys-Lys-Val-Gln-Cys-Xaa1-Ser-Cys-Thr-Xaa3-Cys-Cys-{circumflex over ( )} (SEQ ID NO:18) Name: Bn3.1 Species: bandanus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTATGCTTCTGTTTCCCC (SEQ ID NO:19) TCACTGCTCTTCCGATGGATGGAGATCAACCTGCAGACCGACCTGCAGAGCGTAGT CAGGACGTTTCATCTGAACAGCATCCCTTGTTTGATCCCGTCAAACGGTGTTGCAAC TGGCCATGCTCCATGGGATGCATCCCTTGTTGCTACTATTAATAACGTGTTGATGAC CAACTTTCTCGAG Translation: GSMMSKLGVLLTICMLLFPLTALPMDGDQPADRPAERSQDVSSEQHPLFDPVKRCCNW (SEQ ID NO:20) PCSMGCIPCCYY Toxin Sequence: Cys-Cys-Asn-Xaa4-Xaa3-Cys-Ser-Met-Gly-Cys-Ile-Xaa3-Cys-Cys-Xaa5-Xaa5-{circumflex over ( )} (SEQ ID NO:21) Name: Bt3.1 Species: betulinus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCTTCTG (SEQ ID NO:22) TCTGCTTCTGTTTCCCCTGACTGCTCTTCCGCTGGATGAAGATCAACCTGCAGACCG ACCTGCAGAGCGTATGCAGGACATTTCATCTGAACAGCATCCCTTGTTTGATCCCGT CAAACGGTGTTGCGAATTGCCATGCCATGGATGCGTCCCTTGTTGCTGGCCTTAATA ACGTGTGGATGACCAACTGTGTTATCACGGCCACGTCAAGTGTCTAATGAATAAGT AAAATGATTGCAGT Translation: MMSKLGVLLTFCLLLFPLTALPLDEDQPADRPAERMQDISSEQHPLFDPVKRCCELPCH (SEQ ID NO:23) GCVPCCWP Toxin Sequence: Cys-Cys-Xaa1-Leu-Xaa3-Cys-His-Gly-Cys-Val-Xaa3-Cys-Xaa3-{circumflex over ( )} (SEQ ID NO:24) Name: Bt3.2 Species: betulinus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCTTCTG (SEQ ID NO:25) TCTGCTTCTGTTTCCCCTGACTGCTCTTCCGCTGGATGAAGATCAACCTGCAGACCG ACATGCAGAGCGTATGCAGGACATTTCACCTGAACAGCATCCCTCGTTTGATCCCGT CAAACGGTGTTGCGGGCTGCCATGCAATGGATGCGTCCCTTGTTGCTGGCCTTCATA ACGTGTGGACGACCAACTTTGTTATCACGGCCACGTCAAGTGTCTGATGAATAAGTA AAACGATTGCAGT Translation: MMSKLGVLLTFCLLLFPLTALPLDEDQPADRHAERMQDISPEQRPSFDPVKRCCGLPCN (SEQ ID NO:26) GCVPCCWPS Toxin Sequence: Cys-Cys-Gly-Leu-Xaa3-Cys-Asn-Gly-Cys-Val-Xaa3-Cys-Cys-Xaa4-Xaa3-Ser-{circumflex over ( )} (SEQ ID NO:27) ------------------------------- Name: Bt3.3 Species: betulinus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTTTAAACTGGGAGTCTTGTTGACCATCTA (SEQ ID NO:28) TATGCTTCTGTTTCCCTTTACTGCTCTTCCGCTGGATGGAGATCAACCTGCAGACCAA CCTCTAGAGCGCATGCAGTATGACATGTTACGTGCAGTGAATCCCTGGTTTGATCCC GTCAAAAGGTGCTGCTCGAGGAACTGCGCAGTATGCATCCCTTGTTGCCCGAATTGG CCAGCTTGATTATCGCGGCCAAGAGTCTAATGAATAAGTAAAACGATTGCAGT Translation: MMFKLGVLLTIYMLLFPFTALPLDGDQPADQPLERMQYDMLRAVNPWFDPVKRCCSR (SEQ ID NO:29) NCAVCIPCCPNWPA Toxin Sequence: Cys-Cys-Ser-Arg-Asn-Cys-Ala-Val-Cys-Ile-Xaa3-Cys-Cys-Xaa3-Asn-Xaa4-Xaa3-Ala-{circumflex over ( )} (SEQ ID NO:30) Name: Bu3.1 Species: bullatus Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:31) TCTGCTTCTGTTTCCCCTTTTTGCTCTTCCGCAGGATGGAGATCAACCTGCAGACCGA CCTGCAGAGCGTATGCAGGACGACATTTCATCTGAGCAGAATTCCTTGCTTGAGAA GAGAGTTACTGACAGGTGCTGCAAAGGGAAGAGGGAATGCGGCAGATGGTGCAGA GATCACTCGCGTTGTTGCGGTCGACGATAAGCTGTTGATGACCAGCTTTGTTATCAC GGCTACATCAAGTGTCTAGTGAATAAGTAAAATGATTGCAGT Translation: MMSKLGVLLTICLLLFPLFALPQDGDQPADRPAERMQDDISSEQNSLLEKRVTDRCCKG (SEQ ID NO:32) KRECGRWCRDHSRCCGRR Toxin Sequence: Val-Thr-Asp-Arg-Cys-Cys-Lys-Gly-Lys-Arg-Xaa1-Cys-Gly-Arg-Xaa4-Cys-Arg-Asp-His-Ser- (SEQ ID NO:33) Arg-Cys-Cys-# Name: Bu3.1A Species: bullatus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:34) TCTGCTTCTGTTTCCCCTTTTTGCTCTTCGGCAGGATGGAGATCAACCTGCAGACCGA CCTGCAGAGCGTATGCAGGATGACATTTCATCTGAGCAGAATCCCTTGCTTGAGAA GAGAGTTGGTGACAGGTGCTGCAAAGGGAAGAGGGGGTGCGGCAGATGGTGCAGA GATCACTCACGTTGTTGCGGTCGACGATAACGTGTTGATGACCAGCTTTGTTATCAC GGCTACATCAAGTGTCTTAGTGATTAAGTAAAACGATTGCAGT Translation: MMSKLGVLLTICLLLFPLFALRQDGDQPADRPAERMQDDISSEQNPLLEKRVGDRCCK (SEQ ID NO:35) GKRGCGRWCRDHSRCCGRR Toxin Sequence: Val-Gly-Asp-Arg-Cys-Cys-Lys-Gly-Lys-Arg-Gly-Cys-Gly-Arg-Xaa4-Cys-Arg-Asp-His-Ser- (SEQ ID NO:36) Arg-Cys-Cys-# Name: Bu3.2 Species: bullatus Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:37) TCTGCTTCTGTTTCCCCTTTTTGCTCTTCCGCAGGATGGAGATCAACCTGCAGACCGA CCTGCAGAGCGTATGCAGGACGACATTTCATCTGAGCAGAATCCCTTGCTTGAGAA GAGAGTTGGTGAAAGGTGCTGCAAAAACGGGAAGAGGGGGTGCGGCAGATGGTGC AGAGATCACTCACGTTGTTGCGGTCGACGATAACGTGTTGATGACCGAGGCTTTCGT TATCACGGCTACATCAAGTGTCTAGTGAATAAGTAAAACGATTGCAGT Translation: MMSKLGVLLTICLLLFPLFALPQDGDQPADRPAERMQDDISSEQNPLLEKRVGERCCKN (SEQ ID NO:38) GKRGCGRWCRDHSRCCGRR Toxin Sequence: Val-Gly-Xaa1-Arg-Cys-Cys-Lys-Asn-Gly-Lys-Arg-Gly-Cys-Gly-Arg-Xaa4-Cys-Arg-Asp-His-Ser- (SEQ ID NO:39) Arg-Cys-Cys-# Name: Bu3.3 Species: bullatus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:40) TCTGCTTCTGTTTCCCCTTTTTGCTCTTCCGCAGGACGGAGATCAACCTGCAGACCG ACCTGCAGAGCGTATGCAGGACGACCTTTCATCTGAGCAGCATCCCTTGTTTGAGAA GAGAATTGTTGACAGGTGCTGCAACAAAGGGAACGGGAAGAGGGGGTGCAGCAGA TGGTGCAGAGATCACTCACGTTGTTGCGGTCGACGATGAACTGTTGATGACCGAGG CTTTGGTTATCACGGCTACATCAAGTGTCTAGTGAATAAGTAAAACGATTGCAGT Translation: MMSKLGVLLTICLLLFPLFALPQDGDQPADRPAERMQDDLSSEQHPLFEKLRIVDRCCNK (SEQ ID NO:41) GNGKRGCSRWCRDHSRCCGRR Toxin Sequence: Ile-Val-Asp-Arg-Cys-Cys-Asn-Lys-Gly-Asn-Gly-Lys-Arg-Gly-Cys-Ser-Arg-Xaa4-Cys-Arg- (SEQ ID NO:42) Asp-His-Ser-Arg-Cys-Cys-# Name: Bu3.4 Species: bullatus Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:43) TCTGCTTCTGTTTCCCCTTTTTGCTCTTCCGCAGGATGGAGATCAACCTGCAGACCGA CCTGCTGAGCGTATGCAGGACGACATTTCATCTGAGCGGAATCCCTTGTTTGAGAAG AGCGTTGGTTTATATTGCTGCCGACCCAAACCCAACGGGCAGATGATGTGCGACAG ATGGTGCGAAAAAAACTCACGTTGTTGCGGTCGACGATAATGTGTTGATGACCAGC TTTGTTATCAAGGCTACATCAAGTATCTAGTGAATAAGTAAAACGATTGCAGT Translation: MMSKLGVLLTICLLLFPLFALPQDGDQPADRPAERMQDDISSERNPLFEKSVGLYCCRP (SEQ ID NO:44) KPNGQMMCDRWCEKNSRCCGRR Toxin Sequence: Val-Gly-Leu-Xaa5-Cys-Cys-Arg-Xaa3-Lys-Xaa3-Asn-Gly-Gln-Met-Met-Cys-Asp-Arg-Xaa4- (SEQ ID NO:45) Cys-Xaa1-Lys-Asn-Ser-Arg-Cys-Cys-# ------------------------------- Name: Bu3.5 Species: bullatus Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTTTTGTTGACCATCTG (SEQ ID NO:46) TCTGCTTCTGTTTCCCCTTACTGCTCTTCCGATGGATGGAGATCAATCTGTAGACCGA CCTGCAGAACGTATGCAGGACGACCTTTCATCTGAGCAGCATCCCTTGTTTGTTCAG AAAAGAAGGTGTTGCGGCGAAGGCTTGACATGCCCCAGATATTGGAAAAACAGTCA GATTTGTGCTTGTTGTTAAATGACAACGTGTCGATGACCAACTTCGGTATCACGACT ACGCCAAGTGTCTAATGAATAAGTAAAACGATTGCAGT Translation: MMSKLGVLLTICLLLFPLTALPMDGDQSVDRPAERMQDDLSSEQHPLFVQKRRCCGEG (SEQ ID NO:47) LTCPRYWKINSQICACC Toxin Sequence: Arg-Cys-Cys-Gly-Xaa1-GIy-Leu-Thr-Cys-Xaa3-Arg-Xaa5-Xaa4-Lys-Asn-Ser-Gln-Ile-Cys-Ala- (SEQ ID NO:48) Cys-Cys-{circumflex over ( )} Name: Bu3.5A Species: bullatus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:49) TCTGCTTCTGTTTCCCCTTTTTGCTCTTCCGCAGGATGGAGATCAACCTGCAGACCGA CCTGCTGAGCGTATGCAGGACGACATTTCATCTGAGCAGGATCCCTTGTTTGTTCAG AAAAGAAGGTGTTGCGGCGAAGGCTTGACATGCCCCAGATATTGGAAAAACAGTCA GATTTGTGCTTGTTGTTAAATGACAACGTGTGATGACCAACTTCGGTATCACGACTA CGCCAAGTGTCTAATGAATAAGTAAAACGATTGCAGT Translation: MMSKLGVLLTICLLLFPLFALPQDGDQPADRPAERMQDDISSEQDPLFVQKRRCCGEGL (SEQ ID NO:50) TCPRYWKNSQICACC Toxin Sequence: Arg-Cys-Cys-Gly-Xaa1-Gly-Leu-Thr-Cys-Xaa3-Arg-Xaa5-Xaa4-Lys-Asn-Ser-Gln-Ile-CyS-Ala- (SEQ ID NO:51) Cys-Cys-{circumflex over ( )} Name: Cp3.1 Species: capitaneus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGGTGACCATCTGCCTGCTTCTGTTTCCC (SEQ ID NO:52) CTTGCTGCTTTTCCACTGGATGGAATCAACCTGCAGACCACCCTGCAAAGCGTACG CAAGATGACAGTTCAGCTGCCCTGATCAATACCTGGATTGATCATTCCCATTCTTGC TGCAGGGACTGCGGTGAAGATTGTGTTGGTTGTTGCCGGTAACGTGTTGATGACCAA CTTTCTCGAG Translation: GSMMSKLGVLVTICLLLFPLAAFPLDGNQPADHPAKRTQDDSSAALINTWIDHSHSCCR (SEQ ID NO:53) DCGEDCVGCCR Toxin Sequence: Ser-Cys-Cys-Arg-Asp-Cys-Gly-Xaa1-Asp-Cys-Val-Gly-Cys-Cys-Arg-{circumflex over ( )} (SEQ ID NO:54) Name: Ca3.1 Species: caracteristicus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:55) TCTGCTTCTGTTTCCCCTTACTGCTCTTCCAATGGATGGAGATCAACCTGCAGACCA ACCTGCAGATCGTATGCAGGACGACATTTCATCTGAGCAGTATCCCTTGTTTGATAT GAGAAAAAGGTGTTGCGGCCCCGGCGGTTCATGCCCCGTATATTTCAGAGACAATT TTATTTGTGGTTGTTGTTAAATGACAACGTGTCGATGACCAACTTCATTATCACGAC TACGCCAAGTGTCTAATGAATAAGTAAAATGATTGCAGT Translation: MMSKLGVLLTICLLLFPLTALPMDGDQPADQPADRMQDDISSEQYPLFDMRKRCCGPG (SEQ ID NO:56) GSCPVYFRDNTICGCC Toxin Sequence: Cys-Cys-Gly-Xaa3-Gly-Gly-Ser-Cys-Xaa3-Val-Xaa5-Phe-Arg-Asp-Asn-Phe-Ile-Cys-Gly-Cys- (SEQ ID NO:57) Cys-{circumflex over ( )} Name: Ca3.2 Species: caracteristicus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:58) TCTGCTTCTGTTTCCCCTTACTGCTCTTCCGATGGATGGAGATGAACCTGCAAACCG ACCTGTCGAGCGTATGCAGGACAACATTTCATCTGAGCAGTATCCCTTGTTTGAGAA GAGACGAGATTGTTGCACTCCGCCGAAGAAATGCAAAGACCGACAATGCAAACCCC AGAGATGTTGCGCTGGACGATAACGTGTTGATGACCAACTTTATCACGGCTACGTCA AGTGTTTAGTGAATAAGTAAAATGATTGCAGT Translation: MMSKLGVLLTICLLLFPLTALPMDGDEPANPVERMQDNISSEQYPLFEKRRDCCTPPK (SEQ ID NO:59) KCKDRQCKPQRCCAGR Toxin Sequence: Arg-Asp-Cys-Cys-Thr-Xaa3-Xaa3-Lys-Lys-Cys-Lys-Asp-Arg-Gln-Cys-Lys-Xaa3-Gln-Arg- (SEQ ID NO:60) Cys-Cys-Ala-# Name: Ca3.3 Species: caracteristicus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:61) TCTGCTTCTGTTTCCCCTTACTGCTCTTCCACTGGATGGAGATCAACCTGCAGATCAA TCTGCAGAGCGACCTGCAGAGCGTACGCAGGACGACATTCAGCAGCATCCGTTATA TGATCCGAAAAGAAGGTGTTGCCGTTATCCATGCCCCGACAGCTGCCACGGATCTTG CTGCTATAAGTGATAACATGTTGATGGCCAGCTTTGTTATCACGGCCACGTCAAGTG TCTTAATGAATAAGTAAAACGATTGCAGT Translation: MMSKLGVLLTICLLLFPLTALPLDGDQPADQSAERPAERTQDDIQQHPLYDPKRRCCRY (SEQ ID NO:62) PCPDSCHGSCCYK Toxin Sequence: Arg-Cys-Cys-Arg-Xaa5-Xaa3-Cys-Xaa3-Asp-Ser-Cys-His-Gly-Ser-Cys-Cys-Xaa5-Lys-{circumflex over ( )} (SEQ ID NO:63) Name: Ca3.4 Species: caracteristicus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGCCTTGTTGACCATCT (SEQ ID NO:64) GTCTACTTCTGTTTTCCCTTACTGCTGTTCCGCTGGATGGAGATCAACATGCAGACC AACCTGCACAGCGTCTGCAGGACCGCATTCCAACTGAAGATCATCCCTTATTTGATC CCAACAAACGGTGTTGCCCGCCGGTGGCATGCAACATGGGATGCAAGCCTTGTTGT GGATGACCAGCTTTGTTATCGCGGTCTTCATGAAGTGTCTTAATGAATAAGTAAAAT GATTGCAGT Translation: MMSKLGALLTICLLLFSLTAVPLDGDQHADQPAQRLQDRIPTEDHPLFDPNKRCCPPVA (SEQ ID NO:65) CNMGCKPCCG Toxin Sequence: Cys-Cys-Xaa3-Xaa3-Val-Ala-Cys-Asn-Met-Gly-Cys-Lys-Xaa3-Cys-Cys-# (SEQ ID NO:66) Name: Ca3.5 Species: caracteristicus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGCCTTGTTGACCATCT (SEQ ID NO:67) GTCTACTTCTGTTTTCCCTAACTGCTGTTCCGCTGGATGGAGATCAACATGCAGACC AACCTGCAGAGCGTCTGCATGACCGCCTTCCAACTGAAAATCATCCCTTATATGATC CCGTCAAACGGTGTTGCGATGATTCGGAATGCGACTATTCTTGCTGGCCTTGCTGTA TGTTTGGATAACCTTTGTTATCGCGGCCTCATCAAGTGTCTAATGAATAAGTAAAAC GATTGCAGT Translation: MMSKLGALLTICLLLFSLTAVPLDGDQHADQPAERLHDRLPTENHPLYDPVKRCCDDSE (SEQ ID NO:68) CDYSCWPCCMFG Toxin Sequence: Cys-Cys-Asp-Asp-Ser-Xaa1-Cys-Asp-Xaa5-Ser-Cys-Xaa4-Xaa3-Cys-Cys-Met-Phe-# (SEQ ID NO:69) Name: Ca3.6 Species: caracteristicus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:70) TTACTGCTGTTCCGCTGGATGGAGATCAACCTGCAGACCGACCTGCAGAGCGTAAG CAGGACGTTTCATCTGAACAGCATCCCTTCTTTGATCCCGTCAAACGGTGTTGCCGC CGGTGTTACATGGGATGCATCCCTTGTTGCTTTTAACGTGTTGATGACCAACTTTCTC GAG Translation: GSMMSKLGVLLTICLLLFPLTAVPLDGDQPADRPAERKQDVSSEQKPFFDPVKRCCRRC (SEQ ID NO:71) YMGCIPCCFID Toxin Sequence: Cys-Cys-Arg-Arg-Cys-Xaa5-Met-Gly-Cys-Ile-Xaa3-Cys-Cys-Phe-{circumflex over ( )} (SEQ ID NO:72) Name: Cr3.1 Species: circumcisus Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGGGTATTGTTGACCATCT (SEQ ID NO:73) GTCTGCTTCTGTTTCCCCTTACTGCTCTTCCAATGGATGGAGATCAACCTGCAGACC AACCTGCAGATCGTATGCAGGACGACATTTCATCTGAGCAGTATCCCTTGTTTGATA AGAGACGAAAGTGTTGCGGCAAAGACGGGCCATGCCCCAAATATTTCAAAGACAAT TTTATTTGTGGTTGTTGTTAAATGACAACGTGTCGATGACCAACTTCGTTATCACGAT TCGCCAAGTGTCTTAATGAATAAGTAAAATGATTGCAGT Translation: MMSKLGVLLTICLLLFPLTALPMDGDQPADQPADRMQDDISSEQYPLFDKRRKCCGKD (SEQ ID NO:74) GPCPKYFKDKFICGCC Toxin Sequence: Arg-Lys-Cys-Cys-Gly-Lys-Asp-Gly-Xaa3-Cys-Xaa3-Lys-Xaa5-Phe-Lys-Asp-Asn-Phe-Ile-Cys- (SEQ ID NO:75) Gly-Cys-Cys-{circumflex over ( )} Name: Da3.1 Species: dalli Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGCCTTGTTGACCATCT (SEQ ID NO:76) GTCTACTTCTGTTTTCCCTAACTGCTGTTCCGCTGGATGGAGATCAACATGCAGACC AACCTGCAGAGCGTCTGCAGGACCGCCTTCCAACTGAAAATCATCCCTTATATGATC CCGTCAAACGGTGTTGCGATGATTCGGAATGCGACTATTCTTGCTGGCCTTGCTGTA TTTTATCATAACCTTTGTTATCGCGGCCTCATCAAGTGTCAAATGAATAAGTAAAAT GATTGCAGT Translation: MMSKLGALLTICLLLFSLTAVPLDGDQHADQPAERLQDRLPTENHPLYDPVKRCCDDSE (SEQ ID NO:77) CDYSCWPCCILS Toxin Sequence: Cys-Cys-Asp-Asp-Ser-Xaa1-Cys-Asp-Xaa5-Ser-Cys-Xaa4-Xaa3-Cys-Cys-Ile-Leu-Ser-{circumflex over ( )} (SEQ ID NO:78) Name: Da3.2 Species: dalli Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATTTG (SEQ ID NO:79) TCTACTTCTGTTTCCCCTTACTGCTGTTCCACTGGATGGAGATCAGCCTGCAGACCG ACCTGCAGAGCGTATGCAGGACGGCATTTCATCTGAACATCATCCATTTTTTGATTC CGTCAAAAAGAAACAACAGTGTTGCCCGCCGGTGGCATGCAACATGGGATGCGAGC CTTGTTGTGGATGACCAGCTTTGTTATCGCGGCTCATGAAGTGTCCTAATGAATAAG TAAAACGATTGCAGT Translation: MMSKLGVLLTICLLLFPLTAVPLDGDQPADRPAERMQDGISSEHHPFFDSVKKKQQCCP (SEQ ID NO:80) PVACNMGCEPCCG Toxin Sequence: Xaa2-Gln-Cys-Cys-Xaa3-Xaa3-Val-Ala-Cys-Asn-Met-Gly-Cys-Xaa1-Xaa3-Cys-Cys-# (SEQ ID NO:81) Name: Da3.3 Species: dalli Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGATCATATG (SEQ ID NO:82) TCTATTTCTGTTTCCCCTTACTGCTGTTCAGCTCAATGGAGATCAGCCTGCAGACCAA TCTGCAGAGCGTATGCAGGACAAAATTTCATCTGAACATCATCCCTTTTTTGATCCC GTCAAACGTTGTTGCAACGCGGGGTTTTGCCGCTTCGGATGCACGCCTTGTTGTTGG TGACCAGCTTTGTTATCGCGGCCTCATCAAGTGTCTAATGAATAAGTAAAATGATTG CAGT Translation: MMSKLGVLLIICLFLFPLTAVQLNGDQPADQSAERMQDKISSEHHPFFDPYKRCCNAGF (SEQ ID NO:83) CRFGCTPCCW Toxin Sequence: Cys-Cys-Asn-Ala-Gly-Phe-Cys-Arg-Phe-Gly-Cys-Thr-Xaa3-Cys-Cys-Xaa4-{circumflex over ( )} (SEQ ID NO:84) Name: Di3.1 Species: distans Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGCTGACCATCTT (SEQ ID NO:85) TCTGCTTCTGTTTCCCCTTACTGCTGTTCCGCTGGATGGAGATCAACCCGCAGACGG ACTTGCAGAGCGCATGCAGGACGACAGTTCAGCTGCACTGATTAGAGACTGGCTTC TTCAAACCCGACAGTGTTGTGTGCATCCATGCCCATGCACGCCTTGCTGTAGATGAC CAGCTTTGTCATCGCGGCTACGTCAAGTATCTAATGAATAAGTAAGTAAAACGATTG CAGT Translation: MMSKLGVLLTIFLLLFPLTAVPLDGDQPADGLAERMQDDSSAALIRDWLLQTRQCCVH (SEQ ID NO:86) PCPCTPCCR Toxin Sequence: Xaa2-Cys-Cys-Val-His-Xaa3-Cys-Xaa3-Cys-Thr-Xaa3-Cys-Cys-Arg-{circumflex over ( )} (SEQ ID NO:87) Name: E6.1 Species: ermineus Cloned: Yes DNA Sequence: ACCTCAAGAGGGATCGATCGCAGTTCATGATGTCTAAACTGGGAGCCTTGTTGACC (SEQ ID NO:88) ATCTGTCTGCTTCTGTTTCCCATTACTGCTCTTCTGATGGATGGAGATCAGCCTGCAG ACCGACCTGCAGAGCGTACGGAGGATGACATTTCATCTGACTACATTCCCTGTTGCA GTTGGCCATGCCCCCGATACTCCAACGGTAAACTTGTTTGTTTTTGTTGCCTTGGATG ATAATGTGTTGATGACCAACTTTGTTATCACGGCTACGTCAAGTGTCTACTGAATAA GTAAAATGATTGCAGTA Translation: MMSKLGALLTICLLLFPITALLMDGDQPADRPAERTEDDISSDYIPCCSWPCPRYSNGKL (SEQ ID NO:89) VCFCCLG Toxin Sequence: Cys-Cys-Ser-Xaa4-Xaa3-Cys-Xaa3-Arg-Xaa5-Ser-Asn-Gly-Lys-Leu-Val-Cys-Phe-Cys-Cys- (SEQ ID NO:90) Leu-# Name: Ge3.2 Species: generalis Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGGTTCTGTTTCCCC (SEQ ID NO:91) TTACTGCTCTTCCACTGGATGGAGAACAACCTGTAGACCGACATGCCGAGCATATGC AGGATGACAATTCAGCTGCACAGAACCCCTGGGTTATTGCCATCAGACAGTGTTGC ACGTTCTGCAACTTTGGATGCCAACCTTGTTGCCTCACCTGATAACGTGTTGATGAC CAACTTTCTCGAG Translation: GSMMSKLGVLLTICLVLFPLTALPLDGEQPVDRHAEHMQDDNSAAQNPWVIAIRQCCT (SEQ ID NO:92) FCNFGCQPCCLT Toxin Sequence: Xaa2-Cys-Cys-Thr-Phe-Cys-Asn-Phe-Gly-Cys-Gln-Xaa3-Cys-Cys-Leu-Thr-{circumflex over ( )} (SEQ ID NO:93) Name: Ge3.3 Species: generalis Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGGTTCTGTTTCCCC (SEQ ID NO:94) TTACTGCTCTTCCACTGGATGGAGAACAACCTGTAGACCGACATGCCGAGCATATGC AGGATGACAATTCAGCTGCACAGAACCCCTGGGTTATTGCCATCAGACAGTGTTGC ACGTTCTGCAACTTTGGATGCCAGCCTTGTTGCGTCCCCTGATAACGTGTTGATGAC CAACTTTCTCGAG Translation: GSMMSKLGVLLTICLVLFPLTALPLDGEQPVDRHAEHMQDDNSAAQNPWVIAIRQCCT (SEQ ID NO:95) FCNFGCQPCCVP Toxin Sequence: Xaa2-Cys-Cys-Thr-Phe-Cys-Asn-Phe-Gly-Cys-Gln-Xaa3-Cys-Cys-Val-Xaa3-{circumflex over ( )} (SEQ ID NO:96) Name: μ-GIIIA Species: geographus Cloned: Yes DNA Sequence: GTCGACTCTAGAGGATCCGACAACAAAGAGTCAACCCCACTGCCACGTCAAGAGCG (SEQ ID NO:97) AAGCGCCACAGCTAAGACAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGG AGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCCCTTACTGCTCTTCCGATGGATGGA GATGAACCTGCAAACCGACCTGTCGAGCGTATGCAGGACAACATTTCATCTGAGCA GTATCCCTTGTTTGAGAAGAGACGAGATTGTTGCACTCCGCCGAAGAAATGCAAAG ACCGACAATGCAAACCCCAGAGATGTTGCGCTGGACGATAACGTGTTGATGACCAA CTTTATCACGGCTACGTCAAGTGTTTAGTGAATAAGTAAAATGATTGCAGTCTTGCT CAGATTTGCTTTTGTGTTTTGGTCTAAAGATCAATGACCAAACCGTTGTTTTGATGCG GATTGTCATATATTTCTCGATTCCAATCCAACACTAGATGATTTAATCACGATAGAT TAATTTTCTATCAATGCCTTGATTTTTCGTCTGTCATATCAGTTTTGTTTATATTTATT TTTTCGTCACTGTCTACACAAACGCATGCATGCACGCATGCACGCACACACGCACGC ACGCTCGCACAAACATGCGCGCGCACGCACACACACACACACACACACAAACACA CACACAAGCAATCACACAATTATTGACATTATTTATTTATTCATTGATGTATTTGTTA TTCGTTTGCTTGTTTTTAGAATAGTTTGAGGCCGTCTTTTTGGATTTATTTGAACTGC TTTATTGTATACGAGTACTTCGTGCTTTGAAACACTGCTGAAAATAAAACAAACACT GACGTAGC Translation: MMSKLGVLLTICLLLFPLTALPMDGDEPANRPVERMQDNISSEQYPLFEKRRDCCTPPK (SEQ ID NO:98) KCKDRQCRPQRCCAGR Toxin Sequence: Arg-Asp-Cys-Cys-Thr-Xaa3-Xaa3-Lys-Lys-Cys-Lys-Asp-Arg-Gln-Cys-Lys-Xaa3-Gln-Arg- (SEQ ID NO:99) Cys-Cys-Ala-# Name: μ-GIIIB Species: geographus Isolated: Yes Cloned: Yes DNA Sequence: GGCCAGACGACAACAAAGAGTCAACCCCACTGCCACGTCAAGAGCGAAGCGCCAC (SEQ ID NO:100) AGCTAAGACAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTT GACCATCTGTCTGCTTCTGTTTCCCCTTACTGCTCTTCCGATGGATGGAGATGAACCT GCAAACCGACCTGTCGAGCGTATGCAGGACAACATTTCATCTGAGCAGTATCCCTTG TTTGAGAAGAGACGAGATTGTTGCACTCCGCCGAGGAAATGCAAAGACCGACGATG CAAACCCATGAAATGTTGCGCTGGACGATAACGTGTTGATGACCAACTTTATCACG GCTAGCTCAGTGTTTAGTGAATAAGTAAAATGATTGCAGTCTTGCTCAGATTGCTTT TGTGTTTTGGTCTAAGATCAATGACCAAACCGTTGTTTTGATGCGGATTGTCATATA TTTCTCGATTCCAATCCAACACTAGATGATTTAATCACGATAGATTAATTTTCTATCA ATGCCTTGATTTTTCGTCTGTCATATCAGTTTTGTTTATATTTATTTTTTCGTCACTGT CTACACAAACGCATGCATGCACGCATGCACGCACACACGCACGCACGCTCGCACAA ACATGCGCGCGCACGCACACACACACACACACACAAACACACACACGAAGCAATC ACACAATTAGTTGACATTATTTATTTATTCATTGATGTATTTGTTATTCGTTTGCTTGT TTTTAGAATAGTTTGAGGCCGTCTTTTTGGATTTATTTGAACTGCTTTATTGTATACG AGTACTTCGTGCTTTGAAACACTGCTGAAAATAAAACAAACACTGACGTAGCAAAA AAAAAAA Translation: MMSKLGVLLTICLLLFPLTALPMDGDEPANRPVERMQDNISSEQYPLFEKRRDCCTPPR (SEQ ID NO:101) KCKDRRCKPMKCCAGR Toxin Sequence: Arg-Asp-Cys-Cys-Thr-Xaa3-Xaa3-Xaa3-Arg-Lys-Cys-Lys-Asp-Arg-Arg-Cys-Lys-Xaa3-Met-Lys- (SEQ ID NO:102) Cys-Cys-Ala-# Name: μ-GIIIC Species: geographus Isolated: Yes Toxin Sequence: Arg-Asp-Cys-Cys-Thr-Xaa3-Xaa3-Lys-Lys-Cys-Lys-Asp-Arg-Arg-Cys-Lys-Xaa3-Leu-Lys- (SEQ ID NO:103) Cys-Cys-Ala-# Name: Gm3.1 Species: gloriamaris Cloned: Yes DNA Sequence: CTCACTATAGGAATTCGAGCTCGGTACACGGGATCGATAGCAGTTCATGATGTCTAA (SEQ ID NO:104) ACTGGGAGCCTTGTTGACCATCTGTCTACTTCTGTTTTCCCTAACTGCTGTTCCGCTG GATGGAGATCAACATGCAGACCAACCTGCAGAGCGTCTGCATGACCGCCTTCCAAC TGAAAATCATCCCTTATATGATCCCGTCAAACGGTGTTGCGATGATTCGGAATGCGA CTATTCTTGCTGGCCTTGCTGTATGTTTGGATAACCTTTGTTATCGCGGCCTCGATAA GTGTCTAATGAATAAGTAAAACGATTGCAGTAGGC Translation: MMSKGALLTICLLLFSLTAVPLDGDQHADQPAHDQPAERLHDRLPTENHPLYDPVKRCCDDSE (SEQ ID NO:105) CDYSCWPCCMFG Toxin Sequence: Cys-Cys-Asp-Asp-Ser-Xaa1-Cys-Asp-Xaa5-Ser-Cys-Xaa4-Xaa3-Cys-Cys-Met-Phe-# (SEQ ID NO:106) Name: Gm3.2 Species: gloriamaris Cloned: Yes DNA Sequence: GTTCATGATGTCTAAACTGGGAGTCTTGTTGATCATCTGTCTACTTCTGTTTCCCCTT (SEQ ID NO:107) ACTGCTGTTCCGCTGGATGGAGATCAACCTGCAGACCGATATGCAGAGCGTATGCA GGACGACATTTCATCTGAACATCATCCCATGTTTGATGCCGTCAGAGGGTGTTGCCA TCTGTTGGCATGCCGCTTCGGATGCTCGCCTTGTTGTTGGTGATCAGCTTTGTTATCG CGGCCTCATCAAGTGACTCTAATGCAAA Translation: MMSKLGVLLIICLLLFPLTAVPLDGDQPADRYAERMQDDISSEHHPMFDAVRGCCHLLA (SEQ ID NO:108) CRFGCSPCCW Toxin Sequence: Gly-Cys-Cys-His-Leu-Leu-Ala-Cys-Arg-Phe-Gly-Cys-Ser-Xaa3-Cys-Cys-Xaa4-{circumflex over ( )} (SEQ ID NO:109) Name: Gm3.3 Species: gloriamaris Cloned: Yes DNA Sequence: GAGACGACAAGGAACAGTCAACCCCACAGCCACGCCAAGAGCAGACAGCCACAGC (SEQ ID NO:110) TACGTGAAGAAGGGTGGAGAGAGGTTCGTGATGTTGAAAATGGGAGTGGTGCTATT CATCTTCCTGGTACTGTTTCCCCTGGCAACGCTCCAGCTGGATGCAGATCAACCTGT AGAACGATATGCGGAGAACAAACAGCTCCTCAACCCAGATGAAAGGAGGGAAATC ATATTGCATGCTCTGGGGACGCGATGCTGTTCTTGGGATGTGTGCGACCACCCGAGT TGTACTTGCTGCGGCGGTTAGCGCCGAACATCCATGGCGCTGTGCTGGGCGGTTTTA TCCAACAACGACAGCGTTTGTTGATTTCATGTATCATTGCGCCCACGTCTCTTGTCTA AGAATGACGAACATGATTGCACTCTGGTTCAGATTTCGTGTTCTTTTCTGACAATAA ATGACAAAACTCCAAAAAA Translation: MLKMGVVLFIFLVLFPLATLQLDADQPVERYAENKQLLNPDERREIILHALGTRCCSWD (SEQ ID NO:111) VCDHPSCTCCGG Toxin Sequence: Cys-Cys-Ser-Xaa4-Asp-Val-Cys-Asp-His-Xaa3-Ser-Cys-Thr-Cys-Cys-Gly-# (SEQ ID NO:112) Name: La3.1 Species: laterculatus Cloned: Yes DNA Sequence: CGACCTCAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGA (SEQ ID NO:113) CCATCTGTCTGCTTCTGTTTCCCCTTACTGCTCTTCCGATGGATGGAGATCAACCTGC AGACCGACCTGCAGAGCGTATGCAGGACGTTTCATCTGAACAGCATCCCTTGTATG ATCCCGTCAAACGGTGTTGCGACTGGCCATGCAGCGGATGCATCCCTTGTTGCTAAT AGTAACAACGTGTTGATAACCAACTTTCTTACCACGACTACGTCAAGTGTCTAATGA ATAAGTAAAATGATTGCAGT Translation: MMSKLGVLLTICLLLFPLTALPMDGDQPADRPAERMQDVSSEQHPLYDPVKRCCDWPC (SEQ ID NO:114) SGCIPCC Toxin Sequence: Cys-Cys-Asp-Xaa4-Xaa3-Cys-Ser-Gly-Cys-Ile-Xaa3-Cys-Cys-{circumflex over ( )} (SEQ ID NO:115) Name: La3.2 Species: laterculatus Cloned: Yes DNA Sequence: CGACCTCAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGA (SEQ ID NO:116) CCATCTGTCTGCTTCTGTTTCCCCTTACTGCTCTGGATGGAGATCAACCTGCAGACC GACTTGCAGAGCGTATGCAGGACGACATTTCATCTGAGCAGCATCCCTTTGAAAAG AGACGAGACTGTTGCACACCTCCGAAGAAATGCAGAGACCGACAATGCAAACCTGC ACGTTGTTGCGGAGGATAACGTGTTGATGACCAACTTTGTTATCACGGCTACGTCAA GTGTCTAGTGAATAAGTAAAACGATTGCAGT Translation: MMSKLGVLLTICLLLFPLTALDGDQPADRLAERMQDDISSEQHPFEKRRDCCTPPKKCR (SEQ ID NO:117) DRQCKPARCCGG Toxin Sequence: Arg-Asp-Cys-Cys-Thr-Xaa3-Xaa3-Lys-Lys-Cys-Arg-Asp-Arg-Gln-Cys-Lys-Xaa3-Ala-Arg- (SEQ ID NO:118) Cys-Cys-Gly-# Name: La3.3 Species: laterculatus Cloned: Yes DNA Sequence: GGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGC (SEQ ID NO:119) TTCTGTTTCCCCTTACTGCTCTTCCGATGGATGGAGATCAACTTGCACGCCGATCTGC AGAGCGTATGCAGGACAACATTTCATCTGAGCAGCATCACCTCTTTGAAAAGAGAC GACCACCATGTTGCACCTATGACGGGAGTTGCCTAAAAGAATCATGCATGCGTAAA GCTTGTTGCGGATGATAACGTGTTGATGACCAACTTTGTTATCACGGCTACTCAAGT GTCTAATGAATAAGTAAAATGATTGCAGTA Translation: MMSKLGVLLTICLLLFPLTALPMDGDQLARRSAERMQDNISSEQHHLFEKRRPPCCTYD (SEQ ID NO:120) GSCLKESCMRKACCG Toxin Sequence: Arg-Xaa3-Xaa3-Cys-Cys-Thr-Xaa5-Asp-Gly-Ser-Cys-Leu-Lys-Xaa1-Ser-Cys-Met-Arg-Lys- (SEQ ID NO:121) Ala-Cys-Cys-# Name: La3.3A Species: laterculatus Cloned: Yes DNA Sequence: GGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCACCTGTCTGC (SEQ ID NO:122) TTCTGTTTCCCCTTACTGCTCTTCCGATGGATGGAGATCAACTTGCACGCCGACCTG CAGAGCGTATGCAGGACAACATTTCATCTGAGCAGCATCCCTTCTTTGAAAGGAGA CGACCACCATGTTGCACCTATGACGGGAGTTGCCTAAAAGAATCATGCAAGCGTAA AGCTTGTTGCGGATAATAACGTGTTGATGACCAACTTTGTTATCACGGCTACTCAAG TGTCTAATGAATAAGTAAAATGATTGCAGTA Translation: MMSKLGVLLTTCLLLFPLTALPMDGDQLARRPAERMQDNISSEQHPFFERRRPPCCTYD (SEQ ID NO:123) GSCLKESCKRKACCG Toxin Sequence: Arg-Xaa3-Xaa3-Cys-Cys-Thr-Xaa5-Asp-Gly-Ser-Cys-Leu-Lys-Xaa1-Ser-Cys-Lys-Arg-Lys- (SEQ ID NO:124) Ala-Cys-Cys-# Name: Lp3.1 Species: leopardus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCGTCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:125) TTACTGCTCTTCGGCTGGTTGGAGATCAACCTGCAGAGCGACCTGCAAAGCGTACGC AGGACGACATTCCAGATGGACAGCATCCGTTAAATGATAGGCAGATAAACTGTTGC CCGTGGCCATGCCCTAGTACATGCCGCCATCAATGCTGCCATTAATGATAACGTGTT GATGACCAACTTTCTCGAG Translation: GSMMSKLGVLLTVCLLLFPLTALRLVGDQPAERPAKRTQDDIPDGQHPLNDRQINCCP (SEQ ID NO:126) WPCPSTCRHQCCH Toxin Sequence: Xaa2-Ile-Asn-Cys-Cys-Xaa3-Xaa4-Xaa3-Cys-Xaa3-Ser-Thr-Cys-Arg-His-Gln-Cys-Cys-His-{circumflex over ( )} (SEQ ID NO:127) Name: Lv3.1 Species: lividus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCGTCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:128) TTACTGCTCTTCGGCTGGTTAGAGATCAACCTGCAGAGCGACCTGCAAAGCGTACGC AGGACGACATTCCAAATGGACAGGATCCGTTAATTGATAGGCAGATAAATTGTTGC CCTTGGCCATGCCCTGATTCATGCCACTATCAATGCTGCCACTGATAACGTGTTGAT GACCAACTTTCTCGAG Translation: GSMMSKLGVLLTVCLLLFPLTALRLVRDQPAERPAKRTQDDIPNGQDPLIDRQTNCCPW (SEQ ID NO:129) PCPDSCHYQCCH Toxin Sequence: Xaa2-Ile-Asn-Cys-Cys-Xaa3-Xaa4_Xaa3-Cys-Xaa3-Asp-Ser-Cys-His-Xaa5-Gln-Cys-Cys-His-{circumflex over ( )} (SEQ ID NO:130) Name: L3.1 Species: lynceus Cloned: Yes DNA Sequence: AAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTG (SEQ ID NO:131) CTTCTGTTTCCCCTTACTGCTCTTCCGATGGATGGAGATCAATCTGCAGACCGACTTG CAGAGCGTATGCAGGACAACATTTCATCTGAGCAGCATCCCTTCTTTGAAAAGAGA GGACGAGACTGTTGCACACCTCCGAGGAAATGCAGAGACCGAGCCTGCAAACCTCA ACGTTGTTGCGGAGGATAAGCTGTTGATGACCAACTTTGTTATACGGC Translation: MMSKLGVLLTICLLLFPLTALPMDGDQSADRLAERMQDNISSEQHPFFEKRGRDCCTPP (SEQ ID NO:132) RKCRDRACKPQRCCGG Toxin Sequence: Gly-Arg-Asp-Cys-Cys-Thr-Xaa3-Xaa3-Arg-Lys-Cys-Arg-Asp-Arg-Ala-Cys-Lys-Xaa3-GLn- (SEQ ID NO:133) Arg-Cys-Cys-Gly-# Name: M3.1 Species: magus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:134) TCTGCTTCTGTTTCCCCTTACTGCTCTTCCGATGGATGGAGATGAACCTGCAAACCG ACCTGTCGAGCGTATGCAGGACAACATTTCATCTGAGCAGTATCCCTTGTTTGAGAA GAGACGAGATTGTTGCACTCCGCCGAAGAAATGCAAAGACCGACAATGCAAACCCC AGAGATGTTGCGCTGGACGATAACGTGTTGATGACCAACTTTATCACGGCTACGTCA AGTGTTTAGTGAATAAGTAAAATGATTGCAGTCTTGCTCAGATTTGCTTTTGTGTTTT GGTCTAAAGATCAATGACCAAACCGTTGTTTTGATGCGGATTGTCATATATTTCTCG ATTCCAATCCAACACTAGATGATTTAATCACGATAGATTAATTTTCTATCAATGCCT TGATTTTTCGTCTGTCATATCAGTTTTGTTTATATTTATTTTTTCGTCACTGTCTACAC AAACGCATGCATGCACGCATGCACGCACACACGCACGCACGCTCGCACAAACATGC GCGCGCACGCACACACACACACACACACACAAACACACACACGAAGCAATCACAC AATTAGTTGACATTATTTATTTATTCATTGATGTATTTGTTATTCGTTTGCTTGTTTTT AGAATAGTTTGAGGCCGTCTTTTTGGATTTATTTGAACTGCTTTATTGTATACGAGTA CTTCGTGCGGGGAAACACTGCTGAAAATAAAACAAACACTGACGTAGCAAAAAAA AAAAA Translation: MMSKLGVLLTICLLLFPLTALPMDGDEPANRPVERMQDNISSEQYPLFEKRRDCCTPPK (SEQ ID NO:135) KCKDRQCKPQRCCAGR Toxin Sequence: Arg-Asp-Cys-Cys-Thr-Xaa3-Xaa3-Lys-Lys-Cys-Lys-Asp-Arg-Gln-Cys-Lys-Xaa3-Gln-Arg- (SEQ ID NO:136) Cys-Cys-Ala-# Name: M3.2 Species: magus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:137) TCTGCTTCTGTTTCCCCTTACTGCTCTTCCAATGGATGGAGATCAACCTGCAGACCA ACCTGCAGATCGTATGCAGGACGACATTTCATCTGAGCAGTATCCCTTGTTTGATAT GAGAAAAAGGTGTTGCGGCCCCGGCGGTTCATGCCCCGTATATTTCAGAGACAATT TTATTTGTGGTTGTTGTTAAATGACAACGTGTCGATGACCAACTTCATTATCACGAC TACGCCAAGTGTCTAATGAATAAATAAAATGATTGCAGTCTCGCTCAGATTTGCTTT TGTATTTTGGTCTAAAGATCAATGACCAAACCGTTGTTTTGGTGTGGATTTTCATATA TTTCTCGAGTCCTATCCAACACTAGATGATTTAATCACGATAGATCTGATTTTTTTAT CAAAGGCTTGGTTTTTCGTCTGTCACATCAGTTTTGTTTATATTTAATTTTTCGTCACT GATTACACACACGCATGAACGCACAGAGTACTAACACATACACACACACACACACA CACACACACACACACACACACACACACACACACACACACACGCGCGCGCGCGGCG CCATCTAGTAGCGCCGCGACGACACACAC Translation: MMSKLGVLLTICLLLFPLTALPMDGDQPADQPADRMQDDISSEQYPLFDMRKRCCGPG (SEQ ID NO:138) GSCPVYFRDNFICGCC Toxin Sequence: Cys-Cys-Gly-Xaa3-Gly-Gly-Ser-Cys-Xaa3-Val-Xaa5-Phe-Arg-Asp-Asn-Phe-Ile-Cys-Gly-Cys- (SEQ ID NO:139) Cys-{circumflex over ( )} Name: M3.3 Species: magus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:140) TTTGCTTCTGTTTCCCCTTACTGCTCTTCCGAGGGATGGAGATCAATCTGTAGACCGA CCTGCAGAGCGTATGCAGGACGACATTTCATCTGAGCTGCATCCCTTGTCAATCAGA AAAAGAATGTGTTGCGGCGAGAGTGCGCCATGCCCCAGCTATTTCAGAAACAGTCA GATTTGTCATTGTTGTTAAATGACAACGTGTCGATGACCACCTTCGTTATCACGACT AATGATAAGTAAAATGATTGCAGTCTCGCTCAGATTTGCTTTTGTATTTTGGTCTAA AGATCAATGACCAAACCGTTGTTTTGATGTGGATTTTCATATATTTCTCGAGTCCTAT CCAACACTAGATGATTTAATCACGATAGATCTGATTTTTTTATCAAAGCCTTGGTTTT TCGTCTGTCACATCAGTTTTGTTTATATTTAATTTTTCGTCACTGATTACACACACGC ATGAACGCACAGACGTACTAACACATACACACACACACACACACACACACACACAC ACACACACACACACACACACAC Translation: MMSKLGVLLTICLLLFPLTALPRDGDQSVDRPAERMQDDISSELHPLSIRKRMCCGESAP (SEQ ID NO:141) CPSYFRNSQICHCC Toxin Sequence: Met-Cys-Cys-Gly-Xaa1-Ser-Ala-Xaa3-Cys-Xaa3-Ser-Xaa5-Phe-Arg-Asn-Ser-Gln-Ile-Cys-His- (SEQ ID NO:142) Cys-Cys-{circumflex over ( )} Name: M3.4 Species: magus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:143) TCTGCTTCTGTTTCCCCTTACTGCTCTTCCAATGGATGGAGATCAACCTGCAGACCA ACCTGCAGATCGTATGCAGGACGACATTTCATCTGAGCAGTATCCCTTGTTTGATAA GAGACAAAAGTGTTGCGGCCCCGGCGGTTCATGCCCCGTATATTTCACAGACAATTT TATTTGTGGTTGTTGTTAAATGACAACGTGTCGATGACCAACTTCATTATCACGACT ACGCCAAGTGTCTAATGAATAAATAAAATGATTGCAGTCTCGCTCAGATTTGCTTTT GTATTTGGTCTAAAGATCAATGACCAAACCGTTGTTTTGGTGCTGGATTTTCATATA TTTCTCGATTCCTATCCAACACTAGATGATTTAATCACGATAGATCTGATTTTTTTAT CAATGCCTTAATTTTTTGCTCTGTCATATCAGTTTTGTTTATAT Translation: MMSKLGVLLTICLLLFPLTALPMDGDQPADQPADRMQDDISSEQYPLFDKRQKCCGPG (SEQ ID NO:144) GSCPVYFTDNFICGCC Toxin Sequence: Xaa2-Lys-Cys-Cys-Gly-Xaa3-Gly-Gly-Ser-Cys-Xaa3-Val-Xaa5-Phe-Thr-Asp-Asn-Phe-Ile-Cys- (SEQ ID NO:145) Gly-Cys-Cys-{circumflex over ( )} Name: M3.5 Species: magus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:146) TCTGCTTCTGTTTCCCCTTACTGCTCTTCCAATGGATGGAGATCAACCTGCAGACCA ACCTGCAGATCGTATGCAGGACGACATTTCATCTGAGCAGTATCCCTTGTTTGATAA GAGACAAAAGTGTTGCGGCCCCGGCGGTTCATGCCCCGTATATTTCAGAGACAATTT TATTTGTGGTTGTTGTTAAATGACAACGTGTCGATGACCATCTTCATTATCACGACT ACGCCAAGTGTCTAATGAATAAATAAAATGATTGCAGTCTCGCTCAGATTTGCTTTT GTATTTTGGTCTAAAGATCAATGACCAAACCGTTGTTTTGGTGTGGATTTTCATATAT TTCTCGATTCCTATCCAACACTAGATGATTTAATCACGATAGATCTGATTTTTT Translation: MMSKLGVLLTICLLLFPLTALPMDGDQPADQPADRMQDDISSEQYPLFDKRQKCCGPG (SEQ ID NO:147) GSCPVYFRDNFICGCC Toxin Sequence: Xaa2-Lys-Cys-Cys-Gly-Xaa3-Gly-Gly-Ser-Cys-Xaa3-Val-Xaa5-Phe-Arg-Asp-Asn-Phe-Ile- (SEQ ID NO:148) Cys-Gly-Cys-Cys-{circumflex over ( )} Name: U001 Species: magus Isolated: No Toxin Sequence: Xaa2-Lys-Cys-Cys-Ser-Gly-Gly-Ser-Cys-Xaa3-Leu-Xaa5-Phe-Arg-Asp-Arg-Leu-Ile-Cys-Xaa3- (SEQ ID NO:149) Cys-Cys-{circumflex over ( )} Name: Comatose/Death Species: marmoreus Isolated: Yes Toxin Sequence: Ser-Lys-Gln-Cys-Cys-His-Leu-Ala-Ala-Cys-Arg-Phe-Gly-Cys-Thr-Xaa3-Cys-Cys-Asn-{circumflex over ( )} (SEQ ID NO:150) Name: Mr3.1 Species: marmoreus Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:151) TCTGCTTCTGTTTCCCGTTACTGCTCTTCCGATGGATGGTGATCAACCTGCAGACCGA CTTGTAGAGCGTATGCAGGACAACATTTCATCTGAGCAGCATCCCTTCTTTGAAAAG AGAAGAGGAGGCTGTTGCACACCTCCGAGGAAATGCAAAGACCGAGCCTGCAAAC CTGCACGTTGCTGCGGCCCAGGATAACGTGTTGATGACCAACTTTGTTATCACGGCT ACGTCAAGTGTCTAGTGAATAAGTAAAACGATTGCAG Translation: MMSKLGVLLTICLLLFPVTALPMDGDQPADRLVERMQDNISSEQHPFFEKRRGGCCTPP (SEQ ID NO:152) RKCKDRACKPARCCGPG Toxin Sequence: Arg-Gly-Gly-Cys-Cys-Thr-Xaa3-Xaa3-Arg-Lys-Cys-Lys-Asp-Arg-Ala-Cys-Lys-Xaa3-Ala-Arg- (SEQ ID NO:153) Cys-Cys-Gly-Xaa3-# Name: Mr3.2 Species: marmoreus Cloned: Yes DNA Sequence: GAGCTCGGTACCCCGACCTCAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTG (SEQ ID NO:154) GGAATCTTGTTGACCATCTGTCTACTTCTATTTCCCCTTACTGCTGTTCCGCTGGATG GAGATCAACCTGCAGACCGACCTGCAGAGCGTATGCAGGACGACATTTCATCTGAA CATCATCCCTTTTTTGATCCCGTCAAACGGTGTTGCAGGTTATCATGCGGCCTGGGA TGCCACCCTTGTTGTGGATGACCAGCTTTGTTATCGCGGCCTCATCAAGTGTCTAAT GAATAAGTAAAA Translation: MMSKLGILLTICLLLFPLTAVPLDGDQPADRPAERMQDDISSEHHPFFDPVKRCCRLSCG (SEQ ID NO:155) LGCHPCCG Toxin Sequence: Cys-Cys-Arg-Leu-Ser-Cys-Gly-Leu-Gly-Cys-His-Xaa3-Cys-Cys-# (SEQ ID NO:156) Name: Mr3.3 Species: marmoreus Cloned: Yes DNA Sequence: GGCCTACACCAAGCTTGCATGCCTGCAGGTCGACTCTAGAGGATCCCCGATCGATA (SEQ ID NO:157) GCAGTTCATGATGTCTAGACTGGGAGTCTTGTTGACCATCTGTCTACTTCTGTTTCCC CTTACTGCTGTTCCGCTGGATGGAGATCAACCTGCGGACCGACCTGCAGAGCGCCTG CAGGACGACATTTCATCTGAACATCATCCCCATTTTGATTCCGGCAGAGAGTGTTGC GGTTCGTTCGCATGCCGCTTTGGATGCGTGCCTTGTTGTGTATGACCAGCTTTGTTAT CACGGCCTCATCGAGTGTCTAATGAATAAGTAAAACGATTGCAGTAGGCGGGTACC GAGCTCGAATTCC Translation: MMSRLGVLLTICLLLFPLTAVPLDGDQPADRPAERLQDDISSEHHPHFDSGRECCGSFAC (SEQ ID NO:158) RFGCVPCCV Toxin Sequence: Xaa1-Cys-Cys-Gly-Ser-Phe-Ala-Cys-Arg-Phe-Gly-Cys-Val-Xaa3-Cys-Cys-Val-{circumflex over ( )} (SEQ ID NO:159) Name: Mr3.4 Species: marmoreus Cloned: Yes DNA Sequence: CGACCTCAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGA (SEQ ID NO:160) CCATCTGTCTACTTCTATTTCCCCTTACTGCTGTTCCGCTGGATGGAGACCAACCTGC AGACCGACCTGCAGAGCGTATGCAGGACGACATTTCATCTGAACGTCATCCTTTTTT TGATCGCAGCAAACAGTGTTGCCATCTGCCGGCATGCCGCTTCGGATGTACGCCTTG TTGTTGGTGATCAGCTTTGTTATCGCGTCCTCATCAAGTGTCTAATGAATAAGTAAA ATGATTGCAG Translation: MMSKLGVLLTICLLLFPLTAVPLDGDQPADRPAERMQDDISSERHPFFDRSKQCCHLPA (SEQ ID NO:161) CRFGCTPCCW Toxin Sequence: Ser-Lys-Gln-Cys-Cys-His-Leu-Xaa3-Ala-Cys-Arg-Phe-Gly-Cys-Thr-Xaa3-Cys-Cys-Xaa4-{circumflex over ( )} (SEQ ID NO:162) Name: Mr3.5 Species: marmoreus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:163) TTACTGCTCTTCCGCTGGATGGAGATCAACCTGCAGACCAACGTGCAGAGCGTACG CAGGCCGAGAAGCATTCCTTGCCTGATCCGAGAATGGGCTGTTGCCCGTTTCCATGC AAAACCAGTTGCACTACTTTGTGTTGCGGGTGATGATAACGTGTTGATGACCAACTT TCTCGAG Translation: GSMMSKLGVLLTICLLLFPLTALPLDGDQPADQRAERTQAEKHSLPDPRMGCCPFPCKT (SEQ ID NO:164) SCTTLCCG Toxin Sequence: Met-Gly-Cys-Cys-Xaa3-Phe-Xaa3-Cys-Lys-Thr-Ser-Cys-Thr-Thr-Leu-Cys-Cys-# (SEQ ID NO:165) Name: U014 Species: marmoreus Isolated: Yes Toxin Sequence: Cys-Cys-His-Xaa4-Asn-Xaa4-Cys-Asp-His-Leu-Cys-Ser-Cys-Ser-Cys-Cys-Gly-Ser-{circumflex over ( )} (SEQ ID NO:166) Name: U017 Species: marmoreus Cloned: Yes DNA Sequence: GCCAAGCTTGCATGCCTGCAGGATGACTCTAGAGGATCCCCACCTCAAGAGGGATC (SEQ ID NO:167) GATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTACTTCTGTT TGCCCTTACTGCTGTTCCGCTGGATGGAGATCAACCTGCAGACCGACCTGCAGAACG TATGCAGGACGACATTTCATCTGAACGTCATCCCATGTTTGATGCCGTCAGAGATTG TTGCCCGTTGCCGGCATGCCCCTTTGGATGCAACCCTTGTTGTGGATGACCAGCTTT GTTATCGGGACCTCATCAAGTGTCTAATGAATAAGTAAAAAACGATTCGAGTGGGT ACCGAGCTCGAATTCC Translation: MMSKLGVLLTICLLLFALTAVPLDGDQPADRPAERMQDDISSERHPMFDAVRDCCPLP (SEQ ID NO:168) ACPFGCNPCCG Toxin Sequence: Asp-Cys-Cys-Xaa3-Leu-Xaa3-Ala-Cys-Xaa3-Phe-Gly-Cys-Asn-Xaa3-Cys-Cys-# (SEQ ID NO:169) Name: U019 Species: marmoreus Isolated: Yes Toxin Sequence: Cys-Cys-Ala-Xaa3-Ser-Ala-Cys-Arg-Leu-Gly-Cys-Arg-Xaa3-Cys-Cys-Arg-{circumflex over ( )} (SEQ ID NO:170) Name: U020 Species: marmoreus Isolated: Yes Toxin Sequence: Cys-Cys-Ala-Xaa3-Ser-Ala-Cys-Arg-Leu-Gly-Cys-Arg-Xaa3-Cys-Cys-Arg-{circumflex over ( )} (SEQ ID NO:171) Name: U022 Species: marmoreus Isolated: Yes Toxin Sequence: Cys-Cys-Ala-Xaa3-Ser-Ala-Cys-Arg-Leu-Gly-Cys-Arg-Xaa3-Cys-Cys-Arg-{circumflex over ( )} (SEQ ID NO:172) Name: U024 Species: marmoreus Isolated: Yes Toxin Sequence: Gly-Cys-Cys-Gly-Ser-Phe-Ala-Cys-Arg-Phe-Gly-Cys-Val-Xaa3-Cys-Cys-Val-{circumflex over ( )} (SEQ ID NO:173) Name: Nb3.1 Species: nobilis C1oned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTACTTCTGTTTCCCC (SEQ ID NO:174) TTACTGCTCTTCCGCTGGATGAAGATCAACCGGTACACCGACCTGCAGAGCGTATGC AGGACATTTCATCTGATCAACATCTCTTCTTTGATCTCATCAAACGGTGCTGCGAGT TGCCATGCGGGCCAGGCTTTTGCGTCCCTTGTTGCTGACATCAATAACGTGTTGATG ACCAACTTTCTCGAG Translation: GSMMSKLGVLLTICLLLFPLTALPLDEDQPVHRPAERMQDISSDQHLFFDLIKRCCELPC (SEQ ID NO:175) GPGFCVPCC Toxin Sequence: Cys-Cys-Xaa1-Leu-Xaa3-Cys-Gly-Xaa3-Gly-Phe-Cys-Val-Xaa3-Cys-Cys-{circumflex over ( )} (SEQ ID NO:176) Name: Nb3.2 Species: nobilis Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTACTTGTGTTTCCCC (SEQ ID NO:177) TTACTGCTTTTCCGATGGATGGAGATCAACCTGCAGACCAACCTGCAGATCGTATGC AGGACGACATTTCATCTGAGCAGTATCCCTTGTTTGATAAGAGACAAAAGTGTTGCA CTGGGAAGAAGGGGTCATGCTCCGGCAAAGCATGCAAAAATCTCAAATGTTGCTCT GGACGATAACGTGTTGATGACCAACTTTCTCGAG Translation: GSMMSKLGVLLTICLLLFPLTAFPMDGDQPADQPADRMQDDISSEQYPLFDKRQKCCT (SEQ ID NO:178) GKKGSCSGKACKNLKCCSGR Toxin Sequence: Xaa2-Lys-Cys-Cys-Thr-Gly-Lys-Lys-Gly-Ser-Cys-Ser-Gly-Lys-Ala-Cys-Lys-Asn-Leu-Lys- (SEQ ID NO:179) Cys-Cys-Ser-# Name: Pu3.1 Species: pulicarius Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTTTTGTTGACCATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:180) TTACTGCTGTTCCGCTGGATGGAGATCAACCTGCAGACCGACCTGCAGAGCGTATGC AGGACATTGCAACTGAACAGCATCCCTTCTTTGATCCCGTCAAACGGTGTTGCAACA GCTGTTACATGGGATGCATCCCTTGTTGCTTCTAGTAATAACGTGTTGATGACCAAC TTTCTCGAG Translation: GSMMSRLGVLLTICLLLFPLTAVPLDGDQPADRPAERMQDIATEQHPFFDPVKCCNSC (SEQ ID NO:181) YMGCIPCCF Toxin Sequence: Cys-Cys-Asn-Ser-Cys-Xaa5-Met-Gly-Cys-Ile-Xaa3-Cys-Cys-Phe-{circumflex over ( )} (SEQ ID NO:182) Name: Qc3.1 Species: quercinus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:183) TTACAGCTCTTCAGCTGGATGGAGATCAACCTGCAGACCGACCTGCAGAGCGTACG CAGGACATTGCATCTGAACAGTATCGAAAGTTTGATCAGAGACAGAGGTGTTGCCA GTGGCCATGCCCCGGTAGTTGCAGATGCTGCCGTACTGGTTAACGTGTTGATGACCA ACTTTCTCGAG Translation: GSMMSKLGVLLTICLLLFPLTALQLDGDQPADRPAERTQDIASEQYRKFDQRQRCCQW (SEQ ID NO:184) PCPGSCRCCRTG Toxin Sequence: Xaa2-Arg-Cys-Cys-Gln-Xaa4-Xaa3-Cys-Xaa3-Gly-Ser-Cys-Arg-Cys-Cys-Arg-Thr-# (SEQ ID NO:185) Name: QcIIIA Species: quercinus Isolated: Yes Toxin Sequence: Cys-Cys-Ser-Gln-Asp-Cys-Leu-Val-Cys-Ile-Xaa3-Cys-Cys-Xaa3-Asn-# (SEQ ID NO:186) Name: QcIIIB Species: quercinus Isolated: Yes Toxin Sequence: Cys-Cys-Ser-Arg-His-Cys-Xaa4-Val-Cys-Ile-Xaa3-Cys-Cys-Xaa3-Asn-# (SEQ ID NO:187) Name: R3.1 Species: radiatus Isolated: Yes Cloned: Yes DNA Sequence: TCAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCT (SEQ ID NO:188) GTCTGCTTCTGTTTCCCCTTACTGCTCTTCCGATGGATGGAGATCAACCTGTAGACCG ACTTGCAGAGCGTATGCAGGACAACATTTCATCTGAGCAGCATACCTTCTTTGAAAA GAGACTACCATCGTGTTGCTCCCTTAACTTGCGGCTTTGCCCAGTACCAGCATGCAA ACGTAACCCTTGTTGCACAGGATAACGTGTTGATGACCAACTTTGTTATCACGGCTA CGTCAAGTGTCTAGTGAATAAGTAAAACGATTGCAGT Translation: MMSKLGVLLTICLLLFPLTALPMDGDQPVDRLAERMQDNISSEQHTFFEKRLPSCCSLN (SEQ ID NO:189) LRLCPVPACKRNPCCTG Toxin Sequence: Leu-Xaa3-Ser-Cys-Cys-Ser-Leu-Asn-Leu-Arg-Leu-Cys-Xaa3-Val-Xaa3-Ala-Cys-LyS-Arg-Asn- (SEQ ID NO:190) Xaa3-Cys-Cys-Thr-# Name: R3.2 Species: radiatus Cloned: Yes DNA Sequence: AGGTCGACTCTAGAGGATCCCCAAGGATCGATAGCAGTTCATGATGTCTAAACTGG (SEQ ID NO:191) GAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCCCTTACTGCTCTTCCGATGGATGG AGATCAACCTGCAGACCGACTTGCAGAGCGTATGCAGGACGACATTTCATCTGAGC AGCATCCCTTCTTTAAAAAGAGACAACAAAGATGTTGCACCGTTAAGAGGATTTGT CCAGTACCAGCATGCAGAAGTAAACCTTGTTGCAAATCATAACGTATTGATGACCA ACTTTGTTATCACGGCTACGTCAAGTGTCTAGTGAATAAGTAAAATGATTGCAG Translation: MMSKLGVLLTICLLLFPLTALPMDGDQPADRLAERMQDDISSEQHPFFKKRQQRCCTV (SEQ ID NO:192) KRICPVPACRSKPCCKS Toxin Sequence: Xaa2-Gln-Arg-Cys-Cys-Thr-Val-Lys-Arg-Ile-Cys-Xaa3-Val-Xaa3-Ala-Cys-Arg-Ser-Lys-Xaa3- (SEQ ID NO:193) Cys-Cys-Lys-Ser-# Name: R3.3 Species: radiatus Cloned: Yes DNA Sequence: ACCTCAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACC (SEQ ID NO:194) ATCTGTCTGCTTCTGTTTCCCGTTACTGCTCTTCCGATGGATGGTGATCAACCTGCAG ACCGACTTGTAGAGCGTATGCAGGACAACATTTCATCTGAGCAGCATCCCTTCTTTG AAAAGAGAAGAGGAGGCTGTTGCACACCTCCGAGGAAATGCAAAGACCGAGCCTG CAAACCTGCACGTTGCTGCGGCCCAGGATAACGTGTTGATGACCAACTTTGTTATCA CGGCTACGTCAAGTGTCTAGTGAATAAGTAAAACGATTGCAGT Translation: MMSKLGVLLTICLLLFPVTALPMDGDQPADRLVERMQDNISSEQHPFFEKRRGGCCTPP (SEQ ID NO:195) RKCKDRACKPARCCGPG Toxin Sequence: Arg-Gly-Gly-Cys-Cys-Thr-Xaa3-Xaa3-Arg-Lys-Cys-Lys-Asp-Arg-Ala-Cys-Lys-Xaa3-Ala-Arg- (SEQ ID NO:196) Cys-Cys-Gly-Xaa3-# Name: Ra3.1 Species: rattus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGGTGACCATCTGCCTGCTTCTGTTCCCT (SEQ ID NO:197) CTTGCTGCTTTTCCACTGGATGGAGATCAACCTGCAGACCACCCTGCAAAGCGTACG CAAGATGACAGTTCAGCTGCCCTGATCAATGCCTGGCTTGATGAATCCCAGACTTGC TGCAGTAACTGCGGTGAAGATTGTGATGGTTGTTGCCAGTAACGTGTTGATGACCAA CTTTCTCGAG Translation: GSMMSKLGVLVTICLLLFPLAAFPLDGDQPADHPAKRTQDDSSAALINAWLDESQTCCS (SEQ ID NO:198) NCGEDCDGCCQ Toxin Sequence: Xaa2-Thr-Cys-Cys-Ser-Asn-Cys-Gly-Xaa1-Asp-Cys-Asp-Gly-Cys-Cys-Gln-{circumflex over ( )} (SEQ ID NO:199) Name: Sm3.1 Species: stercusmuscarum Cloned: Yes DNA Sequence: GACCTCAAGAGGGATCGATAGCAGTTCGTGATGTCTAAACTGGGAGTCTTGTTGAC (SEQ ID NO:200) CATCTGTCTGCTTCTGTTTCCTCTTACTGCTCTTCCGATGGATGGAGATCAACCTGCA GACCAACCTGCAGATCGTATGCAGGACGACATTTCATCTGAGCAGTATCCCTTGTTT GATAAGAGACAAAAGTGTTGCACTGGGAAGAAGGGGTCATGCTCCGGCAAAGCAT GCAAAAATCTCAAATGTTGCTCTGGACGATAACGTGTTGATGACCAACTTTGTTATC ACGGCTACGTCAAGTGTCTAATGAATAAGTAAAACGATTGCAGT Translation: MSKLGVLLTICLLLFPLTALPMDGDQPADQPADRMQDDISSEQYPLFDRRQKCCTGKK (SEQ ID NO:201) GSCSGKACKNLKCCSGR Toxin Sequence: Xaa2-Lys-Cys-Cys-Thr-Gly-Lys-Lys-Gly-Ser-Cys-Ser-Gly-Lys-Ala-Cys-Lys-Asn-Leu-Lys- (SEQ ID NO:202) Cys-Cys-Ser-# Name: U034 Species: stercusmuscarum Isolated: Yes Cloned: Yes DNA Sequence: GATCGATAGCAGTTCGTGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTT (SEQ ID NO:203) CTGTTTCCCCTTACTGCTCTTCCGATGGATGGAGATCAACCTGCAGACCAACCTGCA GATCGTATGCAGAACGACATTTCATCTGAGCAGTATCCCTTGTTTGATAAGAGACAA AAGTGTTGCGGCCCCGGCGCGTCATGCCCCAGATATTTCAAAGACAATTTTATTTGT GGTTGTTGTTAAATGACAACGTGTCGATGACCAACTTCGTTATCACGACTTCGCCAA GTGTCTAATGAATAAGTAAAACGATTGCAGT Translation: MSKLGVLLTICLLLFPLTALPMDGDQPADQPADRMQNDISSEQYPLFDKRQKCCGPGAS (SEQ ID NO:204) CPRYFKDNFICGCC Toxin Sequence: Xaa2-Lys-Cys-Cys-Gly-Xaa3-Gly-Ala-Ser-Cys-Xaa3-Arg-Xaa5-Phe-Lys-Asp-Asn-Phe-Ile- (SEQ ID NO:205) Cys-Gly-Cys-Cys-{circumflex over ( )} Name: S3.1 Species: striatus Cloned: Yes DNA Sequence: CGACCTTTCAAGAGGGATCGATAGCAGTTCGCGATGTCTAAACTGGGGGTATTGTTG (SEQ ID NO:206) ACCATCTGTCTGCTTCTGTTTCCCCTTACTGCTCTTCCGATGGATGAAGATCAACCTG CAGACCAACTTGAAGATCGTATGCAGGACGACATTTCATCTGAGCAGTATCCCTCGT TTGTTAGGAGACAAAAGTGTTGCGGCGAAGGCTCGTCATGCCCCAAATATTTCAAA AACAATTTTATTTGTGGTTGTTGTTAAATGACAACGTGTCGATGACCAACTTCGTTA TCACGACTACGCCAAGTGTCTTGTCTAATGATAATAAAATGATTCC Translation: MSKLGVLLTICLLLFPLTALPMDEDQPADQLEDRMQDDISSEQYPSFVRRQKCCGEGSS (SEQ ID NO:207) CPKYFKNNFICGCC Toxin Sequence: Xaa2-Lys-Cys-Cys-Gly-Xaa1-Gly-Ser-Ser-Cys-Xaa3-Lys-Xaa5-Phe-Lys-Asn-Asn-Phe-Ile-Cys- (SEQ ID NO:208) Gly-Cys-Cys-{circumflex over ( )} Name: S3.2 Species: striatus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCGTCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:209) TTACTGCTCTTCCGCTGGATGGAGATCAACCTGCAGACCGACCTGCAGAGCGTATGC AGGACGACATTTCATCTGACGAGCATCCCTTGTTTGATAAGAGACAAAACTGTTGCA ATGGGGGATGCTCCAGCAAATGGTGCAGAGATCACGCACGTTGTTGCGGTCGATGA TAACGTGTTGATGACCAACTTTCTCGAG Translation: GSMMSKLGVLLTVCLLLFPLTALPLDGDQPADRPAERMQDDISSDEHPLFDKRQNCCN (SEQ ID NO:210) GGCSSKWCRDHARCCGR Toxin Sequence: Xaa2-Asn-Cys-Cys-Asn-Gly-Gly-Cys-Ser-Ser-Lys-Xaa4-Cys-Arg-Asp-His-Als-Arg-Cys-Cys-# (SEQ ID NO:211) Name: Ts3.1 Species: tessulatus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATGTGTCTGCTTCTGTTTCCCC (SEQ ID NO:212) TTACTGCTGTTCCGCTGGATGGAGATCAACCTGCAGACCGACCTGCAGAGCGTAGG CAGGACATTGCAACTGACGATCATCCTTTGTTTGATCCCGTCAAACGGTGCTGCCAC AAATGCTATATGGGATGCATCCCTTGTTGCATTTAGTAACGTGTTGATGACCAACTT TCTCGAG Translation: GSMMSKLGVLLTMCLLLFPLTAVPLDGDQPADRPAERRQDIATDDHPLFDPVKRCCHK (SEQ ID NO:213) CYMGCIPCCI Toxin Sequence: Cys-Cys-His-Lys-Cys-Xaa5-Met-Gly-Cys-Ile-Xaa3-Cys-Cys-Ile-{circumflex over ( )} (SEQ ID NO:214) Name: Ts3.2 Species: tessulatus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTGTGCTTCTGTTTCCCC (SEQ ID NO:215) TTACTGCTGTTCCGCTGGATGGAGATCAACCTGCAGACCAACCTGCAGAGCGTACG CAGAACGAGCAGCATCCCTTGTATGATCAGAAAAGAAAGTGTTGCCGGCCGCCATG CGCCATGAGCTGCGGCATGGCTAGGTGTTGCTATTAATGATAACGTGTTGATGACCA ACTTTCTCGAG Translation: GSMMSKLGVLLTICVLLFPLTAVPLDGDQPADQPAERTQNEQHPLYDQKRKCCRPPCA (SEQ ID NO:216) MSCGMARCCY Toxin Sequence: Lys-Cys-Cys-Arg-Xaa3-Xaa3-Cys-Ala-Met-Ser-Cys-Gly-Met-Ala-Arg-Cys-Cys-Xaa5-{circumflex over ( )} (SEQ ID NO:217) Name: Circling Species: textile Isolated: Yes Cloned: Yes DNA Sequence: GAGTCAACCCACTGTCACGCCAAGAGCGGACGCCACAGCTAAGGCAAGAAGGATC (SEQ ID NO:218) GATAGCAGTTCATGATGTCTAAACTGGGAGCCTTGTTGACCATCTGTCTACTTCTGT TTTCCCTTACTGCTGTTCCGCTGGATGGAGATCAACATGCAGACCAACCTGCACAGC GTCTGCAGGACCGCATTCCAACTGAAGATCATCCCTTATTTGATCCCAACAAACGGT GTTGCCCGCCGGTGGCATGCAACATGGGATGCAAGCCTTGTTGTGGATGACCAGCTT TGTTATCGCGGTCTCATGAAGTGTCTAATGAATAAGTAAAACGATTGCAGTTTCGTT CAGATTTGCTGTTGTATTTTGGTCTAAAGATTAATGACCAAACTGTTCTTTTGATCCG GATTTTCACGTATTTCTCGATTCCTATTCAACACTAGATAAGTTAATCACGACAGAT CTGATTTTCCATCAATGCCTTGCTTTTTGGTCTGTCATATAAATCTTGTTTATATTTAA TTTCTCGTCACTTTCAACACGCACACACACACACACACACACGCGCGCGC Translation: MMSKLGALLTICLLLFSLTAVPLDGDQHADQPAQRLQDRIPTEDHPLFDPNKRCCPPVA (SEQ ID NO:219) CNMGCKPCCG Toxin Sequence: Cys-Cys-Xaa3-Xaa3-Val-Ala-Cys-Asn-Met-Gly-Cys-Lys-Xaa3-Cys-Cys-Gly-{circumflex over ( )} (SEQ ID NO:220) Name: Scratcher I Species: textile Cloned: Yes DNA Sequence: GGATCCAGACGACAAAGAAGAGTCAACCCACTGCCACGTCAAGAGCAGAGCCCAC (SEQ ID NO:221) AGCTAAGACAAGAAGGATCGATAGCAGTTCATGATGTTTAAACTGGGAGTCTTGTT GACCATCTGTCTCCTTCTGTTTTCCCTTAATGCTGTTCCGTTGGATGGAGATCAACCT GCAGACCAACCTGCAGAGCGTCTGCTGGACGACATTTCATTTGAAAATAATCCCTTT TATGATCCCGCCAAACGGTGTTGCAGGACTTGCTTCGGTTGCACACCTTGTTGTGGA TGACCAGCCTCATCAAGTGTCTAACGAATAAGTAAAGCGATTGCAGTCTCGTTCAG ATTTACTTTTGTATTCTGGTCTAAAGATTAATGACCAAACTCTTCTTTTGATCCGGAT GTACATATATTTCTCGATTCCTATCCAACGCTAGATAAGCTAATCACGACAGATCTG ATTTTCTGTCAATGCCTTGCTTTTTGGTCTCTCATATCACTCTTGTTTATATTTAATTT CTCGTCACTATATATATATATACACACACACACACACGGAATTCCGATTGTCCAGTA CCGTTCTTGGGATCGAGGTATTGCTGCGATGGCTTATTCTGTACTCTTTTCTTCTGCG CTTGATAGTGATGTCTTCTACTCCCATCTGTGCTACCCCTGGCTTGATCTTTGATAGG CGTGTGCCCTTCACTGGTTATAAACCCCTCTGATCCTACTCTCTGGACGCCTCGGGG GCCCAACCTCCAAATAAAGCGACATCCAATGAAAAAA Translation: MMFKLGVLLTICLLLFSLNAVPLDGDQPADQPAERLLDDISFENNPFYDPAKRCCRTCF (SEQ ID NO:222) GCTPCCG Toxin Sequence: Cys-Cys-Arg-Thr-Cys-Phe-Gly-Cys-Thr-Xaa3-Cys-Cys-# (SEQ ID NO:223) Name: Tx3.1 Species: textile Cloned: Yes DNA Sequence: GGAACAGTCAACCCCACAGCCACGCCAAGAGCAGACAGCCACAGCTACGTGAAGA (SEQ ID NO:224) AGGGTGGAGAGAGGTTCATGATGTTGAAAATGGGAGTGGTGCTATTCATCTTTCTGG TACTGTTTCCCCTGGCAACGCTCCAGCTGGATGCAGATCAACCTGTAGAACGATATG CGGAGAACAAACAGCTCCTCAACCCAGATGAAAGGAGGGAAATCCTATTGCCTGCT CTGAGGAAGTTCTGCTGTGATTCGAATTGGTGCCACATTTCGGATTGTGAGTGCTGC TACGGTTAGCGCCGAACATCCATGGCACTGTGCTGGGCGGTTTCATCCCAACAACG ACAGCGTTTGTTGATTTCATGTATCATTGCGCCCACGTCTCTTGTCTAAGAATGACG AACATGATTGCACTCTGGTTCAGATTTCGTGTTCTTTTCTGACAATAAATGACAAAcC TCC Translation: MMLKMGVVLFIFLVLFPLATLQLDADQPVERYAENKQLLNPDERREILLPALRKIFCCDS (SEQ ID NO:225) NWCHISDCECCYG Toxin Sequence: Phe-Cys-Cys-Asp-Ser-Asn-Xaa4-Cys-His-Ile-Ser-Asp-Cys-Xaa1-Cys-Cys-Xaa5-# (SEQ ID NO:226) Name: U031 Species: textile Isolated: Yes Cloned: Yes DNA Sequence: CAAGGAACAGTCAACCCCACAGCCACGCCAAGAGCAGACAGCCACAGCTACGTGA (SEQ ID NO:227) AGAAGGGTGGAGAGAGGTTCGTGATGTTGAAAATGGGAGTGGTGCTATTCATCTTC CTGGTACTGTTTCCCGTGGCAACGCTCCAGCTGGATGCAGATCAACCTGTAGAACGA TATGCGGAGAACAAACAGCTCCTCAGCCCAGATGAAAGGAGGGAAATCATATTGCA TGCTCTGGGGACGCGATGCTGTTCTTGGGATGTGTGCGACCACCCGAGTTGTACTTG CTGCGGTTAGCGCCGAACATCCATGGCGCTGTGCTGGGCGGTTTTATCCCAACAACG ACAGCGTTTGTTGATTTCATGTATCATTGCGCCCACGTCTCTTGTCTAAGAATGACG AACATGATTGCACTCTGGTTCAGATTTCGTGTTCTTTTCTGACAATAATGACAAAA CNCC Translation: MLKMGVVLFIFLVLFPLATLQLDADQPVERYAENKQLLSPDERRIILHALGTRCCSWD (SEQ ID NO:228) VCDHPSCTCCG Toxin Sequence: Cys-Cys-Ser-Xaa4-Asp-Val-Cys-Asp-His-Xaa3-Ser-Cys-Thr-Cys-Cys-# (SEQ ID NO:229) Name: U032 Species: textile Isolated: Yes Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:230) TTACTGCTCTTCCGCTGGATGGAGATCAACCCGCAGACCAAGCTGCAGAGCGTATG CAGGCCGAGCAGCATCCCTTGTTTGATCAGAAAAGACGGTGCTGCAAGTTTCCATG CCCCGATAGTTGCAGATATTTGTGTTGCGGGTGATGATAACGTGTTGATGACCAACT TTCTCGAG Translation: GSMMSKLGVLLTICLLLFPLTALPLDGDQPADQAAERMQAEQHPLFDQKRRCCKFPCP (SEQ ID NO:231) DSCRYLCCG Toxin Sequence: Arg-Cys-Cys-Lys-Phe-Xaa3-Cys-Xaa3-Asp-Ser-Cys-Arg-Xaa5-Leu-Cys-Cys-# (SEQ ID NO:232) Name: T3.1 Species: tulipa Cloned: Yes DNA Sequence: CGACCTCAAGAGGGATCGATAGCAGTTCATGTCTAAACTGGGAGTCTTGTTGACAA (SEQ ID NO:233) TCTGTCTGCTTCTGTTTCCCCTTACTGCTCTGCCGATGGATGGAGATGAACCTGCAG ACCGACCTGCAGAGCGTATGCAGGACAACATTTCATCTGAGCAGCATCCCTTGTTTG AGGAGAGACACGGATGTTGCAAGGGGCCCGAAGGATGCTCCTCCAGAGAATGCAG ACCCCAACATTGTTGCGGTCGACGATAACGTGTTGAGGGCCAACTTTGTTATCACGG CTACGTCAAGTGTTTAGTGAATAAGTAAAATGATTGCAG Translation: MSKLGVLLTICLLLFPLTALPMDGDEPADRPAERMQDNISSEQHPLFEERHGCCKGPEG (SEQ ID NO:234) CSSRECRPQHCCGRR Toxin Sequence: His-Gly-Cys-Cys-Lys-Gly-Xaa3-Xaa1-Gly-Cys-Ser-Ser-Arg-Xaa1-Cys-Arg-Xaa3-Gln-His- (SEQ ID NO:235) Cys-Cys-# Name: Fi3.1 Species: figulinus Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGCTGACCATCT (SEQ ID NO:236) GTCTGCTTCTGATTCCCCTTACTGCTCTTTCGCTGGATGGAGATCAACCTGCAGACC GACCTGCAGAGCGTATGCAGGATGGAATTTCATCTGAACAGCATCCCATGTTTGATC CCGTCAGACGGTGTTGCCCGTGGCCATGCAACATAGGATGCGTACCTTGTTGTTGAT GACCAGTTTTGTTATCGCGGCCTCATCAAATGTCTAATGAATAAGTAAAACGATTGC AGT Translation: MMSKLGVLLTICLLLIPLTALSLDGDQPADRPAERMQDGISSEQHPMFDPVRRCCPWPC (SEQ ID NO:237) NIGCVPCC Toxin Sequence: Cys-Cys-Xaa3-Xaa4-Xaa3-Cys-Asn-Ile-Gly-Cys-Val-Xaa3-Cys-Cys-{circumflex over ( )} (SEQ ID NO:238) Name: Fi3.2 Species: figulinus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTTTAAACTGGGAGTCCTGTTGACCATCTG (SEQ ID NO:239) TATGCTTCTGTTTCCCTTTACTGCTCTTCCGCTGGATGGAGAGCAACCTGCAGACCA ACCTGCAGAGCGCATGCAGTATGACATGTTACGTGCAATGAATCCCTGGTTTGATCC CGTCAAAAGGTGCTGCTCGAAGAACTGCGCAGTATGCATCCCTTGTTGCCCGTAACT GACCAGCTTGATTATCGCGGCCAAGGCTCTAATGAATAAGTAAAACGATTGCAGT Translation: MMFKLGVLLTICMLLFPFTALPLDGEQPA QPAERMQYDMLRAMNPWFDPVRRCCSK (SEQ ID NO:240) NCAVCIPCCP Toxin Sequence: Cys-Cys-Ser-Lys-Asn-Cys-Ala-Val-Cys-Ile-Xaa3-Cys-Cys-Xaa3-{circumflex over ( )} (SEQ ID NO:241) Name: Fi3.3 Species: figulinus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGAGAGTCTTGTTGACCTTATG (SEQ ID NO:242) TCTGCTTCTGTTTCCCCTTACTGCTCTTCCGCTGAATGAAGATCAACCTGCAGAGCGT ATGCAGGACGACAATTCATCTGAGCAGCACCCCTTGTATGACCACAAACGAAAGTG TTGCCGGTGGCCATGCCCCGCAAGATGCGGCTCTTGTTGCCTGTAATAACGTGTTGG CCAACTTTGTTATCACGGCCACGTCAAATGTTTAATGAATAAGTAAAACGATTGCAG T Translation: MMSKLRVLLTLCLLLFPLTALPLNEDQPAERMQDDNSSEQHPLYDHKRKCCRWPCPAR (SEQ ID NO:243) CGSCCL Toxin Sequence: Cys-Cys-Arg-Xaa4-Xaa3-Cys-Xaa3-Ala-Arg-Cys-Gly-Ser-Cys-Cys-Leu-{circumflex over ( )} (SEQ ID NO:244) Name: Fi3.4 Species: figulinus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCTTATG (SEQ ID NO:245) TCTGCTTCTGTTTCCCCTGACTGCTCTTCCGCTGGATGAAGATCAAGCTGCAGACCG ACCTGCAGAGCGTATGCAGGGCATGTCATCTGAACAGCATCCCTTCTTTGATCCCGT CAAACGGTGTTGCGAGTTGTCACGCTGCCTTGGATGCGTCCCTTGTTGCACATCTTA ATAACGTGTGGATGACCAACTGTGTTATCACGGCCACGTCAAGTGTCTAATGAATA AGTAAAATGATTGCAGT Translation: MMSKLGVLLTLCLLLFPLTALPLDEDQAADRPAERMQGMSSEQHPFFDPVKRCCELSR (SEQ ID NO:246) CLGCVPCCTS Toxin Sequence: Cys-Cys-Xaa1-Leu-Ser-Arg-Cys-Leu-Gly-Cys-Val-Xaa3-Cys-Cys-Thr-Ser-{circumflex over ( )} (SEQ ID NO:247) Name: Fi3.5 Species: figulinus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCTTATG (SEQ ID NO:248) TCTGCTTCTGTTTCCCCTGACTGCTCTTCCGCTGGATGAAGATCAACCTGCAGACCG ACCTGCAGAGCGTATGCAGGGCATGTCATCTGAACAGCATCCCTTCTTTGATCCCGT CAAACGGTGTTGCGAGTTGTCAAAATGCCATGGATGCGTCCCTTGTTGCATACCTTA ATAACGTGCGGATGACCAACTGTGTTATCACGGCCACGTCAAGTGTCTAATGAATA AGTAAAATGATTGCAGT Translation: MMSKLGVLLTLCLLLFPLTALPLDEDQPADRPAERMQGMSSEQHPFFDPVKRCCELSK (SEQ ID NO:249) CHGCVPCCIP Toxin Sequence: Cys-Cys-Xaa1-Leu-Ser-Lys-Cys-His-Gly-Cys-Val-Xaa3-Cys-Cys-Ile-Xaa3-{circumflex over ( )} (SEQ ID NO:250) Name: Qc3.2 Species: quercinus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTCGGAGTCTTGTTGACCATCTG (SEQ ID NO:251) TCTGGTTCTGTTTCCCCTTACAGCTCTTCAGCTGGATGGAGATCAACCTGCAGACCG ACCTGCAGAGCGTACGCAGGACATTTCATCTGAACAGTATCGAAAGTTTGATCAGA GACAGAGGTGTTGCCGGTGGCCATGCCCCGGTAGTTGCAGATGCTGCCGTTATCGTT AACGTGTTGGTGACCAGCTTTGTTATCACGACCACGCCAAGTGTCTAACGAATAAGT AAAATGATTGCAGT Translation: MMSKLGVLLTICLVLFPLTALQLDGDQPADRPAERTQDISSEQYRKFDQRQRCCRWPCP (SEQ ID NO:252) GSCRCCRYR Toxin Sequence: Xaa2-Arg-Cys-Cys-Arg-Xaa4-Xaa3-Cys-Xaa3-Gly-Ser-Cys-Arg-Cys-Cys-Arg-Xaa5-Arg-{circumflex over ( )} (SEQ ID NO:253) Name: Qc3.3 Species: quercinus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:254) TCTGCTTCTGTTTCCCCTTACTGCTCTTCCACTGGATGGAGATCAACCTGCAGATCAA TCTGCAGAGCGACCTGCAGAGCGTACGCAGGACGACATTCAGCAGCATCCGTTATA TGATCCGAAAAGAAGGTGTTGCCGTTATCCATGCCCCGACAGCTGCCACGGATCTTG CTGCTATAAGTGATAACATGTTGATGGCCAGCTTTGTTATCACGGCCACGTCAAGTG TCTAATGAATAAGTAAAACGATTGCAGT Translation: MMSKLGVLLTICLLLFPLTALPLDGDQPADQSAERPAERTQDDIQQHPLYDPKRRCCRY (SEQ ID NO:255) PCPDSCHGSCCYK Toxin Sequence: Arg-Cys-Cys-Arg-Xaa5-Xaa3-Cys-Xaa3-Asp-Ser-Cys-His-Gly-Ser-Cys-Cys-Xaa5-Lys-{circumflex over ( )} (SEQ ID NO:256) Name: Wi3.1 Species: wittigi Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCCA (SEQ ID NO:257) TTACTGCTCTTCCGGTGGGTGGAGATCAGCCTGCAGACCGACTTGCAGAGCGTATGC AGGACGACACTTCATCTGAGCAGCATCCCTTTGAAAAGAGACTACCATCATGTTGC GACTTTGAGAGGCTTTGCGTAGTACCAGCATGCATACGTCATCAGTGTTGCACAGGA TAACGTGTTGATGACCAACTTTCTCGAG Translation: MMSKLGVLLTICLLLFPITALPVGGDQPADRLAERMQDDTSSEQHPFEKRLPSCCDFERL (SEQ ID NO:258) CVVPACIRHQCCTG Toxin Sequence: Leu-Xaa3-Ser-Cys-Cys-Asp-Phe-Xaa1-Arg-Leu-Cys-Val-Val-Xaa3-Ala-Cys-Ile-Arg-His-Gln- (SEQ ID NO:259) Cys-Cys-Thr-# Name: bt3a Species: betulinus Isolated: Yes Toxin Sequence: Cys-Cys-Lys-Gln-Ser-Cys-Thr-Thr-Cys-Met-Xaa3-Cys-Cys-Xaa4-{circumflex over ( )} (SEQ ID NO:260) Name: T3.2 Species: tulipa Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACAATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:261) TTACTGCTCTGCCGATGGATGGAGATGAACCTGCAGACCGACCTGCAGAGCGTATG CAGGACAACATTTCATCTGAGCAGCATCCCTTGTTTGAGGAGAGACACGGATGTTG CGAGGGGCCGAAGGGATGCTCCTCCAGAGAATGCAGACCCCAACATTGTTGCGGTC GACGATAACGTGTTGATGACCAACTNTCTCGAG Translation: MMSKLGVLLTICLLLFPLTALPMDGDEPADRAPAERMQDNISSEQHPLFEERHGCCEGPK (SEQ ID NO:262) GCSSRECRPQHCCGRR Toxin Sequence: His-Gly-Cys-Cys-Xaa1-Gly-Xaa3-Lys-Gly-Cys-Ser-Ser-Arg-Xaa1-Cys-Arg-Xaa3-Gln-His- (SEQ ID NO:263) Cys-Cys-# Name: A3.5 Species: aurisiacus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTACTTCTGTTTCCCC (SEQ ID NO:264) TTACTGCTTTTCCGATGGATGGAGATCAACCTGCAGACCAACCTGCAGATCGTATGC AGGACGACATTTCATCTGAGCAGTATCCCTTGTTTGATAAGAGACAAAGTGTTGCA CTGGGAGGAAGGGGTCATGCTCCGGCAAAGCATGCAAAAATCTCAAATGTTGCTCT GGACGATAACGTGTTGATGACCAACTTTCTCGAN Translation: MMSKLGVLLTICLLLFPLTAFPMDGDQPADQPADRMQDDISSEQYPLFDKRQKCCTGR (SEQ ID NO:265) KGSCSGKACKNLKCCSGR Toxin Sequence: Xaa2-Lys-Cys-Cys-Thr-Gly-Arg-Lys-Gly-Ser-Cys-Ser-Gly-Lys-Ala-Cys-Lys-Asn-Leu-Lys- (SEQ ID NO:266) Cys-Cys-Ser-# Name: Bt3.5 Species: betulinus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:267) TTACTGCTGTTCCGTTGGATGGAGATCAACCTGCAGACCAACCTGCAGAGCGTATGC AGAACGAGCAGCATCCCTCGTTTGATCAGAAAAGAAGGTGCTGCCGGTGGCCATGC CCCAGTATATGCGGCATGGCTAGGTGTTGCTTCGTCATGATAACGTGTTGATGACCA ACTTTCTCGAG Translation: MMSKLGVLLTICLLLFPLTAVPLDGDQPADQPAERMQNEQHPSFDQKRRCCRWPCPSIC (SEQ ID NO:268) GMARCCFVMITC Toxin Sequence: Arg-Cys-Cys-Arg-Xaa4-Xaa3-Cys-Xaa3-Ser-Ile-Cys-Gly-Met-Ala-Arg-Cys-Cys-Phe-Val-Met- (SEQ ID NO:269) IIe-Thr-Cys-{circumflex over ( )} Name: Bt3.6 Species: betulinus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGATCATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:270) TTACTGCTGTTCCGCTGGATGGAGATCAGCCTGCAGAGCGTACGCAGATCGAGCAG CATCCCTTGTTTGACCAGAAAAGAAGGTGTTGCCGGTGGCCATGCCCCAGTAGATG CGGCATGGCTAGGTGTTGCTTCGTCATGATAACGTGTTGATGANCGACCTCTCNAG Translation: MMSKGVLLIICLLLFPLTAVPLDGDQPAERTQIEQHPLFDQKRRCCRWPCPSRCGMAR (SEQ ID NO:271) CCFVMITC Toxin Sequence: Arg-Cys-Cys-Arg-Xaa4-Xaa3-Cys-Xaa3-Ser-Arg-Cys-Gly-Met-Ala-Arg-Cys-Cys-Phe-Val- (SEQ ID NO:272) Met-Ile-Thr-Cys-{circumflex over ( )} Name: Pr3.1 Species: parius Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:273) TTACTGCTCTTCCGATGGATGGTGATCAACCTGCAGACCGACTTGTAGAGCGTATGC AGGACAACATTTCATCTGAGCAGCATCCCTTCTTTGAAAAGAGAAGAGGAGGCTGT TGCACACCTCCGAAGAAATGCAAAGACCGAGCCTGCAAACCTGCACGTTGCTGCGG CCCAGGATAACGTGTTGATGACCAACTTTCTCGCC Translation: MMSKLGVLLTICLLLFPLTALPMDGDQPADRLVERMQDNISSEQHPFFEKRRGGCCTPP (SEQ ID NO:274) KKCKDRACKPARCCGPG Toxin Sequence: Arg-Gly-Gly-Cys-Cys-Thr-Xaa3-Xaa3-Lys-Lys-Cys-Lys-Asp-Arg-Ala-Cys-Lys-Xaa3-Ala-Arg- (SEQ ID NO:275) Cys-Cys-Gly-Xaa3-# Name: Pr3.2 Species: parius Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:276) TTACTGCTCTTCCGATGGATGGTGATCAACCTGCAGACCGACTTGTAGAGCGTATGC AGGACAACATTTCATCTGAGCAGCATCCCTTCTTTGAAAAGAGAAGAGGCTGTTGC ACACCTCCGAGGAAATGCAAAGACCGAGCCTGCAAACCTGCACGTTGTTGCGGCCC AGGATAACGTGTTGATGACCAACTTTCTCGAG Translation: MMSKLGVLLTICLLLFPLTALPMDGDQPADRLVERMQDNISSEQHPFFEKRRGCCTPPR (SEQ ID NO:277) KCKDRACKPARCCGPG Toxin Sequence: Arg-Gly-Cys-Cys-Thr-Xaa3-Xaa3-Arg-Lys-Cys-Lys-Asp-Arg-Ala-Cys-Lys-Xaa3-Ala-Arg- (SEQ ID NO:278) Cys-Cys-Gly-Xaa3-# Name: Ct3.1 Species: coronatus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCAA (SEQ ID NO:279) TTACTGCCCTTCCGCTGGATGAAGATCAACCTGCAGACCGACCTGCAGAGCGTATGC AGGACATTGCAACTGAACAGCATCCCTTGTTTGATCCCGTCAAACGGTGCTGCGATT GGCCATGCATCCCAGGATGCACCCCTTGTTGCTTGCCTTGATAACGTGTTGATGACC AACTTTCTCGAG Translation: MMSKLGVLLTICLLLFPITALPLDEDQPADRPAERMQDIATEQHPLFDPVKRCCDWPCIP (SEQ ID NO:280) GCTPCCLP Toxin Sequence: Cys-Cys-Asp-Xaa4-Xaa3-Cys-Ile-Xaa3-Gly-Cys-Thr-Xaa3-Cys-Cys-Leu-Xaa3-{circumflex over ( )} (SEQ ID NO:281) Name: Ms3.1 Species: musicus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCCTGTTGACCATCTGTCTGCTTCTGTTTCCTC (SEQ ID NO:282) TTTCTGCTCTTCCGATGGATGAAGATCAACTTGCAGACCTACCTGCAGAGCGTATGC GGGACACTGCAACTGTAGATCATCCCTCCTATGATCCTGACAAAGCGTGCTGCGAG CAGAGCTGTACAACATGCTTTCCGTGCTGCTAGCCTTGAACACAGTAACGTGTTGAT GACCAACTTTCTCGAG Translation: MMSKLGVLLTICLLLFPLSALPMDEDQLADLPAERMRDTATVDHPSYDPDKACCEQSC (SEQ ID NO:283) TTCFPCC Toxin Sequence: Ala-Cys-Cys-Xaa1-Gln-Ser-Cys-Thr-Thr-Cys-Phe-Xaa3-Cys-Cys-{circumflex over ( )} (SEQ ID NO:284) Name: bt3b Species: betulinus Isolated: Yes Toxin Sequence: Ala-Cys-Cys-Xaa1-Gln-Ser-Cys-Thr-Thr-Cys-Met-Xaa3-Cys-Cys-{circumflex over ( )} (SEQ ID NO:285) Name: bt3c Species: betulinus Isolated: Yes Toxin Sequence: Cys-Cys-Xaa1-Gln-Ser-Cys-Thr-Thr-Cys-Met-Xaa3-Cys-Cys-Xaa4-# (SEQ ID NO:286) Name: Pn3.2 Species: pennaceus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:287) TTACTGCTCTTCCGCTGGATGGAGATCAACCTGCATACCAAGCTGCAGAGCGTATGC AGGCCGAGCATCATCCCTTGTTTGATCAGAAAAGACGGTGCTGCAAGTTTCCATGCC CCGATAGTTGCAAATATTTGTGTTGCGGGTGATGATAACATGTTGATGACCAACTTT CTTGAG Translation: MMSKLGVLLTICLLLFPLTALPLDGDQPAYQAAERMQAEHHPLFDQKRRCCKEPCPDS (SEQ ID NO:288) CKYLCCG Toxin Sequence: Arg-Cys-Cys-Lys-Phe-Xaa3-Cys-Xaa3-Asp-Ser-Cys-Lys-Xaa5-Leu-Cys-Cys-# (SEQ ID NO:289) Name: Pu3.2 Species: pulicarius Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:290) TTACTGCTCTTCCGATGGATGGTGATCAACTTGCAGACCGACTTGTAGAGCGTATGC AGGACAACATTTCATCTGAGCAGCATCCCTTCTTTGATCCCGTCAAACGGTGTTGCG TCAGCTGTTACATGGGATGCATCCCTTGTTGCTTCTAGTAATAACGTGTTGATGACC AACTTTCTCGAG Translation: MMSKLGVLLTICLLLFPLTALPMDGDQLADRLVERMQDNISSEQHPFFDPVKRCCVSCY (SEQ ID NO:291) MGCIPCCF Toxin Sequence: Cys-Cys-Val-Ser-Cys-Xaa5-Met-Gly-Cys-Ile-Xaa3-Cys-Cys-Phe-{circumflex over ( )} (SEQ ID NO:292) Name: Pu3.3 Species: pulicarius Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCGTCTGTCTGCTTCTGTGTCCCC (SEQ ID NO:293) TTACTGCTCTTCCACTGGATGAAGATCAACTTGCAGACCGACCTGCAGAGCGTATGC AGGATGACACTTCAGCTGCACAGATTTTCGGGTTTGATCCCGTCAAACGGTGCTGCA AATTGCTATGCTACTCGGGATGCACTCCTTGTTGCCATATTTGATAACGTGTTGATG ACCAACTTTCTCGAG Translation: MMSKLGVLLTVCLLLCPLTALPLDEDQLADRPAERMQDDTSAAQIFGFDPVKRCCKLL (SEQ ID NO:294) CYSGCTPCCHI Toxin Sequence: Cys-Cys-Lys-Leu-Leu-Cys-Xaa5-Ser-Gly-Cys-Thr-Xaa3-Cys-Cys-His-Ile-{circumflex over ( )} (SEQ ID NO:295) Name: Ra3.2 Species: rattus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTGTGTTTCCGC (SEQ ID NO:296) TTACTGCTCTTCCGATGGATGGTGATCAACCTGCAGACCGACTTGTAGAGCGTATAC AGGACAACATTTCATCTGAGCAGCATCCCTTCTTTGAAAAGAGAAGAGGCTGTTGC GCACCTCCGAGGAAATGCAAAGACCGAGCCTGCAAACCTGCACGTTGCTGCGGCCC AGGATAACGTGTTGATGACCAACTTTCTCGAG Translation: MMSKLGVLLTICLLVFPLTALPMDGDQPADRLVERQDNISSEQHPFFERGCCAAPPRK (SEQ ID NO:297) CKDRACKPARCCGPG Toxin Sequence: Arg-Gly-Cys-Cys-Ala-Xaa3-Xaa3-Arg-Lys-Cys-Lys-Asp-Arg-Ala-Cys-Lys-Xaa3-Ala-Arg- (SEQ ID NO:298) Cys-Cys-Gly-Xaa3-# Name: Sm3.3 Species: stercusmuscarum Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACAATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:299) TTATTGCTCTTCCGCTGGATGGAGATCAACCTGCAGACCGACCTGCAGAGCGTATGC AGGACGACATTTCATCTGAGAAGCATCCCTTGTTTGATAAGAGACAACGGTGTTGC AATGGGCGGAGGGGATGCTCCAGCAGATGGTGCAGAGATCACTCACGTTGTTGCGG TCGACGATAACGTGTTGATGACCAACTTTCTCGAG Translation: MMSKLGVLLTICLLLFPLIALPLDGDQPADRPAERMQDDISSEKHPLFDKRQRCCNGRR (SEQ ID NO:300) GCSSRWCRDHSRCCGRR Toxin Sequence: Xaa2-Arg-Cys-Cys-Asn-Gly-Arg-Arg-Gly-Cys-Ser-Ser-Arg-Xaa4-Cys-Arg-Asp-His-Ser-Arg- (SEQ ID NO:301) Cys-Cys-# Name: Eb3.1 Species: ebraeus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:302) TTACTGCTCTTCCACTGGATGAAGGTCAACCTGCAGACCTACCTGCAGAGCGTATGC AGGACATTGCAACTGAACAGCATCCCTTGTTTGATCCTGTCAAACGGTGTTGCGAGC AGCCATGCTACATGGGATGCATCCCTTGTTGC TCTAATAATAACGTGTTGATGACC AACTTTCTCGAG Translation: MMSKLGVLLTICLLLFPLTALPLDEGQPADLPAERMQDIATEQHPLFDPVKRCCEQPCY (SEQ ID NO:303) MGCIPCCF Toxin Sequence: Cys-Cys-Xaa1-Gln-Xaa3-Cys-Xaa5-Met-Gly-Cys-Ile-Xaa3-Cys-Cys-Phe-{circumflex over ( )} (SEQ ID NO:304) Name: Eb3.2 Species: ebraeus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:305) TTACTGCTCTTCCACTGGATGAAGATCAACCTGCAGACCTACCTGCAGAGCGTATGC AGGACATTGCAACTGAACAGCATCCCTTGTTTGATCCTGTCAAACGGTGCTGCGCGC AGCCATGCTACATGGGATGCATCCCTTGTTGCTTCTAATAATAACGTGTTGATGACC AACTTTCTCGAG Translation: MMSKLGVLLTICLLLFPLTALPLDEDQPADLPAERMQDIATEQHPLFDPVKRCCAQPCY (SEQ ID NO:306) MGCIPCCF Toxin Sequence: Cys-Cys-Ala-Gln-Xaa3-Cys-Xaa5-Met-Gly-Cys-Ile-Xaa3-Cys-Cys-Phe-{circumflex over ( )} (SEQ ID NO:307) Name: Fd3.2 Species: flavidus Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCCC (SEQ ID NO:308) TTACTGCTGTTCCGTTGGATGGAGATCAACCTGCAGACCAGCCTGCAGAGCGTATGC AGAACGAGCAGCATCCCTTGTTTGATCAGAAAAGAAGGTGCTGCCGGTGGCCATGC CCCAGTATATGCGGCATGGCTAGGTGTTGCTCGTCATGATAACGTGTTGATGACCAA CTTTCTCGAG Translation: MMSKLGVLLTICLLLFPLTAVPLDGDQPADQPAERMQNEQHPLFDQKRRCCRWPCPSIC (SEQ ID NO:309) GMARCCSS Toxin Sequence: Arg-Cys-Cys-Arg-Xaa4-Xaa3-Cys-Xaa3-Ser-Ile-Cys-Gly-Met-Ala-Arg-Cys-Cys-Ser-Ser-{circumflex over ( )} (SEQ ID NO:310) Name: Mf3.1 Species: miliaris Cloned: Yes DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTGTCTGCTTCTGTTTCCAA (SEQ ID NO:311) TTACTGCCCTTCCACTGGATGAAGATCAACCTGCAGACCGACCTGCAGAGCGTATGC AGGACATTGCAACTGAACAGCATCCCTTGTTTGATCCCGTCAAACGGTGTTGCGATT GGCCATGCAGCGCAGGATGCTACCCTTGTTGCTTCCCTTAATAACGTGTTGATGACC AACTNANGNAAAAAAA Translation: MMSKLGVLLTICLLLFPITALPLDEDQPADRPAERMQDIATEQHPLFDPVKRCCDWPCS (SEQ ID NO:312) AGCYPCCFP Toxin Sequence: Cys-Cys-Asp-Xaa4-Xaa3-Cys-Ser-Ala-Gly-Cys-Xaa5-Xaa3-Cys-Cys-Phe-Xaa3-{circumflex over ( )} (SEQ ID NO:313) Name: Mf3.2 Species: miliaris Cloned: Yes Notes: DNA Sequence: GGATCCATGATGTCTAAACTGGGAGTGGTGCCATTCGTCTTTCTGGTCCTGTTTCCCC (SEQ ID NO:314) TGGCAACACTCCAACTGGATGCAGATCAACCTGCAGACCGACCTGCGCGTAAAAAG GGCATTGCAACTAAACGGCATCCCTTGTCTGATCCTGTCAGAGGGTGTTGCCCTCCA ATGTGCACACCATGCTTCCCTTGCTGTTTTCGTTAATAACGTGTTGATGNATGATGN AN Translation: MMSKLGVVPFVFLVLFPLATLQLDADQPADRPARKKGIATKRHPLSDPVRGCCPPMCTPCFPCC (SEQ ID NO:315) FR Toxin Sequence: Gly-Cys-Cys-Xaa3-Xaa3-Met-Cys-Thr-Xaa3-Cys-Phe-Xaa3-Cys-Cys-Phe-Arg-{circumflex over ( )} (SEQ ID NO:316) Name: Af3.1 Species: ammiralis Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:317) TCTGCTTCTGTTTCCCCTTACTGCTCTTCCGCTGGATGGAGATCAACCTGCAGACCA AGCTGCAGAGCGTATGCAGGCCGAGCAGCATCCCTTGTTTGATCAGAAAAGACGGT GTTGCAGGTTTCCATGCCCCGATACTTGCAGACATTTGTGTTGCGGGTGATGATAAC GTGCTGATGACCCACTTTGTCATCACGGCTACGTCAAGTGTCTAATGAATAAGTAAA ATGATTGCAGT Translation: MMSKLGVLLTICLLLFPLTALPLDGDQPADQAAERMQAEQHPLFDQKRRCCRFPCPDT (SEQ ID NO:318) CRLHLCCG Toxin Sequence: Arg-Cys-Cys-Arg-Phe-Xaa3-Cys-Xaa3-Asp-Thr-Cys-Arg-His-Leu-Cys-Cys-# (SEQ ID NO:319) Name: Af3.2 Species: ammiralis Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTTTAAACTGGGAGTCTTGCTGACCATCTG (SEQ ID NO:320) TCTACTTCTGTTTTCCCTTAATGCTGTTCCGCTGGATGGAGATCAACCTGCAGACCA ACCTGCAGAGCGTCTGCTGGACGACATTTCATCTGAAAATAATCCCTTTTATGATCC CGCCAAACGGTGTTGCATGACTTGCTTCGGTTGCACACCTTGTTGTGGATGACCAGC CTCATCAAGTGTCTAACGAATAAGTAAAACGATTGCAGT Translation: MMFKILGVLLTICLLLFSLNAVPLDGDQPADQPAERLLDDISSENNPFYDPAKRCCMTCF (SEQ ID NO:321) GCTPCCG Toxin Sequence: Cys-Cys-Met-Thr-Cys-Phe-Gly-Cys-Thr-Xaa3-Cys-Cys-# (SEQ ID NO:322) Name: Af3.3 Species: ammiralis Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGCCTTGTTGACCATCT (SEQ ID NO:323) GTCTACTTCTGTTTTCCCTTACTGCTGTTCCGCTGGATGGAGATCAACATGCAGACC AACCTGCAGAGCGTCTGCAGGACCGCCTTCCAACTGAAAATCATCCCTTATATGATC CCGTCAAACGGTGTTGCGATGATTCGGAATGCGACTATTCTTGCTGGCCTTGCTGTA TTTTTTCATAACCTTTGTTATCGCGGCCTCATCCTAGTGTCAAATGAATAAGTAAAA CGATTGCAGT Translation: MMSKLGALLTICLLLFSLTAVPLDGDQHADQPAERLQDRLPTENHPLYDPVKRCCDDSE (SEQ ID NO:324) CDYSCWPCCIFS Toxin Sequence: Cys-Cys-Asp-Asp-Ser-Xaa1-Cys-Asp-Xaa5-Ser-Cys-Xaa4-Xaa3-Cys-Cys-Ile-Phe-Ser-{circumflex over ( )} (SEQ ID NO:325) Name: Af3.4 Species: ammiralis Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTTTAAACTCGGAGTCTTGCTGACCATCTG (SEQ ID NO:326) TCTACTTCTGTTTTCCCTAATtGCTGTTCCGCTGGATGGAGATCAACATGCAGACCAA CCTGCAGAGCGTCTGCAGGACCGCCTTCCAACTGAAAATCATCCCTTATATGATCCC GTCAAACGGTGTTGCAGGTTGTTATGCCTCAGTTGCAACCCTTGTTGTGGATGACCA GCTTTGTTATCACGGCCTCATCAAGTGTCTAATGAATAAGTAAAACGATTGCAGT Translation: MMFKLGVLLTICLLLFSLIAVPLDGDQHADQPAERLQDRLPTENHPLYDPVKRCCRLLC (SEQ ID NO:327) LSCNPCCG Toxin Sequence: Cys-Cys-Arg-Leu-Leu-Cys-Leu-Ser-Cys-Asn-Xaa3-Cys-Cys-# (SEQ ID NO:328) Name: Af3.6 Species: ammiralis Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGCCTTGTTGACCATCT (SEQ ID NO:329) GTCTACTTCTGTTTTCCCTTACTGCTGTTCCGCTGGATGGAGATCAACATGCAGACC AACCTGCAGAGCGTCTGCAGGACCGCATTCCAACTGAAGATCATCCCTTATTTGATC CCAACAAACGGTGTTGCGATGATTCGGAATGCGGCTATTCATGCTGGCCTTGCTGTT ATGGATAAGCTTTGTTATCGCGGCCTCATCCAGTGTCAACGAATAAGTAAAACGATT GCAGT Translation: MMSKLGALLTICLLLFSLTAVPLDGDQHADQPAERLQDRIPTEDHPLFDPNKRCCDDSE (SEQ ID NO:330) CGYSCWPCCYG Toxin Sequence: Cys-Cys-Asp-Asp-Ser-Xaa1-Cys-Gly-Xaa5-Ser-Cys-Xaa4-Xaa3-Cys-Cys-Xaa5-# (SEQ ID NO:331) Name: Sf3.1 Species: spurius Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGCTGACCATCT (SEQ ID NO:332) GTCTGCTTCTGTTTCCACGTACTTCTCTTCCGCTGGATGGAGATCAACCTGCAGTCCG ATCTGCAAAGCGTATGCATTCATCTATACAGCGTCGTTTCTTTGATCCCGTCAAACG GTGTTGCCCTAGATGCAGCGAGTGCAACCCTTGTTGTGGATGACCAGCTTTGTCATC GCGGCCTCATTAAGTGTCTAATGAATAAGTAAAATGATTGCAGT Translation: MMSKLGVLLTICLLLFPRTSLPLDGDQPAVRSAKRMHSSIQRRFFDPVKRCCPRCSECNP (SEQ ID NO:333) CCG Toxin Sequence: Cys-Cys-Xaa3-Arg-Cys-Ser-Xaa1-Cys-Asn-Xaa3-Cys-Cys-# (SEQ ID NO:334) Name: Om3.1 Species: omaria Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTCGTTGACCATCT (SEQ ID NO:335) GTCTACTTCTATTTTCCCTTACTGCTGTTCCGCTTGATGGAGATCAACATGCAGACCA ACCTGCAGAGCGTCTGCAGGGCGACATTTTATCTGAAAAGCATCCCTTATTTAATCC CGTCAAACGGTGTTGCGATGAGGAAGAATGCAGCAGTGCATGCTGGCCTTGTTGTT GGGGGTGATCAGCTTTGTTATCGCGGCCTCATCAAGTGTCTAATGAATAAGTAAAAT GATTGCAGT Translation: MMSKLGVSLTICLLLFSLTAVPLDGDQHADQPAERLQGDILSEKHPLFNPVKRCCDEEE (SEQ ID NO:336) CSSACWPCCWG Toxin Sequence: Cys-Cys-Asp-Xaa1-Xaa1-Xaa1-Cys-Ser-Ser-Ala-Cys-Xaa4-Xaa3-Cys-Cys-Xaa4-# (SEQ ID NO:337) Name: Om3.2 Species: omaria Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGATCATCTG (SEQ ID NO:338) TCTACTTCTGTGTCCCCTTACTGCTGTTCTGGAGGATGGAGATCAACCTGCAGACCG ACCTGCAGAGCGTATGCAGGACGACATTTCAACTGAGCATCATCCCTTTTATGATCC CGTCAAACGGTGTTGCAAGTACGGGTGGACATGCTTGCTAGGATGCACTCCTTGTGA TTGTTGACCAGTTTTGTTATCGCGGCCTCGTCAAGTGTCTAATGAATAAGTAAAACG ATTGCAGT Translation: MMSKLGVLLIICLLLCPLTAVLEDGDQPADRPAERMQDDISTEHHPFYDPVKRCCKYG (SEQ ID NO:339) WTCLLGCTPCDC Toxin Sequence: Cys-Cys-Lys-Xaa5-Gly-Xaa4-Thr-Cys-Leu-Leu-Gly-Cys-Thr-Xaa3-Cys-Asp-Cys-{circumflex over ( )} (SEQ ID NO:340) Name: Om3.3 Species: omaria Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTATACTGGGAGTCTTGTTGATCATCTG (SEQ ID NO:341) TCTACTTCTGTGTCCCCTTACTGCTGTTCTGGAGGATGGAGATCAACCTGCAGACCG ACCTGCAGAGCGTATGCAGGACGGCATTTCATCTGAACATCATCCCTTTTTGGATCC CGTCAAACGGTGTTGCCATCTATTGGCATGCCGCTTTGGATGCTCGCCTTGTTGTTG GTGACCAGCTTTGTTATCGCGGCCTCATCAAGTGTCTAATGAATAAGTAAAACGATT GCAGT Translation: MMSILGVLLIICLLLCPLTAVLEDGDQPADRPAERMQDGISSEHHPFLDPVKRCCHLLAC (SEQ ID NO:342) RFGCSPCCW Toxin Sequence: Cys-Cys-His-Leu-Leu-Ala-Cys-Cys-Arg-Phe-Gly-Cys-Ser-Xaa3-Cys-Cys-Xaa4-{circumflex over ( )} (SEQ ID NO:343) Name: Om3.4 Species: omaria Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGATCATCTG (SEQ ID NO:344) TCTACTTCTTTGTCCCCTTACTGCTGTTCCGCAGGATGGAGATCAACCTGCAGACCG ACCTGCAGAGCGTATGCAGGGCGGCATTTCATCTGAACATCATCCCTTTTTTGATCC CGTCAAACGGTGTTGCAGGTACGGGTGGACATGCTGGCTAGGATGCACTCCCTGTG GTTGTTGACCAGCTTTGTTATCGCGGCCTCATCAAGTGTCTAATGAATAAGTAAAAC GATTGCAGT Translation: MMSKLGVLLIICLLLCPLTAVPQDGDQPADRPAERMQGGISSEHHPFFDPVKRCCRYGW (SEQ ID NO:345) TCWLGCTPCGC Toxin Sequence: Cys-Cys-Arg-Xaa5-Gly-Xaa4-Thr-Cys-Xaa4-Leu-Gly-Cys-Thr-Xaa3-Cys-Gly-Cys-{circumflex over ( )} (SEQ ID NO:346) Name: Ep3.1 Species: episcopatus Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:347) TCTACTTCTGTTTTCCCTTATTGCTGTTCCGCTTGATGGAGATCAACATGCAGACCAA CCTGCAGAGCGTCTGCAGGGCGACATTTTATCTGAAAAGCATCCCTTATTTATGCCT GTCAAACGGTGTTGCGATGAGGACGAATGCAACAGTTCATGCTGGCCTTGTTGTTGG GGGTGATCAGCTTTGTTATCGCGGCCTGATCAAGTGTATAATGAATAAGTAAAACG ATTGCAGT Translation: MMSKLGVLLTICLLLFSLIAVPLDGDQHADQPAERLQGDILSEKHPLFMPVKRCCDEDE (SEQ ID NO:348) CNSSCWPCCWG Toxin Sequence: Cys-Cys-Asp-Xaa1-Asp-Xaa1-Cys-Asn-Ser-Ser-Cys-Xaa4-Xaa3-Cys-Cys-Xaa4-# (SEQ ID NO:349) Name: Ep3.2 Species: episcopatus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:350) TCTACTTCTGTTTTCCCTTATTGCTGTTCCGCTTGATGGAGATCAACATGCAGACCAA CCTGCAGAGCGTCTGCAGGGCGACATTTTATCTGAAAAGCATCCCTTATTTATGCCT GTCAAACGGTGTTGCGATGAGGACGAATGCAGCAGTTCATGCTGGCCTTGTTGTTGG GGATGAGCAGCTTTGTTATCGCGGCCTCATCAAGTGTCTAATGAATAAGTAAAACG ATTGCAGT Translation: MMSKLGVLLTICLLLFSLIAVPLDGDQHADQPAERLQGDILSEKHPLFMPVKRCCDEDE (SEQ ID NO:351) CSSSCWPCCWG Toxin Sequence: Cys-Cys-Asp-Xaa1-Asp-Xaa1-Cys-Ser-Ser-Ser-Cys-Xaa4-Xaa3-Cys-Cys-Xaa4-# (SEQ ID NO:352) Name: Ep3.3 Species: episcopatus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:353) TCTACTTCTGTTTTCCCTTACTGCTGTTCCGCTTGATGGAGATCAACATGCAGACCAA CCTGCAGAGCGTCTGCAGGGCGACATTTTATCTGAAAAGCATCCCTTATTTAATCCC GTCAAACGGTGTTGCCCGGCGGCGGCATGTGCCATGGGATGCAAGCCTTGTTGTGG ATGAGCAGCTTTGTTATCGTGGCCTCATCAAGTGTCTAATGAATAAGTAAAACGATT GCAGT Translation: MMSKLGVLLTICLLLFSLTAVPLDGDQHADQPAERLQGDILSEKHPLFNPVKRCCPAAA (SEQ ID NO:354) CAMGCKPCCG Toxin Sequence: Cys-Cys-Xaa3-Ala-Ala-Ala-Cys-Ala-Met-Gly-Cys-Lys-Xaa3-Cys-Cys-# (SEQ ID NO:355) Name: Au3.2 Species: aulicus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:356) TCTGCTTCTGTTTTCCGTTACTGCTCTTCCGCCGGATGGAGATCAACCTGCAGACCG AGCTGCAGAGCGTAGGCAGGTCGAGCAGCATCCCGTGTTTGATCATGAAAGAGGGT GTTGCTCGCCACCATGCCACAGTATTTGCGCTGCTTTCTGTTGCGGGTGATGATAAC GTGTTGATGACCCACTTTGTCATCACGGCTGCGTCAAGTGTCTAATGAATAAGTAAA ATGATTGCAGT Translation: MMSKLGVLLTICLLLFSVTALPPDGDQPADRAAERRQVEQHPVFDHERGCCSPPCHSIC (SEQ ID NO:357) AAFCCG Toxin Sequence: Gly-Cys-Cys-Ser-Xaa3-Xaa3-Cys-His-Ser-Ile-Cys-Ala-Ala-Phe-Cys-Cys-# (SEQ ID NO:358) Name: Au3.3 Species: aulicus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:359) TCTACTTCTGTTTTCCCTTACTGCTGTTCCGCTTGATGGAGATCAACATGCAGACCAA CCTGCAGAGCGTCTGCAGGGCGACATTTTATCTGAAAAGCATCCCTTATTTAATCCC GTCAAACGGTGTTGCCGACCGGTGGCATGTGCCATGGGATGCAAGCCTTGTTGTGG ATGAGCAGCTTTGTTATCGTGGCCTCATCAAGTGTCTAATGAATAAGTAAAATGATT GCAGT Translation: MMSKLGVLLTICLLLFSLTAVPLDGDQHADQPAERLQGDILSEKHPLFNPVKRCCRPVA (SEQ ID NO:360) CAMGCKPCCG Toxin Sequence: Cys-Cys-Arg-Xaa3-Val-Ala-Cys-Ala-Met-Gly-Cys-Lys-Xaa3-Cys-Cys-# (SEQ ID NO:361) Name: Au3.4 Species: aulicus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCaTGATGTCTAAACTGGGAGTCTTGTTGATCATCTG (SEQ ID NO:362) TCTACTTCTGTCTCCCCTTACTGCTGTTCCGCTGGATGGAGATCAACCTGCAGACCG ACCTGCAGAGCGTATGCAGGACGACATTTCATCTGAACATCAACCCATGTTTGATGC CATCAGACAGTGTTGCCCGGCGGTGGCATGCGCCATGGGATGCGAGCCTTGTTGTG GATGACCAGCTTTGTTATCGCGGCCTCATCAAGTGTCTAATGAATAAGTAAAATGAT TGCAGT Translation: MMSKLGVLLIICLLLSPLTAVPLDGDQPADRPAERMQDDISSEHQPMFDAIRQCCPAVA (SEQ ID NO:363) CAMGCEPCCG Toxin Sequence: Xaa2-Cys-Cys-Xaa3-Ala-Val-Ala-Cys-Ala-Met-Gly-Cys-Xaa1-Xaa3-Cys-Cys-# (SEQ ID NO:364) Name: Ae3.1 Species: aureus Cloned: Yes DNA Sequence: CAAGAAGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGCCTTGTTGACCATCT (SEQ ID NO:365) GTCTACTTCTGTTTTCCCTTACTGCTGTTCCGCTGGATGGAGATCAACATGCAGACC AACATGCAGAGCGTCTGCATGACCGCCTTCCAACTGAAAATCATCCCTTATATGATC CCGTCAAACGGTGTTGCGATGATTCGGAATGCGACTATTCTTGCTGGCCTTGCTGTA TTTTTGGATAACCTTTGTTATCGCGGCCTCATCAAGTGTCAAATGAATAAGTAAAAC GATTGCAGT Translation: MMSKLGALLTICLLLFSLTAVPLDGDQHADQHAERLHDRLPTENHPLYDPVKRCCDDS (SEQ ID NO:366) ECDYSCWPCCIFG Toxin Sequence: Cys-Cys-Asp-Asp-Ser-Xaa1-Cys-Asp-Xaa5-Ser-Cys-Xaa4-Xaa3-Cys-Cys-Ile-Phe-# (SEQ ID NO:367) Name: Ae3.2 Species: aureus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGCCTTGTTGACCATCT (SEQ ID NO:368) GTCTACTTCTGTTTTCCCTAACTGCTGTTCCGCTGGATGGAGATCAACATGCAGACC AACCTGCAGAGCGTCTGCAGGACCGCATTCCAACTGAAAATCATCCCTTATTTGATC CGAACAAACGGTGTTGCAATGATTGGGAATGCGACGATTCATGCTGGCCTTGCTGTT ATGGATAACCTTTGTTATCGCGGCCTCATCAAGTGTCAAATGAATAAGTAAAACGAT TGCAGT Translation: MMSKLGALLTICLLLFSLTAVPLDGDQHADQPAERLQDRIPTENHPLFDPNKRCCNPWE (SEQ ID NO:369) CDDSCWPCCYG Toxin Sequence: Cys-Cys-Asn-Asp-Xaa4-Xaa1-Cys-Asp-Asp-Ser-Cys-Xaa4-Xaa3-Cys-Cys-Xaa5-# (SEQ ID NO:370) Name: Cn3.1 Species: consors Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:371) TTTGCTTCTGTTTCCCCTTACTGCTCTTCCAATGGATGGAGATCAATCTGTAGACCGA CCTGCAGAGCGTATGCAGGACGACATTTCATCTGAGCTGCATCCCTTGTTCAATCAG AAAAGAATGTGTTGCGGCGAAGGTGCGCCATGCCCCAGCTATTTCAGAAACAGTCA GATTTGTCATTGTTGTTAAATGACAACGTGTCGATGACCAACTTCGTTATCACGACT AATGAATAAGTAAAATGATTGCAGT Translation: MMSKLGVLLTICLLLFPLTALPMDGDQSVDRPAERMQDDISSELHPLFNQKRMCCGEG (SEQ ID NO:372) APCPSYFRNSQICHCC Toxin Sequence: Met-Cys-Cys-Gly-Xaa1-Gly-Ala-Xaa3-Cys-Xaa3-Ser-Xaa5-Phe-Arg-Asn-Ser-Gln-Ile-Cys-His- (SEQ ID NO:373) Cys-Cys-{circumflex over ( )} Name: Cn3.3 Species: consors Cloned: Yes DNA Sequence: TAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACCATCTG (SEQ ID NO:374) TCTGCTTCTGTTTCCCCTTATTGCTCTTCCAATGGATGGAGATCAACCTGCAGACCGA CCTGCAGAGCGTATGCAgGACGACATTTCATCTCAGCAGCATCCCTTGTTTGATAAG AGAGGCCGCTGTTGCGATGTGCCGAACGCATGCTCCGGCAGATGGTGCAGAGATCA CGCACAATGTTGCGGATGACGATAACGTGTTGATGACCAACTTTGTGATCACGGCTA CATCAAGTGAATAAGTAAAACGATTGCAGT Translation: MMSKLGVLLTICLLLFPLIALPMDGDQPADRPAERMQDDISSQQHPLFDKRGRCCDVPN (SEQ ID NO:375) ACSGRWCRDHAQCCG Toxin Sequence: Gly-Arg-Cys-Cys-Asp-Val-Xaa3-Asn-Ala-Cys-Ser-Gly-Arg-Xaa4-Cys-Arg-Asp-His-Ala-Gln- (SEQ ID NO:376) Cys-Cys-# Name: Cn3.4 Species: consors Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGTTGACTGTCTG (SEQ ID NO:377) TTTGCTTCTGTTTCCCCTTACTGCTCTTCCGATGGATGGAGATCAACCTGCAGACCAA CCTGCAGAGCGTATGCAGGACGACATTTCATCTGAGCAGCATCCCTTGTTTGATAAG AGACAAAGGTGTTGCACTGGGAAGAAGGGGTCATGCTCCGGTAAAGCATGCAAAA GTCTCAAATGTTGCTCTGGACGATAACGTGTTGATGACCAACTTTGTTATCACGGCT ACGTCAAGTGTCTAGTGAATAAGTAAAACGATTGCAGT Translation: MMSKLGVLLTVCLLLFPLTALPMDGDQPADQPAERMQDDISSEQHPLFDKRQRCCTGK (SEQ ID NO:378) KGSCSGKACKSLKCCSGR Toxin Sequence: Xaa2-Arg-Cys-Cys-Thr-Gly-Lys-Lys-Gly-Ser-Cys-Ser-Gly-Lys-Ala-Cys-Lys-Ser-Leu-Lys-Cys- (SEQ ID NO:379) Cys-Ser-# Name: Em3.1 Species: emaciatus Cloned: Yes DNA Sequence: CAAGAGGGATCGATAGCAGTTCATGATGTCTAAACTGGGAGTCTTGCTGACCATCTGTCTGCTTCTGTT (SEQ ID NO:380) TCCCCTTACTGTTCTTCCGATGGATGGAGATCAACCTGCAGACCTACCTGCATTGCGTGCGCAGTTCTT TGCAGGTGAACATAGTCCCCGGTTGACCCCGTCAAACGGTGCTGCTCGCGGGATTGCAGTGTTTGCAT CCCTTGTTGCCCGTATGGATCACCTTGATTATTGCGGCCACGTCAAGTGTCTAATGAATAAGTAAAATG ATTGCAGT Translation: MMSKLGVLLTICLLLFPLTVLPMDGDQPADLPALRAQFFAPEHSPRFDPVKRCCSRDCSVCIPCCPYGSP (SEQ ID NO:381) Toxin Sequence: Cys-Cys-Ser-Arg-Asp-Cys-Ser-Val-Cys-Ile-Xaa3-Cys-Cys-Xaa3-Xaa5-Gly-Ser-Xaa3-{circumflex over ( )} (SEQ ID NO:382)

Where:

Xaa1 is Glu or γ-carboxy-Glu

Xaa2 is Gln or pyro-Glu

Xaa3 is Pro or hydroxy-Pro

Xaa4 is Trp or bromo-Trp

Xaa5 is Tyr, ¹²⁵I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr or O-phospho-Tyr

{circumflex over ( )} is free carboxyl or amidated C-terminus, preferably free carboxyl

# is free carboxyl or amidated C-terminus, preferably amidated

?=Status of C-term not known.

TABLE 2 Alignment of μ-Conopeptides (SEQ ID NO:) TYPE 1 A3.4 ---CCKVQ-CES--C---TPCC{circumflex over ( )} (383) (F283) Ak3.1 ---CCELP-CGBGFC---VPCC{circumflex over ( )} (384) (F585) Ar3.1 ---CCERP-CNIG-C---VPCC{circumflex over ( )} (385) Bn3.1 ---CCNWP-CSMG-C---IPCCYY{circumflex over ( )} (386) (F586) Bt3.1 ---CCELP-CH-G-C---VPCCWP{circumflex over ( )} (387) Bt3.2 ---CCGLP-CN-G-C---VPCCWPS{circumflex over ( )} (388) Bt3.3 ---CCSRN-CAV--C---IPCCPNWPA{circumflex over ( )} (389) bt3a ---CCKQS-CTT--C---MPCCW{circumflex over ( )} (390) bt3b --ACCXQS-CTT--C---MPCC{circumflex over ( )} (391) bt3c ---CCEQS-CTT--C---MPCCW? (392) Ca3.3 R--CCRYP-CPDS-C--HGSCCYK{circumflex over ( )} (393) Ca3.4 ---CCPPVACNMG-C---KPCC# (394) Ca3.5 ---CCDDSECDYS-C---WPCCMF# (395) Ca3.6 ---CCRR--CYMG-C---IPCCF{circumflex over ( )} (396) (P349) Circling ---CCPPVACNMG-C---KPCCG{circumflex over ( )} (397) Comatose/ SKQCCHLAACRFG-C---TOCCN{circumflex over ( )} (398) Death Cp3.1 S--CCR--DCGED-C---VGCCR{circumflex over ( )} (399) (F594) Ct3.1 ---CCDWP-CIPG-C---TPCCLP{circumflex over ( )} (400) (Z726) Da3.1 ---CCDDSECDYS-C---WPCCILS{circumflex over ( )} (401) Da3.2 Z-QCCPPVACNMG-C---EPCC# (402) Da3.3 ---CCNAGFCRFG-C---TPCCW{circumflex over ( )} (403) Di3.1 Z--CCVHP-C-P--C---TPCCR{circumflex over ( )} (404) Fi3.1 ---CCPWP-CNIG-C---VPCC{circumflex over ( )} (405) Fi3.2 ---CCSKN-CAV--C---IPCCP{circumflex over ( )} (406) Fi3.3 ---CCRWP-CP-ARC---GSCCL{circumflex over ( )} (407) Fi3.4 ---CCELSRCL-G-C---VPCCTS{circumflex over ( )} (408) Fi3.5 ---CCELSKCH-G-C---VPCCIP{circumflex over ( )} (409) Ge3.1 Z--CCTF--CNFG-C---QPCCVP{circumflex over ( )} (410) (F590) Ge3.2 Z--CCTF--CNFG-C---QPCCLT{circumflex over ( )} (411) (F343/Z734) Ge3.3 Z--CCTF--CNFG-C---QPCCVP{circumflex over ( )} (412) (F590 Gm3.1 ---CCDDSECDYS-C---WPCCMF# (413) Gm3.2 G--CCHLLACRFG-C---SPCCW{circumflex over ( )} (414) Gm3.3 ---CCSWDVCDHPSC---T-CCG# (415) La3.1 ---CCDWP-CS-G-C---IPCC{circumflex over ( )} (416) Lp3.1 ZINCCPWP-CPST-C--RHQCCH{circumflex over ( )} (417) (F340) Lv3.1 ZINCCPWP-CPDS-C--HYQCCH{circumflex over ( )} (418) (F341) Mr3.2 ---CCRLS-CGLG-C---HPCC# (419) Mr3.3 --ECCGSFACRFG-C---VPCCV{circumflex over ( )} (420) Mr3.4 SKQCCHLPACRFG-C---TPCCW{circumflex over ( )} (421) Mr3.5 -MGCCPFP-CKTS-C--TTLCC# (422) (F286) Ms3.1 --ACCEQS-CTT--C---FPCC{circumflex over ( )} (423) (Z738) Nb3.1 ---CCELP-CGPGFC---VPCC{circumflex over ( )} (424) (F87) Pu3.1 ---CCN-S-CYMG-C---IPCCF{circumflex over ( )} (425) (F339) Qc3.1 ZR-CCQWP-CPGS-C----RCCRT# (426) (F342) Qc3.2 ZR-CCRWP-CPGS-C----RCCRYR{circumflex over ( )} (427) Qc3.3 R--CCRYP-CPDS-C--HGSCCYK{circumflex over ( )} (428) QcIIIA ---CCSQD-CLV--C---IOCCPN# (429) QcIIIB ---CCSRH-CWV--C---IOCCPN? (430) Ra3.1 Z-TCCS-N-CGED-C---DGCCQ{circumflex over ( )} (431) (P351) Scratcher I ---CCR-T-C-FG-C---TOCC# (433) Ts3.1 ---CCH-K-CYMG-C---IPCCI{circumflex over ( )} (434) (F592) Ts3.2 K--CCRPP-CAMS-C-GMARCCY{circumflex over ( )} (435) (F345) Bt3.5 R--CCRWP-CPSI-C-GMARCCFVMITC{circumflex over ( )} (436) (Z495) Bt3.6 R--CCRWP-CP-SRC-GMARCCFVMITC{circumflex over ( )} (437) (Z497) Tx3.1 F--CCDSNWCHISDC----ECCY# (438) U014 ---CCHWNWCDHL-C----SCCGS{circumflex over ( )} (439) U017 --DCCOLPACPFG-C---NOCC# (440) U019 ---CCAPSACRLG-C---ROCCR{circumflex over ( )} (441) U020 ---CCAOSACRLG-C---ROCCR{circumflex over ( )} (442) U022 ---CCAPSACRLG-C---RPCCR{circumflex over ( )} (443) U024 --GCCGSFACRFG-C---VOCCV{circumflex over ( )} (444) U031 ---CCSWDVCDHPSC----TCC# (445) U032 R--CCKFP-CPDS-C--RYLCC# (446) (F353) Ae3.1 ---CCDDSECDYS-C---WPCCIF# (447) Ae3.2 ---CCNDWECDDS-C---WPCCY# (448) Af3.1 R--CCR-FPCPDT-C---RHLCC# (449) Af3.2 ---CC--MTC-FG-C---TPCC# (450) Af3.3 ---CCDDSECDYS-C---WPCCIFS{circumflex over ( )} (451) Af3.4 ---CCR-LLC-LS-C---NPCC# (452) Af3.6 ---CCDDSECGYS-C---WPCCY# (453) Au3.2 G--CCS-PPCHSI-C--AAFCC# (454) Au3.3 ---CCRPVACAMG-C---KPCC# (455) Au3.4 Z--CCPAVACAMG-C---EPCC# (456) Em3.1 ---CCS-RDC-SV-C---IPCCPYGSP{circumflex over ( )} (457) Ep3.1 ---CCDEDECNSS-C---WPCCW# (458) Ep3.2 ---CCDEDECSSS-C---WPCCW# (459) Ep3.3 ---CCPAAACAMG-C---KPCC# (460) Om3.1 ---CCDEEECSSA-C---WPCCW# (461) Om3.3 ---CCHLLACRFG-C---SPCCW{circumflex over ( )} (462) Sf3.1 ---CC--PRC-SE-C---NPCC# (463) TYPE 2 Pn3.2 -RCC--KFP-CPDS-C--KYLCC# (464) (AA049) Fd3.2 -RCC--RWP-CPSI-C-GMARCCSS{circumflex over ( )} (465) (Z831) Pu3.3 --CC--KLL-CYSG-C---TPCCHI{circumflex over ( )} (466) (AA405) Eb3.1 --CC--EQP-CYMG-C---IPCCF{circumflex over ( )} (467) (Z821) Eb3.2 --CC--AQP-CYMG-C---IPCCF{circumflex over ( )} (468) (Z822) Pu3.2 --CC--V-S-CYMG-C---IPCCF{circumflex over ( )} (469) (AA403) Mf3.1 --CC--DWP-CSAG-C---YPCCFP{circumflex over ( )} (470) (Z882) Mf3.2 -GCC--PPM-C-TP-C---FPCCFR{circumflex over ( )} (471) (Z885) Ra3.2 RGCCAPPRK-CKDRACK-PARCCGP# (472) (AA414) Sm3.3 ZRCCNGRRG-CSSRWCRDHSRCC# (473) (AA419) Cn3.3 GRCCDVPNA-CSGRWCRDHAQCC# (474) Cn3.4 ZRCCTGKKGSCSGKACKSL-KCCS# (475) TYPE 3 A3.1 -MCCGEGRKCPSYFRNSQICHCC{circumflex over ( )} (476) A3.2 --CCR--WPCPRQIDGEY-CGCCL# (477) (P84) Bu3.5 -RCCGEGLTCPRYWKNSQICACC{circumflex over ( )} (478) Ca3.1 --CCGPGGSCPVYFRDNFICGCC{circumflex over ( )} (479) Cr3.1 RKCCGKDGPCPKYFKDNFICGCC{circumflex over ( )} (480) E3.1 --CCS--WPCPRYSNGKLVCFCCL# (481) M3.2 --CCGPGGSCPVYFRDNFICGCC{circumflex over ( )} (482) M3.3 -MCCGESAPCPSYFRNSQICHCC{circumflex over ( )} (483) M3.4 ZKCCGPGGSCPVYFTDNFICGCC{circumflex over ( )} (484) M3.5 ZKCCGPGGSCPVYFRDNFICGCC{circumflex over ( )} (485) S3.1 ZKCCGEGSSCPKYFKNNFICGCC{circumflex over ( )} (486) U001 ZKCCS-GGSCPLYFRDRLICPCC{circumflex over ( )} (487) U034 ZKCCGPGASCPRYFKDNFICGCC{circumflex over ( )} (488) Cn3.1 -MCCGEGAPCPSYFPNSQICHCC{circumflex over ( )} (489) TYPE 4 A3.3 ZK--CCTGK---KGSCSGKACKNL-KCCS# (490) (F83) A3.5 ZK--CCTGR---KGSCSGKACKNL-KCCS# (491) (Z488) Bu3.1 VTDRCCK----GKREC-GRWCRDHSRCC# (492) Bu3.1A VGDRCCK----GKRGC-GRWCRDHSRCC# (493) Bu3.2 VGERCCK---NGKRGC-GRWCRDHSRCC# (494) Bu3.3 IVDRCCN-KGNGKRGC-SRWCRDHSRCC# (495) Bu3.4 VGLYCCRPKPNGQMMC-DRWCEKNSRCC# (496) Ca3.2 -RD-CCTPP---KK-CKDRQCKPQ-RCCA# (497) L3.1 GRD-CCTPP---RK-CRDRACKPQ-RCCG# (498) L3.2 ZRL-CCGFP---KS-CRSRQCKPH--RCC# (499) La3.2 -RD-CCTPP---KK-CRDRQCKPA-RCCG# (500) La3.3 RPP-CCTYD---GS-CLKESCMRK-ACC# (501) La3.3A RPP-CCTYD---GS-CLKESCKRK-ACC# (502) μ-GIIIA -RD-CCTOO---KK-CKDRQCKOQ-RCCA# (503) μ-GIIIB -RD-CCTOO---RK-CKDRRCKOM-KCCA# (504) μ-GIIIC -RD-CCTOO---KK-CKDRRCKOL-KCCA# (505) μ-PIIIA ZRL-CCGFO---KS-CRSRQCKOH-RCC# (506) M3.1 -RD-CCTPP---KK--CKDRQCKPQ-RCCA# (507) Mr3.1 RGG-CCTPP---RK-CKDPACKPA-RCCGP# (508) Nb3.2 ZK--CCTGK---KGSCSGKACKNL-KCCS# (509) (F582) Pr3.1 RGG-CCTPP---KK-CKDPACKPA-RCCGP# (510) (Z500) Pr3.2 -RG-CCTPP---RK-CKDRACKPA-RCCGP# (511) (Z501) R3.1 LOS-CCSLN---LRLCOVOACKRN-OCCT# (512) R3.2 ZQR-CCTVK----RICOVOACRSK-OCCKS{circumflex over ( )} (513) R3.3 RGG-CCTPP---RK-CKDPACKPA-RCCGP# (514) Sm3.1 ZK--CCTGK---KGSCSGKACKNL-KCCS# (515) T3.1 H-G-CCKGO---EG-CSSRECROQ-HCC# (516) T3.2 H-G-CCEGP---KG-CSSRECRPQ-HCC# (517) (Y088) Wi3.1 LPS-CCDFE----RLCVVPACTRH-QCCT# (518) (M548) Type 5 Om3.2 CCKYGWTCLLGCTPCDC{circumflex over ( )} (519) Om3.4 CCRYGWTCWLGCTPCGC{circumflex over ( )} (520) Type 6 S3.2 Z-NCCNGG-CSSKWCRDHARCC# (432) (F352)

Example 3 Effect of Intrathecal Administration of μ-Conopeptides

Male C57 black mice (20-25 g) are obtained from Charles River Laboratories. These mice and the animals are housed in a temperature controlled (23°±3° C.) room with a 12 hour light-dark cycle with free access to food and water. All animals are euthanized in accordance with Public Health Service policies on the humane care of laboratory animals.

Intrathecal (it) drug injections are performed as described (Hylden and Wilcox, 1980). A μ-conopeptide or vehicle is administered in a volume of 5 μl. Duration of hind-limb paralysis is assessed. This experiment reveals that injection of μ-conopeptides into the intrathecal space of C57 black mice produced a paralysis of the animal. The animals in this experiment recovered fully.

Example 4 Effect of μ-Conopeptides as a Local Anesthetic

Male Hartley guinea pigs (retired breeders) are obtained form Charles River Laboratories. The local anesthetic test is performed essentially as described (Bulbring and Wajda, 1945). On the day prior to test day, a patch on the back of the guinea pig is denuded of hair, first by shaving with electric clippers and subsequently with depilatory cream (Nair®). Depilatory cream is applied for five minutes and removed with a warm washcloth. The guinea pigs are dried and returned to their cages. On the following day, intradermal injections (0.1 ml vols) of lidocaine, bupivacaine, a μ-conopeptide or vehicle (0.5% cyclodextran) are made into the denuded patch. The injection produced a raised wheal on the surface of the skin which is circled with a felt-tipped pen. Typically, four injections are made on the back of each guinea pig. In some cases, guinea pigs are reused following at least one week of recovery and injecting into an unused portion of the skin. The stimulus consists of mild pin pricks (not hard enough to break the skin) with a 26 G needle. The response is a localized skin twitch caused by contraction of cutaneous muscles. A unit test consisted of six uniform pin pricks, 3-5 seconds apart, within the injected area. Unit scores range from 0 (complete anesthesia) to 6 (no anesthesia). For potency experiments, the unit test is repeated at each site at five minute intervals for 30 minutes, and unit test scores summed (with 36 representing no anesthesia to 0 representing complete anesthesia. For duration experiments, unit tests are performed as described over the course of several hours to days.

μ-Conopeptides of the present invention produce a potent and long lasting local anesthetic effect in the intracutaneous wheal test in the guinea pig. As expected, bupivacaine has a slightly longer duration thatn lidocaine, consistent with clinical observations.

Example 5 Muscle Relaxant Effect of μ-Conopeptides in Anesthetized Monkeys

μ-Conopeptides are dissolved 0.9 percent saline at a concentration of 2 mg/ml. Rhesus monkeys are anesthetized with halothane, nitrous oxide and oxygen. The maintenance concentration of halothane is 1.0%. Arterial and venous catheters are placed in the femoral vessels for drug administration and recording of the arterial pressure. Controlled ventilation is accomplished via an endotrachael tube. Twitch and tetanic contractions of the tibialis arterior muscle are elicited indirectly via the sciatic nerve. Recordings of arterial pressure electrocardiogram (lead I), heart rate, and muscle function are made simultaneously. Four to six animals received each listed compound. Four additional animals received succinylcholine chloride or d-tubocurarine chloride as controls. It is seen that the tested μ-conopeptides generally provide similar or better results than those seen for succinylcholine chloride or d-tubocurarine chloride.

Example 6 In vivo Activity of μ-Conopeptides in Pain Models

The anti-pain activity of μ-conopeptides is shown in several animal models. These models include the nerve injury model (Chaplan, et al., 1997), the nocioceptive response to s.c. formalin injection in rats (Codene, 1993) and an NMDA-induced persistent pain model (Liu, et al., 1997). In each of these models it is seen that the μ-conopeptides and μ-conopeptides derivatives have analgesic properties.

More specifically, this study evaluates the effect of intrathecal administration of μ-conopeptides in mice models of nocioceptive and neuropathic pain. For nocioceptive pain, the effect of the μ-conopeptides is studied in two different tests of inflammatory pain. The first is the formalin test, ideal because it produces a relatively short-lived, but reliable pain behavior that is readily quantified. There are two phases of pain behavior, the second of which is presumed to result largely from formalin-evoked inflammation of the hind paw. A μ-conopeptide is administered 10 minutes prior to injection of formalin. The number of flinches and/or the duration of licking produced by the injection is monitored. Since the first phase is presumed to be due to direct activation of primary afferents, and thus less dependent on long term changes in the spinal cord, μ-conopeptides are presumed to have greatest effect on the magnitude of pain behavior in the second phase.

The mechanical and thermal thresholds in animals that received an injection of complete Freund's adjuvant into the hind paw are also studied. This produces a localized inflammation including swelling of the hind paw and a profound decrease in mechanical and thermal thresholds, that are detected within 24 hours after injection. The changes in thresholds in rats that receive μ-conopeptides are compared with those of rats that receive vehicle intrathecal injections.

An important issue is whether the drugs are effective when administered after the pain model has been established, or whether they are effective only if used as a pretreatment. Clearly, the clinical need is for drugs that are effective after the pain has developed. To address this issue, animals are studied in which μ-conopeptides are administered repeatedly, after the inflammation (CFA) or nerve injury has been established. In these experiments, a μ-conopeptide is injected daily by the intrathecal (i.t.) route. The mechanical and thermal thresholds (measured, respectively, with von Frey hairs in freely moving animals and with the Hargreave's test, also in freely moving animals) are repeated for a 2 to 4 week period after the injury is induced and the changes in pain measured monitored over time.

Example 7 Effect of μ-Conotoxins in a Pain Model

Analgesic activity of μ-conotoxins is also tested in pain models as follows.

Persistent pain (formalin test). Intrathecal (it) drug injections are performed as described by Hylden and Wilcox (1980). An μ-conopeptide or vehicle is administered in a volume of 5 μl. Fifteen minutes after the i.t. injection, the right hindpaw is injected with 20 μl of 5% formalin. Animals are placed in clear plexiglass cylinders backed by mirrors to facilitate observation. Animals are closely observed for 2 minutes per 5 minute period, and the amount of time the animal spent licking the injected paw is recorded in this manner for a total of 45-50 minutes. Results are expressed as licking time in seconds per five minutes. At the end of the experiment, all animals are placed on an accelerating rotorod and the latency to first fall was recorded. μ-Conopeptides are found to be active in this model which is predictive of efficacy for treating neuropathic pain.

Acute pain (tail-flick). A μ-conopeptide or saline is administered intrathecally (i.t.) according to the method of Hylden and Wilcox (1980) in a constant volume of 5 μl. Mice are gently wrapped in a towel with the tail exposed. At various time-points following the i.t. injection, the tail is dipped in a water bath maintained at 54° C. and the time to a vigorous tail withdrawal is recorded. If there is no withdrawal by 8 seconds, the tail is removed to avoid tissue damage.

Neuropathic vain. The partial sciatic nerve ligation model is used to assess the efficacy of μ-conopeptides in neuropathic pain. Nerve injury is produced according to the methods of Malmberg and Basbaum (1998). Animals are anesthetized with a ketamine/xylazine solution, the sciatic nerve is exposed and tightly ligated with 8-0 silk suture around ⅓ to ½ of the nerve. In sham-operated mice the nerve is exposed, but not ligated. Animals are allowed to recover for at least 1 week before testing is performed. On the testing day, mice are placed in plexiglass cylinders on a wire mesh frame and allowed to habituate for at least 60 minutes. Mechanical allodynia is assessed with calibrated von Frey filaments using the up-down method as described by Chaplan et al. (1994), and the 50% withdrawal threshold is calculated. Animals that did not respond to any of the filaments in the series are assigned a maximal value of 3.6 grams, which is the filament that typically lifted the hindlimb without bending, and corresponds to approximately {fraction (1/10)} the animal's body weight.

The data obtained demonstrate that μ-conopeptides have potent analgesic properties in three commonly used models of pain: acute, persistent/inflammatory and neuropathic pain models.

Example 8 Activity of μ-Conopeptide S3.2 on Neuronal Sodium Channels

μ-Conopeptide S3.2 was tested for activity on sodium channels as follows. S3.2 was administered to mice by intracerbroventricular (ICV) injection. Administration of S3.2 in this manner caused mice to show a spectrum of activity that is charcteristic of all sodium channel blockers, including rapid loss of righting reflex, coma-like inactivity and spastic uncontrolled limb movement. Following intrathecal (it) administration to mice, S3.2 causes rapid hindlimb paralysis that spreads to include the entire body over a course of 10-20 minutes followed by death, presumably due to respiratory paralysis. However, unlike classic μ-conopeptides, S3.2 has no significant activity following intravenous administration (iv) to mice. Classic μ-conopeptides, such as GIIIA and PIIIA, cause rapid paralysis and death following iv administration, indicating their activity at skeletal muscle sodium channels. To confirm the selectivity of S3.2, 80 nmol was administered iv to rats. The effect of S3.2 was measured on skeletal muscle contraction, blood pressure and heart rate. S3.2 was found to have no effect on any of these parameters. Controls were performed using classical μ-conopeptides, including Sm3.1, Sm3.3 and Bu3.1 described herein, also administered iv at 80 mmol. These control peptides caused a dramatic decrease in skeletal muscle contractility, as well as a significant drop in systemic blood pressure. Thus, μ-conopeptide S3.2 suprisingly is selective for neuronal sodium channels. The most obvious difference between the S3.2 sequence and the sequences of these other peptides is a shortened first loop (the first loop between cysteine residues) which lacks a charged amino acid.

It will be appreciated that the methods and compositions of the instant invention can be incorporated in the form of a variety of embodiments, only a few of which are disclosed herein. It will be apparent to the artisan that other embodiments exist and do not depart from the spirit of the invention. Thus, the described embodiments are illustrative and should not be construed as restrictive.

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Published PCT Application WO 98/03189.

Published PCT Application WO 00/23092.

                   #             SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 520 <210> SEQ ID NO 1 <211> LENGTH: 280 <212> TYPE: DNA <213> ORGANISM: Conus arentus <400> SEQUENCE: 1 caagaaggat cgatagcagt tcatgatgtc taaactggga gtcttcttga cc #atctgtat     60 gcttctgttt ccccttactg ctcttccgct ggatggggat caacctgcag ac #cgacctgc    120 agagcgtatg caggacgact ttataactga gcatcatccc ctgtttgatc ct #gtcaaacg    180 gtgttgcgag aggccatgca acataggatg cgtaccttgt tgttaatgac ca #gctttgtc    240 atcgcggcct catcaagcga ataagtaaaa cgattgcagt      #                   #   280 <210> SEQ ID NO 2 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus arentus <400> SEQUENCE: 2 Met Met Ser Lys Leu Gly Val Phe Leu Thr Il #e Cys Met Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Phe Ile Thr Gl #u His His Pro Leu Phe         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys Glu Arg Pro Cy #s Asn Ile Gly Cys Val     50               #    55               #    60 Pro Cys Cys 65 <210> SEQ ID NO 3 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus arentus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(14) <223> OTHER INFORMATION: Xaa at residue 3 is  #Glu or gamma-carboxy Glu;       Xaa at residue 5 an d 12 is # Pro or Hyp <400> SEQUENCE: 3 Cys Cys Xaa Arg Xaa Cys Asn Ile Gly Cys Va #l Xaa Cys Cys 1               5    #                10 <210> SEQ ID NO 4 <211> LENGTH: 244 <212> TYPE: DNA <213> ORGANISM: Conus atlanticus <400> SEQUENCE: 4 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttccactt     60 actgctcttc cgctggatga agatcaaccg gtacaccgac ctgcagagcg ta #tgcaggac    120 atttcatctg atcaacatct cttctttgat ctcatcaaac ggtgctgcga gt #tgccatgc    180 gggccaggct tttgcgtccc ttgttgctga catcaataac gtgttgatga cc #aactttct    240 cgag                  #                   #                   #            244 <210> SEQ ID NO 5 <211> LENGTH: 69 <212> TYPE: PRT <213> ORGANISM: Conus atlanticus <400> SEQUENCE: 5 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Ile Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Leu Pro Leu Asp Gl #u Asp Gln Pro Val His             20       #            25       #            30 Arg Pro Ala Glu Arg Met Gln Asp Ile Ser Se #r Asp Gln His Leu Phe         35           #        40           #        45 Phe Asp Leu Ile Lys Arg Cys Cys Glu Leu Pr #o Cys Gly Pro Gly Phe     50               #    55               #    60 Cys Val Pro Cys Cys 65 <210> SEQ ID NO 6 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus atlanticus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Xaa at residue 3 is  #Glu or gamma-carboxy Glu;       Xaa at residue 5, 8 and 13  #is Pro or Hyp <400> SEQUENCE: 6 Cys Cys Xaa Leu Xaa Cys Gly Xaa Gly Phe Cy #s Val Xaa Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 7 <211> LENGTH: 310 <212> TYPE: DNA <213> ORGANISM: Conus aurisiacus <400> SEQUENCE: 7 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgttt     60 gcttctgttt ccccttactg ctcttccgat ggatggagat caatctgtag ac #cgacctga    120 agagcgtatg caggacgaca tttcatctga gcagcatccc ttgtttaatc ag #aaaagaat    180 gtgttgcggc gaaggccgga aatgccccag ctatttcaga aacagtcaga tt #tgtcattg    240 ttgttaaatg acaacgtgtc gatgaccaac ttcgttatca cgactaatga at #aagtaaaa    300 cgattgcagt                 #                   #                   #       310 <210> SEQ ID NO 8 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <400> SEQUENCE: 8 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Ser Val Asp Arg Pro             20       #            25       #            30 Glu Glu Arg Met Gln Asp Asp Ile Ser Ser Gl #u Gln His Pro Leu Phe         35           #        40           #        45 Asn Gln Lys Arg Met Cys Cys Gly Glu Gly Ar #g Lys Cys Pro Ser Tyr     50               #    55               #    60 Phe Arg Asn Ser Gln Ile Cys His Cys Cys 65                   #70 <210> SEQ ID NO 9 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 5 is  #Glu or gamma-carboxy Glu;       Xaa at residue 10 is Pro or  #Hyp; Xaa at residue 12 is Tyr,       125I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O #-sulpho-Tyr or       O-phospho-Tyr <400> SEQUENCE: 9 Met Cys Cys Gly Xaa Gly Arg Lys Cys Xaa Se #r Xaa Phe Arg Asn Ser 1               5    #                10   #                15 Gln Ile Cys His Cys Cys             20 <210> SEQ ID NO 10 <211> LENGTH: 257 <212> TYPE: DNA <213> ORGANISM: Conus aurisiacus <400> SEQUENCE: 10 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtttgcttct gt #ttcccctt     60 actgctcttc cgatcgatgg agatcaatct gtagaccgac ctgcagagcg ta #tgcaggat    120 gacatttcat ctgagcagca tcgcttgttc aatcagaaaa gaaggtgctg cc #ggtggcca    180 tgcccccgac aaatcgacgg tgaatattgt ggctgttgcc ttggatgata ac #cgtgttga    240 tgaccaactt tctcgag              #                   #                   #  257 <210> SEQ ID NO 11 <211> LENGTH: 75 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <400> SEQUENCE: 11 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Ile Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Leu Pro Ile Asp Gl #y Asp Gln Ser Val Asp             20       #            25       #            30 Arg Pro Ala Glu Arg Met Gln Asp Asp Ile Se #r Ser Glu Gln His Arg         35           #        40           #        45 Leu Phe Asn Gln Lys Arg Arg Cys Cys Arg Tr #p Pro Cys Pro Arg Gln     50               #    55               #    60 Ile Asp Gly Glu Tyr Cys Gly Cys Cys Leu Gl #y 65                   #70                   #75 <210> SEQ ID NO 12 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(19) <223> OTHER INFORMATION: Xaa at residue 13 is  #Glu or gamma-carboxy Glu;       Xaa at residue 5 and 7 is P #ro or Hyp; Xaa at residue 4 is Trp or       Bromo Trp; Xaa at residue 14 i #s Tyr, 125I-Tyr, mono-iodo-Tyr,       di-iodo-Tyr, O-sulpho-Tyr or O-phospho- #Tyr <400> SEQUENCE: 12 Cys Cys Arg Xaa Xaa Cys Xaa Arg Gln Ile As #p Gly Xaa Xaa Cys Gly 1               5    #                10   #                15 Cys Cys Leu <210> SEQ ID NO 13 <211> LENGTH: 262 <212> TYPE: DNA <213> ORGANISM: Conus aurisiacus <400> SEQUENCE: 13 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctacttct gt #ttcccctt     60 actgcttttc cgatggatgg agatcaacct gcagaccaac ctgcagatcg ta #tgcaggac    120 gacatttcat ctgagcagta tcccttgttt gataagagac aaaagtgttg ca #ctgggaag    180 aaggggtcat gctccggcaa agcatgcaaa aatctcaaat gttgctctgg ac #gataacgt    240 gttgatgacc aactttctcg ag            #                   #                262 <210> SEQ ID NO 14 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <400> SEQUENCE: 14 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Ile Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Phe Pro Met Asp Gl #y Asp Gln Pro Ala Asp             20       #            25       #            30 Gln Pro Ala Asp Arg Met Gln Asp Asp Ile Se #r Ser Glu Gln Tyr Pro         35           #        40           #        45 Leu Phe Asp Lys Arg Gln Lys Cys Cys Thr Gl #y Lys Lys Gly Ser Cys     50               #    55               #    60 Ser Gly Lys Ala Cys Lys Asn Leu Lys Cys Cy #s Ser Gly Arg 65                   #70                   #75 <210> SEQ ID NO 15 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu <400> SEQUENCE: 15 Xaa Lys Cys Cys Thr Gly Lys Lys Gly Ser Cy #s Ser Gly Lys Ala Cys 1               5    #                10   #                15 Lys Asn Leu Lys Cys Cys Ser             20 <210> SEQ ID NO 16 <211> LENGTH: 232 <212> TYPE: DNA <213> ORGANISM: Conus aurisiacus <400> SEQUENCE: 16 ggatccatga tgtctaaact gggagtcttg ctgaccatct gtctgcttct gt #ttccactt     60 actgctgttc cgctggatgg agatcaacct ctagaccgac acgcggagcg ta #tgcatgat    120 ggcatttcac ctaaacgcca tccctggttt gatcccgtca aacggtgttg ca #aggtgcaa    180 tgcgagtctt gcaccccttg ttgctaacgt gttgatgacc aactttctcg ag #            232 <210> SEQ ID NO 17 <211> LENGTH: 68 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <400> SEQUENCE: 17 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Ile Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Val Pro Leu Asp Gl #y Asp Gln Pro Leu Asp             20       #            25       #            30 Arg His Ala Glu Arg Met His Asp Gly Ile Se #r Pro Lys Arg His Pro         35           #        40           #        45 Trp Phe Asp Pro Val Lys Arg Cys Cys Lys Va #l Gln Cys Glu Ser Cys     50               #    55               #    60 Thr Pro Cys Cys 65 <210> SEQ ID NO 18 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(13) <223> OTHER INFORMATION: Xaa at residue 7 is  #Glu or gamma-carboxy Glu;       Xaa at residue 11 is Pro or  #Hyp <400> SEQUENCE: 18 Cys Cys Lys Val Gln Cys Xaa Ser Cys Thr Xa #a Cys Cys 1               5    #                10 <210> SEQ ID NO 19 <211> LENGTH: 241 <212> TYPE: DNA <213> ORGANISM: Conus bandus <400> SEQUENCE: 19 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtatgcttct gt #ttcccctc     60 actgctcttc cgatggatgg agatcaacct gcagaccgac ctgcagagcg ta #gtcaggac    120 gtttcatctg aacagcatcc cttgtttgat cccgtcaaac ggtgttgcaa ct #ggccatgc    180 tccatgggat gcatcccttg ttgctactat taataacgtg ttgatgacca ac #tttctcga    240 g                   #                   #                   #              241 <210> SEQ ID NO 20 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus bandus <400> SEQUENCE: 20 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Ile Cys Met Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Leu Pro Met Asp Gl #y Asp Gln Pro Ala Asp             20       #            25       #            30 Arg Pro Ala Glu Arg Ser Gln Asp Val Ser Se #r Glu Gln His Pro Leu         35           #        40           #        45 Phe Asp Pro Val Lys Arg Cys Cys Asn Trp Pr #o Cys Ser Met Gly Cys     50               #    55               #    60 Ile Pro Cys Cys Tyr Tyr 65                   #70 <210> SEQ ID NO 21 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus bandus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 5 and  #12 is Pro or Hyp; Xaa at       residue 4 is Trp or bromo-Trp;  #Xaa at residue 15 and 16 is Tyr,       125I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O #-sulpho-Tyr or       O-phospho-Tyr <400> SEQUENCE: 21 Cys Cys Asn Xaa Xaa Cys Ser Met Gly Cys Il #e Xaa Cys Cys Xaa Xaa 1               5    #                10   #                15 <210> SEQ ID NO 22 <211> LENGTH: 298 <212> TYPE: DNA <213> ORGANISM: Conus betulinus <400> SEQUENCE: 22 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #ttctgtct     60 gcttctgttt cccctgactg ctcttccgct ggatgaagat caacctgcag ac #cgacctgc    120 agagcgtatg caggacattt catctgaaca gcatcccttg tttgatcccg tc #aaacggtg    180 ttgcgaattg ccatgccatg gatgcgtccc ttgttgctgg ccttaataac gt #gtggatga    240 ccaactgtgt tatcacggcc acgtcaagtg tctaatgaat aagtaaaatg at #tgcagt      298 <210> SEQ ID NO 23 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <400> SEQUENCE: 23 Met Met Ser Lys Leu Gly Val Leu Leu Thr Ph #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Leu Asp Glu Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Ile Ser Ser Glu Gl #n His Pro Leu Phe Asp         35           #        40           #        45 Pro Val Lys Arg Cys Cys Glu Leu Pro Cys Hi #s Gly Cys Val Pro Cys     50               #    55               #    60 Cys Trp Pro 65 <210> SEQ ID NO 24 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Xaa at residue 3 is  #Glu or gamma-carboxy Glu;       Xaa at residue 5, 11 and 15  #is Pro or Hyp; Xaa at residue 14 is       Trp or bromo-Trp <400> SEQUENCE: 24 Cys Cys Xaa Leu Xaa Cys His Gly Cys Val Xa #a Cys Cys Xaa Xaa 1               5    #                10   #                15 <210> SEQ ID NO 25 <211> LENGTH: 298 <212> TYPE: DNA <213> ORGANISM: Conus betulinus <400> SEQUENCE: 25 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #ttctgtct     60 gcttctgttt cccctgactg ctcttccgct ggatgaagat caacctgcag ac #cgacatgc    120 agagcgtatg caggacattt cacctgaaca gcatccctcg tttgatcccg tc #aaacggtg    180 ttgcgggctg ccatgcaatg gatgcgtccc ttgttgctgg ccttcataac gt #gtggacga    240 ccaactttgt tatcacggcc acgtcaagtg tctgatgaat aagtaaaacg at #tgcagt      298 <210> SEQ ID NO 26 <211> LENGTH: 68 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <400> SEQUENCE: 26 Met Met Ser Lys Leu Gly Val Leu Leu Thr Ph #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Leu Asp Glu Asp Gl #n Pro Ala Asp Arg His             20       #            25       #            30 Ala Glu Arg Met Gln Asp Ile Ser Pro Glu Gl #n His Pro Ser Phe Asp         35           #        40           #        45 Pro Val Lys Arg Cys Cys Gly Leu Pro Cys As #n Gly Cys Val Pro Cys     50               #    55               #    60 Cys Trp Pro Ser 65 <210> SEQ ID NO 27 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 5, 11  #and 15 is Pro or Hyp;       Xaa at residue 14 is Trp or  #bromo-Trp <400> SEQUENCE: 27 Cys Cys Gly Leu Xaa Cys Asn Gly Cys Val Xa #a Cys Cys Xaa Xaa Ser 1               5    #                10   #                15 <210> SEQ ID NO 28 <211> LENGTH: 282 <212> TYPE: DNA <213> ORGANISM: Conus betulinus <400> SEQUENCE: 28 caagagggat cgatagcagt tcatgatgtt taaactggga gtcttgttga cc #atctatat     60 gcttctgttt ccctttactg ctcttccgct ggatggagat caacctgcag ac #caacctct    120 agagcgcatg cagtatgaca tgttacgtgc agtgaatccc tggtttgatc cc #gtcaaaag    180 gtgctgctcg aggaactgcg cagtatgcat cccttgttgc ccgaattggc ca #gcttgatt    240 atcgcggcca agagtctaat gaataagtaa aacgattgca gt     #                   # 282 <210> SEQ ID NO 29 <211> LENGTH: 71 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <400> SEQUENCE: 29 Met Met Phe Lys Leu Gly Val Leu Leu Thr Il #e Tyr Met Leu Leu Phe 1               5    #                10   #                15 Pro Phe Thr Ala Leu Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Gln Pro             20       #            25       #            30 Leu Glu Arg Met Gln Tyr Asp Met Leu Arg Al #a Val Asn Pro Trp Phe         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys Ser Arg Asn Cy #s Ala Val Cys Ile Pro     50               #    55               #    60 Cys Cys Pro Asn Trp Pro Ala 65                   #70 <210> SEQ ID NO 30 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(18) <223> OTHER INFORMATION: Xaa at residue 11, 14  #and 17 is Pro or Hyp;       Xaa at residue 16 is Trp or  #bromo-Trp <400> SEQUENCE: 30 Cys Cys Ser Arg Asn Cys Ala Val Cys Ile Xa #a Cys Cys Xaa Asn Xaa 1               5    #                10   #                15 Xaa Ala <210> SEQ ID NO 31 <211> LENGTH: 325 <212> TYPE: DNA <213> ORGANISM: Conus bullatus <400> SEQUENCE: 31 caagaaggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt cccctttttg ctcttccgca ggatggagat caacctgcag ac #cgacctgc    120 agagcgtatg caggacgaca tttcatctga gcagaattcc ttgcttgaga ag #agagttac    180 tgacaggtgc tgcaaaggga agagggaatg cggcagatgg tgcagagatc ac #tcgcgttg    240 ttgcggtcga cgataagctg ttgatgacca gctttgttat cacggctaca tc #aagtgtct    300 agtgaataag taaaatgatt gcagt           #                   #              325 <210> SEQ ID NO 32 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <400> SEQUENCE: 32 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Phe Ala Leu Pro Gln Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser Gl #u Gln Asn Ser Leu Leu         35           #        40           #        45 Glu Lys Arg Val Thr Asp Arg Cys Cys Lys Gl #y Lys Arg Glu Cys Gly     50               #    55               #    60 Arg Trp Cys Arg Asp His Ser Arg Cys Cys Gl #y Arg Arg 65                   #70                   #75 <210> SEQ ID NO 33 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 11 is  #Glu or gamma-carboxy Glu;       Xaa at residue 15 is Trp or  #bromo-Trp <400> SEQUENCE: 33 Val Thr Asp Arg Cys Cys Lys Gly Lys Arg Xa #a Cys Gly Arg Xaa Cys 1               5    #                10   #                15 Arg Asp His Ser Arg Cys Cys             20 <210> SEQ ID NO 34 <211> LENGTH: 326 <212> TYPE: DNA <213> ORGANISM: Conus bullatus <400> SEQUENCE: 34 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt cccctttttg ctcttcggca ggatggagat caacctgcag ac #cgacctgc    120 agagcgtatg caggatgaca tttcatctga gcagaatccc ttgcttgaga ag #agagttgg    180 tgacaggtgc tgcaaaggga agagggggtg cggcagatgg tgcagagatc ac #tcacgttg    240 ttgcggtcga cgataacgtg ttgatgacca gctttgttat cacggctaca tc #aagtgtct    300 tagtgattaa gtaaaacgat tgcagt           #                   #             326 <210> SEQ ID NO 35 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <400> SEQUENCE: 35 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Phe Ala Leu Arg Gln Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser Gl #u Gln Asn Pro Leu Leu         35           #        40           #        45 Glu Lys Arg Val Gly Asp Arg Cys Cys Lys Gl #y Lys Arg Gly Cys Gly     50               #    55               #    60 Arg Trp Cys Arg Asp His Ser Arg Cys Cys Gl #y Arg Arg 65                   #70                   #75 <210> SEQ ID NO 36 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 15 is  #Trp or bromo-Trp <400> SEQUENCE: 36 Val Gly Asp Arg Cys Cys Lys Gly Lys Arg Gl #y Cys Gly Arg Xaa Cys 1               5    #                10   #                15 Arg Asp His Ser Arg Cys Cys             20 <210> SEQ ID NO 37 <211> LENGTH: 331 <212> TYPE: DNA <213> ORGANISM: Conus bullatus <400> SEQUENCE: 37 caagaaggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt cccctttttg ctcttccgca ggatggagat caacctgcag ac #cgacctgc    120 agagcgtatg caggacgaca tttcatctga gcagaatccc ttgcttgaga ag #agagttgg    180 tgaaaggtgc tgcaaaaacg ggaagagggg gtgcggcaga tggtgcagag at #cactcacg    240 ttgttgcggt cgacgataac gtgttgatga ccgaggcttt cgttatcacg gc #tacatcaa    300 gtgtctagtg aataagtaaa acgattgcag t         #                   #         331 <210> SEQ ID NO 38 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <400> SEQUENCE: 38 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Phe Ala Leu Pro Gln Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser Gl #u Gln Asn Pro Leu Leu         35           #        40           #        45 Glu Lys Arg Val Gly Glu Arg Cys Cys Lys As #n Gly Lys Arg Gly Cys     50               #    55               #    60 Gly Arg Trp Cys Arg Asp His Ser Arg Cys Cy #s Gly Arg Arg 65                   #70                   #75 <210> SEQ ID NO 39 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(24) <223> OTHER INFORMATION: Xaa at residue 3 is  #Glu or gamma-carboxy Glu;       Xaa at residue 16 is Trp or  #bromo-Trp <400> SEQUENCE: 39 Val Gly Xaa Arg Cys Cys Lys Asn Gly Lys Ar #g Gly Cys Gly Arg Xaa 1               5    #                10   #                15 Cys Arg Asp His Ser Arg Cys Cys             20 <210> SEQ ID NO 40 <211> LENGTH: 337 <212> TYPE: DNA <213> ORGANISM: Conus bullatus <400> SEQUENCE: 40 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt cccctttttg ctcttccgca ggacggagat caacctgcag ac #cgacctgc    120 agagcgtatg caggacgacc tttcatctga gcagcatccc ttgtttgaga ag #agaattgt    180 tgacaggtgc tgcaacaaag ggaacgggaa gagggggtgc agcagatggt gc #agagatca    240 ctcacgttgt tgcggtcgac gatgaactgt tgatgaccga ggctttggtt at #cacggcta    300 catcaagtgt ctagtgaata agtaaaacga ttgcagt       #                   #     337 <210> SEQ ID NO 41 <211> LENGTH: 80 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <400> SEQUENCE: 41 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Phe Ala Leu Pro Gln Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Leu Ser Ser Gl #u Gln His Pro Leu Phe         35           #        40           #        45 Glu Lys Arg Ile Val Asp Arg Cys Cys Asn Ly #s Gly Asn Gly Lys Arg     50               #    55               #    60 Gly Cys Ser Arg Trp Cys Arg Asp His Ser Ar #g Cys Cys Gly Arg Arg 65                   #70                   #75                   #80 <210> SEQ ID NO 42 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(26) <223> OTHER INFORMATION: Xaa at residue 18 is  #Trp or bromo-Trp <400> SEQUENCE: 42 Ile Val Asp Arg Cys Cys Asn Lys Gly Asn Gl #y Lys Arg Gly Cys Ser 1               5    #                10   #                15 Arg Xaa Cys Arg Asp His Ser Arg Cys Cys             20       #            25 <210> SEQ ID NO 43 <211> LENGTH: 337 <212> TYPE: DNA <213> ORGANISM: Conus bullatus <400> SEQUENCE: 43 caagaaggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt cccctttttg ctcttccgca ggatggagat caacctgcag ac #cgacctgc    120 tgagcgtatg caggacgaca tttcatctga gcggaatccc ttgtttgaga ag #agcgttgg    180 tttatattgc tgccgaccca aacccaacgg gcagatgatg tgcgacagat gg #tgcgaaaa    240 aaactcacgt tgttgcggtc gacgataatg tgttgatgac cagctttgtt at #caaggcta    300 catcaagtat ctagtgaata agtaaaacga ttgcagt       #                   #     337 <210> SEQ ID NO 44 <211> LENGTH: 77 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <400> SEQUENCE: 44 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Phe Ala Leu Pro Gln Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser As #n Pro Leu Phe Glu Lys         35           #        40           #        45 Ser Val Gly Cys Cys Arg Pro Lys Pro Asn Gl #y Gln Met Met Cys Asp     50               #    55               #    60 Arg Trp Cys Glu Lys Asn Ser Arg Cys Cys Gl #y Arg Arg 65                   #70                   #75 <210> SEQ ID NO 45 <211> LENGTH: 27 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(27) <223> OTHER INFORMATION: Xaa at residue 21 is  #Glu or gamma-carboxy Glu;       Xaa at residue 8 and 10 is  #Pro or Hyp; Xaa at residue 19 is Trp or       bromo-Trp; Xaa at residue 4 is  #Tyr, 125I-Tyr, mono-iodo-Tyr,       di-iodo-Tyr, O-sulpho-Tyr or O-phospho- #Tyr <400> SEQUENCE: 45 Val Gly Leu Xaa Cys Cys Arg Xaa Lys Xaa As #n Gly Gln Met Met Cys 1               5    #                10   #                15 Asp Arg Xaa Cys Xaa Lys Asn Ser Arg Cys Cy #s             20       #            25 <210> SEQ ID NO 46 <211> LENGTH: 323 <212> TYPE: DNA <213> ORGANISM: Conus bullatus <400> SEQUENCE: 46 caagaaggat cgatagcagt tcatgatgtc taaactggga gttttgttga cc #atctgtct     60 gcttctgttt ccccttactg ctcttccgat ggatggagat caatctgtag ac #cgacctgc    120 agaacgtatg caggacgacc tttcatctga gcagcatccc ttgtttgttc ag #aaaagaag    180 gtgttgcggc gaaggcttga catgccccag atattggaaa aacagtcaga tt #tgtgcttg    240 ttgttaaatg acaacgtgtc gatgaccaac ttcggtatca cgactacgcc aa #gtgtctaa    300 tgaataagta aaacgattgc agt            #                   #               323 <210> SEQ ID NO 47 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <400> SEQUENCE: 47 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Ser Val Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Leu Ser Ser Gl #u Gln His Pro Leu Phe         35           #        40           #        45 Val Gln Lys Arg Arg Cys Cys Gly Glu Gly Le #u Thr Cys Pro Arg Tyr     50               #    55               #    60 Trp Lys Asn Ser Gln Ile Cys Ala Cys Cys 65                   #70 <210> SEQ ID NO 48 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 5 is  #Glu or gamma-carboxy Glu;       Xaa at residue 10 is Pro or  #Hyp; Xaa at residue 13 is Trp or       bromo-Trp; Xaa at residue 12 is  #Tyr, 125I-Tyr, mono-iodo-Tyr,       di-iodo-Tyr, O-sulpho-Tyr or O-phospho- #Tyr <400> SEQUENCE: 48 Arg Cys Cys Gly Xaa Gly Leu Thr Cys Xaa Ar #g Xaa Xaa Lys Asn Ser 1               5    #                10   #                15 Gln Ile Cys Ala Cys Cys             20 <210> SEQ ID NO 49 <211> LENGTH: 322 <212> TYPE: DNA <213> ORGANISM: Conus bullatus <400> SEQUENCE: 49 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt cccctttttg ctcttccgca ggatggagat caacctgcag ac #cgacctgc    120 tgagcgtatg caggacgaca tttcatctga gcaggatccc ttgtttgttc ag #aaaagaag    180 gtgttgcggc gaaggcttga catgccccag atattggaaa aacagtcaga tt #tgtgcttg    240 ttgttaaatg acaacgtgtg atgaccaact tcggtatcac gactacgcca ag #tgtctaat    300 gaataagtaa aacgattgca gt            #                   #                322 <210> SEQ ID NO 50 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <400> SEQUENCE: 50 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Phe Ala Leu Pro Gln Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser Gl #u Gln Asp Pro Leu Phe         35           #        40           #        45 Val Gln Lys Arg Arg Cys Cys Gly Glu Gly Le #u Thr Cys Pro Arg Tyr     50               #    55               #    60 Trp Lys Asn Ser Gln Ile Cys Ala Cys Cys 65                   #70 <210> SEQ ID NO 51 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 5 is  #Glu or gamma-carboxy Glu;       Xaa at residue 10 is Pro or  #Hyp; Xaa at residue 13 is Trp or       bromo-Trp; Xaa at residue 12 is  #Tyr, 125I-Tyr, mono-iodo-Tyr,       di-iodo-Tyr, O-sulpho-Tyr or O-phospho- #Tyr <400> SEQUENCE: 51 Arg Cys Cys Gly Xaa Gly Leu Thr Cys Xaa Ar #g Xaa Xaa Lys Asn Ser 1               5    #                10   #                15 Gln Ile Cys Ala Cys Cys             20 <210> SEQ ID NO 52 <211> LENGTH: 238 <212> TYPE: DNA <213> ORGANISM: Conus capitaneus <400> SEQUENCE: 52 ggatccatga tgtctaaact gggagtcttg gtgaccatct gcctgcttct gt #ttcccctt     60 gctgcttttc cactggatgg aaatcaacct gcagaccacc ctgcaaagcg ta #cgcaagat    120 gacagttcag ctgccctgat caatacctgg attgatcatt cccattcttg ct #gcagggac    180 tgcggtgaag attgtgttgg ttgttgccgg taacgtgttg atgaccaact tt #ctcgag      238 <210> SEQ ID NO 53 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus capitaneus <400> SEQUENCE: 53 Gly Ser Met Met Ser Lys Leu Gly Val Leu Va #l Thr Ile Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Ala Ala Phe Pro Leu Asp Gl #y Asn Gln Pro Ala Asp             20       #            25       #            30 His Pro Ala Lys Arg Thr Gln Asp Asp Ser Se #r Ala Ala Leu Ile Asn         35           #        40           #        45 Thr Trp Ile Asp His Ser His Ser Cys Cys Ar #g Asp Cys Gly Glu Asp     50               #    55               #    60 Cys Val Gly Cys Cys Arg 65                   #70 <210> SEQ ID NO 54 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus capitaneus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Xaa at residue 8 is  #Glu or gamma-carboxy Glu <400> SEQUENCE: 54 Ser Cys Cys Arg Asp Cys Gly Xaa Asp Cys Va #l Gly Cys Cys Arg 1               5    #                10   #                15 <210> SEQ ID NO 55 <211> LENGTH: 323 <212> TYPE: DNA <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 55 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt ccccttactg ctcttccaat ggatggagat caacctgcag ac #caacctgc    120 agatcgtatg caggacgaca tttcatctga gcagtatccc ttgtttgata tg #agaaaaag    180 gtgttgcggc cccggcggtt catgccccgt atatttcaga gacaatttta tt #tgtggttg    240 ttgttaaatg acaacgtgtc gatgaccaac ttcattatca cgactacgcc aa #gtgtctaa    300 tgaataagta aaatgattgc agt            #                   #               323 <210> SEQ ID NO 56 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 56 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Pro Ala Asp Gln Pro             20       #            25       #            30 Ala Asp Arg Met Gln Asp Asp Ile Ser Ser Gl #u Gln Tyr Pro Leu Phe         35           #        40           #        45 Asp Met Arg Lys Arg Cys Cys Gly Pro Gly Gl #y Ser Cys Pro Val Tyr     50               #    55               #    60 Phe Arg Asp Asn Phe Ile Cys Gly Cys Cys 65                   #70 <210> SEQ ID NO 57 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(21) <223> OTHER INFORMATION: Xaa at residue 4 and  #9 is Pro or Hyp; Xaa at       residue 11 is Tyr, 125I-Tyr, mono #-iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 57 Cys Cys Gly Xaa Gly Gly Ser Cys Xaa Val Xa #a Phe Arg Asp Asn Phe 1               5    #                10   #                15 Ile Cys Gly Cys Cys             20 <210> SEQ ID NO 58 <211> LENGTH: 316 <212> TYPE: DNA <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 58 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt ccccttactg ctcttccgat ggatggagat gaacctgcaa ac #cgacctgt    120 cgagcgtatg caggacaaca tttcatctga gcagtatccc ttgtttgaga ag #agacgaga    180 ttgttgcact ccgccgaaga aatgcaaaga ccgacaatgc aaaccccaga ga #tgttgcgc    240 tggacgataa cgtgttgatg accaacttta tcacggctac gtcaagtgtt ta #gtgaataa    300 gtaaaatgat tgcagt              #                   #                   #   316 <210> SEQ ID NO 59 <211> LENGTH: 75 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 59 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #u Pro Ala Asn Arg Pro             20       #            25       #            30 Val Glu Arg Met Gln Asp Asn Ile Ser Ser Gl #u Gln Tyr Pro Leu Phe         35           #        40           #        45 Glu Lys Arg Arg Asp Cys Cys Thr Pro Pro Ly #s Lys Cys Lys Asp Arg     50               #    55               #    60 Gln Cys Lys Pro Gln Arg Cys Cys Ala Gly Ar #g 65                   #70                   #75 <210> SEQ ID NO 60 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 6, 7  #and 17 is Pro or Hyp <400> SEQUENCE: 60 Arg Asp Cys Cys Thr Xaa Xaa Lys Lys Cys Ly #s Asp Arg Gln Cys Lys 1               5    #                10   #                15 Xaa Gln Arg Cys Cys Ala             20 <210> SEQ ID NO 61 <211> LENGTH: 314 <212> TYPE: DNA <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 61 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt ccccttactg ctcttccact ggatggagat caacctgcag at #caatctgc    120 agagcgacct gcagagcgta cgcaggacga cattcagcag catccgttat at #gatccgaa    180 aagaaggtgt tgccgttatc catgccccga cagctgccac ggatcttgct gc #tataagtg    240 ataacatgtt gatggccagc tttgttatca cggccacgtc aagtgtctta at #gaataagt    300 aaaacgattg cagt               #                   #                   #    314 <210> SEQ ID NO 62 <211> LENGTH: 72 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 62 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Gln Ser             20       #            25       #            30 Ala Glu Arg Pro Ala Glu Arg Thr Gln Asp As #p Ile Gln Gln His Pro         35           #        40           #        45 Leu Tyr Asp Pro Lys Arg Arg Cys Cys Arg Ty #r Pro Cys Pro Asp Ser     50               #    55               #    60 Cys His Gly Ser Cys Cys Tyr Lys 65                   #70 <210> SEQ ID NO 63 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(18) <223> OTHER INFORMATION: Xaa at residue 6 and  #8 is Pro or Hyp; Xaa at       residue 5 and 17 is Tyr, 125I- #Tyr, mono-iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 63 Arg Cys Cys Arg Xaa Xaa Cys Xaa Asp Ser Cy #s His Gly Ser Cys Cys 1               5    #                10   #                15 Xaa Lys <210> SEQ ID NO 64 <211> LENGTH: 292 <212> TYPE: DNA <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 64 caagagggat cgatagcagt tcatgatgtc taaactggga gccttgttga cc #atctgtct     60 acttctgttt tcccttactg ctgttccgct ggatggagat caacatgcag ac #caacctgc    120 acagcgtctg caggaccgca ttccaactga agatcatccc ttatttgatc cc #aacaaacg    180 gtgttgcccg ccggtggcat gcaacatggg atgcaagcct tgttgtggat ga #ccagcttt    240 gttatcgcgg tcttcatgaa gtgtcttaat gaataagtaa aatgattgca gt #            292 <210> SEQ ID NO 65 <211> LENGTH: 69 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 65 Met Met Ser Lys Leu Gly Ala Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n His Ala Asp Gln Pro             20       #            25       #            30 Ala Gln Arg Leu Gln Asp Arg Ile Pro Thr Gl #u Asp His Pro Leu Phe         35           #        40           #        45 Asp Pro Asn Lys Arg Cys Cys Pro Pro Val Al #a Cys Asn Met Gly Cys     50               #    55               #    60 Lys Pro Cys Cys Gly 65 <210> SEQ ID NO 66 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Xaa at residue 3, 4  #and 13 is Pro or Hyp <400> SEQUENCE: 66 Cys Cys Xaa Xaa Val Ala Cys Asn Met Gly Cy #s Lys Xaa Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 67 <211> LENGTH: 293 <212> TYPE: DNA <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 67 caagagggat cgatagcagt tcatgatgtc taaactggga gccttgttga cc #atctgtct     60 acttctgttt tccctaactg ctgttccgct ggatggagat caacatgcag ac #caacctgc    120 agagcgtctg catgaccgcc ttccaactga aaatcatccc ttatatgatc cc #gtcaaacg    180 gtgttgcgat gattcggaat gcgactattc ttgctggcct tgctgtatgt tt #ggataacc    240 tttgttatcg cggcctcatc aagtgtctaa tgaataagta aaacgattgc ag #t           293 <210> SEQ ID NO 68 <211> LENGTH: 71 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 68 Met Met Ser Lys Leu Gly Ala Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n His Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Leu His Asp Arg Leu Pro Thr Gl #u Asn His Pro Leu Tyr         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys Asp Asp Ser Gl #u Cys Asp Tyr Ser Cys     50               #    55               #    60 Trp Pro Cys Cys Met Phe Gly 65                   #70 <210> SEQ ID NO 69 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(17) <223> OTHER INFORMATION: Xaa at residue 6 is  #Glu or gamma-carboxy Glu;       Xaa at residue 13 is Pro or  #Hyp; Xaa at residue 12 is Trp or       bromo-Trp; Xaa at residue 9 is  #Tyr, 125I-Tyr, mono-iodo-Tyr,       di-iodo-Tyr, O-sulpho-Tyr or O-phospho- #Tyr <400> SEQUENCE: 69 Cys Cys Asp Asp Ser Xaa Cys Asp Xaa Ser Cy #s Xaa Xaa Cys Cys Met 1               5    #                10   #                15 Phe <210> SEQ ID NO 70 <211> LENGTH: 232 <212> TYPE: DNA <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 70 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttcccctt     60 actgctgttc cgctggatgg agatcaacct gcagaccgac ctgcagagcg ta #agcaggac    120 gtttcatctg aacagcatcc cttctttgat cccgtcaaac ggtgttgccg cc #ggtgttac    180 atgggatgca tcccttgttg cttttaacgt gttgatgacc aactttctcg ag #            232 <210> SEQ ID NO 71 <211> LENGTH: 68 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 71 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Ile Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Val Pro Leu Asp Gl #y Asp Gln Pro Ala Asp             20       #            25       #            30 Arg Pro Ala Glu Arg Lys Gln Asp Val Ser Se #r Glu Gln His Pro Phe         35           #        40           #        45 Phe Asp Pro Val Lys Arg Cys Cys Arg Arg Cy #s Tyr Met Gly Cys Ile     50               #    55               #    60 Pro Cys Cys Phe 65 <210> SEQ ID NO 72 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(14) <223> OTHER INFORMATION: Xaa at residue 11 is  #Pro or Hyp; Xaa at       residue 6 is Tyr, 125I-Tyr, mono- #iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 72 Cys Cys Arg Arg Cys Xaa Met Gly Cys Ile Xa #a Cys Cys Phe 1               5    #                10 <210> SEQ ID NO 73 <211> LENGTH: 323 <212> TYPE: DNA <213> ORGANISM: Conus circumcisus <400> SEQUENCE: 73 caagaaggat cgatagcagt tcatgatgtc taaactgggg gtattgttga cc #atctgtct     60 gcttctgttt ccccttactg ctcttccaat ggatggagat caacctgcag ac #caacctgc    120 agatcgtatg caggacgaca tttcatctga gcagtatccc ttgtttgata ag #agacgaaa    180 gtgttgcggc aaagacgggc catgccccaa atatttcaaa gacaatttta tt #tgtggttg    240 ttgttaaatg acaacgtgtc gatgaccaac ttcgttatca cgattcgcca ag #tgtcttaa    300 tgaataagta aaatgattgc agt            #                   #               323 <210> SEQ ID NO 74 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <400> SEQUENCE: 74 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Pro Ala Asp Gln Pro             20       #            25       #            30 Ala Asp Arg Met Gln Asp Asp Ile Ser Ser Gl #u Gln Tyr Pro Leu Phe         35           #        40           #        45 Asp Lys Arg Arg Lys Cys Cys Gly Lys Asp Gl #y Pro Cys Pro Lys Tyr     50               #    55               #    60 Phe Lys Asp Asn Phe Ile Cys Gly Cys Cys 65                   #70 <210> SEQ ID NO 75 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 9 and  #11 is Pro or Hyp; Xaa at       residue 13 is Tyr, 125I-Tyr, mono #-iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 75 Arg Lys Cys Cys Gly Lys Asp Gly Xaa Cys Xa #a Lys Xaa Phe Lys Asp 1               5    #                10   #                15 Asn Phe Ile Cys Gly Cys Cys             20 <210> SEQ ID NO 76 <211> LENGTH: 293 <212> TYPE: DNA <213> ORGANISM: Conus dalli <400> SEQUENCE: 76 caagagggat cgatagcagt tcatgatgtc taaactggga gccttgttga cc #atctgtct     60 acttctgttt tccctaactg ctgttccgct ggatggagat caacatgcag ac #caacctgc    120 agagcgtctg caggaccgcc ttccaactga aaatcatccc ttatatgatc cc #gtcaaacg    180 gtgttgcgat gattcggaat gcgactattc ttgctggcct tgctgtattt ta #tcataacc    240 tttgttatcg cggcctcatc aagtgtcaaa tgaataagta aaatgattgc ag #t           293 <210> SEQ ID NO 77 <211> LENGTH: 71 <212> TYPE: PRT <213> ORGANISM: Conus dalli <400> SEQUENCE: 77 Met Met Ser Lys Leu Gly Ala Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n His Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Leu Gln Asp Arg Leu Pro Thr Gl #u Asn His Pro Leu Tyr         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys Asp Asp Ser Gl #u Cys Asp Tyr Ser Cys     50               #    55               #    60 Trp Pro Cys Cys Ile Leu Ser 65                   #70 <210> SEQ ID NO 78 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(18) <223> OTHER INFORMATION: Xaa at residue 6 is  #Glu or gamma-carboxy Glu;       Xaa at residue 13 is Pro or  #Hyp; Xaa at residue 12 is Trp or       bromo-Trp; Xaa at residue 9 is  #Tyr, 125I-Tyr, mono-iodo-Tyr,       di-iodo-Tyr, O-sulpho-Tyr or O-phospho- #Tyr <400> SEQUENCE: 78 Cys Cys Asp Asp Ser Xaa Cys Asp Xaa Ser Cy #s Xaa Xaa Cys Cys Ile 1               5    #                10   #                15 Leu Ser <210> SEQ ID NO 79 <211> LENGTH: 299 <212> TYPE: DNA <213> ORGANISM: Conus dalli <400> SEQUENCE: 79 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atttgtct     60 acttctgttt ccccttactg ctgttccact ggatggagat cagcctgcag ac #cgacctgc    120 agagcgtatg caggacggca tttcatctga acatcatcca ttttttgatt cc #gtcaaaaa    180 gaaacaacag tgttgcccgc cggtggcatg caacatggga tgcgagcctt gt #tgtggatg    240 accagctttg ttatcgcggc tcatgaagtg tcctaatgaa taagtaaaac ga #ttgcagt     299 <210> SEQ ID NO 80 <211> LENGTH: 72 <212> TYPE: PRT <213> ORGANISM: Conus dalli <400> SEQUENCE: 80 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Gly Ile Ser Ser Gl #u His His Pro Phe Phe         35           #        40           #        45 Asp Ser Val Lys Lys Lys Gln Gln Cys Cys Pr #o Pro Val Ala Cys Asn     50               #    55               #    60 Met Gly Cys Glu Pro Cys Cys Gly 65                   #70 <210> SEQ ID NO 81 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(17) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 14 is Glu or gamma-carbox #y Glu; Xaa at residue 5, 6 and       15 is Pro or Hyp <400> SEQUENCE: 81 Xaa Gln Cys Cys Xaa Xaa Val Ala Cys Asn Me #t Gly Cys Xaa Xaa Cys 1               5    #                10   #                15 Cys <210> SEQ ID NO 82 <211> LENGTH: 290 <212> TYPE: DNA <213> ORGANISM: Conus dalli <400> SEQUENCE: 82 caagaaggat cgatagcagt tcatgatgtc taaactggga gtcttgttga tc #atatgtct     60 atttctgttt ccccttactg ctgttcagct caatggagat cagcctgcag ac #caatctgc    120 agagcgtatg caggacaaaa tttcatctga acatcatccc ttttttgatc cc #gtcaaacg    180 ttgttgcaac gcggggtttt gccgcttcgg atgcacgcct tgttgttggt ga #ccagcttt    240 gttatcgcgg cctcatcaag tgtctaatga ataagtaaaa tgattgcagt   #             290 <210> SEQ ID NO 83 <211> LENGTH: 69 <212> TYPE: PRT <213> ORGANISM: Conus dalli <400> SEQUENCE: 83 Met Met Ser Lys Leu Gly Val Leu Leu Ile Il #e Cys Leu Phe Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Val Gln Leu Asn Gly Asp Gl #n Pro Ala Asp Gln Ser             20       #            25       #            30 Ala Glu Arg Met Gln Asp Lys Ile Ser Ser Gl #u His His Pro Phe Phe         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys Asn Ala Gly Ph #e Cys Arg Phe Gly Cys     50               #    55               #    60 Thr Pro Cys Cys Trp 65 <210> SEQ ID NO 84 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus dalli <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 13 is  #Pro or Hyp; Xaa at       residue 16 is Trp or bromo-Trp <400> SEQUENCE: 84 Cys Cys Asn Ala Gly Phe Cys Arg Phe Gly Cy #s Thr Xaa Cys Cys Xaa 1               5    #                10   #                15 <210> SEQ ID NO 85 <211> LENGTH: 288 <212> TYPE: DNA <213> ORGANISM: Conus distans <400> SEQUENCE: 85 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgctga cc #atctttct     60 gcttctgttt ccccttactg ctgttccgct ggatggagat caacccgcag ac #ggacttgc    120 agagcgcatg caggacgaca gttcagctgc actgattaga gactggcttc tt #caaacccg    180 acagtgttgt gtgcatccat gcccatgcac gccttgctgt agatgaccag ct #ttgtcatc    240 gcggctacgt caagtatcta atgaataagt aagtaaaacg attgcagt   #               288 <210> SEQ ID NO 86 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus distans <400> SEQUENCE: 86 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Phe Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Gly Leu             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ser Ser Ala Al #a Leu Ile Arg Asp Trp         35           #        40           #        45 Leu Leu Gln Thr Arg Gln Cys Cys Val His Pr #o Cys Pro Cys Thr Pro     50               #    55               #    60 Cys Cys Arg 65 <210> SEQ ID NO 87 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus distans <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(14) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 6, 8 and 11 is Pro  #or Hyp <400> SEQUENCE: 87 Xaa Cys Cys Val His Xaa Cys Xaa Cys Thr Xa #a Cys Cys Arg 1               5    #                10 <210> SEQ ID NO 88 <211> LENGTH: 303 <212> TYPE: DNA <213> ORGANISM: Conus ermineus <400> SEQUENCE: 88 acctcaagag ggatcgatcg cagttcatga tgtctaaact gggagccttg tt #gaccatct     60 gtctgcttct gtttcccatt actgctcttc tgatggatgg agatcagcct gc #agaccgac    120 ctgcagagcg tacggaggat gacatttcat ctgactacat tccctgttgc ag #ttggccat    180 gcccccgata ctccaacggt aaacttgttt gtttttgttg ccttggatga ta #atgtgttg    240 atgaccaact ttgttatcac ggctacgtca agtgtctact gaataagtaa aa #tgattgca    300 gta                   #                   #                   #            303 <210> SEQ ID NO 89 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus ermineus <400> SEQUENCE: 89 Met Met Ser Lys Leu Gly Ala Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Ile Thr Ala Leu Leu Met Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Thr Glu Asp Asp Ile Ser Ser As #p Tyr Ile Pro Cys Cys         35           #        40           #        45 Ser Trp Pro Cys Pro Arg Tyr Ser Asn Gly Ly #s Leu Val Cys Phe Cys     50               #    55               #    60 Cys Leu Gly 65 <210> SEQ ID NO 90 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Conus ermineus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(20) <223> OTHER INFORMATION: Xaa at residue 5 and  #7 is Pro or Hyp; Xaa at       residue 4 is Trp or bromo-Trp;  #Xaa at residue 9 is Tyr, 125I-Tyr,       mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr  #or O-phospho-Tyr <400> SEQUENCE: 90 Cys Cys Ser Xaa Xaa Cys Xaa Arg Xaa Ser As #n Gly Lys Leu Val Cys 1               5    #                10   #                15 Phe Cys Cys Leu             20 <210> SEQ ID NO 91 <211> LENGTH: 241 <212> TYPE: DNA <213> ORGANISM: Conus generalis <400> SEQUENCE: 91 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctggttct gt #ttcccctt     60 actgctcttc cactggatgg agaacaacct gtagaccgac atgccgagca ta #tgcaggat    120 gacaattcag ctgcacagaa cccctgggtt attgccatca gacagtgttg ca #cgttctgc    180 aactttggat gccaaccttg ttgcctcacc tgataacgtg ttgatgacca ac #tttctcga    240 g                   #                   #                   #              241 <210> SEQ ID NO 92 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus generalis <400> SEQUENCE: 92 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Ile Cys Leu Val 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Leu Pro Leu Asp Gl #y Glu Gln Pro Val Asp             20       #            25       #            30 Arg His Ala Glu His Met Gln Asp Asp Asn Se #r Ala Ala Gln Asn Pro         35           #        40           #        45 Trp Val Ile Ala Ile Arg Gln Cys Cys Thr Ph #e Cys Asn Phe Gly Cys     50               #    55               #    60 Gln Pro Cys Cys Leu Thr 65                   #70 <210> SEQ ID NO 93 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus generalis <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 12 is Pro or Hyp <400> SEQUENCE: 93 Xaa Cys Cys Thr Phe Cys Asn Phe Gly Cys Gl #n Xaa Cys Cys Leu Thr 1               5    #                10   #                15 <210> SEQ ID NO 94 <211> LENGTH: 241 <212> TYPE: DNA <213> ORGANISM: Conus generalis <400> SEQUENCE: 94 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctggttct gt #ttcccctt     60 actgctcttc cactggatgg agaacaacct gtagaccgac atgccgagca ta #tgcaggat    120 gacaattcag ctgcacagaa cccctgggtt attgccatca gacagtgttg ca #cgttctgc    180 aactttggat gccagccttg ttgcgtcccc tgataacgtg ttgatgacca ac #tttctcga    240 g                   #                   #                   #              241 <210> SEQ ID NO 95 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus generalis <400> SEQUENCE: 95 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Ile Cys Leu Val 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Leu Pro Leu Asp Gl #y Glu Gln Pro Val Asp             20       #            25       #            30 Arg His Ala Glu His Met Gln Asp Asp Asn Se #r Ala Ala Gln Asn Pro         35           #        40           #        45 Trp Val Ile Ala Ile Arg Gln Cys Cys Thr Ph #e Cys Asn Phe Gly Cys     50               #    55               #    60 Gln Pro Cys Cys Val Pro 65                   #70 <210> SEQ ID NO 96 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus generalis <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 12 and 16 is Pro or  #Hyp <400> SEQUENCE: 96 Xaa Cys Cys Thr Phe Cys Asn Phe Gly Cys Gl #n Xaa Cys Cys Val Xaa 1               5    #                10   #                15 <210> SEQ ID NO 97 <211> LENGTH: 862 <212> TYPE: DNA <213> ORGANISM: Conus geographus <400> SEQUENCE: 97 gtcgactcta gaggatccga caacaaagag tcaaccccac tgccacgtca ag #agcgaagc     60 gccacagcta agacaagagg gatcgatagc agttcatgat gtctaaactg gg #agtcttgt    120 tgaccatctg tctgcttctg tttcccctta ctgctcttcc gatggatgga ga #tgaacctg    180 caaaccgacc tgtcgagcgt atgcaggaca acatttcatc tgagcagtat cc #cttgtttg    240 agaagagacg agattgttgc actccgccga agaaatgcaa agaccgacaa tg #caaacccc    300 agagatgttg cgctggacga taacgtgttg atgaccaact ttatcacggc ta #cgtcaagt    360 gtttagtgaa taagtaaaat gattgcagtc ttgctcagat ttgcttttgt gt #tttggtct    420 aaagatcaat gaccaaaccg ttgttttgat gcggattgtc atatatttct cg #attccaat    480 ccaacactag atgatttaat cacgatagat taattttcta tcaatgcctt ga #tttttcgt    540 ctgtcatatc agttttgttt atatttattt tttcgtcact gtctacacaa ac #gcatgcat    600 gcacgcatgc acgcacacac gcacgcacgc tcgcacaaac atgcgcgcgc ac #gcacacac    660 acacacacac acacaaacac acacacaagc aatcacacaa ttattgacat ta #tttattta    720 ttcattgatg tatttgttat tcgtttgctt gtttttagaa tagtttgagg cc #gtcttttt    780 ggatttattt gaactgcttt attgtatacg agtacttcgt gctttgaaac ac #tgctgaaa    840 ataaaacaaa cactgacgta gc            #                   #                862 <210> SEQ ID NO 98 <211> LENGTH: 75 <212> TYPE: PRT <213> ORGANISM: Conus geographus <400> SEQUENCE: 98 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #u Pro Ala Asn Arg Pro             20       #            25       #            30 Val Glu Arg Met Gln Asp Asn Ile Ser Ser Gl #u Gln Tyr Pro Leu Phe         35           #        40           #        45 Glu Lys Arg Arg Asp Cys Cys Thr Pro Pro Ly #s Lys Cys Lys Asp Arg     50               #    55               #    60 Gln Cys Lys Pro Gln Arg Cys Cys Ala Gly Ar #g 65                   #70                   #75 <210> SEQ ID NO 99 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus geographus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 6, 7  #and 17 is Pro or Hyp <400> SEQUENCE: 99 Arg Asp Cys Cys Thr Xaa Xaa Lys Lys Cys Ly #s Asp Arg Gln Cys Lys 1               5    #                10   #                15 Xaa Gln Arg Cys Cys Ala             20 <210> SEQ ID NO 100 <211> LENGTH: 860 <212> TYPE: DNA <213> ORGANISM: Conus geographus <400> SEQUENCE: 100 ggccagacga caacaaagag tcaaccccac tgccacgtca agagcgaagc gc #cacagcta     60 agacaagagg gatcgatagc agttcatgat gtctaaactg ggagtcttgt tg #accatctg    120 tctgcttctg tttcccctta ctgctcttcc gatggatgga gatgaacctg ca #aaccgacc    180 tgtcgagcgt atgcaggaca acatttcatc tgagcagtat cccttgtttg ag #aagagacg    240 agattgttgc actccgccga ggaaatgcaa agaccgacga tgcaaaccca tg #aaatgttg    300 cgctggacga taacgtgttg atgaccaact ttatcacggc tagctcagtg tt #tagtgaat    360 aagtaaaatg attgcagtct tgctcagatt gcttttgtgt tttggtctaa ga #tcaatgac    420 caaaccgttg ttttgatgcg gattgtcata tatttctcga ttccaatcca ac #actagatg    480 atttaatcac gatagattaa ttttctatca atgccttgat ttttcgtctg tc #atatcagt    540 tttgtttata tttatttttt cgtcactgtc tacacaaacg catgcatgca cg #catgcacg    600 cacacacgca cgcacgctcg cacaaacatg cgcgcgcacg cacacacaca ca #cacacaca    660 aacacacaca cgaagcaatc acacaattag ttgacattat ttatttattc at #tgatgtat    720 ttgttattcg tttgcttgtt tttagaatag tttgaggccg tctttttgga tt #tatttgaa    780 ctgctttatt gtatacgagt acttcgtgct ttgaaacact gctgaaaata aa #acaaacac    840 tgacgtagca aaaaaaaaaa             #                   #                   #860 <210> SEQ ID NO 101 <211> LENGTH: 75 <212> TYPE: PRT <213> ORGANISM: Conus geographus <400> SEQUENCE: 101 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #u Pro Ala Asn Arg Pro             20       #            25       #            30 Val Glu Arg Met Gln Asp Asn Ile Ser Ser Gl #u Gln Tyr Pro Leu Phe         35           #        40           #        45 Glu Lys Arg Arg Asp Cys Cys Thr Pro Pro Ar #g Lys Cys Lys Asp Arg     50               #    55               #    60 Arg Cys Lys Pro Met Lys Cys Cys Ala Gly Ar #g 65                   #70                   #75 <210> SEQ ID NO 102 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus geographus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 6, 7  #and 17 is Pro or Hyp <400> SEQUENCE: 102 Arg Asp Cys Cys Thr Xaa Xaa Arg Lys Cys Ly #s Asp Arg Arg Cys Lys 1               5    #                10   #                15 Xaa Met Lys Cys Cys Ala             20 <210> SEQ ID NO 103 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus geographus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 6, 7  #and 17 is Pro or Hyp <400> SEQUENCE: 103 Arg Asp Cys Cys Thr Xaa Xaa Lys Lys Cys Ly #s Asp Arg Arg Cys Lys 1               5    #                10   #                15 Xaa Leu Lys Cys Cys Ala             20 <210> SEQ ID NO 104 <211> LENGTH: 321 <212> TYPE: DNA <213> ORGANISM: Conus gloriamaris <400> SEQUENCE: 104 ctcactatag gaattcgagc tcggtacacg ggatcgatag cagttcatga tg #tctaaact     60 gggagccttg ttgaccatct gtctacttct gttttcccta actgctgttc cg #ctggatgg    120 agatcaacat gcagaccaac ctgcagagcg tctgcatgac cgccttccaa ct #gaaaatca    180 tcccttatat gatcccgtca aacggtgttg cgatgattcg gaatgcgact at #tcttgctg    240 gccttgctgt atgtttggat aacctttgtt atcgcggcct cgataagtgt ct #aatgaata    300 agtaaaacga ttgcagtagg c            #                   #                 321 <210> SEQ ID NO 105 <211> LENGTH: 71 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <400> SEQUENCE: 105 Met Met Ser Lys Leu Gly Ala Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n His Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Leu His Asp Arg Leu Pro Thr Gl #u Asn His Pro Leu Tyr         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys Asp Asp Ser Gl #u Cys Asp Tyr Ser Cys     50               #    55               #    60 Trp Pro Cys Cys Met Phe Gly 65                   #70 <210> SEQ ID NO 106 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(17) <223> OTHER INFORMATION: Xaa at residue is 6  #Glu or gamma-carboxy Glu;       Xaa at residue 13 is Pro or  #Hyp; Xaa at residue 12 is Trp or       bromo-Trp; Xaa at residue 9 is  #Tyr, 125I-Tyr, mono-iodo-Tyr,       di-iodo-Tyr, O-sulpho-Tyr or O-phospho- #Tyr <400> SEQUENCE: 106 Cys Cys Asp Asp Ser Xaa Cys Asp Xaa Ser Cy #s Xaa Xaa Cys Cys Met 1               5    #                10   #                15 Phe <210> SEQ ID NO 107 <211> LENGTH: 257 <212> TYPE: DNA <213> ORGANISM: Conus gloriamaris <400> SEQUENCE: 107 gttcatgatg tctaaactgg gagtcttgtt gatcatctgt ctacttctgt tt #ccccttac     60 tgctgttccg ctggatggag atcaacctgc agaccgatat gcagagcgta tg #caggacga    120 catttcatct gaacatcatc ccatgtttga tgccgtcaga gggtgttgcc at #ctgttggc    180 atgccgcttc ggatgctcgc cttgttgttg gtgatcagct ttgttatcgc gg #cctcatca    240 agtgactcta atgcaaa              #                   #                   #  257 <210> SEQ ID NO 108 <211> LENGTH: 69 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <400> SEQUENCE: 108 Met Met Ser Lys Leu Gly Val Leu Leu Ile Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Arg Tyr             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser Gl #u His His Pro Met Phe         35           #        40           #        45 Asp Ala Val Arg Gly Cys Cys His Leu Leu Al #a Cys Arg Phe Gly Cys     50               #    55               #    60 Ser Pro Cys Cys Trp 65 <210> SEQ ID NO 109 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(17) <223> OTHER INFORMATION: Xaa at residue 14 is  #Pro or Hyp; Xaa at       residue 17 is Trp or bromo-Trp <400> SEQUENCE: 109 Gly Cys Cys His Leu Leu Ala Cys Arg Phe Gl #y Cys Ser Xaa Cys Cys 1               5    #                10   #                15 Xaa <210> SEQ ID NO 110 <211> LENGTH: 471 <212> TYPE: DNA <213> ORGANISM: Conus gloriamaris <400> SEQUENCE: 110 gagacgacaa ggaacagtca accccacagc cacgccaaga gcagacagcc ac #agctacgt     60 gaagaagggt ggagagaggt tcgtgatgtt gaaaatggga gtggtgctat tc #atcttcct    120 ggtactgttt cccctggcaa cgctccagct ggatgcagat caacctgtag aa #cgatatgc    180 ggagaacaaa cagctcctca acccagatga aaggagggaa atcatattgc at #gctctggg    240 gacgcgatgc tgttcttggg atgtgtgcga ccacccgagt tgtacttgct gc #ggcggtta    300 gcgccgaaca tccatggcgc tgtgctgggc ggttttatcc aacaacgaca gc #gtttgttg    360 atttcatgta tcattgcgcc cacgtctctt gtctaagaat gacgaacatg at #tgcactct    420 ggttcagatt tcgtgttctt ttctgacaat aaatgacaaa actccaaaaa a  #            471 <210> SEQ ID NO 111 <211> LENGTH: 71 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <400> SEQUENCE: 111 Met Leu Lys Met Gly Val Val Leu Phe Ile Ph #e Leu Val Leu Phe Pro 1               5    #                10   #                15 Leu Ala Thr Leu Gln Leu Asp Ala Asp Gln Pr #o Val Glu Arg Tyr Ala             20       #            25       #            30 Glu Asn Lys Gln Leu Leu Asn Pro Asp Glu Ar #g Arg Glu Ile Ile Leu         35           #        40           #        45 His Ala Leu Gly Thr Arg Cys Cys Ser Trp As #p Val Cys Asp His Pro     50               #    55               #    60 Ser Cys Thr Cys Cys Gly Gly 65                   #70 <210> SEQ ID NO 112 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 10 is  #Pro or Hyp; Xaa at       residue 4 is Trp or bromo-Trp <400> SEQUENCE: 112 Cys Cys Ser Xaa Asp Val Cys Asp His Xaa Se #r Cys Thr Cys Cys Gly 1               5    #                10   #                15 <210> SEQ ID NO 113 <211> LENGTH: 304 <212> TYPE: DNA <213> ORGANISM: Conus laterculatus <400> SEQUENCE: 113 cgacctcaag aaggatcgat agcagttcat gatgtctaaa ctgggagtct tg #ttgaccat     60 ctgtctgctt ctgtttcccc ttactgctct tccgatggat ggagatcaac ct #gcagaccg    120 acctgcagag cgtatgcagg acgtttcatc tgaacagcat cccttgtatg at #cccgtcaa    180 acggtgttgc gactggccat gcagcggatg catcccttgt tgctaatagt aa #caacgtgt    240 tgataaccaa ctttcttacc acgactacgt caagtgtcta atgaataagt aa #aatgattg    300 cagt                  #                   #                   #            304 <210> SEQ ID NO 114 <211> LENGTH: 65 <212> TYPE: PRT <213> ORGANISM: Conus laterculatus <400> SEQUENCE: 114 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Val Ser Ser Glu Gl #n His Pro Leu Tyr Asp         35           #        40           #        45 Pro Val Lys Arg Cys Cys Asp Trp Pro Cys Se #r Gly Cys Ile Pro Cys     50               #    55               #    60 Cys 65 <210> SEQ ID NO 115 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Conus laterculatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(13) <223> OTHER INFORMATION: Xaa at residue 5 and  #11 is Pro or Hyp; Xaa at       residue 4 is Trp or bromo-Trp <400> SEQUENCE: 115 Cys Cys Asp Xaa Xaa Cys Ser Gly Cys Ile Xa #a Cys Cys 1               5    #                10 <210> SEQ ID NO 116 <211> LENGTH: 313 <212> TYPE: DNA <213> ORGANISM: Conus laterculatus <400> SEQUENCE: 116 cgacctcaag aaggatcgat agcagttcat gatgtctaaa ctgggagtct tg #ttgaccat     60 ctgtctgctt ctgtttcccc ttactgctct ggatggagat caacctgcag ac #cgacttgc    120 agagcgtatg caggacgaca tttcatctga gcagcatccc tttgaaaaga ga #cgagactg    180 ttgcacacct ccgaagaaat gcagagaccg acaatgcaaa cctgcacgtt gt #tgcggagg    240 ataacgtgtt gatgaccaac tttgttatca cggctacgtc aagtgtctag tg #aataagta    300 aaacgattgc agt               #                   #                   #     313 <210> SEQ ID NO 117 <211> LENGTH: 71 <212> TYPE: PRT <213> ORGANISM: Conus laterculatus <400> SEQUENCE: 117 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Asp Gly Asp Gln Pro Al #a Asp Arg Leu Ala Glu             20       #            25       #            30 Arg Met Gln Asp Asp Ile Ser Ser Glu Gln Hi #s Pro Phe Glu Lys Arg         35           #        40           #        45 Arg Asp Cys Cys Thr Pro Pro Lys Lys Cys Ar #g Asp Arg Gln Cys Lys     50               #    55               #    60 Pro Ala Arg Cys Cys Gly Gly 65                   #70 <210> SEQ ID NO 118 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus laterculatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 6, 17  #and 17 is Pro or Hyp <400> SEQUENCE: 118 Arg Asp Cys Cys Thr Xaa Xaa Lys Lys Cys Ar #g Asp Arg Gln Cys Lys 1               5    #                10   #                15 Xaa Ala Arg Cys Cys Gly             20 <210> SEQ ID NO 119 <211> LENGTH: 314 <212> TYPE: DNA <213> ORGANISM: Conus laterculatus <400> SEQUENCE: 119 gggatcgata gcagttcatg atgtctaaac tgggagtctt gttgaccatc tg #tctgcttc     60 tgtttcccct tactgctctt ccgatggatg gagatcaact tgcacgccga tc #tgcagagc    120 gtatgcagga caacatttca tctgagcagc atcacctctt tgaaaagaga cg #accaccat    180 gttgcaccta tgacgggagt tgcctaaaag aatcatgcat gcgtaaagct tg #ttgcggat    240 gataacgtgt tgatgaccaa ctttgttatc acggctactc aagtgtctaa tg #aataagta    300 aaatgattgc agta               #                   #                   #    314 <210> SEQ ID NO 120 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Conus laterculatus <400> SEQUENCE: 120 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Leu Ala Arg Arg Ser             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asn Ile Ser Ser Gl #u Gln His His Leu Phe         35           #        40           #        45 Glu Lys Arg Arg Pro Pro Cys Cys Thr Tyr As #p Gly Ser Cys Leu Lys     50               #    55               #    60 Glu Ser Cys Met Arg Lys Ala Cys Cys Gly 65                   #70 <210> SEQ ID NO 121 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus laterculatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 14 is  #Glu or gamma-carboxy Glu;       Xaa at residue 2 and 3 is P #ro or Hyp; Xaa at residue 7 is Tyr,       125I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O #-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 121 Arg Xaa Xaa Cys Cys Thr Xaa Asp Gly Ser Cy #s Leu Lys Xaa Ser Cys 1               5    #                10   #                15 Met Arg Lys Ala Cys Cys             20 <210> SEQ ID NO 122 <211> LENGTH: 314 <212> TYPE: DNA <213> ORGANISM: Conus laterculatus <400> SEQUENCE: 122 gggatcgata gcagttcatg atgtctaaac tgggagtctt gttgaccacc tg #tctgcttc     60 tgtttcccct tactgctctt ccgatggatg gagatcaact tgcacgccga cc #tgcagagc    120 gtatgcagga caacatttca tctgagcagc atcccttctt tgaaaggaga cg #accaccat    180 gttgcaccta tgacgggagt tgcctaaaag aatcatgcaa gcgtaaagct tg #ttgcggat    240 aataacgtgt tgatgaccaa ctttgttatc acggctactc aagtgtctaa tg #aataagta    300 aaatgattgc agta               #                   #                   #    314 <210> SEQ ID NO 123 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Conus laterculatus <400> SEQUENCE: 123 Met Met Ser Lys Leu Gly Val Leu Leu Thr Th #r Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Leu Ala Arg Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asn Ile Ser Ser Gl #u Gln His Pro Phe Phe         35           #        40           #        45 Glu Arg Arg Arg Pro Pro Cys Cys Thr Tyr As #p Gly Ser Cys Leu Lys     50               #    55               #    60 Glu Ser Cys Lys Arg Lys Ala Cys Cys Gly 65                   #70 <210> SEQ ID NO 124 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus laterculatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 14 is  #Glu or gamma-carboxy Glu;       Xaa at residue 2 and 3 is P #ro or Hyp; Xaa at residue7  is Tyr,       125I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O #-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 124 Arg Xaa Xaa Cys Cys Thr Xaa Asp Gly Ser Cy #s Leu Lys Xaa Ser Cys 1               5    #                10   #                15 Lys Arg Lys Ala Cys Cys             20 <210> SEQ ID NO 125 <211> LENGTH: 247 <212> TYPE: DNA <213> ORGANISM: Conus leopardus <400> SEQUENCE: 125 ggatccatga tgtctaaact gggagtcttg ttgaccgtct gtctgcttct gt #ttcccctt     60 actgctcttc ggctggttgg agatcaacct gcagagcgac ctgcaaagcg ta #cgcaggac    120 gacattccag atggacagca tccgttaaat gataggcaga taaactgttg cc #cgtggcca    180 tgccctagta catgccgcca tcaatgctgc cattaatgat aacgtgttga tg #accaactt    240 tctcgag                  #                   #                   #         247 <210> SEQ ID NO 126 <211> LENGTH: 71 <212> TYPE: PRT <213> ORGANISM: Conus leopardus <400> SEQUENCE: 126 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Val Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Leu Arg Leu Val Gl #y Asp Gln Pro Ala Glu             20       #            25       #            30 Arg Pro Ala Lys Arg Thr Gln Asp Asp Ile Pr #o Asp Gly Gln His Pro         35           #        40           #        45 Leu Asn Asp Arg Gln Ile Asn Cys Cys Pro Tr #p Pro Cys Pro Ser Thr     50               #    55               #    60 Cys Arg His Gln Cys Cys His 65                   #70 <210> SEQ ID NO 127 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Conus leopardus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(19) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 6, 8 and 10 is Pro  #or Hyp; Xaa at residue 7 is Trp or       bromo-Trp <400> SEQUENCE: 127 Xaa Ile Asn Cys Cys Xaa Xaa Xaa Cys Xaa Se #r Thr Cys Arg His Gln 1               5    #                10   #                15 Cys Cys His <210> SEQ ID NO 128 <211> LENGTH: 244 <212> TYPE: DNA <213> ORGANISM: Conus lividus <400> SEQUENCE: 128 ggatccatga tgtctaaact gggagtcttg ttgaccgtct gtctgcttct gt #ttcccctt     60 actgctcttc ggctggttag agatcaacct gcagagcgac ctgcaaagcg ta #cgcaggac    120 gacattccaa atggacagga tccgttaatt gataggcaga taaattgttg cc #cttggcca    180 tgccctgatt catgccacta tcaatgctgc cactgataac gtgttgatga cc #aactttct    240 cgag                  #                   #                   #            244 <210> SEQ ID NO 129 <211> LENGTH: 71 <212> TYPE: PRT <213> ORGANISM: Conus lividus <400> SEQUENCE: 129 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Val Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Leu Arg Leu Val Ar #g Asp Gln Pro Ala Glu             20       #            25       #            30 Arg Pro Ala Lys Arg Thr Gln Asp Asp Ile Pr #o Asn Gly Gln Asp Pro         35           #        40           #        45 Leu Ile Asp Arg Gln Ile Asn Cys Cys Pro Tr #p Pro Cys Pro Asp Ser     50               #    55               #    60 Cys His Tyr Gln Cys Cys His 65                   #70 <210> SEQ ID NO 130 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Conus lividus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(19) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 6, 8 and 10 is Pro  #or Hyp; Xaa at residue 7 is Trp or       bromo-Trp; Xaa at residue 15 is  #Tyr, 125I-Tyr, mono-iodo-Tyr,       di-iodo-Tyr, O-sulpho-Tyr or O-phospho- #Tyr <400> SEQUENCE: 130 Xaa Ile Asn Cys Cys Xaa Xaa Xaa Cys Xaa As #p Ser Cys His Xaa Gln 1               5    #                10   #                15 Cys Cys His <210> SEQ ID NO 131 <211> LENGTH: 275 <212> TYPE: DNA <213> ORGANISM: Conus lynceus <400> SEQUENCE: 131 aaggatcgat agcagttcat gatgtctaaa ctgggagtct tgttgaccat ct #gtctgctt     60 ctgtttcccc ttactgctct tccgatggat ggagatcaat ctgcagaccg ac #ttgcagag    120 cgtatgcagg acaacatttc atctgagcag catcccttct ttgaaaagag ag #gacgagac    180 tgttgcacac ctccgaggaa atgcagagac cgagcctgca aacctcaacg tt #gttgcgga    240 ggataagctg ttgatgacca actttgttat acggc        #                   #      275 <210> SEQ ID NO 132 <211> LENGTH: 75 <212> TYPE: PRT <213> ORGANISM: Conus lynceus <400> SEQUENCE: 132 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Ser Ala Asp Arg Leu             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asn Ile Ser Ser Gl #u Gln His Pro Phe Phe         35           #        40           #        45 Glu Lys Arg Gly Arg Asp Cys Cys Thr Pro Pr #o Arg Lys Cys Arg Asp     50               #    55               #    60 Arg Ala Cys Lys Pro Gln Arg Cys Cys Gly Gl #y 65                   #70                   #75 <210> SEQ ID NO 133 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus lynceus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 7, 8  #and 18 is Pro or Hyp <400> SEQUENCE: 133 Gly Arg Asp Cys Cys Thr Xaa Xaa Arg Lys Cy #s Arg Asp Arg Ala Cys 1               5    #                10   #                15 Lys Xaa Gln Arg Cys Cys Gly             20 <210> SEQ ID NO 134 <211> LENGTH: 803 <212> TYPE: DNA <213> ORGANISM: Conus magus <400> SEQUENCE: 134 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt ccccttactg ctcttccgat ggatggagat gaacctgcaa ac #cgacctgt    120 cgagcgtatg caggacaaca tttcatctga gcagtatccc ttgtttgaga ag #agacgaga    180 ttgttgcact ccgccgaaga aatgcaaaga ccgacaatgc aaaccccaga ga #tgttgcgc    240 tggacgataa cgtgttgatg accaacttta tcacggctac gtcaagtgtt ta #gtgaataa    300 gtaaaatgat tgcagtcttg ctcagatttg cttttgtgtt ttggtctaaa ga #tcaatgac    360 caaaccgttg ttttgatgcg gattgtcata tatttctcga ttccaatcca ac #actagatg    420 atttaatcac gatagattaa ttttctatca atgccttgat ttttcgtctg tc #atatcagt    480 tttgtttata tttatttttt cgtcactgtc tacacaaacg catgcatgca cg #catgcacg    540 cacacacgca cgcacgctcg cacaaacatg cgcgcgcacg cacacacaca ca #cacacaca    600 caaacacaca cacgaagcaa tcacacaatt agttgacatt atttatttat tc #attgatgt    660 atttgttatt cgtttgcttg tttttagaat agtttgaggc cgtctttttg ga #tttatttg    720 aactgcttta ttgtatacga gtacttcgtg cggggaaaca ctgctgaaaa ta #aaacaaac    780 actgacgtag caaaaaaaaa aaa            #                   #               803 <210> SEQ ID NO 135 <211> LENGTH: 75 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 135 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #u Pro Ala Asn Arg Pro             20       #            25       #            30 Val Glu Arg Met Gln Asp Asn Ile Ser Ser Gl #u Gln Tyr Pro Leu Phe         35           #        40           #        45 Glu Lys Arg Arg Asp Cys Cys Thr Pro Pro Ly #s Lys Cys Lys Asp Arg     50               #    55               #    60 Gln Cys Lys Pro Gln Arg Cys Cys Ala Gly Ar #g 65                   #70                   #75 <210> SEQ ID NO 136 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 6 and  #7 is Pro or Hyp <400> SEQUENCE: 136 Arg Asp Cys Cys Thr Xaa Xaa Lys Lys Cys Ly #s Asp Arg Gln Cys Lys 1               5    #                10   #                15 Xaa Gln Arg Cys Cys Ala             20 <210> SEQ ID NO 137 <211> LENGTH: 656 <212> TYPE: DNA <213> ORGANISM: Conus magus <400> SEQUENCE: 137 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt ccccttactg ctcttccaat ggatggagat caacctgcag ac #caacctgc    120 agatcgtatg caggacgaca tttcatctga gcagtatccc ttgtttgata tg #agaaaaag    180 gtgttgcggc cccggcggtt catgccccgt atatttcaga gacaatttta tt #tgtggttg    240 ttgttaaatg acaacgtgtc gatgaccaac ttcattatca cgactacgcc aa #gtgtctaa    300 tgaataaata aaatgattgc agtctcgctc agatttgctt ttgtattttg gt #ctaaagat    360 caatgaccaa accgttgttt tggtgtggat tttcatatat ttctcgagtc ct #atccaaca    420 ctagatgatt taatcacgat agatctgatt tttttatcaa aggcttggtt tt #tcgtctgt    480 cacatcagtt ttgtttatat ttaatttttc gtcactgatt acacacacgc at #gaacgcac    540 agagtactaa cacatacaca cacacacaca cacacacaca cacacacaca ca #cacacaca    600 cacacacaca cacgcgcgcg cgcggcgcca tctagtagcg ccgcgacgac ac #acac        656 <210> SEQ ID NO 138 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 138 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Pro Ala Asp Gln Pro             20       #            25       #            30 Ala Asp Arg Met Gln Asp Asp Ile Ser Ser Gl #u Gln Tyr Pro Leu Phe         35           #        40           #        45 Asp Met Arg Lys Arg Cys Cys Gly Pro Gly Gl #y Ser Cys Pro Val Tyr     50               #    55               #    60 Phe Arg Asp Asn Phe Ile Cys Gly Cys Cys 65                   #70 <210> SEQ ID NO 139 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(21) <223> OTHER INFORMATION: Xaa at residue 4 and  #9 is Pro or Hyp; Xaa at       residue is 11 Tyr, 125I-Tyr, mono #-iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 139 Cys Cys Gly Xaa Gly Gly Ser Cys Xaa Val Xa #a Phe Arg Asp Asn Phe 1               5    #                10   #                15 Ile Cys Gly Cys Cys             20 <210> SEQ ID NO 140 <211> LENGTH: 594 <212> TYPE: DNA <213> ORGANISM: Conus magus <400> SEQUENCE: 140 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgttt     60 gcttctgttt ccccttactg ctcttccgag ggatggagat caatctgtag ac #cgacctgc    120 agagcgtatg caggacgaca tttcatctga gctgcatccc ttgtcaatca ga #aaaagaat    180 gtgttgcggc gagagtgcgc catgccccag ctatttcaga aacagtcaga tt #tgtcattg    240 ttgttaaatg acaacgtgtc gatgaccacc ttcgttatca cgactaatga ta #agtaaaat    300 gattgcagtc tcgctcagat ttgcttttgt attttggtct aaagatcaat ga #ccaaaccg    360 ttgttttgat gtggattttc atatatttct cgagtcctat ccaacactag at #gatttaat    420 cacgatagat ctgatttttt tatcaaagcc ttggtttttc gtctgtcaca tc #agttttgt    480 ttatatttaa tttttcgtca ctgattacac acacgcatga acgcacagac gt #actaacac    540 atacacacac acacacacac acacacacac acacacacac acacacacac ac #ac          594 <210> SEQ ID NO 141 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 141 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Arg Asp Gly Asp Gl #n Ser Val Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser Gl #u Leu His Pro Leu Ser         35           #        40           #        45 Ile Arg Lys Arg Met Cys Cys Gly Glu Ser Al #a Pro Cys Pro Ser Tyr     50               #    55               #    60 Phe Arg Asn Ser Gln Ile Cys His Cys Cys 65                   #70 <210> SEQ ID NO 142 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 5 is  #Glu or gamma-carboxy Glu;       Xaa at residue 8 and 10 is  #Pro or Hyp; Xaa at residue 12 is Tyr,       125I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O #-sulpho-Tyr or       O-phospho-Tyr <400> SEQUENCE: 142 Met Cys Cys Gly Xaa Ser Ala Xaa Cys Xaa Se #r Xaa Phe Arg Asn Ser 1               5    #                10   #                15 Gln Ile Cys His Cys Cys             20 <210> SEQ ID NO 143 <211> LENGTH: 501 <212> TYPE: DNA <213> ORGANISM: Conus magus <400> SEQUENCE: 143 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt ccccttactg ctcttccaat ggatggagat caacctgcag ac #caacctgc    120 agatcgtatg caggacgaca tttcatctga gcagtatccc ttgtttgata ag #agacaaaa    180 gtgttgcggc cccggcggtt catgccccgt atatttcaca gacaatttta tt #tgtggttg    240 ttgttaaatg acaacgtgtc gatgaccaac ttcattatca cgactacgcc aa #gtgtctaa    300 tgaataaata aaatgattgc agtctcgctc agatttgctt ttgtatttgg tc #taaagatc    360 aatgaccaaa ccgttgtttt ggtgctggat tttcatatat ttctcgattc ct #atccaaca    420 ctagatgatt taatcacgat agatctgatt tttttatcaa tgccttaatt tt #ttgctctg    480 tcatatcagt tttgtttata t            #                   #                 501 <210> SEQ ID NO 144 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 144 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Pro Ala Asp Gln Pro             20       #            25       #            30 Ala Asp Arg Met Gln Asp Asp Ile Ser Ser Gl #u Gln Tyr Pro Leu Phe         35           #        40           #        45 Asp Lys Arg Gln Lys Cys Cys Gly Pro Gly Gl #y Ser Cys Pro Val Tyr     50               #    55               #    60 Phe Thr Asp Asn Phe Ile Cys Gly Cys Cys 65                   #70 <210> SEQ ID NO 145 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 6 and 11 is Pro or  #Hyp; Xaa at residue 13 is Tyr,       125I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O #-sulpho-Tyr or       O-phospho-Tyr <400> SEQUENCE: 145 Xaa Lys Cys Cys Gly Xaa Gly Gly Ser Cys Xa #a Val Xaa Phe Thr Asp 1               5    #                10   #                15 Asn Phe Ile Cys Gly Cys Cys             20 <210> SEQ ID NO 146 <211> LENGTH: 454 <212> TYPE: DNA <213> ORGANISM: Conus magus <400> SEQUENCE: 146 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt ccccttactg ctcttccaat ggatggagat caacctgcag ac #caacctgc    120 agatcgtatg caggacgaca tttcatctga gcagtatccc ttgtttgata ag #agacaaaa    180 gtgttgcggc cccggcggtt catgccccgt atatttcaga gacaatttta tt #tgtggttg    240 ttgttaaatg acaacgtgtc gatgaccatc ttcattatca cgactacgcc aa #gtgtctaa    300 tgaataaata aaatgattgc agtctcgctc agatttgctt ttgtattttg gt #ctaaagat    360 caatgaccaa accgttgttt tggtgtggat tttcatatat ttctcgattc ct #atccaaca    420 ctagatgatt taatcacgat agatctgatt tttt        #                   #       454 <210> SEQ ID NO 147 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 147 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Pro Ala Asp Gln Pro             20       #            25       #            30 Ala Asp Arg Met Gln Asp Asp Ile Ser Ser Gl #u Gln Tyr Pro Leu Phe         35           #        40           #        45 Asp Lys Arg Gln Lys Cys Cys Gly Pro Gly Gl #y Ser Cys Pro Val Tyr     50               #    55               #    60 Phe Arg Asp Asn Phe Ile Cys Gly Cys Cys 65                   #70 <210> SEQ ID NO 148 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 6 and 11 is Pro or  #Hyp; Xaa at residue 13 is Tyr,       125I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O #-sulpho-Tyr or       O-phospho-Tyr <400> SEQUENCE: 148 Xaa Lys Cys Cys Gly Xaa Gly Gly Ser Cys Xa #a Val Xaa Phe Arg Asp 1               5    #                10   #                15 Asn Phe Ile Cys Gly Cys Cys             20 <210> SEQ ID NO 149 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus magus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 10 and 20 is Pro or  #Hyp; Xaa at residue 12 is Tyr,       125I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O #-sulpho-Tyr or       O-phospho-Tyr <400> SEQUENCE: 149 Xaa Lys Cys Cys Ser Gly Gly Ser Cys Xaa Le #u Xaa Phe Arg Asp Arg 1               5    #                10   #                15 Leu Ile Cys Xaa Cys Cys             20 <210> SEQ ID NO 150 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(19) <223> OTHER INFORMATION: Xaa at residue 16 is  #Pro or Hyp <400> SEQUENCE: 150 Ser Lys Gln Cys Cys His Leu Ala Ala Cys Ar #g Phe Gly Cys Thr Xaa 1               5    #                10   #                15 Cys Cys Asn <210> SEQ ID NO 151 <211> LENGTH: 321 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 151 caagaaggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt cccgttactg ctcttccgat ggatggtgat caacctgcag ac #cgacttgt    120 agagcgtatg caggacaaca tttcatctga gcagcatccc ttctttgaaa ag #agaagagg    180 aggctgttgc acacctccga ggaaatgcaa agaccgagcc tgcaaacctg ca #cgttgctg    240 cggcccagga taacgtgttg atgaccaact ttgttatcac ggctacgtca ag #tgtctagt    300 gaataagtaa aacgattgca g            #                   #                 321 <210> SEQ ID NO 152 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 152 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Val Thr Ala Leu Pro Met Asp Gly Asp Gl #n Pro Ala Asp Arg Leu             20       #            25       #            30 Val Glu Arg Met Gln Asp Asn Ile Ser Ser Gl #u Gln His Pro Phe Phe         35           #        40           #        45 Glu Lys Arg Arg Gly Gly Cys Cys Thr Pro Pr #o Arg Lys Cys Lys Asp     50               #    55               #    60 Arg Ala Cys Lys Pro Ala Arg Cys Cys Gly Pr #o Gly 65                   #70                   #75 <210> SEQ ID NO 153 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(24) <223> OTHER INFORMATION: Xaa at residue 3, 8,  #18 and 24 is Pro or Hyp <400> SEQUENCE: 153 Arg Gly Gly Cys Cys Thr Xaa Xaa Arg Lys Cy #s Lys Asp Arg Ala Cys 1               5    #                10   #                15 Lys Xaa Ala Arg Cys Cys Gly Xaa             20 <210> SEQ ID NO 154 <211> LENGTH: 296 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 154 gagctcggta ccccgacctc aagagggatc gatagcagtt catgatgtct aa #actgggaa     60 tcttgttgac catctgtcta cttctatttc cccttactgc tgttccgctg ga #tggagatc    120 aacctgcaga ccgacctgca gagcgtatgc aggacgacat ttcatctgaa ca #tcatccct    180 tttttgatcc cgtcaaacgg tgttgcaggt tatcatgcgg cctgggatgc ca #cccttgtt    240 gtggatgacc agctttgtta tcgcggcctc atcaagtgtc taatgaataa gt #aaaa        296 <210> SEQ ID NO 155 <211> LENGTH: 68 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 155 Met Met Ser Lys Leu Gly Ile Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser Gl #u His His Pro Phe Phe         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys Arg Leu Ser Cy #s Gly Leu Gly Cys His     50               #    55               #    60 Pro Cys Cys Gly 65 <210> SEQ ID NO 156 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(14) <223> OTHER INFORMATION: Xaa at residue 12 is  #Pro or Hyp <400> SEQUENCE: 156 Cys Cys Arg Leu Ser Cys Gly Leu Gly Cys Hi #s Xaa Cys Cys 1               5    #                10 <210> SEQ ID NO 157 <211> LENGTH: 355 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 157 ggcctacacc aagcttgcat gcctgcaggt cgactctaga ggatccccga tc #gatagcag     60 ttcatgatgt ctagactggg agtcttgttg accatctgtc tacttctgtt tc #cccttact    120 gctgttccgc tggatggaga tcaacctgcg gaccgacctg cagagcgcct gc #aggacgac    180 atttcatctg aacatcatcc ccattttgat tccggcagag agtgttgcgg tt #cgttcgca    240 tgccgctttg gatgcgtgcc ttgttgtgta tgaccagctt tgttatcacg gc #ctcatcga    300 gtgtctaatg aataagtaaa acgattgcag taggcgggta ccgagctcga at #tcc         355 <210> SEQ ID NO 158 <211> LENGTH: 69 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 158 Met Met Ser Arg Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Leu Gln Asp Asp Ile Ser Ser Gl #u His His Pro His Phe         35           #        40           #        45 Asp Ser Gly Arg Glu Cys Cys Gly Ser Phe Al #a Cys Arg Phe Gly Cys     50               #    55               #    60 Val Pro Cys Cys Val 65 <210> SEQ ID NO 159 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(17) <223> OTHER INFORMATION: Xaa at residue 1 is  #Glu or gamma-carboxy Glu;       Xaa at residue 14 is Pro or  #Hyp <400> SEQUENCE: 159 Xaa Cys Cys Gly Ser Phe Ala Cys Arg Phe Gl #y Cys Val Xaa Cys Cys 1               5    #                10   #                15 Val <210> SEQ ID NO 160 <211> LENGTH: 295 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 160 cgacctcaag agggatcgat agcagttcat gatgtctaaa ctgggagtct tg #ttgaccat     60 ctgtctactt ctatttcccc ttactgctgt tccgctggat ggagaccaac ct #gcagaccg    120 acctgcagag cgtatgcagg acgacatttc atctgaacgt catccttttt tt #gatcgcag    180 caaacagtgt tgccatctgc cggcatgccg cttcggatgt acgccttgtt gt #tggtgatc    240 agctttgtta tcgcgtcctc atcaagtgtc taatgaataa gtaaaatgat tg #cag         295 <210> SEQ ID NO 161 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 161 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser Hi #s Pro Phe Phe Asp Arg         35           #        40           #        45 Ser Lys Gln Cys Cys His Leu Pro Ala Cys Ar #g Phe Gly Cys Thr Pro     50               #    55               #    60 Cys Cys Trp 65 <210> SEQ ID NO 162 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(19) <223> OTHER INFORMATION: Xaa at residue 8 and  #16 is Pro or Hyp; Xaa at       residue 19 is Trp or bromo-Trp <400> SEQUENCE: 162 Ser Lys Gln Cys Cys His Leu Xaa Ala Cys Ar #g Phe Gly Cys Thr Xaa 1               5    #                10   #                15 Cys Cys Xaa <210> SEQ ID NO 163 <211> LENGTH: 235 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 163 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttcccctt     60 actgctcttc cgctggatgg agatcaacct gcagaccaac gtgcagagcg ta #cgcaggcc    120 gagaagcatt ccttgcctga tccgagaatg ggctgttgcc cgtttccatg ca #aaaccagt    180 tgcactactt tgtgttgcgg gtgatgataa cgtgttgatg accaactttc tc #gag         235 <210> SEQ ID NO 164 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 164 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Ile Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Leu Pro Leu Asp Gl #y Asp Gln Pro Ala Asp             20       #            25       #            30 Gln Arg Ala Glu Arg Thr Gln Ala Glu Lys Hi #s Ser Leu Pro Asp Pro         35           #        40           #        45 Arg Met Gly Cys Cys Pro Phe Pro Cys Lys Th #r Ser Cys Thr Thr Leu     50               #    55               #    60 Cys Cys Gly 65 <210> SEQ ID NO 165 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(17) <223> OTHER INFORMATION: Xaa at residue 5 and  #7 is Pro or Hyp <400> SEQUENCE: 165 Met Gly Cys Cys Xaa Phe Xaa Cys Lys Thr Se #r Cys Thr Thr Leu Cys 1               5    #                10   #                15 Cys <210> SEQ ID NO 166 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 4 and  #6 is Trp or bromo-Trp <400> SEQUENCE: 166 Cys Cys His Xaa Asn Xaa Cys Asp His Leu Cy #s Ser Cys Cys Gly Ser 1               5    #                10   #                15 <210> SEQ ID NO 167 <211> LENGTH: 357 <212> TYPE: DNA <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 167 gccaagcttg catgcctgca ggatgactct agaggatccc cacctcaaga gg #gatcgata     60 gcagttcatg atgtctaaac tgggagtctt gttgaccatc tgtctacttc tg #tttgccct    120 tactgctgtt ccgctggatg gagatcaacc tgcagaccga cctgcagaac gt #atgcagga    180 cgacatttca tctgaacgtc atcccatgtt tgatgccgtc agagattgtt gc #ccgttgcc    240 ggcatgcccc tttggatgca acccttgttg tggatgacca gctttgttat cg #ggacctca    300 tcaagtgtct aatgaataag taaaaaacga ttcgagtggg taccgagctc ga #attcc       357 <210> SEQ ID NO 168 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 168 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ala Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser Hi #s Pro Met Phe Asp Ala         35           #        40           #        45 Val Arg Asp Cys Cys Pro Leu Pro Ala Cys Pr #o Phe Gly Cys Asn Pro     50               #    55               #    60 Cys Cys Gly 65 <210> SEQ ID NO 169 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 4, 6,  #9 and 14 is Pro or Hyp <400> SEQUENCE: 169 Asp Cys Cys Xaa Leu Xaa Ala Cys Xaa Phe Gl #y Cys Asn Xaa Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 170 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 4 and  #13 is Pro or Hyp <400> SEQUENCE: 170 Cys Cys Ala Xaa Ser Ala Cys Arg Leu Gly Cy #s Arg Xaa Cys Cys Arg 1               5    #                10   #                15 <210> SEQ ID NO 171 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 4 and  #13 is Pro or Hyp <400> SEQUENCE: 171 Cys Cys Ala Xaa Ser Ala Cys Arg Leu Gly Cy #s Arg Xaa Cys Cys Arg 1               5    #                10   #                15 <210> SEQ ID NO 172 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 4 and  #13 is Pro or Hyp <400> SEQUENCE: 172 Cys Cys Ala Xaa Ser Ala Cys Arg Leu Gly Cy #s Arg Xaa Cys Cys Arg 1               5    #                10   #                15 <210> SEQ ID NO 173 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(17) <223> OTHER INFORMATION: Xaa at residue 14 is  #Pro or Hyp <400> SEQUENCE: 173 Gly Cys Cys Gly Ser Phe Ala Cys Arg Phe Gl #y Cys Val Xaa Cys Cys 1               5    #                10   #                15 Val <210> SEQ ID NO 174 <211> LENGTH: 244 <212> TYPE: DNA <213> ORGANISM: Conus nobilis <400> SEQUENCE: 174 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctacttct gt #ttcccctt     60 actgctcttc cgctggatga agatcaaccg gtacaccgac ctgcagagcg ta #tgcaggac    120 atttcatctg atcaacatct cttctttgat ctcatcaaac ggtgctgcga gt #tgccatgc    180 gggccaggct tttgcgtccc ttgttgctga catcaataac gtgttgatga cc #aactttct    240 cgag                  #                   #                   #            244 <210> SEQ ID NO 175 <211> LENGTH: 69 <212> TYPE: PRT <213> ORGANISM: Conus nobilis <400> SEQUENCE: 175 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Ile Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Leu Pro Leu Asp Gl #u Asp Gln Pro Val His             20       #            25       #            30 Arg Pro Ala Glu Arg Met Gln Asp Ile Ser Se #r Asp Gln His Leu Phe         35           #        40           #        45 Phe Asp Leu Ile Lys Arg Cys Cys Glu Leu Pr #o Cys Gly Pro Gly Phe     50               #    55               #    60 Cys Val Pro Cys Cys 65 <210> SEQ ID NO 176 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus nobilis <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Xaa at residue 3 is  #Glu or gamma-carboxy Glu;       Xaa at residue 5, 8  and 13 # is Pro or Hyp <400> SEQUENCE: 176 Cys Cys Xaa Leu Xaa Cys Gly Xaa Gly Phe Cy #s Val Xaa Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 177 <211> LENGTH: 262 <212> TYPE: DNA <213> ORGANISM: Conus nobilis <400> SEQUENCE: 177 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctacttct gt #ttcccctt     60 actgcttttc cgatggatgg agatcaacct gcagaccaac ctgcagatcg ta #tgcaggac    120 gacatttcat ctgagcagta tcccttgttt gataagagac aaaagtgttg ca #ctgggaag    180 aaggggtcat gctccggcaa agcatgcaaa aatctcaaat gttgctctgg ac #gataacgt    240 gttgatgacc aactttctcg ag            #                   #                262 <210> SEQ ID NO 178 <211> LENGTH: 78 <212> TYPE: PRT <213> ORGANISM: Conus nobilis <400> SEQUENCE: 178 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Ile Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Phe Pro Met Asp Gl #y Asp Gln Pro Ala Asp             20       #            25       #            30 Gln Pro Ala Asp Arg Met Gln Asp Asp Ile Se #r Ser Glu Gln Tyr Pro         35           #        40           #        45 Leu Phe Asp Lys Arg Gln Lys Cys Cys Thr Gl #y Lys Lys Gly Ser Cys     50               #    55               #    60 Ser Gly Lys Ala Cys Lys Asn Leu Lys Cys Cy #s Ser Gly Arg 65                   #70                   #75 <210> SEQ ID NO 179 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus nobilis <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu <400> SEQUENCE: 179 Xaa Lys Cys Cys Thr Gly Lys Lys Gly Ser Cy #s Ser Gly Lys Ala Cys 1               5    #                10   #                15 Lys Asn Leu Lys Cys Cys Ser             20 <210> SEQ ID NO 180 <211> LENGTH: 238 <212> TYPE: DNA <213> ORGANISM: Conus pulicarius <400> SEQUENCE: 180 ggatccatga tgtctaaact gggagttttg ttgaccatct gtctgcttct gt #ttcccctt     60 actgctgttc cgctggatgg agatcaacct gcagaccgac ctgcagagcg ta #tgcaggac    120 attgcaactg aacagcatcc cttctttgat cccgtcaaac ggtgttgcaa ca #gctgttac    180 atgggatgca tcccttgttg cttctagtaa taacgtgttg atgaccaact tt #ctcgag      238 <210> SEQ ID NO 181 <211> LENGTH: 68 <212> TYPE: PRT <213> ORGANISM: Conus pulicarius <400> SEQUENCE: 181 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Ile Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Val Pro Leu Asp Gl #y Asp Gln Pro Ala Asp             20       #            25       #            30 Arg Pro Ala Glu Arg Met Gln Asp Ile Ala Th #r Glu Gln His Pro Phe         35           #        40           #        45 Phe Asp Pro Val Lys Arg Cys Cys Asn Ser Cy #s Tyr Met Gly Cys Ile     50               #    55               #    60 Pro Cys Cys Phe 65 <210> SEQ ID NO 182 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus pulicarius <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(14) <223> OTHER INFORMATION: Xaa at residue 11 is  #Pro or Hyp; Xaa at       residue 5 is Tyr, 125I-Tyr, mono- #iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 182 Cys Cys Asn Ser Cys Xaa Met Gly Cys Ile Xa #a Cys Cys Phe 1               5    #                10 <210> SEQ ID NO 183 <211> LENGTH: 238 <212> TYPE: DNA <213> ORGANISM: Conus quercinus <400> SEQUENCE: 183 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttcccctt     60 acagctcttc agctggatgg agatcaacct gcagaccgac ctgcagagcg ta #cgcaggac    120 attgcatctg aacagtatcg aaagtttgat cagagacaga ggtgttgcca gt #ggccatgc    180 cccggtagtt gcagatgctg ccgtactggt taacgtgttg atgaccaact tt #ctcgag      238 <210> SEQ ID NO 184 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <400> SEQUENCE: 184 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Ile Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Leu Gln Leu Asp Gl #y Asp Gln Pro Ala Asp             20       #            25       #            30 Arg Pro Ala Glu Arg Thr Gln Asp Ile Ala Se #r Glu Gln Tyr Arg Lys         35           #        40           #        45 Phe Asp Gln Arg Gln Arg Cys Cys Gln Trp Pr #o Cys Pro Gly Ser Cys     50               #    55               #    60 Arg Cys Cys Arg Thr Gly 65                   #70 <210> SEQ ID NO 185 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(17) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 7 and 9 is Pro or H #yp; Xaa at residue 6 is Trp or       bromo-Trp <400> SEQUENCE: 185 Xaa Arg Cys Cys Gln Xaa Xaa Cys Xaa Gly Se #r Cys Arg Cys Cys Arg 1               5    #                10   #                15 Thr <210> SEQ ID NO 186 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Xaa at residue 11 and  #14 is Pro or Hyp <400> SEQUENCE: 186 Cys Cys Ser Gln Asp Cys Leu Val Cys Ile Xa #a Cys Cys Xaa Asn 1               5    #                10   #                15 <210> SEQ ID NO 187 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Xaa at residue 11 14  #is Pro or Hyp; Xaa at       residue 7 is Trp or bromo-Trp <400> SEQUENCE: 187 Cys Cys Ser Arg His Cys Xaa Val Cys Ile Xa #a Cys Cys Xaa Asn 1               5    #                10   #                15 <210> SEQ ID NO 188 <211> LENGTH: 323 <212> TYPE: DNA <213> ORGANISM: Conus radiatus <400> SEQUENCE: 188 tcaagaagga tcgatagcag ttcatgatgt ctaaactggg agtcttgttg ac #catctgtc     60 tgcttctgtt tccccttact gctcttccga tggatggaga tcaacctgta ga #ccgacttg    120 cagagcgtat gcaggacaac atttcatctg agcagcatac cttctttgaa aa #gagactac    180 catcgtgttg ctcccttaac ttgcggcttt gcccagtacc agcatgcaaa cg #taaccctt    240 gttgcacagg ataacgtgtt gatgaccaac tttgttatca cggctacgtc aa #gtgtctag    300 tgaataagta aaacgattgc agt            #                   #               323 <210> SEQ ID NO 189 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <400> SEQUENCE: 189 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Pro Val Asp Arg Leu             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asn Ile Ser Ser Gl #u Gln His Thr Phe Phe         35           #        40           #        45 Glu Lys Arg Leu Pro Ser Cys Cys Ser Leu As #n Leu Arg Leu Cys Pro     50               #    55               #    60 Val Pro Ala Cys Lys Arg Asn Pro Cys Cys Th #r Gly 65                   #70                   #75 <210> SEQ ID NO 190 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(24) <223> OTHER INFORMATION: Xaa at residue 2, 13,  #15 and 21 is Pro or Hyp <400> SEQUENCE: 190 Leu Xaa Ser Cys Cys Ser Leu Asn Leu Arg Le #u Cys Xaa Val Xaa Ala 1               5    #                10   #                15 Cys Lys Arg Asn Xaa Cys Cys Thr             20 <210> SEQ ID NO 191 <211> LENGTH: 336 <212> TYPE: DNA <213> ORGANISM: Conus radiatus <400> SEQUENCE: 191 aggtcgactc tagaggatcc ccaaggatcg atagcagttc atgatgtcta aa #ctgggagt     60 cttgttgacc atctgtctgc ttctgtttcc ccttactgct cttccgatgg at #ggagatca    120 acctgcagac cgacttgcag agcgtatgca ggacgacatt tcatctgagc ag #catccctt    180 ctttaaaaag agacaacaaa gatgttgcac cgttaagagg atttgtccag ta #ccagcatg    240 cagaagtaaa ccttgttgca aatcataacg tattgatgac caactttgtt at #cacggcta    300 cgtcaagtgt ctagtgaata agtaaaatga ttgcag       #                   #      336 <210> SEQ ID NO 192 <211> LENGTH: 75 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <400> SEQUENCE: 192 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Pro Ala Asp Arg Leu             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser Gl #u Gln His Pro Phe Phe         35           #        40           #        45 Lys Lys Arg Gln Gln Arg Cys Cys Thr Val Ly #s Arg Ile Cys Pro Val     50               #    55               #    60 Pro Ala Cys Arg Ser Lys Pro Cys Cys Lys Se #r 65                   #70                   #75 <210> SEQ ID NO 193 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(24) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 12, 14 and 20 is Pro  #or Hyp <400> SEQUENCE: 193 Xaa Gln Arg Cys Cys Thr Val Lys Arg Ile Cy #s Xaa Val Xaa Ala Cys 1               5    #                10   #                15 Arg Ser Lys Xaa Cys Cys Lys Ser             20 <210> SEQ ID NO 194 <211> LENGTH: 326 <212> TYPE: DNA <213> ORGANISM: Conus radiatus <400> SEQUENCE: 194 acctcaagaa ggatcgatag cagttcatga tgtctaaact gggagtcttg tt #gaccatct     60 gtctgcttct gtttcccgtt actgctcttc cgatggatgg tgatcaacct gc #agaccgac    120 ttgtagagcg tatgcaggac aacatttcat ctgagcagca tcccttcttt ga #aaagagaa    180 gaggaggctg ttgcacacct ccgaggaaat gcaaagaccg agcctgcaaa cc #tgcacgtt    240 gctgcggccc aggataacgt gttgatgacc aactttgtta tcacggctac gt #caagtgtc    300 tagtgaataa gtaaaacgat tgcagt           #                   #             326 <210> SEQ ID NO 195 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <400> SEQUENCE: 195 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Val Thr Ala Leu Pro Met Asp Gly Asp Gl #n Pro Ala Asp Arg Leu             20       #            25       #            30 Val Glu Arg Met Gln Asp Asn Ile Ser Ser Gl #u Gln His Pro Phe Phe         35           #        40           #        45 Glu Lys Arg Arg Gly Gly Cys Cys Thr Pro Pr #o Arg Lys Cys Lys Asp     50               #    55               #    60 Arg Ala Cys Lys Pro Ala Arg Cys Cys Gly Pr #o Gly 65                   #70                   #75 <210> SEQ ID NO 196 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(24) <223> OTHER INFORMATION: Xaa at residue 7, 8,  #18 and 24 is Pro or Hyp <400> SEQUENCE: 196 Arg Gly Gly Cys Cys Thr Xaa Xaa Arg Lys Cy #s Lys Asp Arg Ala Cys 1               5    #                10   #                15 Lys Xaa Ala Arg Cys Cys Gly Xaa             20 <210> SEQ ID NO 197 <211> LENGTH: 238 <212> TYPE: DNA <213> ORGANISM: Conus rattus <400> SEQUENCE: 197 ggatccatga tgtctaaact gggagtcttg gtgaccatct gcctgcttct gt #tccctctt     60 gctgcttttc cactggatgg agatcaacct gcagaccacc ctgcaaagcg ta #cgcaagat    120 gacagttcag ctgccctgat caatgcctgg cttgatgaat cccagacttg ct #gcagtaac    180 tgcggtgaag attgtgatgg ttgttgccag taacgtgttg atgaccaact tt #ctcgag      238 <210> SEQ ID NO 198 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus rattus <400> SEQUENCE: 198 Gly Ser Met Met Ser Lys Leu Gly Val Leu Va #l Thr Ile Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Ala Ala Phe Pro Leu Asp Gl #y Asp Gln Pro Ala Asp             20       #            25       #            30 His Pro Ala Lys Arg Thr Gln Asp Asp Ser Se #r Ala Ala Leu Ile Asn         35           #        40           #        45 Ala Trp Leu Asp Glu Ser Gln Thr Cys Cys Se #r Asn Cys Gly Glu Asp     50               #    55               #    60 Cys Asp Gly Cys Cys Gln 65                   #70 <210> SEQ ID NO 199 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus rattus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 9 is Glu or gamma-carboxy # Glu <400> SEQUENCE: 199 Xaa Thr Cys Cys Ser Asn Cys Gly Xaa Asp Cy #s Asp Gly Cys Cys Gln 1               5    #                10   #                15 <210> SEQ ID NO 200 <211> LENGTH: 327 <212> TYPE: DNA <213> ORGANISM: Conus stercusmuscarum <400> SEQUENCE: 200 gacctcaaga gggatcgata gcagttcgtg atgtctaaac tgggagtctt gt #tgaccatc     60 tgtctgcttc tgtttcctct tactgctctt ccgatggatg gagatcaacc tg #cagaccaa    120 cctgcagatc gtatgcagga cgacatttca tctgagcagt atcccttgtt tg #ataagaga    180 caaaagtgtt gcactgggaa gaaggggtca tgctccggca aagcatgcaa aa #atctcaaa    240 tgttgctctg gacgataacg tgttgatgac caactttgtt atcacggcta cg #tcaagtgt    300 ctaatgaata agtaaaacga ttgcagt           #                   #            327 <210> SEQ ID NO 201 <211> LENGTH: 75 <212> TYPE: PRT <213> ORGANISM: Conus stercusmuscarum <400> SEQUENCE: 201 Met Ser Lys Leu Gly Val Leu Leu Thr Ile Cy #s Leu Leu Leu Phe Pro 1               5    #                10   #                15 Leu Thr Ala Leu Pro Met Asp Gly Asp Gln Pr #o Ala Asp Gln Pro Ala             20       #            25       #            30 Asp Arg Met Gln Asp Asp Ile Ser Ser Glu Gl #n Tyr Pro Leu Phe Asp         35           #        40           #        45 Lys Arg Gln Lys Cys Cys Thr Gly Lys Lys Gl #y Ser Cys Ser Gly Lys     50               #    55               #    60 Ala Cys Lys Asn Leu Lys Cys Cys Ser Gly Ar #g 65                   #70                   #75 <210> SEQ ID NO 202 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus stercusmuscarum <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu <400> SEQUENCE: 202 Xaa Lys Cys Cys Thr Gly Lys Lys Gly Ser Cy #s Ser Gly Lys Ala Cys 1               5    #                10   #                15 Lys Asn Leu Lys Cys Cys Ser             20 <210> SEQ ID NO 203 <211> LENGTH: 316 <212> TYPE: DNA <213> ORGANISM: Conus stercusmuscarum <400> SEQUENCE: 203 gatcgatagc agttcgtgat gtctaaactg ggagtcttgt tgaccatctg tc #tgcttctg     60 tttcccctta ctgctcttcc gatggatgga gatcaacctg cagaccaacc tg #cagatcgt    120 atgcagaacg acatttcatc tgagcagtat cccttgtttg ataagagaca aa #agtgttgc    180 ggccccggcg cgtcatgccc cagatatttc aaagacaatt ttatttgtgg tt #gttgttaa    240 atgacaacgt gtcgatgacc aacttcgtta tcacgacttc gccaagtgtc ta #atgaataa    300 gtaaaacgat tgcagt              #                   #                   #   316 <210> SEQ ID NO 204 <211> LENGTH: 73 <212> TYPE: PRT <213> ORGANISM: Conus stercusmuscarum <400> SEQUENCE: 204 Met Ser Lys Leu Gly Val Leu Leu Thr Ile Cy #s Leu Leu Leu Phe Pro 1               5    #                10   #                15 Leu Thr Ala Leu Pro Met Asp Gly Asp Gln Pr #o Ala Asp Gln Pro Ala             20       #            25       #            30 Asp Arg Met Gln Asn Asp Ile Ser Ser Glu Gl #n Tyr Pro Leu Phe Asp         35           #        40           #        45 Lys Arg Gln Lys Cys Cys Gly Pro Gly Ala Se #r Cys Pro Arg Tyr Phe     50               #    55               #    60 Lys Asp Asn Phe Ile Cys Gly Cys Cys 65                   #70 <210> SEQ ID NO 205 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus stercusmuscarum <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 6 and 11 is Pro or  #Hyp; Xaa at residue 13 is Tyr,       125I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O #-sulpho-Tyr or       O-phospho-Tyr <400> SEQUENCE: 205 Xaa Lys Cys Cys Gly Xaa Gly Ala Ser Cys Xa #a Arg Xaa Phe Lys Asp 1               5    #                10   #                15 Asn Phe Ile Cys Gly Cys Cys             20 <210> SEQ ID NO 206 <211> LENGTH: 331 <212> TYPE: DNA <213> ORGANISM: Conus striatus <400> SEQUENCE: 206 cgacctttca agagggatcg atagcagttc gcgatgtcta aactgggggt at #tgttgacc     60 atctgtctgc ttctgtttcc ccttactgct cttccgatgg atgaagatca ac #ctgcagac    120 caacttgaag atcgtatgca ggacgacatt tcatctgagc agtatccctc gt #ttgttagg    180 agacaaaagt gttgcggcga aggctcgtca tgccccaaat atttcaaaaa ca #attttatt    240 tgtggttgtt gttaaatgac aacgtgtcga tgaccaactt cgttatcacg ac #tacgccaa    300 gtgtcttgtc taatgataat aaaatgattc c         #                   #         331 <210> SEQ ID NO 207 <211> LENGTH: 73 <212> TYPE: PRT <213> ORGANISM: Conus striatus <400> SEQUENCE: 207 Met Ser Lys Leu Gly Val Leu Leu Thr Ile Cy #s Leu Leu Leu Phe Pro 1               5    #                10   #                15 Leu Thr Ala Leu Pro Met Asp Glu Asp Gln Pr #o Ala Asp Gln Leu Glu             20       #            25       #            30 Asp Arg Met Gln Asp Asp Ile Ser Ser Glu Gl #n Tyr Pro Ser Phe Val         35           #        40           #        45 Arg Arg Gln Lys Cys Cys Gly Glu Gly Ser Se #r Cys Pro Lys Tyr Phe     50               #    55               #    60 Lys Asn Asn Phe Ile Cys Gly Cys Cys 65                   #70 <210> SEQ ID NO 208 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus striatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 6 is Glu or gamma-carboxy # Glu; Xaa at residue 11 is Pro or       Hyp; Xaa at residue 13 is Tyr, # 125I-Tyr, mono-iodo-Tyr,       di-iodo-Tyr, O-sulpho-Tyr or O-phospho- #Tyr <400> SEQUENCE: 208 Xaa Lys Cys Cys Gly Xaa Gly Ser Ser Cys Xa #a Lys Xaa Phe Lys Asn 1               5    #                10   #                15 Asn Phe Ile Cys Gly Cys Cys             20 <210> SEQ ID NO 209 <211> LENGTH: 256 <212> TYPE: DNA <213> ORGANISM: Conus striatus <400> SEQUENCE: 209 ggatccatga tgtctaaact gggagtcttg ttgaccgtct gtctgcttct gt #ttcccctt     60 actgctcttc cgctggatgg agatcaacct gcagaccgac ctgcagagcg ta #tgcaggac    120 gacatttcat ctgacgagca tcccttgttt gataagagac aaaactgttg ca #atggggga    180 tgctccagca aatggtgcag agatcacgca cgttgttgcg gtcgatgata ac #gtgttgat    240 gaccaacttt ctcgag              #                   #                   #   256 <210> SEQ ID NO 210 <211> LENGTH: 75 <212> TYPE: PRT <213> ORGANISM: Conus striatus <400> SEQUENCE: 210 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Val Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Leu Pro Leu Asp Gl #y Asp Gln Pro Ala Asp             20       #            25       #            30 Arg Pro Ala Glu Arg Met Gln Asp Asp Ile Se #r Ser Asp Glu His Pro         35           #        40           #        45 Leu Phe Asp Lys Arg Gln Asn Cys Cys Asn Gl #y Gly Cys Ser Ser Lys     50               #    55               #    60 Trp Cys Arg Asp His Ala Arg Cys Cys Gly Ar #g 65                   #70                   #75 <210> SEQ ID NO 211 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Conus striatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(20) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 12 is Trp or bromo-Trp <400> SEQUENCE: 211 Xaa Asn Cys Cys Asn Gly Gly Cys Ser Ser Ly #s Xaa Cys Arg Asp His 1               5    #                10   #                15 Ala Arg Cys Cys             20 <210> SEQ ID NO 212 <211> LENGTH: 235 <212> TYPE: DNA <213> ORGANISM: Conus tessulatus <400> SEQUENCE: 212 ggatccatga tgtctaaact gggagtcttg ttgaccatgt gtctgcttct gt #ttcccctt     60 actgctgttc cgctggatgg agatcaacct gcagaccgac ctgcagagcg ta #ggcaggac    120 attgcaactg acgatcatcc tttgtttgat cccgtcaaac ggtgctgcca ca #aatgctat    180 atgggatgca tcccttgttg catttagtaa cgtgttgatg accaactttc tc #gag         235 <210> SEQ ID NO 213 <211> LENGTH: 68 <212> TYPE: PRT <213> ORGANISM: Conus tessulatus <400> SEQUENCE: 213 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Met Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Val Pro Leu Asp Gl #y Asp Gln Pro Ala Asp             20       #            25       #            30 Arg Pro Ala Glu Arg Arg Gln Asp Ile Ala Th #r Asp Asp His Pro Leu         35           #        40           #        45 Phe Asp Pro Val Lys Arg Cys Cys His Lys Cy #s Tyr Met Gly Cys Ile     50               #    55               #    60 Pro Cys Cys Ile 65 <210> SEQ ID NO 214 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus tessulatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(14) <223> OTHER INFORMATION: Xaa at residue 11 is  #Pro or Hyp; Xaa at       residue 6 is Tyr, 125I-Tyr, mono- #iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 214 Cys Cys His Lys Cys Xaa Met Gly Cys Ile Xa #a Cys Cys Ile 1               5    #                10 <210> SEQ ID NO 215 <211> LENGTH: 238 <212> TYPE: DNA <213> ORGANISM: Conus tessulatus <400> SEQUENCE: 215 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtgtgcttct gt #ttcccctt     60 actgctgttc cgctggatgg agatcaacct gcagaccaac ctgcagagcg ta #cgcagaac    120 gagcagcatc ccttgtatga tcagaaaaga aagtgttgcc ggccgccatg cg #ccatgagc    180 tgcggcatgg ctaggtgttg ctattaatga taacgtgttg atgaccaact tt #ctcgag      238 <210> SEQ ID NO 216 <211> LENGTH: 68 <212> TYPE: PRT <213> ORGANISM: Conus tessulatus <400> SEQUENCE: 216 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Ile Cys Val Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Val Pro Leu Asp Gl #y Asp Gln Pro Ala Asp             20       #            25       #            30 Gln Pro Ala Glu Arg Thr Gln Asn Glu Gln Hi #s Pro Leu Tyr Asp Gln         35           #        40           #        45 Lys Arg Lys Cys Cys Arg Pro Pro Cys Ala Me #t Ser Cys Gly Met Ala     50               #    55               #    60 Arg Cys Cys Tyr 65 <210> SEQ ID NO 217 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus tessulatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(18) <223> OTHER INFORMATION: Xaa at residue 5 and  #6 is Pro or Hyp; Xaa at       residue 18 is Tyr, 125I-Tyr, mono #-iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 217 Lys Cys Cys Arg Xaa Xaa Cys Ala Met Ser Cy #s Gly Met Ala Arg Cys 1               5    #                10   #                15 Cys Xaa <210> SEQ ID NO 218 <211> LENGTH: 564 <212> TYPE: DNA <213> ORGANISM: Conus textile <400> SEQUENCE: 218 gagtcaaccc actgtcacgc caagagcgga cgccacagct aaggcaagaa gg #atcgatag     60 cagttcatga tgtctaaact gggagccttg ttgaccatct gtctacttct gt #tttccctt    120 actgctgttc cgctggatgg agatcaacat gcagaccaac ctgcacagcg tc #tgcaggac    180 cgcattccaa ctgaagatca tcccttattt gatcccaaca aacggtgttg cc #cgccggtg    240 gcatgcaaca tgggatgcaa gccttgttgt ggatgaccag ctttgttatc gc #ggtctcat    300 gaagtgtcta atgaataagt aaaacgattg cagtttcgtt cagatttgct gt #tgtatttt    360 ggtctaaaga ttaatgacca aactgttctt ttgatccgga ttttcacgta tt #tctcgatt    420 cctattcaac actagataag ttaatcacga cagatctgat tttccatcaa tg #ccttgctt    480 tttggtctgt catataaatc ttgtttatat ttaatttctc gtcactttca ac #acgcacac    540 acacacacac acacacgcgc gcgc           #                   #               564 <210> SEQ ID NO 219 <211> LENGTH: 69 <212> TYPE: PRT <213> ORGANISM: Conus textile <400> SEQUENCE: 219 Met Met Ser Lys Leu Gly Ala Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n His Ala Asp Gln Pro             20       #            25       #            30 Ala Gln Arg Leu Gln Asp Arg Ile Pro Thr Gl #u Asp His Pro Leu Phe         35           #        40           #        45 Asp Pro Asn Lys Arg Cys Cys Pro Pro Val Al #a Cys Asn Met Gly Cys     50               #    55               #    60 Lys Pro Cys Cys Gly 65 <210> SEQ ID NO 220 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 3, 4  #and 13 is Pro or Hyp <400> SEQUENCE: 220 Cys Cys Xaa Xaa Val Ala Cys Asn Met Gly Cy #s Lys Xaa Cys Cys Gly 1               5    #                10   #                15 <210> SEQ ID NO 221 <211> LENGTH: 780 <212> TYPE: DNA <213> ORGANISM: Conus textile <400> SEQUENCE: 221 ggatccagac gacaaagaag agtcaaccca ctgccacgtc aagagcagag cc #cacagcta     60 agacaagaag gatcgatagc agttcatgat gtttaaactg ggagtcttgt tg #accatctg    120 tctccttctg ttttccctta atgctgttcc gttggatgga gatcaacctg ca #gaccaacc    180 tgcagagcgt ctgctggacg acatttcatt tgaaaataat cccttttatg at #cccgccaa    240 acggtgttgc aggacttgct tcggttgcac accttgttgt ggatgaccag cc #tcatcaag    300 tgtctaacga ataagtaaag cgattgcagt ctcgttcaga tttacttttg ta #ttctggtc    360 taaagattaa tgaccaaact cttcttttga tccggatgta catatatttc tc #gattccta    420 tccaacgcta gataagctaa tcacgacaga tctgattttc tgtcaatgcc tt #gctttttg    480 gtctctcata tcactcttgt ttatatttaa tttctcgtca ctatatatat at #atacacac    540 acacacacac ggaattccga ttgtccagta ccgttcttgg gatcgaggta tt #gctgcgat    600 ggcttattct gtactctttt cttctgcgct tgatagtgat gtcttctact cc #catctgtg    660 ctacccctgg cttgatcttt gataggcgtg tgcccttcac tggttataaa cc #cctctgat    720 cctactctct ggacgcctcg ggggcccaac ctccaaataa agcgacatcc aa #tgaaaaaa    780 <210> SEQ ID NO 222 <211> LENGTH: 66 <212> TYPE: PRT <213> ORGANISM: Conus textile <400> SEQUENCE: 222 Met Met Phe Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Asn Ala Val Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Leu Leu Asp Asp Ile Ser Phe Gl #u Asn Asn Pro Phe Tyr         35           #        40           #        45 Asp Pro Ala Lys Arg Cys Cys Arg Thr Cys Ph #e Gly Cys Thr Pro Cys     50               #    55               #    60 Cys Gly 65 <210> SEQ ID NO 223 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(12) <223> OTHER INFORMATION: Xaa at residue 10 is  #Pro or Hyp <400> SEQUENCE: 223 Cys Cys Arg Thr Cys Phe Gly Cys Thr Xaa Cy #s Cys 1               5    #                10 <210> SEQ ID NO 224 <211> LENGTH: 456 <212> TYPE: DNA <213> ORGANISM: Conus textile <400> SEQUENCE: 224 ggaacagtca accccacagc cacgccaaga gcagacagcc acagctacgt ga #agaagggt     60 ggagagaggt tcatgatgtt gaaaatggga gtggtgctat tcatctttct gg #tactgttt    120 cccctggcaa cgctccagct ggatgcagat caacctgtag aacgatatgc gg #agaacaaa    180 cagctcctca acccagatga aaggagggaa atcctattgc ctgctctgag ga #agttctgc    240 tgtgattcga attggtgcca catttcggat tgtgagtgct gctacggtta gc #gccgaaca    300 tccatggcac tgtgctgggc ggtttcatcc caacaacgac agcgtttgtt ga #tttcatgt    360 atcattgcgc ccacgtctct tgtctaagaa tgacgaacat gattgcactc tg #gttcagat    420 ttcgtgttct tttctgacaa taaatgacaa acctcc       #                   #      456 <210> SEQ ID NO 225 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus textile <400> SEQUENCE: 225 Met Met Leu Lys Met Gly Val Val Leu Phe Il #e Phe Leu Val Leu Phe 1               5    #                10   #                15 Pro Leu Ala Thr Leu Gln Leu Asp Ala Asp Gl #n Pro Val Glu Arg Tyr             20       #            25       #            30 Ala Glu Asn Lys Gln Leu Leu Asn Pro Asp Gl #u Arg Arg Glu Ile Leu         35           #        40           #        45 Leu Pro Ala Leu Arg Lys Phe Cys Cys Asp Se #r Asn Trp Cys His Asp     50               #    55               #    60 Cys Glu Cys Cys Tyr Gly 65                   #70 <210> SEQ ID NO 226 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(17) <223> OTHER INFORMATION: Xaa at residue 14 is  #Glu or gamma-carboxy Glu;       Xaa at residue 7 is Trp or  #bromo-Trp; Xaa at residue 17 is Tyr,       125I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O #-sulpho-Tyr or       O-phospho-Tyr <400> SEQUENCE: 226 Phe Cys Cys Asp Ser Asn Xaa Cys His Ile Se #r Asp Cys Xaa Cys Cys 1               5    #                10   #                15 Xaa <210> SEQ ID NO 227 <211> LENGTH: 456 <212> TYPE: DNA <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (1)..(456) <223> OTHER INFORMATION: n may be any nucleotid #e <400> SEQUENCE: 227 caaggaacag tcaaccccac agccacgcca agagcagaca gccacagcta cg #tgaagaag     60 ggtggagaga ggttcgtgat gttgaaaatg ggagtggtgc tattcatctt cc #tggtactg    120 tttcccctgg caacgctcca gctggatgca gatcaacctg tagaacgata tg #cggagaac    180 aaacagctcc tcagcccaga tgaaaggagg gaaatcatat tgcatgctct gg #ggacgcga    240 tgctgttctt gggatgtgtg cgaccacccg agttgtactt gctgcggtta gc #gccgaaca    300 tccatggcgc tgtgctgggc ggttttatcc caacaacgac agcgtttgtt ga #tttcatgt    360 atcattgcgc ccacgtctct tgtctaagaa tgacgaacat gattgcactc tg #gttcagat    420 ttcgtgttct tttctgacaa taaatgacaa aacncc       #                   #      456 <210> SEQ ID NO 228 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus textile <400> SEQUENCE: 228 Met Leu Lys Met Gly Val Val Leu Phe Ile Ph #e Leu Val Leu Phe Pro 1               5    #                10   #                15 Leu Ala Thr Leu Gln Leu Asp Ala Asp Gln Pr #o Val Glu Arg Tyr Ala             20       #            25       #            30 Glu Asn Lys Gln Leu Leu Ser Pro Asp Glu Ar #g Arg Glu Ile Ile Leu         35           #        40           #        45 His Ala Leu Gly Thr Arg Cys Cys Ser Trp As #p Val Cys Asp His Pro     50               #    55               #    60 Ser Cys Thr Cys Cys Gly 65                   #70 <210> SEQ ID NO 229 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Xaa at residue 10 is  #Pro or Hyp; Xaa at       residue 4 is Trp or bromo-Trp <400> SEQUENCE: 229 Cys Cys Ser Xaa Asp Val Cys Asp His Xaa Se #r Cys Thr Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 230 <211> LENGTH: 235 <212> TYPE: DNA <213> ORGANISM: Conus textile <400> SEQUENCE: 230 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttcccctt     60 actgctcttc cgctggatgg agatcaaccc gcagaccaag ctgcagagcg ta #tgcaggcc    120 gagcagcatc ccttgtttga tcagaaaaga cggtgctgca agtttccatg cc #ccgatagt    180 tgcagatatt tgtgttgcgg gtgatgataa cgtgttgatg accaactttc tc #gag         235 <210> SEQ ID NO 231 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus textile <400> SEQUENCE: 231 Gly Ser Met Met Ser Lys Leu Gly Val Leu Le #u Thr Ile Cys Leu Leu 1               5    #                10   #                15 Leu Phe Pro Leu Thr Ala Leu Pro Leu Asp Gl #y Asp Gln Pro Ala Asp             20       #            25       #            30 Gln Ala Ala Glu Arg Met Gln Ala Glu Gln Hi #s Pro Leu Phe Asp Gln         35           #        40           #        45 Lys Arg Arg Cys Cys Lys Phe Pro Cys Pro As #p Ser Cys Arg Tyr Leu     50               #    55               #    60 Cys Cys Gly 65 <210> SEQ ID NO 232 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 3 and  #8 is Pro or Hyp; Xaa at       residue 13 is Tyr, 125I-Tyr, mono #-iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 232 Arg Cys Cys Lys Phe Xaa Cys Xaa Asp Ser Cy #s Arg Xaa Leu Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 233 <211> LENGTH: 321 <212> TYPE: DNA <213> ORGANISM: Conus tulipa <400> SEQUENCE: 233 cgacctcaag agggatcgat agcagttcat gtctaaactg ggagtcttgt tg #acaatctg     60 tctgcttctg tttcccctta ctgctctgcc gatggatgga gatgaacctg ca #gaccgacc    120 tgcagagcgt atgcaggaca acatttcatc tgagcagcat cccttgtttg ag #gagagaca    180 cggatgttgc aaggggcccg aaggatgctc ctccagagaa tgcagacccc aa #cattgttg    240 cggtcgacga taacgtgttg agggccaact ttgttatcac ggctacgtca ag #tgtttagt    300 gaataagtaa aatgattgca g            #                   #                 321 <210> SEQ ID NO 234 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Conus tulipa <400> SEQUENCE: 234 Met Ser Lys Leu Gly Val Leu Leu Thr Ile Cy #s Leu Leu Leu Phe Pro 1               5    #                10   #                15 Leu Thr Ala Leu Pro Met Asp Gly Asp Glu Pr #o Ala Asp Arg Pro Ala             20       #            25       #            30 Glu Arg Met Gln Asp Asn Ile Ser Ser Glu Gl #n His Pro Leu Phe Glu         35           #        40           #        45 Glu Arg His Gly Cys Cys Lys Gly Pro Glu Gl #y Cys Ser Ser Arg Glu     50               #    55               #    60 Cys Arg Pro Gln His Cys Cys Gly Arg Arg 65                   #70 <210> SEQ ID NO 235 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Conus tulipa <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(21) <223> OTHER INFORMATION: Xaa at residue 8 and  #14 is Glu or gamma-carboxy       Glu; Xaa at residue 7 and 17  #is Pro or Hyp <400> SEQUENCE: 235 His Gly Cys Cys Lys Gly Xaa Xaa Gly Cys Se #r Ser Arg Xaa Cys Arg 1               5    #                10   #                15 Xaa Gln His Cys Cys             20 <210> SEQ ID NO 236 <211> LENGTH: 287 <212> TYPE: DNA <213> ORGANISM: Conus figulinus <400> SEQUENCE: 236 caagaaggat cgatagcagt tcatgatgtc taaactggga gtcttgctga cc #atctgtct     60 gcttctgatt ccccttactg ctctttcgct ggatggagat caacctgcag ac #cgacctgc    120 agagcgtatg caggatggaa tttcatctga acagcatccc atgtttgatc cc #gtcagacg    180 gtgttgcccg tggccatgca acataggatg cgtaccttgt tgttgatgac ca #gttttgtt    240 atcgcggcct catcaaatgt ctaatgaata agtaaaacga ttgcagt    #               287 <210> SEQ ID NO 237 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus figulinus <400> SEQUENCE: 237 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Ile 1               5    #                10   #                15 Pro Leu Thr Ala Leu Ser Leu Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Gly Ile Ser Ser Gl #u Gln His Pro Met Phe         35           #        40           #        45 Asp Pro Val Arg Arg Cys Cys Pro Trp Pro Cy #s Asn Ile Gly Cys Val     50               #    55               #    60 Pro Cys Cys 65 <210> SEQ ID NO 238 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus figulinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(14) <223> OTHER INFORMATION: Xaa at residue 3, 5  #and 12 is Pro or Hyp;       Xaa at residue 4 is Trp or  #bromo-Trp <400> SEQUENCE: 238 Cys Cys Xaa Xaa Xaa Cys Asn Ile Gly Cys Va #l Xaa Cys Cys 1               5    #                10 <210> SEQ ID NO 239 <211> LENGTH: 283 <212> TYPE: DNA <213> ORGANISM: Conus figulinus <400> SEQUENCE: 239 caagagggat cgatagcagt tcatgatgtt taaactggga gtcctgttga cc #atctgtat     60 gcttctgttt ccctttactg ctcttccgct ggatggagag caacctgcag ac #caacctgc    120 agagcgcatg cagtatgaca tgttacgtgc aatgaatccc tggtttgatc cc #gtcaaaag    180 gtgctgctcg aagaactgcg cagtatgcat cccttgttgc ccgtaactga cc #agcttgat    240 tatcgcggcc aaggctctaa tgaataagta aaacgattgc agt     #                   #283 <210> SEQ ID NO 240 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus figulinus <400> SEQUENCE: 240 Met Met Phe Lys Leu Gly Val Leu Leu Thr Il #e Cys Met Leu Leu Phe 1               5    #                10   #                15 Pro Phe Thr Ala Leu Pro Leu Asp Gly Glu Gl #n Pro Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Met Gln Tyr Asp Met Leu Arg Al #a Met Asn Pro Trp Phe         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys Ser Lys Asn Cy #s Ala Val Cys Ile Pro     50               #    55               #    60 Cys Cys Pro 65 <210> SEQ ID NO 241 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus figulinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(14) <223> OTHER INFORMATION: Xaa at residue 11 and  #14 is Pro or Hyp <400> SEQUENCE: 241 Cys Cys Ser Lys Asn Cys Ala Val Cys Ile Xa #a Cys Cys Xaa 1               5    #                10 <210> SEQ ID NO 242 <211> LENGTH: 286 <212> TYPE: DNA <213> ORGANISM: Conus figulinus <400> SEQUENCE: 242 caagagggat cgatagcagt tcatgatgtc taaactgaga gtcttgttga cc #ttatgtct     60 gcttctgttt ccccttactg ctcttccgct gaatgaagat caacctgcag ag #cgtatgca    120 ggacgacaat tcatctgagc agcacccctt gtatgaccac aaacgaaagt gt #tgccggtg    180 gccatgcccc gcaagatgcg gctcttgttg cctgtaataa cgtgttggcc aa #ctttgtta    240 tcacggccac gtcaaatgtt taatgaataa gtaaaacgat tgcagt    #                286 <210> SEQ ID NO 243 <211> LENGTH: 64 <212> TYPE: PRT <213> ORGANISM: Conus figulinus <400> SEQUENCE: 243 Met Met Ser Lys Leu Arg Val Leu Leu Thr Le #u Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Leu Asn Glu Asp Gl #n Pro Ala Glu Arg Met             20       #            25       #            30 Gln Asp Asp Asn Ser Ser Glu Gln His Pro Le #u Tyr Asp His Lys Arg         35           #        40           #        45 Lys Cys Cys Arg Trp Pro Cys Pro Ala Arg Cy #s Gly Ser Cys Cys Leu     50               #    55               #    60 <210> SEQ ID NO 244 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus figulinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Xaa at residue 5 and  #7 is Pro or Hyp; Xaa at       residue 4 is Trp or bromo-Trp <400> SEQUENCE: 244 Cys Cys Arg Xaa Xaa Cys Xaa Ala Arg Cys Gl #y Ser Cys Cys Leu 1               5    #                10   #                15 <210> SEQ ID NO 245 <211> LENGTH: 301 <212> TYPE: DNA <213> ORGANISM: Conus figulinus <400> SEQUENCE: 245 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #ttatgtct     60 gcttctgttt cccctgactg ctcttccgct ggatgaagat caagctgcag ac #cgacctgc    120 agagcgtatg cagggcatgt catctgaaca gcatcccttc tttgatcccg tc #aaacggtg    180 ttgcgagttg tcacgctgcc ttggatgcgt cccttgttgc acatcttaat aa #cgtgtgga    240 tgaccaactg tgttatcacg gccacgtcaa gtgtctaatg aataagtaaa at #gattgcag    300 t                   #                   #                   #              301 <210> SEQ ID NO 246 <211> LENGTH: 68 <212> TYPE: PRT <213> ORGANISM: Conus figulinus <400> SEQUENCE: 246 Met Met Ser Lys Leu Gly Val Leu Leu Thr Le #u Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Leu Asp Glu Asp Gl #n Ala Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Gly Met Ser Ser Glu Gl #n His Pro Phe Phe Asp         35           #        40           #        45 Pro Val Lys Arg Cys Cys Glu Leu Ser Arg Cy #s Leu Gly Cys Val Pro     50               #    55               #    60 Cys Cys Thr Ser 65 <210> SEQ ID NO 247 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus figulinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 3 and  #12 is Pro or Hyp <400> SEQUENCE: 247 Cys Cys Xaa Leu Ser Arg Cys Leu Gly Cys Va #l Xaa Cys Cys Thr Ser 1               5    #                10   #                15 <210> SEQ ID NO 248 <211> LENGTH: 301 <212> TYPE: DNA <213> ORGANISM: Conus figulinus <400> SEQUENCE: 248 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #ttatgtct     60 gcttctgttt cccctgactg ctcttccgct ggatgaagat caacctgcag ac #cgacctgc    120 agagcgtatg cagggcatgt catctgaaca gcatcccttc tttgatcccg tc #aaacggtg    180 ttgcgagttg tcaaaatgcc atggatgcgt cccttgttgc ataccttaat aa #cgtgcgga    240 tgaccaactg tgttatcacg gccacgtcaa gtgtctaatg aataagtaaa at #gattgcag    300 t                   #                   #                   #              301 <210> SEQ ID NO 249 <211> LENGTH: 68 <212> TYPE: PRT <213> ORGANISM: Conus figulinus <400> SEQUENCE: 249 Met Met Ser Lys Leu Gly Val Leu Leu Thr Le #u Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Leu Asp Glu Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Gly Met Ser Ser Glu Gl #n His Pro Phe Phe Asp         35           #        40           #        45 Pro Val Lys Arg Cys Cys Glu Leu Ser Lys Cy #s His Gly Cys Val Pro     50               #    55               #    60 Cys Cys Ile Pro 65 <210> SEQ ID NO 250 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus figulinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 3 is  #Glu or gamma-carboxy Glu;       Xaa at residue 12 and 16 is  #Pro or Hyp <400> SEQUENCE: 250 Cys Cys Xaa Leu Ser Lys Cys His Gly Cys Va #l Xaa Cys Cys Ile Xaa 1               5    #                10   #                15 <210> SEQ ID NO 251 <211> LENGTH: 298 <212> TYPE: DNA <213> ORGANISM: Conus quercinus <400> SEQUENCE: 251 caagagggat cgatagcagt tcatgatgtc taaactcgga gtcttgttga cc #atctgtct     60 ggttctgttt ccccttacag ctcttcagct ggatggagat caacctgcag ac #cgacctgc    120 agagcgtacg caggacattt catctgaaca gtatcgaaag tttgatcaga ga #cagaggtg    180 ttgccggtgg ccatgccccg gtagttgcag atgctgccgt tatcgttaac gt #gttggtga    240 ccagctttgt tatcacgacc acgccaagtg tctaacgaat aagtaaaatg at #tgcagt      298 <210> SEQ ID NO 252 <211> LENGTH: 68 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <400> SEQUENCE: 252 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Val Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Gln Leu Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Thr Gln Asp Ile Ser Ser Glu Gl #n Tyr Arg Lys Phe Asp         35           #        40           #        45 Gln Arg Gln Arg Cys Cys Arg Trp Pro Cys Pr #o Gly Ser Cys Arg Cys     50               #    55               #    60 Cys Arg Tyr Arg 65 <210> SEQ ID NO 253 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(18) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 7 and 9 is Pro or H #yp; Xaa at residue 6 is Trp or       bromo-Trp; Xaa at residue 17 is  #Tyr, 125I-Tyr, mono-iodo-Tyr,       di-iodo-Tyr, O-sulpho-Tyr or O-phospho- #Tyr <400> SEQUENCE: 253 Xaa Arg Cys Cys Arg Xaa Xaa Cys Xaa Gly Se #r Cys Arg Cys Cys Arg 1               5    #                10   #                15 Xaa Arg <210> SEQ ID NO 254 <211> LENGTH: 313 <212> TYPE: DNA <213> ORGANISM: Conus quercinus <400> SEQUENCE: 254 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt ccccttactg ctcttccact ggatggagat caacctgcag at #caatctgc    120 agagcgacct gcagagcgta cgcaggacga cattcagcag catccgttat at #gatccgaa    180 aagaaggtgt tgccgttatc catgccccga cagctgccac ggatcttgct gc #tataagtg    240 ataacatgtt gatggccagc tttgttatca cggccacgtc aagtgtctaa tg #aataagta    300 aaacgattgc agt               #                   #                   #     313 <210> SEQ ID NO 255 <211> LENGTH: 72 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <400> SEQUENCE: 255 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Gln Ser             20       #            25       #            30 Ala Glu Arg Pro Ala Glu Arg Thr Gln Asp As #p Ile Gln Gln His Pro         35           #        40           #        45 Leu Tyr Asp Pro Lys Arg Arg Cys Cys Arg Ty #r Pro Cys Pro Asp Ser     50               #    55               #    60 Cys His Gly Ser Cys Cys Tyr Lys 65                   #70 <210> SEQ ID NO 256 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(18) <223> OTHER INFORMATION: Xaa at residue 6 and  #8 is Pro or Hyp; Xaa at       residue 5 and 17 is Tyr, 125I- #Tyr, mono-iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 256 Arg Cys Cys Arg Xaa Xaa Cys Xaa Asp Ser Cy #s His Gly Ser Cys Cys 1               5    #                10   #                15 Xaa Lys <210> SEQ ID NO 257 <211> LENGTH: 256 <212> TYPE: DNA <213> ORGANISM: Conus wittigi <400> SEQUENCE: 257 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttcccatt     60 actgctcttc cggtgggtgg agatcagcct gcagaccgac ttgcagagcg ta #tgcaggac    120 gacacttcat ctgagcagca tccctttgaa aagagactac catcatgttg cg #actttgag    180 aggctttgcg tagtaccagc atgcatacgt catcagtgtt gcacaggata ac #gtgttgat    240 gaccaacttt ctcgag              #                   #                   #   256 <210> SEQ ID NO 258 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Conus wittigi <400> SEQUENCE: 258 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Ile Thr Ala Leu Pro Val Gly Gly Asp Gl #n Pro Ala Asp Arg Leu             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Thr Ser Ser Gl #u Gln His Pro Phe Glu         35           #        40           #        45 Lys Arg Leu Pro Ser Cys Cys Asp Phe Glu Ar #g Leu Cys Val Val Pro     50               #    55               #    60 Ala Cys Ile Arg His Gln Cys Cys Thr Gly 65                   #70 <210> SEQ ID NO 259 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus wittigi <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 8 is  #Glu or gamma-carboxy Glu;       Xaa at residue 2 and 14 is  #Pro or Hyp <400> SEQUENCE: 259 Leu Xaa Ser Cys Cys Asp Phe Xaa Arg Leu Cy #s Val Val Xaa Ala Cys 1               5    #                10   #                15 Ile Arg His Gln Cys Cys Thr             20 <210> SEQ ID NO 260 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(14) <223> OTHER INFORMATION: Xaa at residue 11 is  #Pro or Hyp; Xaa at       residue 14 is Trp or bromo-Trp <400> SEQUENCE: 260 Cys Cys Lys Gln Ser Cys Thr Thr Cys Met Xa #a Cys Cys Xaa 1               5    #                10 <210> SEQ ID NO 261 <211> LENGTH: 259 <212> TYPE: DNA <213> ORGANISM: Conus tulipa <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (1)..(259) <223> OTHER INFORMATION: n may be any nucleotid #e <400> SEQUENCE: 261 ggatccatga tgtctaaact gggagtcttg ttgacaatct gtctgcttct gt #ttcccctt     60 actgctctgc cgatggatgg agatgaacct gcagaccgac ctgcagagcg ta #tgcaggac    120 aacatttcat ctgagcagca tcccttgttt gaggagagac acggatgttg cg #aggggccg    180 aagggatgct cctccagaga atgcagaccc caacattgtt gcggtcgacg at #aacgtgtt    240 gatgaccaac tntctcgag              #                   #                   #259 <210> SEQ ID NO 262 <211> LENGTH: 75 <212> TYPE: PRT <213> ORGANISM: Conus tulipa <400> SEQUENCE: 262 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #u Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asn Ile Ser Ser Gl #u Gln His Pro Leu Phe         35           #        40           #        45 Glu Glu Arg His Gly Cys Cys Glu Gly Pro Ly #s Gly Cys Ser Ser Arg     50               #    55               #    60 Glu Cys Arg Pro Gln His Cys Cys Gly Arg Ar #g 65                   #70                   #75 <210> SEQ ID NO 263 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Conus tulipa <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(21) <223> OTHER INFORMATION: Xaa at residue 5 and  #14 is Glu or gamma-carboxy       Glu; Xaa at residue 7 and 17  #is Pro or Hyp <400> SEQUENCE: 263 His Gly Cys Cys Xaa Gly Xaa Lys Gly Cys Se #r Ser Arg Xaa Cys Arg 1               5    #                10   #                15 Xaa Gln His Cys Cys             20 <210> SEQ ID NO 264 <211> LENGTH: 262 <212> TYPE: DNA <213> ORGANISM: Conus aurisiacus <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (1)..(262) <223> OTHER INFORMATION: n may be any nucleotid #e <400> SEQUENCE: 264 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctacttct gt #ttcccctt     60 actgcttttc cgatggatgg agatcaacct gcagaccaac ctgcagatcg ta #tgcaggac    120 gacatttcat ctgagcagta tcccttgttt gataagagac aaaagtgttg ca #ctgggagg    180 aaggggtcat gctccggcaa agcatgcaaa aatctcaaat gttgctctgg ac #gataacgt    240 gttgatgacc aactttctcg an            #                   #                262 <210> SEQ ID NO 265 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <400> SEQUENCE: 265 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Phe Pro Met Asp Gly Asp Gl #n Pro Ala Asp Gln Pro             20       #            25       #            30 Ala Asp Arg Met Gln Asp Asp Ile Ser Ser Gl #u Gln Tyr Pro Leu Phe         35           #        40           #        45 Asp Lys Arg Gln Lys Cys Cys Thr Gly Arg Ly #s Gly Ser Cys Ser Gly     50               #    55               #    60 Lys Ala Cys Lys Asn Leu Lys Cys Cys Ser Gl #y Arg 65                   #70                   #75 <210> SEQ ID NO 266 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu <400> SEQUENCE: 266 Xaa Lys Cys Cys Thr Gly Arg Lys Gly Ser Cy #s Ser Gly Lys Ala Cys 1               5    #                10   #                15 Lys Asn Leu Lys Cys Cys Ser             20 <210> SEQ ID NO 267 <211> LENGTH: 239 <212> TYPE: DNA <213> ORGANISM: Conus betulinus <400> SEQUENCE: 267 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttcccctt     60 actgctgttc cgttggatgg agatcaacct gcagaccaac ctgcagagcg ta #tgcagaac    120 gagcagcatc cctcgtttga tcagaaaaga aggtgctgcc ggtggccatg cc #ccagtata    180 tgcggcatgg ctaggtgttg cttcgtcatg ataacgtgtt gatgaccaac tt #tctcgag     239 <210> SEQ ID NO 268 <211> LENGTH: 71 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <400> SEQUENCE: 268 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asn Glu Gln His Pro Se #r Phe Asp Gln Lys Arg         35           #        40           #        45 Arg Cys Cys Arg Trp Pro Cys Pro Ser Ile Cy #s Gly Met Ala Arg Cys     50               #    55               #    60 Cys Phe Val Met Ile Thr Cys 65                   #70 <210> SEQ ID NO 269 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 6 and  #8 is Pro or Hyp; Xaa at       residue 5 is Trp or bromo-Trp <400> SEQUENCE: 269 Arg Cys Cys Arg Xaa Xaa Cys Xaa Ser Ile Cy #s Gly Met Ala Arg Cys 1               5    #                10   #                15 Cys Phe Val Met Ile Thr Cys             20 <210> SEQ ID NO 270 <211> LENGTH: 226 <212> TYPE: DNA <213> ORGANISM: Conus betulinus <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (1)..(226) <223> OTHER INFORMATION: n may be any nucleotid #e <400> SEQUENCE: 270 ggatccatga tgtctaaact gggagtcttg ttgatcatct gtctgcttct gt #ttcccctt     60 actgctgttc cgctggatgg agatcagcct gcagagcgta cgcagatcga gc #agcatccc    120 ttgtttgacc agaaaagaag gtgttgccgg tggccatgcc ccagtagatg cg #gcatggct    180 aggtgttgct tcgtcatgat aacgtgttga tgancgacct ctcnag    #                226 <210> SEQ ID NO 271 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <400> SEQUENCE: 271 Met Met Ser Lys Leu Gly Val Leu Leu Ile Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n Pro Ala Glu Arg Thr             20       #            25       #            30 Gln Ile Glu Gln His Pro Leu Phe Asp Gln Ly #s Arg Arg Cys Cys Arg         35           #        40           #        45 Trp Pro Cys Pro Ser Arg Cys Gly Met Ala Ar #g Cys Cys Phe Val Met     50               #    55               #    60 Ile Thr Cys 65 <210> SEQ ID NO 272 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 6 and  #8 is Pro or Hyp; Xaa at       residue 5 is Trp or bromo-Trp <400> SEQUENCE: 272 Arg Cys Cys Arg Xaa Xaa Cys Xaa Ser Arg Cy #s Gly Met Ala Arg Cys 1               5    #                10   #                15 Cys Phe Val Met Ile Thr Cys             20 <210> SEQ ID NO 273 <211> LENGTH: 262 <212> TYPE: DNA <213> ORGANISM: Conus parius <400> SEQUENCE: 273 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttcccctt     60 actgctcttc cgatggatgg tgatcaacct gcagaccgac ttgtagagcg ta #tgcaggac    120 aacatttcat ctgagcagca tcccttcttt gaaaagagaa gaggaggctg tt #gcacacct    180 ccgaagaaat gcaaagaccg agcctgcaaa cctgcacgtt gctgcggccc ag #gataacgt    240 gttgatgacc aactttctcg cc            #                   #                262 <210> SEQ ID NO 274 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus parius <400> SEQUENCE: 274 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Pro Ala Asp Arg Leu             20       #            25       #            30 Val Glu Arg Met Gln Asp Asn Ile Ser Ser Gl #u Gln His Pro Phe Phe         35           #        40           #        45 Glu Lys Arg Arg Gly Gly Cys Cys Thr Pro Pr #o Lys Lys Cys Lys Asp     50               #    55               #    60 Arg Ala Cys Lys Pro Ala Arg Cys Cys Gly Pr #o Gly 65                   #70                   #75 <210> SEQ ID NO 275 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus parius <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(24) <223> OTHER INFORMATION: Xaa at residue 7, 8,  #18 and 24 is Pro or Hyp <400> SEQUENCE: 275 Arg Gly Gly Cys Cys Thr Xaa Xaa Lys Lys Cy #s Lys Asp Arg Ala Cys 1               5    #                10   #                15 Lys Xaa Ala Arg Cys Cys Gly Xaa             20 <210> SEQ ID NO 276 <211> LENGTH: 259 <212> TYPE: DNA <213> ORGANISM: Conus parius <400> SEQUENCE: 276 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttcccctt     60 actgctcttc cgatggatgg tgatcaacct gcagaccgac ttgtagagcg ta #tgcaggac    120 aacatttcat ctgagcagca tcccttcttt gaaaagagaa gaggctgttg ca #cacctccg    180 aggaaatgca aagaccgagc ctgcaaacct gcacgttgtt gcggcccagg at #aacgtgtt    240 gatgaccaac tttctcgag              #                   #                   #259 <210> SEQ ID NO 277 <211> LENGTH: 75 <212> TYPE: PRT <213> ORGANISM: Conus parius <400> SEQUENCE: 277 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Pro Ala Asp Arg Leu             20       #            25       #            30 Val Glu Arg Met Gln Asp Asn Ile Ser Ser Gl #u Gln His Pro Phe Phe         35           #        40           #        45 Glu Lys Arg Arg Gly Cys Cys Thr Pro Pro Ar #g Lys Cys Lys Asp Arg     50               #    55               #    60 Ala Cys Lys Pro Ala Arg Cys Cys Gly Pro Gl #y 65                   #70                   #75 <210> SEQ ID NO 278 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus parius <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 6, 7,  #17 and 23 is Pro or Hyp <400> SEQUENCE: 278 Arg Gly Cys Cys Thr Xaa Xaa Arg Lys Cys Ly #s Asp Arg Ala Cys Lys 1               5    #                10   #                15 Xaa Ala Arg Cys Cys Gly Xaa             20 <210> SEQ ID NO 279 <211> LENGTH: 241 <212> TYPE: DNA <213> ORGANISM: Conus coronatus <400> SEQUENCE: 279 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttccaatt     60 actgcccttc cgctggatga agatcaacct gcagaccgac ctgcagagcg ta #tgcaggac    120 attgcaactg aacagcatcc cttgtttgat cccgtcaaac ggtgctgcga tt #ggccatgc    180 atcccaggat gcaccccttg ttgcttgcct tgataacgtg ttgatgacca ac #tttctcga    240 g                   #                   #                   #              241 <210> SEQ ID NO 280 <211> LENGTH: 68 <212> TYPE: PRT <213> ORGANISM: Conus coronatus <400> SEQUENCE: 280 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Ile Thr Ala Leu Pro Leu Asp Glu Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Ile Ala Thr Glu Gl #n His Pro Leu Phe Asp         35           #        40           #        45 Pro Val Lys Arg Cys Cys Asp Trp Pro Cys Il #e Pro Gly Cys Thr Pro     50               #    55               #    60 Cys Cys Leu Pro 65 <210> SEQ ID NO 281 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus coronatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 5, 8,  #12 and 16 is Pro or Hyp;       Xaa at residue 4 is Trp or  #bromo-Trp <400> SEQUENCE: 281 Cys Cys Asp Xaa Xaa Cys Ile Xaa Gly Cys Th #r Xaa Cys Cys Leu Xaa 1               5    #                10   #                15 <210> SEQ ID NO 282 <211> LENGTH: 244 <212> TYPE: DNA <213> ORGANISM: Conus musicus <400> SEQUENCE: 282 ggatccatga tgtctaaact gggagtcctg ttgaccatct gtctgcttct gt #ttcctctt     60 tctgctcttc cgatggatga agatcaactt gcagacctac ctgcagagcg ta #tgcgggac    120 actgcaactg tagatcatcc ctcctatgat cctgacaaag cgtgctgcga gc #agagctgt    180 acaacatgct ttccgtgctg ctagccttga acacagtaac gtgttgatga cc #aactttct    240 cgag                  #                   #                   #            244 <210> SEQ ID NO 283 <211> LENGTH: 65 <212> TYPE: PRT <213> ORGANISM: Conus musicus <400> SEQUENCE: 283 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Ser Ala Leu Pro Met Asp Glu Asp Gl #n Leu Ala Asp Leu Pro             20       #            25       #            30 Ala Glu Arg Met Arg Asp Thr Ala Thr Val As #p His Pro Ser Tyr Asp         35           #        40           #        45 Pro Asp Lys Ala Cys Cys Glu Gln Ser Cys Th #r Thr Cys Phe Pro Cys     50               #    55               #    60 Cys 65 <210> SEQ ID NO 284 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus musicus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(14) <223> OTHER INFORMATION: Xaa at residue4  is  #Glu or gamma-carboxy Glu;       Xaa at residue 12 is Pro or  #Hyp <400> SEQUENCE: 284 Ala Cys Cys Xaa Gln Ser Cys Thr Thr Cys Ph #e Xaa Cys Cys 1               5    #                10 <210> SEQ ID NO 285 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(14) <223> OTHER INFORMATION: Xaa at residue 4 is  #Glu or gamma-carboxy Glu;       Xaa at residue 12 is Pro or  #Hyp <400> SEQUENCE: 285 Ala Cys Cys Xaa Gln Ser Cys Thr Thr Cys Me #t Xaa Cys Cys 1               5    #                10 <210> SEQ ID NO 286 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(14) <223> OTHER INFORMATION: Xaa at residue 3 is  #Glu or gamma-carboxy Glu;       Xaa at residue 11 is Pro or  #Hyp; Xaa at residue 14 is Trp or       bromo-Trp <400> SEQUENCE: 286 Cys Cys Xaa Gln Ser Cys Thr Thr Cys Met Xa #a Cys Cys Xaa 1               5    #                10 <210> SEQ ID NO 287 <211> LENGTH: 235 <212> TYPE: DNA <213> ORGANISM: Conus pennaceus <400> SEQUENCE: 287 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttcccctt     60 actgctcttc cgctggatgg agatcaacct gcataccaag ctgcagagcg ta #tgcaggcc    120 gagcatcatc ccttgtttga tcagaaaaga cggtgctgca agtttccatg cc #ccgatagt    180 tgcaaatatt tgtgttgcgg gtgatgataa catgttgatg accaactttc tt #gag         235 <210> SEQ ID NO 288 <211> LENGTH: 65 <212> TYPE: PRT <213> ORGANISM: Conus pennaceus <400> SEQUENCE: 288 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Leu Asp Gly Asp Gl #n Pro Ala Tyr Gln Ala             20       #            25       #            30 Ala Glu Arg Met Gln Ala Glu His His Pro Le #u Phe Asp Gln Lys Arg         35           #        40           #        45 Arg Cys Cys Lys Phe Pro Cys Pro Asp Ser Cy #s Lys Tyr Leu Cys Cys     50               #    55               #    60 Gly 65 <210> SEQ ID NO 289 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus pennaceus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 6 and  #8 is Pro or Hyp; Xaa at       residue 13 is Tyr, 125I-Tyr, mono #-iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 289 Arg Cys Cys Lys Phe Xaa Cys Xaa Asp Ser Cy #s Lys Xaa Leu Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 290 <211> LENGTH: 241 <212> TYPE: DNA <213> ORGANISM: Conus pulicarius <400> SEQUENCE: 290 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttcccctt     60 actgctcttc cgatggatgg tgatcaactt gcagaccgac ttgtagagcg ta #tgcaggac    120 aacatttcat ctgagcagca tcccttcttt gatcccgtca aacggtgttg cg #tcagctgt    180 tacatgggat gcatcccttg ttgcttctag taataacgtg ttgatgacca ac #tttctcga    240 g                   #                   #                   #              241 <210> SEQ ID NO 291 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus pulicarius <400> SEQUENCE: 291 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Leu Ala Asp Arg Leu             20       #            25       #            30 Val Glu Arg Met Gln Asp Asn Ile Ser Ser Gl #u Gln His Pro Phe Phe         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys Val Ser Cys Ty #r Met Gly Cys Ile Pro     50               #    55               #    60 Cys Cys Phe 65 <210> SEQ ID NO 292 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus pulicarius <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(14) <223> OTHER INFORMATION: Xaa at residue 11 is  #Pro or Hyp; Xaa at       residue 6 is Tyr, 125I-Tyr, mono- #iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 292 Cys Cys Val Ser Cys Xaa Met Gly Cys Ile Xa #a Cys Cys Phe 1               5    #                10 <210> SEQ ID NO 293 <211> LENGTH: 244 <212> TYPE: DNA <213> ORGANISM: Conus pulicarius <400> SEQUENCE: 293 ggatccatga tgtctaaact gggagtcttg ttgaccgtct gtctgcttct gt #gtcccctt     60 actgctcttc cactggatga agatcaactt gcagaccgac ctgcagagcg ta #tgcaggat    120 gacacttcag ctgcacagat tttcgggttt gatcccgtca aacggtgctg ca #aattgcta    180 tgctactcgg gatgcactcc ttgttgccat atttgataac gtgttgatga cc #aactttct    240 cgag                  #                   #                   #            244 <210> SEQ ID NO 294 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus pulicarius <400> SEQUENCE: 294 Met Met Ser Lys Leu Gly Val Leu Leu Thr Va #l Cys Leu Leu Leu Cys 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Leu Asp Glu Asp Gl #n Leu Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Thr Ser Ala Al #a Gln Ile Phe Gly Phe         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys Lys Leu Leu Cy #s Gly Cys Thr Pro Cys     50               #    55               #    60 Cys His Ile 65 <210> SEQ ID NO 295 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus pulicarius <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 12 is  #Pro or Hyp; Xaa at       residue 7 is Tyr, 125I-Tyr, mono- #iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 295 Cys Cys Lys Leu Leu Cys Xaa Ser Gly Cys Th #r Xaa Cys Cys His Ile 1               5    #                10   #                15 <210> SEQ ID NO 296 <211> LENGTH: 259 <212> TYPE: DNA <213> ORGANISM: Conus rattus <400> SEQUENCE: 296 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttgt gt #ttccgctt     60 actgctcttc cgatggatgg tgatcaacct gcagaccgac ttgtagagcg ta #tacaggac    120 aacatttcat ctgagcagca tcccttcttt gaaaagagaa gaggctgttg cg #cacctccg    180 aggaaatgca aagaccgagc ctgcaaacct gcacgttgct gcggcccagg at #aacgtgtt    240 gatgaccaac tttctcgag              #                   #                   #259 <210> SEQ ID NO 297 <211> LENGTH: 75 <212> TYPE: PRT <213> ORGANISM: Conus rattus <400> SEQUENCE: 297 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Val Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Pro Ala Asp Arg Leu             20       #            25       #            30 Val Glu Arg Ile Gln Asp Asn Ile Ser Ser Gl #u Gln His Pro Phe Phe         35           #        40           #        45 Glu Lys Arg Arg Gly Cys Cys Ala Pro Pro Ar #g Lys Cys Lys Asp Arg     50               #    55               #    60 Ala Cys Lys Pro Ala Arg Cys Cys Gly Pro Gl #y 65                   #70                   #75 <210> SEQ ID NO 298 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus rattus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 6, 7,  #17 and 23 is Pro or Hyp <400> SEQUENCE: 298 Arg Gly Cys Cys Ala Xaa Xaa Arg Lys Cys Ly #s Asp Arg Ala Cys Lys 1               5    #                10   #                15 Xaa Ala Arg Cys Cys Gly Xaa             20 <210> SEQ ID NO 299 <211> LENGTH: 262 <212> TYPE: DNA <213> ORGANISM: Conus stercusmuscarum <400> SEQUENCE: 299 ggatccatga tgtctaaact gggagtcttg ttgacaatct gtctgcttct gt #ttcccctt     60 attgctcttc cgctggatgg agatcaacct gcagaccgac ctgcagagcg ta #tgcaggac    120 gacatttcat ctgagaagca tcccttgttt gataagagac aacggtgttg ca #atgggcgg    180 aggggatgct ccagcagatg gtgcagagat cactcacgtt gttgcggtcg ac #gataacgt    240 gttgatgacc aactttctcg ag            #                   #                262 <210> SEQ ID NO 300 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus stercusmuscarum <400> SEQUENCE: 300 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Ile Ala Leu Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser Gl #u Lys His Pro Leu Phe         35           #        40           #        45 Asp Lys Arg Gln Arg Cys Cys Asn Gly Arg Ar #g Gly Cys Ser Ser Arg     50               #    55               #    60 Trp Cys Arg Asp His Ser Arg Cys Cys Gly Ar #g Arg 65                   #70                   #75 <210> SEQ ID NO 301 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus stercusmuscarum <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 14 is Trp or bromo-Trp <400> SEQUENCE: 301 Xaa Arg Cys Cys Asn Gly Arg Arg Gly Cys Se #r Ser Arg Xaa Cys Arg 1               5    #                10   #                15 Asp His Ser Arg Cys Cys             20 <210> SEQ ID NO 302 <211> LENGTH: 241 <212> TYPE: DNA <213> ORGANISM: Conus ebraceus <400> SEQUENCE: 302 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttcccctt     60 actgctcttc cactggatga aggtcaacct gcagacctac ctgcagagcg ta #tgcaggac    120 attgcaactg aacagcatcc cttgtttgat cctgtcaaac ggtgttgcga gc #agccatgc    180 tacatgggat gcatcccttg ttgcttctaa taataacgtg ttgatgacca ac #tttctcga    240 g                   #                   #                   #              241 <210> SEQ ID NO 303 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus ebraceus <400> SEQUENCE: 303 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Leu Asp Glu Gly Gl #n Pro Ala Asp Leu Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Ile Ala Thr Glu Gl #n His Pro Leu Phe Asp         35           #        40           #        45 Pro Val Lys Arg Cys Cys Glu Gln Pro Cys Ty #r Met Gly Cys Ile Pro     50               #    55               #    60 Cys Cys Phe 65 <210> SEQ ID NO 304 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus ebraceus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Xaa at residue 3 is  #Glu or gamma-carboxy Glu;       Xaa at residue 5 and 12 is  #Pro or Hyp; Xaa at residue 7 is Tyr,       125I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O #-sulpho-Tyr or       O-phospho-Tyr <400> SEQUENCE: 304 Cys Cys Xaa Gln Xaa Cys Xaa Met Gly Cys Il #e Xaa Cys Cys Phe 1               5    #                10   #                15 <210> SEQ ID NO 305 <211> LENGTH: 241 <212> TYPE: DNA <213> ORGANISM: Conus ebraceus <400> SEQUENCE: 305 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttcccctt     60 actgctcttc cactggatga agatcaacct gcagacctac ctgcagagcg ta #tgcaggac    120 attgcaactg aacagcatcc cttgtttgat cctgtcaaac ggtgctgcgc gc #agccatgc    180 tacatgggat gcatcccttg ttgcttctaa taataacgtg ttgatgacca ac #tttctcga    240 g                   #                   #                   #              241 <210> SEQ ID NO 306 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus ebraceus <400> SEQUENCE: 306 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Leu Asp Glu Asp Gl #n Pro Ala Asp Leu Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Ile Ala Thr Glu Gl #n His Pro Leu Phe Asp         35           #        40           #        45 Pro Val Lys Arg Cys Cys Ala Gln Pro Cys Ty #r Met Gly Cys Ile Pro     50               #    55               #    60 Cys Cys Phe 65 <210> SEQ ID NO 307 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus ebraceus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Xaa at residue 5 and  #12 is Pro or Hyp; Xaa at       residue 7 is Tyr, 125I-Tyr, mono- #iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 307 Cys Cys Ala Gln Xaa Cys Xaa Met Gly Cys Il #e Xaa Cys Cys Phe 1               5    #                10   #                15 <210> SEQ ID NO 308 <211> LENGTH: 238 <212> TYPE: DNA <213> ORGANISM: Conus flavidus <400> SEQUENCE: 308 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttcccctt     60 actgctgttc cgttggatgg agatcaacct gcagaccagc ctgcagagcg ta #tgcagaac    120 gagcagcatc ccttgtttga tcagaaaaga aggtgctgcc ggtggccatg cc #ccagtata    180 tgcggcatgg ctaggtgttg ctcgtcatga taacgtgttg atgaccaact tt #ctcgag      238 <210> SEQ ID NO 309 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus flavidus <400> SEQUENCE: 309 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asn Glu Gln His Pro Le #u Phe Asp Gln Lys Arg         35           #        40           #        45 Arg Cys Cys Arg Trp Pro Cys Pro Ser Ile Cy #s Gly Met Ala Arg Cys     50               #    55               #    60 Cys Ser Ser 65 <210> SEQ ID NO 310 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Conus flavidus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(19) <223> OTHER INFORMATION: Xaa at residue 6 and  #8 is Pro or Hyp; Xaa at       residue 5 is Trp or bromo-Trp <400> SEQUENCE: 310 Arg Cys Cys Arg Xaa Xaa Cys Xaa Ser Ile Cy #s Gly Met Ala Arg Cys 1               5    #                10   #                15 Cys Ser Ser <210> SEQ ID NO 311 <211> LENGTH: 245 <212> TYPE: DNA <213> ORGANISM: Conus miliaris <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (1)..(245) <223> OTHER INFORMATION: n may be any nucleotid #e <400> SEQUENCE: 311 ggatccatga tgtctaaact gggagtcttg ttgaccatct gtctgcttct gt #ttccaatt     60 actgcccttc cactggatga agatcaacct gcagaccgac ctgcagagcg ta #tgcaggac    120 attgcaactg aacagcatcc cttgtttgat cccgtcaaac ggtgttgcga tt #ggccatgc    180 agcgcaggat gctacccttg ttgcttccct taataacgtg ttgatgacca ac #tnangnaa    240 aaaaa                  #                   #                   #           245 <210> SEQ ID NO 312 <211> LENGTH: 68 <212> TYPE: PRT <213> ORGANISM: Conus miliaris <400> SEQUENCE: 312 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Ile Thr Ala Leu Pro Leu Asp Glu Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Ile Ala Thr Glu Gl #n His Pro Leu Phe Asp         35           #        40           #        45 Pro Val Lys Arg Cys Cys Asp Trp Pro Cys Se #r Ala Gly Cys Tyr Pro     50               #    55               #    60 Cys Cys Phe Pro 65 <210> SEQ ID NO 313 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus miliaris <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 5, 12  #and 16 is Pro or Hyp;       Xaa at residue 4 is Trp or  #bromo-Trp; Xaa at residue 11 is Tyr,       125I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O #-sulpho-Tyr or       O-phospho-Tyr <400> SEQUENCE: 313 Cys Cys Asp Xaa Xaa Cys Ser Ala Gly Cys Xa #a Xaa Cys Cys Phe Xaa 1               5    #                10   #                15 <210> SEQ ID NO 314 <211> LENGTH: 230 <212> TYPE: DNA <213> ORGANISM: Conus miliaris <220> FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION: (1)..(230) <223> OTHER INFORMATION: n may be any nucleotid #e <400> SEQUENCE: 314 ggatccatga tgtctaaact gggagtggtg ccattcgtct ttctggtcct gt #ttcccctg     60 gcaacactcc aactggatgc agatcaacct gcagaccgac ctgcgcgtaa aa #agggcatt    120 gcaactaaac ggcatccctt gtctgatcct gtcagagggt gttgccctcc aa #tgtgcaca    180 ccatgcttcc cttgctgttt tcgttaataa cgtgttgatg natgatgnan   #             230 <210> SEQ ID NO 315 <211> LENGTH: 66 <212> TYPE: PRT <213> ORGANISM: Conus miliaris <400> SEQUENCE: 315 Met Met Ser Lys Leu Gly Val Val Pro Phe Va #l Phe Leu Val Leu Phe 1               5    #                10   #                15 Pro Leu Ala Thr Leu Gln Leu Asp Ala Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Arg Lys Lys Gly Ile Ala Thr Lys Arg Hi #s Pro Leu Ser Asp Pro         35           #        40           #        45 Val Arg Gly Cys Cys Pro Pro Met Cys Thr Pr #o Cys Phe Pro Cys Cys     50               #    55               #    60 Phe Arg 65 <210> SEQ ID NO 316 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus miliaris <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 4, 9  #and 12 is Pro or Hyp;       Xaa at residue 5 is Tyr, 125I- #Tyr, mono-iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 316 Gly Cys Cys Xaa Xaa Met Cys Thr Xaa Cys Ph #e Xaa Cys Cys Phe Arg 1               5    #                10   #                15 <210> SEQ ID NO 317 <211> LENGTH: 295 <212> TYPE: DNA <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 317 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt ccccttactg ctcttccgct ggatggagat caacctgcag ac #caagctgc    120 agagcgtatg caggccgagc agcatccctt gtttgatcag aaaagacggt gt #tgcaggtt    180 tccatgcccc gatacttgca gacatttgtg ttgcgggtga tgataacgtg ct #gatgaccc    240 actttgtcat cacggctacg tcaagtgtct aatgaataag taaaatgatt gc #agt         295 <210> SEQ ID NO 318 <211> LENGTH: 65 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 318 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Gln Ala             20       #            25       #            30 Ala Glu Arg Met Gln Ala Glu Gln His Pro Le #u Phe Asp Gln Lys Arg         35           #        40           #        45 Arg Cys Cys Arg Phe Pro Cys Pro Asp Thr Cy #s Arg His Leu Cys Cys     50               #    55               #    60 Gly 65 <210> SEQ ID NO 319 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 6 and  #8 is Pro or Hyp <400> SEQUENCE: 319 Arg Cys Cys Arg Phe Xaa Cys Xaa Asp Thr Cy #s Arg His Leu Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 320 <211> LENGTH: 267 <212> TYPE: DNA <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 320 caagagggat cgatagcagt tcatgatgtt taaactggga gtcttgctga cc #atctgtct     60 acttctgttt tcccttaatg ctgttccgct ggatggagat caacctgcag ac #caacctgc    120 agagcgtctg ctggacgaca tttcatctga aaataatccc ttttatgatc cc #gccaaacg    180 gtgttgcatg acttgcttcg gttgcacacc ttgttgtgga tgaccagcct ca #tcaagtgt    240 ctaacgaata agtaaaacga ttgcagt           #                   #            267 <210> SEQ ID NO 321 <211> LENGTH: 66 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 321 Met Met Phe Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Asn Ala Val Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Leu Leu Asp Asp Ile Ser Ser Gl #u Asn Asn Pro Phe Tyr         35           #        40           #        45 Asp Pro Ala Lys Arg Cys Cys Met Thr Cys Ph #e Gly Cys Thr Pro Cys     50               #    55               #    60 Cys Gly 65 <210> SEQ ID NO 322 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(12) <223> OTHER INFORMATION: Xaa at residue 10 is  #Pro or Hyp <400> SEQUENCE: 322 Cys Cys Met Thr Cys Phe Gly Cys Thr Xaa Cy #s Cys 1               5    #                10 <210> SEQ ID NO 323 <211> LENGTH: 294 <212> TYPE: DNA <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 323 caagaaggat cgatagcagt tcatgatgtc taaactggga gccttgttga cc #atctgtct     60 acttctgttt tcccttactg ctgttccgct ggatggagat caacatgcag ac #caacctgc    120 agagcgtctg caggaccgcc ttccaactga aaatcatccc ttatatgatc cc #gtcaaacg    180 gtgttgcgat gattcggaat gcgactattc ttgctggcct tgctgtattt tt #tcataacc    240 tttgttatcg cggcctcatc ctagtgtcaa atgaataagt aaaacgattg ca #gt          294 <210> SEQ ID NO 324 <211> LENGTH: 71 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 324 Met Met Ser Lys Leu Gly Ala Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n His Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Leu Gln Asp Arg Leu Pro Thr Gl #u Asn His Pro Leu Tyr         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys Asp Asp Ser Gl #u Cys Asp Tyr Ser Cys     50               #    55               #    60 Trp Pro Cys Cys Ile Phe Ser 65                   #70 <210> SEQ ID NO 325 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(18) <223> OTHER INFORMATION: Xaa at residue 6 is  #Glu or gamma-carboxy Glu;       Xaa at residue 13 is Pro or  #Hyp; Xaa at residue 12 is Trp or       bromo-Trp; Xaa at residue 9 is  #Tyr, 125I-Tyr, mono-iodo-Tyr,       di-iodo-Tyr, O-sulpho-Tyr or O-phospho- #Tyr <400> SEQUENCE: 325 Cys Cys Asp Asp Ser Xaa Cys Asp Xaa Ser Cy #s Xaa Xaa Cys Cys Ile 1               5    #                10   #                15 Phe Ser <210> SEQ ID NO 326 <211> LENGTH: 284 <212> TYPE: DNA <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 326 caagagggat cgatagcagt tcatgatgtt taaactcgga gtcttgctga cc #atctgtct     60 acttctgttt tccctaattg ctgttccgct ggatggagat caacatgcag ac #caacctgc    120 agagcgtctg caggaccgcc ttccaactga aaatcatccc ttatatgatc cc #gtcaaacg    180 gtgttgcagg ttgttatgcc tcagttgcaa cccttgttgt ggatgaccag ct #ttgttatc    240 acggcctcat caagtgtcta atgaataagt aaaacgattg cagt    #                   #284 <210> SEQ ID NO 327 <211> LENGTH: 67 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 327 Met Met Phe Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Ile Ala Val Pro Leu Asp Gly Asp Gl #n His Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Leu Gln Asp Arg Leu Pro Thr Gl #u Asn His Pro Leu Tyr         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys Arg Leu Leu Cy #s Leu Ser Cys Asn Pro     50               #    55               #    60 Cys Cys Gly 65 <210> SEQ ID NO 328 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(13) <223> OTHER INFORMATION: Xaa at residue 11 is  #Pro or Hyp <400> SEQUENCE: 328 Cys Cys Arg Leu Leu Cys Leu Ser Cys Asn Xa #a Cys Cys 1               5    #                10 <210> SEQ ID NO 329 <211> LENGTH: 289 <212> TYPE: DNA <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 329 caagaaggat cgatagcagt tcatgatgtc taaactggga gccttgttga cc #atctgtct     60 acttctgttt tcccttactg ctgttccgct ggatggagat caacatgcag ac #caacctgc    120 agagcgtctg caggaccgca ttccaactga agatcatccc ttatttgatc cc #aacaaacg    180 gtgttgcgat gattcggaat gcggctattc atgctggcct tgctgttatg ga #taagcttt    240 gttatcgcgg cctcatccag tgtcaacgaa taagtaaaac gattgcagt   #              289 <210> SEQ ID NO 330 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 330 Met Met Ser Lys Leu Gly Ala Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n His Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Leu Gln Asp Arg Ile Pro Thr Gl #u Asp His Pro Leu Phe         35           #        40           #        45 Asp Pro Asn Lys Arg Cys Cys Asp Asp Ser Gl #u Cys Gly Tyr Ser Cys     50               #    55               #    60 Trp Pro Cys Cys Tyr Gly 65                   #70 <210> SEQ ID NO 331 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue6  is  #Glu or gamma-carboxy Glu;       Xaa at residue 13 is Pro or  #Hyp; Xaa at residue 12 is Trp or       bromo-Trp; Xaa at residue 9 and  #16 is Tyr, 125I-Tyr,       mono-iodo-Tyr, di-iodo-Tyr, O-sulpho-Tyr  #or O-phospho-Tyr <400> SEQUENCE: 331 Cys Cys Asp Asp Ser Xaa Cys Gly Xaa Ser Cy #s Xaa Xaa Cys Cys Xaa 1               5    #                10   #                15 <210> SEQ ID NO 332 <211> LENGTH: 272 <212> TYPE: DNA <213> ORGANISM: Conus spurius <400> SEQUENCE: 332 caagaaggat cgatagcagt tcatgatgtc taaactggga gtcttgctga cc #atctgtct     60 gcttctgttt ccacgtactt ctcttccgct ggatggagat caacctgcag tc #cgatctgc    120 aaagcgtatg cattcatcta tacagcgtcg tttctttgat cccgtcaaac gg #tgttgccc    180 tagatgcagc gagtgcaacc cttgttgtgg atgaccagct ttgtcatcgc gg #cctcatta    240 agtgtctaat gaataagtaa aatgattgca gt        #                   #         272 <210> SEQ ID NO 333 <211> LENGTH: 63 <212> TYPE: PRT <213> ORGANISM: Conus spurius <400> SEQUENCE: 333 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Arg Thr Ser Leu Pro Leu Asp Gly Asp Gl #n Pro Ala Val Arg Ser             20       #            25       #            30 Ala Lys Arg Met His Ser Ser Ile Gln Arg Ar #g Phe Phe Asp Pro Val         35           #        40           #        45 Lys Arg Cys Cys Pro Arg Cys Ser Glu Cys As #n Pro Cys Cys Gly     50               #    55               #    60 <210> SEQ ID NO 334 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Conus spurius <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(12) <223> OTHER INFORMATION: Xaa at residue 7 is  #Glu or gamma-carboxy Glu;       Xaa at residue 3 and 10 is  #Pro or Hyp <400> SEQUENCE: 334 Cys Cys Xaa Arg Cys Ser Xaa Cys Asn Xaa Cy #s Cys 1               5    #                10 <210> SEQ ID NO 335 <211> LENGTH: 293 <212> TYPE: DNA <213> ORGANISM: Conus omaria <400> SEQUENCE: 335 caagagggat cgatagcagt tcatgatgtc taaactggga gtctcgttga cc #atctgtct     60 acttctattt tcccttactg ctgttccgct tgatggagat caacatgcag ac #caacctgc    120 agagcgtctg cagggcgaca ttttatctga aaagcatccc ttatttaatc cc #gtcaaacg    180 gtgttgcgat gaggaagaat gcagcagtgc atgctggcct tgttgttggg gg #tgatcagc    240 tttgttatcg cggcctcatc aagtgtctaa tgaataagta aaatgattgc ag #t           293 <210> SEQ ID NO 336 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 336 Met Met Ser Lys Leu Gly Val Ser Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n His Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Leu Gln Gly Asp Ile Leu Ser Gl #u Lys His Pro Leu Phe         35           #        40           #        45 Asn Pro Val Lys Arg Cys Cys Asp Glu Glu Gl #u Cys Ser Ser Ala Cys     50               #    55               #    60 Trp Pro Cys Cys Trp Gly 65                   #70 <210> SEQ ID NO 337 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 4, 5  #and 6 is Glu or       gamma-carboxy Glu; Xaa at residue  #13 is Pro or Hyp; Xaa at       residue 12 and 16 is Trp or  #bromo-Trp <400> SEQUENCE: 337 Cys Cys Asp Xaa Xaa Xaa Cys Ser Ser Ala Cy #s Xaa Xaa Cys Cys Xaa 1               5    #                10   #                15 <210> SEQ ID NO 338 <211> LENGTH: 293 <212> TYPE: DNA <213> ORGANISM: Conus omaria <400> SEQUENCE: 338 caagaaggat cgatagcagt tcatgatgtc taaactggga gtcttgttga tc #atctgtct     60 acttctgtgt ccccttactg ctgttctgga ggatggagat caacctgcag ac #cgacctgc    120 agagcgtatg caggacgaca tttcaactga gcatcatccc ttttatgatc cc #gtcaaacg    180 gtgttgcaag tacgggtgga catgcttgct aggatgcact ccttgtgatt gt #tgaccagt    240 tttgttatcg cggcctcgtc aagtgtctaa tgaataagta aaacgattgc ag #t           293 <210> SEQ ID NO 339 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 339 Met Met Ser Lys Leu Gly Val Leu Leu Ile Il #e Cys Leu Leu Leu Cys 1               5    #                10   #                15 Pro Leu Thr Ala Val Leu Glu Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Thr Gl #u His His Pro Phe Tyr         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys Lys Tyr Gly Tr #p Thr Cys Leu Leu Gly     50               #    55               #    60 Cys Thr Pro Cys Asp Cys 65                   #70 <210> SEQ ID NO 340 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(17) <223> OTHER INFORMATION: Xaa at residue is 14  #Pro or Hyp; Xaa at       residue 6 is Trp or bromo-Trp;  #Xaa at residue 4 is Tyr,       125I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O #-sulpho-Tyr or       O-phospho-Tyr <400> SEQUENCE: 340 Cys Cys Lys Xaa Gly Xaa Thr Cys Leu Leu Gl #y Cys Thr Xaa Cys Asp 1               5    #                10   #                15 Cys <210> SEQ ID NO 341 <211> LENGTH: 290 <212> TYPE: DNA <213> ORGANISM: Conus omaria <400> SEQUENCE: 341 caagagggat cgatagcagt tcatgatgtc tatactggga gtcttgttga tc #atctgtct     60 acttctgtgt ccccttactg ctgttctgga ggatggagat caacctgcag ac #cgacctgc    120 agagcgtatg caggacggca tttcatctga acatcatccc tttttggatc cc #gtcaaacg    180 gtgttgccat ctattggcat gccgctttgg atgctcgcct tgttgttggt ga #ccagcttt    240 gttatcgcgg cctcatcaag tgtctaatga ataagtaaaa cgattgcagt   #             290 <210> SEQ ID NO 342 <211> LENGTH: 69 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 342 Met Met Ser Ile Leu Gly Val Leu Leu Ile Il #e Cys Leu Leu Leu Cys 1               5    #                10   #                15 Pro Leu Thr Ala Val Leu Glu Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Gly Ile Ser Ser Gl #u His His Pro Phe Leu         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys His Leu Leu Al #a Cys Arg Phe Gly Cys     50               #    55               #    60 Ser Pro Cys Cys Trp 65 <210> SEQ ID NO 343 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 13 is  #Pro or Hyp; Xaa at       residue 16 is Trp or bromo-Trp <400> SEQUENCE: 343 Cys Cys His Leu Leu Ala Cys Arg Phe Gly Cy #s Ser Xaa Cys Cys Xaa 1               5    #                10   #                15 <210> SEQ ID NO 344 <211> LENGTH: 293 <212> TYPE: DNA <213> ORGANISM: Conus omaria <400> SEQUENCE: 344 caagaaggat cgatagcagt tcatgatgtc taaactggga gtcttgttga tc #atctgtct     60 acttctttgt ccccttactg ctgttccgca ggatggagat caacctgcag ac #cgacctgc    120 agagcgtatg cagggcggca tttcatctga acatcatccc ttttttgatc cc #gtcaaacg    180 gtgttgcagg tacgggtgga catgctggct aggatgcact ccctgtggtt gt #tgaccagc    240 tttgttatcg cggcctcatc aagtgtctaa tgaataagta aaacgattgc ag #t           293 <210> SEQ ID NO 345 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 345 Met Met Ser Lys Leu Gly Val Leu Leu Ile Il #e Cys Leu Leu Leu Cys 1               5    #                10   #                15 Pro Leu Thr Ala Val Pro Gln Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Gly Gly Ile Ser Ser Gl #u His His Pro Phe Phe         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys Arg Tyr Gly Tr #p Thr Cys Trp Leu Gly     50               #    55               #    60 Cys Thr Pro Cys Gly Cys 65                   #70 <210> SEQ ID NO 346 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus omaria <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(17) <223> OTHER INFORMATION: Xaa at residue 14 is  #Pro or Hyp; Xaa at       residue 6 and 9 is Trp or b #romo-Trp; Xaa at residue 4 is Tyr,       125I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O #-sulpho-Tyr or       O-phospho-Tyr <400> SEQUENCE: 346 Cys Cys Arg Xaa Gly Xaa Thr Cys Xaa Leu Gl #y Cys Thr Xaa Cys Gly 1               5    #                10   #                15 Cys <210> SEQ ID NO 347 <211> LENGTH: 293 <212> TYPE: DNA <213> ORGANISM: Conus episcopatus <400> SEQUENCE: 347 caagaaggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 acttctgttt tcccttattg ctgttccgct tgatggagat caacatgcag ac #caacctgc    120 agagcgtctg cagggcgaca ttttatctga aaagcatccc ttatttatgc ct #gtcaaacg    180 gtgttgcgat gaggacgaat gcaacagttc atgctggcct tgttgttggg gg #tgatcagc    240 tttgttatcg cggcctgatc aagtgtataa tgaataagta aaacgattgc ag #t           293 <210> SEQ ID NO 348 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus episcopatus <400> SEQUENCE: 348 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Ile Ala Val Pro Leu Asp Gly Asp Gl #n His Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Leu Gln Gly Asp Ile Leu Ser Gl #u Lys His Pro Leu Phe         35           #        40           #        45 Met Pro Val Lys Arg Cys Cys Asp Glu Asp Gl #u Cys Asn Ser Ser Cys     50               #    55               #    60 Trp Pro Cys Cys Trp Gly 65                   #70 <210> SEQ ID NO 349 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus episcopatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 4 and  #6 is Glu or gamma-carboxy       Glu; Xaa at residue 13 is Pro  #or Hyp; Xaa at residue 12 and 16 is       Trp or bromo-Trp <400> SEQUENCE: 349 Cys Cys Asp Xaa Asp Xaa Cys Asn Ser Ser Cy #s Xaa Xaa Cys Cys Xaa 1               5    #                10   #                15 <210> SEQ ID NO 350 <211> LENGTH: 293 <212> TYPE: DNA <213> ORGANISM: Conus episcopatus <400> SEQUENCE: 350 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 acttctgttt tcccttattg ctgttccgct tgatggagat caacatgcag ac #caacctgc    120 agagcgtctg cagggcgaca ttttatctga aaagcatccc ttatttatgc ct #gtcaaacg    180 gtgttgcgat gaggacgaat gcagcagttc atgctggcct tgttgttggg ga #tgagcagc    240 tttgttatcg cggcctcatc aagtgtctaa tgaataagta aaacgattgc ag #t           293 <210> SEQ ID NO 351 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus episcopatus <400> SEQUENCE: 351 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Ile Ala Val Pro Leu Asp Gly Asp Gl #n His Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Leu Gln Gly Asp Ile Leu Ser Gl #u Lys His Pro Leu Phe         35           #        40           #        45 Met Pro Val Lys Arg Cys Cys Asp Glu Asp Gl #u Cys Ser Ser Ser Cys     50               #    55               #    60 Trp Pro Cys Cys Trp Gly 65                   #70 <210> SEQ ID NO 352 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus episcopatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue4 and 6  # is Glu or gamma-carboxy       Glu; Xaa at residue 13 is Pro  #or Hyp; Xaa at residue 12 and 16 is       Trp or bromo-Trp <400> SEQUENCE: 352 Cys Cys Asp Xaa Asp Xaa Cys Ser Ser Ser Cy #s Xaa Xaa Cys Cys Xaa 1               5    #                10   #                15 <210> SEQ ID NO 353 <211> LENGTH: 290 <212> TYPE: DNA <213> ORGANISM: Conus episcopatus <400> SEQUENCE: 353 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 acttctgttt tcccttactg ctgttccgct tgatggagat caacatgcag ac #caacctgc    120 agagcgtctg cagggcgaca ttttatctga aaagcatccc ttatttaatc cc #gtcaaacg    180 gtgttgcccg gcggcggcat gtgccatggg atgcaagcct tgttgtggat ga #gcagcttt    240 gttatcgtgg cctcatcaag tgtctaatga ataagtaaaa cgattgcagt   #             290 <210> SEQ ID NO 354 <211> LENGTH: 69 <212> TYPE: PRT <213> ORGANISM: Conus episcopatus <400> SEQUENCE: 354 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n His Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Leu Gln Gly Asp Ile Leu Ser Gl #u Lys His Pro Leu Phe         35           #        40           #        45 Asn Pro Val Lys Arg Cys Cys Pro Ala Ala Al #a Cys Ala Met Gly Cys     50               #    55               #    60 Lys Pro Cys Cys Gly 65 <210> SEQ ID NO 355 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus episcopatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Xaa at residue 3 and  #13 is Pro or Hyp <400> SEQUENCE: 355 Cys Cys Xaa Ala Ala Ala Cys Ala Met Gly Cy #s Lys Xaa Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 356 <211> LENGTH: 295 <212> TYPE: DNA <213> ORGANISM: Conus aulicus <400> SEQUENCE: 356 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt tccgttactg ctcttccgcc ggatggagat caacctgcag ac #cgagctgc    120 agagcgtagg caggtcgagc agcatcccgt gtttgatcat gaaagagggt gt #tgctcgcc    180 accatgccac agtatttgcg ctgctttctg ttgcgggtga tgataacgtg tt #gatgaccc    240 actttgtcat cacggctgcg tcaagtgtct aatgaataag taaaatgatt gc #agt         295 <210> SEQ ID NO 357 <211> LENGTH: 65 <212> TYPE: PRT <213> ORGANISM: Conus aulicus <400> SEQUENCE: 357 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Val Thr Ala Leu Pro Pro Asp Gly Asp Gl #n Pro Ala Asp Arg Ala             20       #            25       #            30 Ala Glu Arg Arg Gln Val Glu Gln His Pro Va #l Phe Asp His Glu Arg         35           #        40           #        45 Gly Cys Cys Ser Pro Pro Cys His Ser Ile Cy #s Ala Ala Phe Cys Cys     50               #    55               #    60 Gly 65 <210> SEQ ID NO 358 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus aulicus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 5 and  #6 is Pro or Hyp <400> SEQUENCE: 358 Gly Cys Cys Ser Xaa Xaa Cys His Ser Ile Cy #s Ala Ala Phe Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 359 <211> LENGTH: 290 <212> TYPE: DNA <213> ORGANISM: Conus aulicus <400> SEQUENCE: 359 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 acttctgttt tcccttactg ctgttccgct tgatggagat caacatgcag ac #caacctgc    120 agagcgtctg cagggcgaca ttttatctga aaagcatccc ttatttaatc cc #gtcaaacg    180 gtgttgccga ccggtggcat gtgccatggg atgcaagcct tgttgtggat ga #gcagcttt    240 gttatcgtgg cctcatcaag tgtctaatga ataagtaaaa tgattgcagt   #             290 <210> SEQ ID NO 360 <211> LENGTH: 69 <212> TYPE: PRT <213> ORGANISM: Conus aulicus <400> SEQUENCE: 360 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n His Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Leu Gln Gly Asp Ile Leu Ser Gl #u Lys His Pro Leu Phe         35           #        40           #        45 Asn Pro Val Lys Arg Cys Cys Arg Pro Val Al #a Cys Ala Met Gly Cys     50               #    55               #    60 Lys Pro Cys Cys Gly 65 <210> SEQ ID NO 361 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus aulicus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Xaa at residue 4 and  #13 is Pro or Hyp <400> SEQUENCE: 361 Cys Cys Arg Xaa Val Ala Cys Ala Met Gly Cy #s Lys Xaa Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 362 <211> LENGTH: 290 <212> TYPE: DNA <213> ORGANISM: Conus aulicus <400> SEQUENCE: 362 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga tc #atctgtct     60 acttctgtct ccccttactg ctgttccgct ggatggagat caacctgcag ac #cgacctgc    120 agagcgtatg caggacgaca tttcatctga acatcaaccc atgtttgatg cc #atcagaca    180 gtgttgcccg gcggtggcat gcgccatggg atgcgagcct tgttgtggat ga #ccagcttt    240 gttatcgcgg cctcatcaag tgtctaatga ataagtaaaa tgattgcagt   #             290 <210> SEQ ID NO 363 <211> LENGTH: 69 <212> TYPE: PRT <213> ORGANISM: Conus aulicus <400> SEQUENCE: 363 Met Met Ser Lys Leu Gly Val Leu Leu Ile Il #e Cys Leu Leu Leu Ser 1               5    #                10   #                15 Pro Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser Gl #u His Gln Pro Met Phe         35           #        40           #        45 Asp Ala Ile Arg Gln Cys Cys Pro Ala Val Al #a Cys Ala Met Gly Cys     50               #    55               #    60 Glu Pro Cys Cys Gly 65 <210> SEQ ID NO 364 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus aulicus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu; Xaa at       residue 13 is Glu or gamma-carbox #y Glu; Xaa at residue 4 and 14 is       Pro or Hyp <400> SEQUENCE: 364 Xaa Cys Cys Xaa Ala Val Ala Cys Ala Met Gl #y Cys Xaa Xaa Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 365 <211> LENGTH: 293 <212> TYPE: DNA <213> ORGANISM: Conus aureus <400> SEQUENCE: 365 caagaaggat cgatagcagt tcatgatgtc taaactggga gccttgttga cc #atctgtct     60 acttctgttt tcccttactg ctgttccgct ggatggagat caacatgcag ac #caacatgc    120 agagcgtctg catgaccgcc ttccaactga aaatcatccc ttatatgatc cc #gtcaaacg    180 gtgttgcgat gattcggaat gcgactattc ttgctggcct tgctgtattt tt #ggataacc    240 tttgttatcg cggcctcatc aagtgtcaaa tgaataagta aaacgattgc ag #t           293 <210> SEQ ID NO 366 <211> LENGTH: 71 <212> TYPE: PRT <213> ORGANISM: Conus aureus <400> SEQUENCE: 366 Met Met Ser Lys Leu Gly Ala Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n His Ala Asp Gln His             20       #            25       #            30 Ala Glu Arg Leu His Asp Arg Leu Pro Thr Gl #u Asn His Pro Leu Tyr         35           #        40           #        45 Asp Pro Val Lys Arg Cys Cys Asp Asp Ser Gl #u Cys Asp Tyr Ser Cys     50               #    55               #    60 Trp Pro Cys Cys Ile Phe Gly 65                   #70 <210> SEQ ID NO 367 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus aureus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(17) <223> OTHER INFORMATION: Xaa at residue 6 is  #Glu or gamma-carboxy Glu;       Xaa at residue 13 is Pro or  #Hyp; Xaa at residue 12 is Trp or       bromo-Trp; Xaa at residue 9 is  #Tyr, 125I-Tyr, mono-iodo-Tyr,       di-iodo-Tyr, O-sulpho-Tyr or O-phospho- #Tyr <400> SEQUENCE: 367 Cys Cys Asp Asp Ser Xaa Cys Asp Xaa Ser Cy #s Xaa Xaa Cys Cys Ile 1               5    #                10   #                15 Phe <210> SEQ ID NO 368 <211> LENGTH: 290 <212> TYPE: DNA <213> ORGANISM: Conus aureus <400> SEQUENCE: 368 caagagggat cgatagcagt tcatgatgtc taaactggga gccttgttga cc #atctgtct     60 acttctgttt tccctaactg ctgttccgct ggatggagat caacatgcag ac #caacctgc    120 agagcgtctg caggaccgca ttccaactga aaatcatccc ttatttgatc cg #aacaaacg    180 gtgttgcaat gattgggaat gcgacgattc atgctggcct tgctgttatg ga #taaccttt    240 gttatcgcgg cctcatcaag tgtcaaatga ataagtaaaa cgattgcagt   #             290 <210> SEQ ID NO 369 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus aureus <400> SEQUENCE: 369 Met Met Ser Lys Leu Gly Ala Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Ser Leu Thr Ala Val Pro Leu Asp Gly Asp Gl #n His Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Leu Gln Asp Arg Ile Pro Thr Gl #u Asn His Pro Leu Phe         35           #        40           #        45 Asp Pro Asn Lys Arg Cys Cys Asn Asp Trp Gl #u Cys Asp Asp Ser Cys     50               #    55               #    60 Trp Pro Cys Cys Tyr Gly 65                   #70 <210> SEQ ID NO 370 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus aureus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa at residue 6 is  #Glu or gamma-carboxy Glu;       Xaa at residue 13 is Pro or  #Hyp; Xaa at residue 5 and 12 is Trp or       bromo-Trp; Xaa at residue 16 is  #Tyr, 125I-Tyr, mono-iodo-Tyr,       di-iodo-Tyr, O-sulpho-Tyr or O-phospho- #Tyr <400> SEQUENCE: 370 Cys Cys Asn Asp Xaa Xaa Cys Asp Asp Ser Cy #s Xaa Xaa Cys Cys Xaa 1               5    #                10   #                15 <210> SEQ ID NO 371 <211> LENGTH: 310 <212> TYPE: DNA <213> ORGANISM: Conus consors <400> SEQUENCE: 371 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgttt     60 gcttctgttt ccccttactg ctcttccaat ggatggagat caatctgtag ac #cgacctgc    120 agagcgtatg caggacgaca tttcatctga gctgcatccc ttgttcaatc ag #aaaagaat    180 gtgttgcggc gaaggtgcgc catgccccag ctatttcaga aacagtcaga tt #tgtcattg    240 ttgttaaatg acaacgtgtc gatgaccaac ttcgttatca cgactaatga at #aagtaaaa    300 tgattgcagt                 #                   #                   #       310 <210> SEQ ID NO 372 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Conus consors <400> SEQUENCE: 372 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Ser Val Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser Gl #u Leu His Pro Leu Phe         35           #        40           #        45 Asn Gln Lys Arg Met Cys Cys Gly Glu Gly Al #a Pro Cys Pro Ser Tyr     50               #    55               #    60 Phe Arg Asn Ser Gln Ile Cys His Cys Cys 65                   #70 <210> SEQ ID NO 373 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus consors <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 5 is  #Glu or gamma-carboxy Glu;       Xaa at residue 8 and 10 is  #Pro or Hyp; Xaa at residue 12 is Tyr,       125I-Tyr, mono-iodo-Tyr, di-iodo-Tyr, O #-sulpho-Tyr or       O-phospho-Tyr <400> SEQUENCE: 373 Met Cys Cys Gly Xaa Gly Ala Xaa Cys Xaa Se #r Xaa Phe Arg Asn Ser 1               5    #                10   #                15 Gln Ile Cys His Cys Cys             20 <210> SEQ ID NO 374 <211> LENGTH: 315 <212> TYPE: DNA <213> ORGANISM: Conus consors <400> SEQUENCE: 374 taagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga cc #atctgtct     60 gcttctgttt ccccttattg ctcttccaat ggatggagat caacctgcag ac #cgacctgc    120 agagcgtatg caggacgaca tttcatctca gcagcatccc ttgtttgata ag #agaggccg    180 ctgttgcgat gtgccgaacg catgctccgg cagatggtgc agagatcacg ca #caatgttg    240 cggatgacga taacgtgttg atgaccaact ttgtgatcac ggctacatca ag #tgaataag    300 taaaacgatt gcagt               #                   #                   #   315 <210> SEQ ID NO 375 <211> LENGTH: 74 <212> TYPE: PRT <213> ORGANISM: Conus consors <400> SEQUENCE: 375 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Ile Ala Leu Pro Met Asp Gly Asp Gl #n Pro Ala Asp Arg Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser Gl #n Gln His Pro Leu Phe         35           #        40           #        45 Asp Lys Arg Gly Arg Cys Cys Asp Val Pro As #n Ala Cys Ser Gly Arg     50               #    55               #    60 Trp Cys Arg Asp His Ala Gln Cys Cys Gly 65                   #70 <210> SEQ ID NO 376 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus consors <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa at residue 7 is  #Pro or Hyp; Xaa at       residue 14 is Trp or bromo-Trp <400> SEQUENCE: 376 Gly Arg Cys Cys Asp Val Xaa Asn Ala Cys Se #r Gly Arg Xaa Cys Arg 1               5    #                10   #                15 Asp His Ala Gln Cys Cys             20 <210> SEQ ID NO 377 <211> LENGTH: 322 <212> TYPE: DNA <213> ORGANISM: Conus consors <400> SEQUENCE: 377 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgttga ct #gtctgttt     60 gcttctgttt ccccttactg ctcttccgat ggatggagat caacctgcag ac #caacctgc    120 agagcgtatg caggacgaca tttcatctga gcagcatccc ttgtttgata ag #agacaaag    180 gtgttgcact gggaagaagg ggtcatgctc cggtaaagca tgcaaaagtc tc #aaatgttg    240 ctctggacga taacgtgttg atgaccaact ttgttatcac ggctacgtca ag #tgtctagt    300 gaataagtaa aacgattgca gt            #                   #                322 <210> SEQ ID NO 378 <211> LENGTH: 76 <212> TYPE: PRT <213> ORGANISM: Conus consors <400> SEQUENCE: 378 Met Met Ser Lys Leu Gly Val Leu Leu Thr Va #l Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Ala Leu Pro Met Asp Gly Asp Gl #n Pro Ala Asp Gln Pro             20       #            25       #            30 Ala Glu Arg Met Gln Asp Asp Ile Ser Ser Gl #u Gln His Pro Leu Phe         35           #        40           #        45 Asp Lys Arg Gln Arg Cys Cys Thr Gly Lys Ly #s Gly Ser Cys Ser Gly     50               #    55               #    60 Lys Ala Cys Lys Ser Leu Lys Cys Cys Ser Gl #y Arg 65                   #70                   #75 <210> SEQ ID NO 379 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus consors <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(23) <223> OTHER INFORMATION: Xaa at residue 1 is  #Gln or pyro-Glu <400> SEQUENCE: 379 Xaa Arg Cys Cys Thr Gly Lys Lys Gly Ser Cy #s Ser Gly Lys Ala Cys 1               5    #                10   #                15 Lys Ser Leu Lys Cys Cys Ser             20 <210> SEQ ID NO 380 <211> LENGTH: 284 <212> TYPE: DNA <213> ORGANISM: Conus emaciatus <400> SEQUENCE: 380 caagagggat cgatagcagt tcatgatgtc taaactggga gtcttgctga cc #atctgtct     60 gcttctgttt ccccttactg ttcttccgat ggatggagat caacctgcag ac #ctacctgc    120 attgcgtgcg cagttctttg cacctgaaca tagtccccgg tttgaccccg tc #aaacggtg    180 ctgctcgcgg gattgcagtg tttgcatccc ttgttgcccg tatggatcac ct #tgattatt    240 gcggccacgt caagtgtcta atgaataagt aaaatgattg cagt    #                   #284 <210> SEQ ID NO 381 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Conus emaciatus <400> SEQUENCE: 381 Met Met Ser Lys Leu Gly Val Leu Leu Thr Il #e Cys Leu Leu Leu Phe 1               5    #                10   #                15 Pro Leu Thr Val Leu Pro Met Asp Gly Asp Gl #n Pro Ala Asp Leu Pro             20       #            25       #            30 Ala Leu Arg Ala Gln Phe Phe Ala Pro Glu Hi #s Ser Pro Arg Phe Asp         35           #        40           #        45 Pro Val Lys Arg Cys Cys Ser Arg Asp Cys Se #r Val Cys Ile Pro Cys     50               #    55               #    60 Cys Pro Tyr Gly Ser Pro 65                   #70 <210> SEQ ID NO 382 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus emaciatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(18) <223> OTHER INFORMATION: Xaa at residue 11, 14  #and 18 is Pro or Hyp;       Xaa at residue 15 is Tyr, 125I #-Tyr, mono-iodo-Tyr, di-iodo-Tyr,       O-sulpho-Tyr or O-phospho-Tyr <400> SEQUENCE: 382 Cys Cys Ser Arg Asp Cys Ser Val Cys Ile Xa #a Cys Cys Xaa Xaa Gly 1               5    #                10   #                15 Ser Xaa <210> SEQ ID NO 383 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <400> SEQUENCE: 383 Cys Cys Lys Val Gln Cys Glu Ser Cys Thr Pr #o Cys Cys 1               5    #                10 <210> SEQ ID NO 384 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus atlanticus <400> SEQUENCE: 384 Cys Cys Glu Leu Pro Cys Gly Pro Gly Phe Cy #s Val Pro Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 385 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus arentus <400> SEQUENCE: 385 Cys Cys Glu Arg Pro Cys Asn Ile Gly Cys Va #l Pro Cys Cys 1               5    #                10 <210> SEQ ID NO 386 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus bandus <400> SEQUENCE: 386 Cys Cys Asn Trp Pro Cys Ser Met Gly Cys Il #e Pro Cys Cys Tyr Tyr 1               5    #                10   #                15 <210> SEQ ID NO 387 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <400> SEQUENCE: 387 Cys Cys Glu Leu Pro Cys His Gly Cys Val Pr #o Cys Cys Trp Pro 1               5    #                10   #                15 <210> SEQ ID NO 388 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <400> SEQUENCE: 388 Cys Cys Gly Leu Pro Cys Asn Gly Cys Val Pr #o Cys Cys Trp Pro Ser 1               5    #                10   #                15 <210> SEQ ID NO 389 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <400> SEQUENCE: 389 Cys Cys Ser Arg Asn Cys Ala Val Cys Ile Pr #o Cys Cys Pro Asn Trp 1               5    #                10   #                15 Pro Ala <210> SEQ ID NO 390 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <400> SEQUENCE: 390 Cys Cys Lys Gln Ser Cys Thr Thr Cys Met Pr #o Cys Cys Trp 1               5    #                10 <210> SEQ ID NO 391 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(14) <223> OTHER INFORMATION: Xaa is Glu or gamma-ca #rboxy Glu <400> SEQUENCE: 391 Ala Cys Cys Xaa Gln Ser Cys Thr Thr Cys Me #t Pro Cys Cys 1               5    #                10 <210> SEQ ID NO 392 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <400> SEQUENCE: 392 Cys Cys Glu Gln Ser Cys Thr Thr Cys Met Pr #o Cys Cys Trp 1               5    #                10 <210> SEQ ID NO 393 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 393 Arg Cys Cys Arg Tyr Pro Cys Pro Asp Ser Cy #s His Gly Ser Cys Cys 1               5    #                10   #                15 Tyr Lys <210> SEQ ID NO 394 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 394 Cys Cys Pro Pro Val Ala Cys Asn Met Gly Cy #s Lys Pro Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 395 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 395 Cys Cys Asp Asp Ser Glu Cys Asp Tyr Ser Cy #s Trp Pro Cys Cys Met 1               5    #                10   #                15 Phe <210> SEQ ID NO 396 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 396 Cys Cys Arg Arg Cys Tyr Met Gly Cys Ile Pr #o Cys Cys Phe 1               5    #                10 <210> SEQ ID NO 397 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus textile <400> SEQUENCE: 397 Cys Cys Pro Pro Val Ala Cys Asn Met Gly Cy #s Lys Pro Cys Cys Gly 1               5    #                10   #                15 <210> SEQ ID NO 398 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(19) <223> OTHER INFORMATION: Xaa is Hyp <400> SEQUENCE: 398 Ser Lys Gln Cys Cys His Leu Ala Ala Cys Ar #g Phe Gly Cys Thr Xaa 1               5    #                10   #                15 Cys Cys Asn <210> SEQ ID NO 399 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus capitaneus <400> SEQUENCE: 399 Ser Cys Cys Arg Asp Cys Gly Glu Asp Cys Va #l Gly Cys Cys Arg 1               5    #                10   #                15 <210> SEQ ID NO 400 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus coronatus <400> SEQUENCE: 400 Cys Cys Asp Trp Pro Cys Ile Pro Gly Cys Th #r Pro Cys Cys Leu Pro 1               5    #                10   #                15 <210> SEQ ID NO 401 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus dalli <400> SEQUENCE: 401 Cys Cys Asp Asp Ser Glu Cys Asp Tyr Ser Cy #s Trp Pro Cys Cys Ile 1               5    #                10   #                15 Leu Ser <210> SEQ ID NO 402 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus dalli <400> SEQUENCE: 402 Glx Gln Cys Cys Pro Pro Val Ala Cys Asn Me #t Gly Cys Glu Pro Cys 1               5    #                10   #                15 Cys <210> SEQ ID NO 403 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus dalli <400> SEQUENCE: 403 Cys Cys Asn Ala Gly Phe Cys Arg Phe Gly Cy #s Thr Pro Cys Cys Trp 1               5    #                10   #                15 <210> SEQ ID NO 404 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus distans <400> SEQUENCE: 404 Glx Cys Cys Val His Pro Cys Pro Cys Thr Pr #o Cys Cys Arg 1               5    #                10 <210> SEQ ID NO 405 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus figulinus <400> SEQUENCE: 405 Cys Cys Pro Trp Pro Cys Asn Ile Gly Cys Va #l Pro Cys Cys 1               5    #                10 <210> SEQ ID NO 406 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus figulinus <400> SEQUENCE: 406 Cys Cys Ser Lys Asn Cys Ala Val Cys Ile Pr #o Cys Cys Pro 1               5    #                10 <210> SEQ ID NO 407 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus figulinus <400> SEQUENCE: 407 Cys Cys Arg Trp Pro Cys Pro Ala Arg Cys Gl #y Ser Cys Cys Leu 1               5    #                10   #                15 <210> SEQ ID NO 408 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus figulinus <400> SEQUENCE: 408 Cys Cys Glu Leu Ser Arg Cys Leu Gly Cys Va #l Pro Cys Cys Thr Ser 1               5    #                10   #                15 <210> SEQ ID NO 409 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus figulinus <400> SEQUENCE: 409 Cys Cys Glu Leu Ser Lys Cys His Gly Cys Va #l Pro Cys Cys Ile Pro 1               5    #                10   #                15 <210> SEQ ID NO 410 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus generalis <400> SEQUENCE: 410 Glx Cys Cys Thr Phe Cys Asn Phe Gly Cys Gl #n Pro Cys Cys Val Pro 1               5    #                10   #                15 <210> SEQ ID NO 411 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus generalis <400> SEQUENCE: 411 Glx Cys Cys Thr Phe Cys Asn Phe Gly Cys Gl #n Pro Cys Cys Leu Thr 1               5    #                10   #                15 <210> SEQ ID NO 412 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus generalis <400> SEQUENCE: 412 Glx Cys Cys Thr Phe Cys Asn Phe Gly Cys Gl #n Pro Cys Cys Val Pro 1               5    #                10   #                15 <210> SEQ ID NO 413 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <400> SEQUENCE: 413 Cys Cys Asp Asp Ser Glu Cys Asp Tyr Ser Cy #s Trp Pro Cys Cys Met 1               5    #                10   #                15 Phe <210> SEQ ID NO 414 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <400> SEQUENCE: 414 Gly Cys Cys His Leu Leu Ala Cys Arg Phe Gl #y Cys Ser Pro Cys Cys 1               5    #                10   #                15 Trp <210> SEQ ID NO 415 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus gloriamaris <400> SEQUENCE: 415 Cys Cys Ser Trp Asp Val Cys Asp His Pro Se #r Cys Thr Cys Cys Gly 1               5    #                10   #                15 <210> SEQ ID NO 416 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Conus laterculatus <400> SEQUENCE: 416 Cys Cys Asp Trp Pro Cys Ser Gly Cys Ile Pr #o Cys Cys 1               5    #                10 <210> SEQ ID NO 417 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Conus leopardus <400> SEQUENCE: 417 Glx Ile Asn Cys Cys Pro Trp Pro Cys Pro Se #r Thr Cys Arg His Gln 1               5    #                10   #                15 Cys Cys His <210> SEQ ID NO 418 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Conus lividus <400> SEQUENCE: 418 Glx Ile Asn Cys Cys Pro Trp Pro Cys Pro As #p Ser Cys His Tyr Gln 1               5    #                10   #                15 Cys Cys His <210> SEQ ID NO 419 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 419 Cys Cys Arg Leu Ser Cys Gly Leu Gly Cys Hi #s Pro Cys Cys 1               5    #                10 <210> SEQ ID NO 420 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 420 Glu Cys Cys Gly Ser Phe Ala Cys Arg Phe Gl #y Cys Val Pro Cys Cys 1               5    #                10   #                15 Val <210> SEQ ID NO 421 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 421 Ser Lys Gln Cys Cys His Leu Pro Ala Cys Ar #g Phe Gly Cys Thr Pro 1               5    #                10   #                15 Cys Cys Trp <210> SEQ ID NO 422 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 422 Met Gly Cys Cys Pro Phe Pro Cys Lys Thr Se #r Cys Thr Thr Leu Cys 1               5    #                10   #                15 Cys <210> SEQ ID NO 423 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus musicus <400> SEQUENCE: 423 Ala Cys Cys Glu Gln Ser Cys Thr Thr Cys Ph #e Pro Cys Cys 1               5    #                10 <210> SEQ ID NO 424 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus nobilis <400> SEQUENCE: 424 Cys Cys Glu Leu Pro Cys Gly Pro Gly Phe Cy #s Val Pro Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 425 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus pulicarius <400> SEQUENCE: 425 Cys Cys Asn Ser Cys Tyr Met Gly Cys Ile Pr #o Cys Cys Phe 1               5    #                10 <210> SEQ ID NO 426 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <400> SEQUENCE: 426 Glx Arg Cys Cys Gln Trp Pro Cys Pro Gly Se #r Cys Arg Cys Cys Arg 1               5    #                10   #                15 Thr <210> SEQ ID NO 427 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <400> SEQUENCE: 427 Glx Arg Cys Cys Arg Trp Pro Cys Pro Gly Se #r Cys Arg Cys Cys Arg 1               5    #                10   #                15 Tyr Arg <210> SEQ ID NO 428 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <400> SEQUENCE: 428 Arg Cys Cys Arg Tyr Pro Cys Pro Asp Ser Cy #s His Gly Ser Cys Cys 1               5    #                10   #                15 Tyr Lys <210> SEQ ID NO 429 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Xaa is Hyp <400> SEQUENCE: 429 Cys Cys Ser Gln Asp Cys Leu Val Cys Ile Xa #a Cys Cys Pro Asn 1               5    #                10   #                15 <210> SEQ ID NO 430 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus quercinus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(15) <223> OTHER INFORMATION: Xaa is Hyp <400> SEQUENCE: 430 Cys Cys Ser Arg His Cys Trp Val Cys Ile Xa #a Cys Cys Pro Asn 1               5    #                10   #                15 <210> SEQ ID NO 431 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus rattus <400> SEQUENCE: 431 Glx Thr Cys Cys Ser Asn Cys Gly Glu Asp Cy #s Asp Gly Cys Cys Gln 1               5    #                10   #                15 <210> SEQ ID NO 432 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Conus striatus <400> SEQUENCE: 432 Glx Asn Cys Cys Asn Gly Gly Cys Ser Ser Ly #s Trp Cys Arg Asp His 1               5    #                10   #                15 Ala Arg Cys Cys             20 <210> SEQ ID NO 433 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Conus textile <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(12) <223> OTHER INFORMATION: Xaa is Hyp <400> SEQUENCE: 433 Cys Cys Arg Thr Cys Phe Gly Cys Thr Xaa Cy #s Cys 1               5    #                10 <210> SEQ ID NO 434 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus tessulatus <400> SEQUENCE: 434 Cys Cys His Lys Cys Tyr Met Gly Cys Ile Pr #o Cys Cys Ile 1               5    #                10 <210> SEQ ID NO 435 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus tessulatus <400> SEQUENCE: 435 Lys Cys Cys Arg Pro Pro Cys Ala Met Ser Cy #s Gly Met Ala Arg Cys 1               5    #                10   #                15 Cys Tyr <210> SEQ ID NO 436 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <400> SEQUENCE: 436 Arg Cys Cys Arg Trp Pro Cys Pro Ser Ile Cy #s Gly Met Ala Arg Cys 1               5    #                10   #                15 Cys Phe Val Met Ile Thr Cys             20 <210> SEQ ID NO 437 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus betulinus <400> SEQUENCE: 437 Arg Cys Cys Arg Trp Pro Cys Pro Ser Arg Cy #s Gly Met Ala Arg Cys 1               5    #                10   #                15 Cys Phe Val Met Ile Thr Cys             20 <210> SEQ ID NO 438 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus textile <400> SEQUENCE: 438 Phe Cys Cys Asp Ser Asn Trp Cys His Asp Cy #s Glu Cys Cys Tyr 1               5    #                10   #                15 <210> SEQ ID NO 439 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 439 Cys Cys His Trp Asn Trp Cys Asp His Leu Cy #s Ser Cys Cys Gly Ser 1               5    #                10   #                15 <210> SEQ ID NO 440 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa is Hyp <400> SEQUENCE: 440 Asp Cys Cys Xaa Leu Pro Ala Cys Pro Phe Gl #y Cys Asn Xaa Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 441 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa is Hyp <400> SEQUENCE: 441 Cys Cys Ala Pro Ser Ala Cys Arg Leu Gly Cy #s Arg Xaa Cys Cys Arg 1               5    #                10   #                15 <210> SEQ ID NO 442 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(16) <223> OTHER INFORMATION: Xaa is Hyp <400> SEQUENCE: 442 Cys Cys Ala Xaa Ser Ala Cys Arg Leu Gly Cy #s Arg Xaa Cys Cys Arg 1               5    #                10   #                15 <210> SEQ ID NO 443 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 443 Cys Cys Ala Pro Ser Ala Cys Arg Leu Gly Cy #s Arg Pro Cys Cys Arg 1               5    #                10   #                15 <210> SEQ ID NO 444 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(17) <223> OTHER INFORMATION: Xaa is Hyp <400> SEQUENCE: 444 Gly Cys Cys Gly Ser Phe Ala Cys Arg Phe Gl #y Cys Val Xaa Cys Cys 1               5    #                10   #                15 Val <210> SEQ ID NO 445 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus textile <400> SEQUENCE: 445 Cys Cys Ser Trp Asp Val Cys Asp His Pro Se #r Cys Thr Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 446 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus textile <400> SEQUENCE: 446 Arg Cys Cys Lys Phe Pro Cys Pro Asp Ser Cy #s Arg Tyr Leu Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 447 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus aureus <400> SEQUENCE: 447 Cys Cys Asp Asp Ser Glu Cys Asp Tyr Ser Cy #s Trp Pro Cys Cys Ile 1               5    #                10   #                15 Phe <210> SEQ ID NO 448 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus aureus <400> SEQUENCE: 448 Cys Cys Asn Asp Trp Glu Cys Asp Asp Ser Cy #s Trp Pro Cys Cys Tyr 1               5    #                10   #                15 <210> SEQ ID NO 449 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 449 Arg Cys Cys Arg Phe Pro Cys Pro Asp Thr Cy #s Arg His Leu Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 450 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 450 Cys Cys Met Thr Cys Phe Gly Cys Thr Pro Cy #s Cys 1               5    #                10 <210> SEQ ID NO 451 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 451 Cys Cys Asp Asp Ser Glu Cys Asp Tyr Ser Cy #s Trp Pro Cys Cys Ile 1               5    #                10   #                15 Phe Ser <210> SEQ ID NO 452 <211> LENGTH: 13 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 452 Cys Cys Arg Leu Leu Cys Leu Ser Cys Asn Pr #o Cys Cys 1               5    #                10 <210> SEQ ID NO 453 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus ammiralis <400> SEQUENCE: 453 Cys Cys Asp Asp Ser Glu Cys Gly Tyr Ser Cy #s Trp Pro Cys Cys Tyr 1               5    #                10   #                15 <210> SEQ ID NO 454 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus aulicus <400> SEQUENCE: 454 Gly Cys Cys Ser Pro Pro Cys His Ser Ile Cy #s Ala Ala Phe Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 455 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus aulicus <400> SEQUENCE: 455 Cys Cys Arg Pro Val Ala Cys Ala Met Gly Cy #s Lys Pro Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 456 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus aulicus <400> SEQUENCE: 456 Glx Cys Cys Pro Ala Val Ala Cys Ala Met Gl #y Cys Glu Pro Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 457 <211> LENGTH: 18 <212> TYPE: PRT <213> ORGANISM: Conus emaciatus <400> SEQUENCE: 457 Cys Cys Ser Arg Asp Cys Ser Val Cys Ile Pr #o Cys Cys Pro Tyr Gly 1               5    #                10   #                15 Ser Pro <210> SEQ ID NO 458 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus episcopatus <400> SEQUENCE: 458 Cys Cys Asp Glu Asp Glu Cys Asn Ser Ser Cy #s Trp Pro Cys Cys Trp 1               5    #                10   #                15 <210> SEQ ID NO 459 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus episcopatus <400> SEQUENCE: 459 Cys Cys Asp Glu Asp Glu Cys Ser Ser Ser Cy #s Trp Pro Cys Cys Trp 1               5    #                10   #                15 <210> SEQ ID NO 460 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus episcopatus <400> SEQUENCE: 460 Cys Cys Pro Ala Ala Ala Cys Ala Met Gly Cy #s Lys Pro Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 461 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 461 Cys Cys Asp Glu Glu Glu Cys Ser Ser Ala Cy #s Trp Pro Cys Cys Trp 1               5    #                10   #                15 <210> SEQ ID NO 462 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 462 Cys Cys His Leu Leu Ala Cys Arg Phe Gly Cy #s Ser Pro Cys Cys Trp 1               5    #                10   #                15 <210> SEQ ID NO 463 <211> LENGTH: 12 <212> TYPE: PRT <213> ORGANISM: Conus spurius <400> SEQUENCE: 463 Cys Cys Pro Arg Cys Ser Glu Cys Asn Pro Cy #s Cys 1               5    #                10 <210> SEQ ID NO 464 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus pennaceus <400> SEQUENCE: 464 Arg Cys Cys Lys Phe Pro Cys Pro Asp Ser Cy #s Lys Tyr Leu Cys Cys 1               5    #                10   #                15 <210> SEQ ID NO 465 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Conus flavidus <400> SEQUENCE: 465 Arg Cys Cys Arg Trp Pro Cys Pro Ser Ile Cy #s Gly Met Ala Arg Cys 1               5    #                10   #                15 Cys Ser Ser <210> SEQ ID NO 466 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus pulicarius <400> SEQUENCE: 466 Cys Cys Lys Leu Leu Cys Gly Cys Thr Pro Cy #s Cys His Ile 1               5    #                10 <210> SEQ ID NO 467 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus ebraceus <400> SEQUENCE: 467 Cys Cys Glu Gln Pro Cys Tyr Met Gly Cys Il #e Pro Cys Cys Phe 1               5    #                10   #                15 <210> SEQ ID NO 468 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Conus ebraceus <400> SEQUENCE: 468 Cys Cys Ala Gln Pro Cys Tyr Met Gly Cys Il #e Pro Cys Cys Phe 1               5    #                10   #                15 <210> SEQ ID NO 469 <211> LENGTH: 14 <212> TYPE: PRT <213> ORGANISM: Conus pulicarius <400> SEQUENCE: 469 Cys Cys Val Ser Cys Tyr Met Gly Cys Ile Pr #o Cys Cys Phe 1               5    #                10 <210> SEQ ID NO 470 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus miliaris <400> SEQUENCE: 470 Cys Cys Asp Trp Pro Cys Ser Ala Gly Cys Ty #r Pro Cys Cys Phe Pro 1               5    #                10   #                15 <210> SEQ ID NO 471 <211> LENGTH: 16 <212> TYPE: PRT <213> ORGANISM: Conus miliaris <400> SEQUENCE: 471 Gly Cys Cys Pro Pro Met Cys Thr Pro Cys Ph #e Pro Cys Cys Phe Arg 1               5    #                10   #                15 <210> SEQ ID NO 472 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus rattus <400> SEQUENCE: 472 Arg Gly Cys Cys Ala Pro Pro Arg Lys Cys Ly #s Asp Arg Ala Cys Lys 1               5    #                10   #                15 Pro Ala Arg Cys Cys Gly Pro             20 <210> SEQ ID NO 473 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus stercusmuscarum <400> SEQUENCE: 473 Glx Arg Cys Cys Asn Gly Arg Arg Gly Cys Se #r Ser Arg Trp Cys Arg 1               5    #                10   #                15 Asp His Ser Arg Cys Cys             20 <210> SEQ ID NO 474 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus consors <400> SEQUENCE: 474 Gly Arg Cys Cys Asp Val Pro Asn Ala Cys Se #r Gly Arg Trp Cys Arg 1               5    #                10   #                15 Asp His Ala Gln Cys Cys             20 <210> SEQ ID NO 475 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus consors <400> SEQUENCE: 475 Glx Arg Cys Cys Thr Gly Lys Lys Gly Ser Cy #s Ser Gly Lys Ala Cys 1               5    #                10   #                15 Lys Ser Leu Lys Cys Cys Ser             20 <210> SEQ ID NO 476 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <400> SEQUENCE: 476 Met Cys Cys Gly Glu Gly Arg Lys Cys Pro Se #r Tyr Phe Arg Asn Ser 1               5    #                10   #                15 Gln Ile Cys His Cys Cys             20 <210> SEQ ID NO 477 <211> LENGTH: 19 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <400> SEQUENCE: 477 Cys Cys Arg Trp Pro Cys Pro Arg Gln Ile As #p Gly Glu Tyr Cys Gly 1               5    #                10   #                15 Cys Cys Leu <210> SEQ ID NO 478 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <400> SEQUENCE: 478 Arg Cys Cys Gly Glu Gly Leu Thr Cys Pro Ar #g Tyr Trp Lys Asn Ser 1               5    #                10   #                15 Gln Ile Cys Ala Cys Cys             20 <210> SEQ ID NO 479 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 479 Cys Cys Gly Pro Gly Gly Ser Cys Pro Val Ty #r Phe Arg Asp Asn Phe 1               5    #                10   #                15 Ile Cys Gly Cys Cys             20 <210> SEQ ID NO 480 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus circumcisus <400> SEQUENCE: 480 Arg Lys Cys Cys Gly Lys Asp Gly Pro Cys Pr #o Lys Tyr Phe Lys Asp 1               5    #                10   #                15 Asn Phe Ile Cys Gly Cys Cys             20 <210> SEQ ID NO 481 <211> LENGTH: 20 <212> TYPE: PRT <213> ORGANISM: Conus ermineus <400> SEQUENCE: 481 Cys Cys Ser Trp Pro Cys Pro Arg Tyr Ser As #n Gly Lys Leu Val Cys 1               5    #                10   #                15 Phe Cys Cys Leu             20 <210> SEQ ID NO 482 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 482 Cys Cys Gly Pro Gly Gly Ser Cys Pro Val Ty #r Phe Arg Asp Asn Phe 1               5    #                10   #                15 Ile Cys Gly Cys Cys             20 <210> SEQ ID NO 483 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 483 Met Cys Cys Gly Glu Ser Ala Pro Cys Pro Se #r Tyr Phe Arg Asn Ser 1               5    #                10   #                15 Gln Ile Cys His Cys Cys             20 <210> SEQ ID NO 484 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 484 Glx Lys Cys Cys Gly Pro Gly Gly Ser Cys Pr #o Val Tyr Phe Thr Asp 1               5    #                10   #                15 Asn Phe Ile Cys Gly Cys             20 <210> SEQ ID NO 485 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 485 Glx Lys Cys Cys Gly Pro Gly Gly Ser Cys Pr #o Val Tyr Phe Arg Asp 1               5    #                10   #                15 Asn Phe Ile Cys Gly Cys Cys             20 <210> SEQ ID NO 486 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus striatus <400> SEQUENCE: 486 Glx Lys Cys Cys Gly Glu Gly Ser Ser Cys Pr #o Lys Tyr Phe Lys Asn 1               5    #                10   #                15 Asn Phe Ile Cys Gly Cys Cys             20 <210> SEQ ID NO 487 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 487 Glx Lys Cys Cys Ser Gly Gly Ser Cys Pro Le #u Tyr Phe Arg Asp Arg 1               5    #                10   #                15 Leu Ile Cys Pro Cys Cys             20 <210> SEQ ID NO 488 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus stercusmuscarum <400> SEQUENCE: 488 Glx Lys Cys Cys Gly Pro Gly Ala Ser Cys Pr #o Arg Tyr Phe Lys Asp 1               5    #                10   #                15 Asn Phe Ile Cys Gly Cys Cys             20 <210> SEQ ID NO 489 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus consors <400> SEQUENCE: 489 Met Cys Cys Gly Glu Gly Ala Pro Cys Pro Se #r Tyr Phe Arg Asn Ser 1               5    #                10   #                15 Gln Ile Cys His Cys Cys             20 <210> SEQ ID NO 490 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <400> SEQUENCE: 490 Glx Lys Cys Cys Thr Gly Lys Lys Gly Ser Cy #s Ser Gly Lys Ala Cys 1               5    #                10   #                15 Lys Asn Leu Lys Cys Cys Ser             20 <210> SEQ ID NO 491 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus aurisiacus <400> SEQUENCE: 491 Glx Lys Cys Cys Thr Gly Arg Lys Gly Ser Cy #s Ser Gly Lys Ala Cys 1               5    #                10   #                15 Lys Asn Leu Lys Cys Cys Ser             20 <210> SEQ ID NO 492 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <400> SEQUENCE: 492 Val Thr Asp Arg Cys Cys Lys Gly Lys Arg Gl #u Cys Gly Arg Trp Cys 1               5    #                10   #                15 Arg Asp His Ser Arg Cys Cys             20 <210> SEQ ID NO 493 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <400> SEQUENCE: 493 Val Gly Asp Arg Cys Cys Lys Gly Lys Arg Gl #y Cys Gly Arg Trp Cys 1               5    #                10   #                15 Arg Asp His Ser Arg Cys Cys             20 <210> SEQ ID NO 494 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <400> SEQUENCE: 494 Val Gly Glu Arg Cys Cys Lys Asn Gly Lys Ar #g Gly Cys Gly Arg Trp 1               5    #                10   #                15 Cys Arg Asp His Ser Arg Cys Cys             20 <210> SEQ ID NO 495 <211> LENGTH: 26 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <400> SEQUENCE: 495 Ile Val Asp Arg Cys Cys Asn Lys Gly Asn Gl #y Lys Arg Gly Cys Ser 1               5    #                10   #                15 Arg Trp Cys Arg Asp His Ser Arg Cys Cys             20       #            25 <210> SEQ ID NO 496 <211> LENGTH: 25 <212> TYPE: PRT <213> ORGANISM: Conus bullatus <400> SEQUENCE: 496 Val Gly Cys Cys Arg Pro Lys Pro Asn Gly Gl #n Met Met Cys Asp Arg 1               5    #                10   #                15 Trp Cys Glu Lys Asn Ser Arg Cys Cys             20       #            25 <210> SEQ ID NO 497 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus caracteristicus <400> SEQUENCE: 497 Arg Asp Cys Cys Thr Pro Pro Lys Lys Cys Ly #s Asp Arg Gln Cys Lys 1               5    #                10   #                15 Pro Gln Arg Cys Cys Ala             20 <210> SEQ ID NO 498 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus lynceus <400> SEQUENCE: 498 Gly Arg Asp Cys Cys Thr Pro Pro Arg Lys Cy #s Arg Asp Arg Ala Cys 1               5    #                10   #                15 Lys Pro Gln Arg Cys Cys Gly             20 <210> SEQ ID NO 499 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus lynceus <400> SEQUENCE: 499 Glx Arg Leu Cys Cys Gly Phe Pro Lys Ser Cy #s Arg Ser Arg Gln Cys 1               5    #                10   #                15 Lys Pro His Arg Cys Cys             20 <210> SEQ ID NO 500 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus laterculatus <400> SEQUENCE: 500 Arg Asp Cys Cys Thr Pro Pro Lys Lys Cys Ar #g Asp Arg Gln Cys Lys 1               5    #                10   #                15 Pro Ala Arg Cys Cys Gly             20 <210> SEQ ID NO 501 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus laterculatus <400> SEQUENCE: 501 Arg Pro Pro Cys Cys Thr Tyr Asp Gly Ser Cy #s Leu Lys Glu Ser Cys 1               5    #                10   #                15 Met Arg Lys Ala Cys Cys             20 <210> SEQ ID NO 502 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus laterculatus <400> SEQUENCE: 502 Arg Pro Pro Cys Cys Thr Tyr Asp Gly Ser Cy #s Leu Lys Glu Ser Cys 1               5    #                10   #                15 Lys Arg Lys Ala Cys Cys             20 <210> SEQ ID NO 503 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus geographus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa is Hyp <400> SEQUENCE: 503 Arg Asp Cys Cys Thr Xaa Xaa Lys Lys Cys Ly #s Asp Arg Gln Cys Lys 1               5    #                10   #                15 Xaa Gln Arg Cys Cys Ala             20 <210> SEQ ID NO 504 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus geographus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa is Hyp <400> SEQUENCE: 504 Arg Asp Cys Cys Thr Xaa Xaa Arg Lys Cys Ly #s Asp Arg Arg Cys Lys 1               5    #                10   #                15 Xaa Met Lys Cys Cys Ala             20 <210> SEQ ID NO 505 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus geographus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa is Hyp <400> SEQUENCE: 505 Arg Asp Cys Cys Thr Xaa Xaa Lys Lys Cys Ly #s Asp Arg Arg Cys Lys 1               5    #                10   #                15 Xaa Leu Lys Cys Cys Ala                    #20 <210> SEQ ID NO 506 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus purpurascens <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(22) <223> OTHER INFORMATION: Xaa is Hyp <400> SEQUENCE: 506 Glx Arg Leu Cys Cys Gly Phe Xaa Lys Ser Cy #s Arg Ser Arg Gln Cys 1               5    #                10   #                15 Lys Xaa His Arg Cys Cys             20 <210> SEQ ID NO 507 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Conus magus <400> SEQUENCE: 507 Arg Asp Cys Cys Thr Pro Pro Lys Lys Cys Ly #s Asp Arg Gln Cys Lys 1               5    #                10   #                15 Pro Gln Arg Cys Cys Ala             20 <210> SEQ ID NO 508 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus marmoreus <400> SEQUENCE: 508 Arg Gly Gly Cys Cys Thr Pro Pro Arg Lys Cy #s Lys Asp Arg Ala Cys 1               5    #                10   #                15 Lys Pro Ala Arg Cys Cys Gly Pro             20 <210> SEQ ID NO 509 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus nobilis <400> SEQUENCE: 509 Glx Lys Cys Cys Thr Gly Lys Lys Gly Ser Cy #s Ser Gly Lys Ala Cys 1               5    #                10   #                15 Lys Asn Leu Lys Cys Cys Ser             20 <210> SEQ ID NO 510 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus parius <400> SEQUENCE: 510 Arg Gly Gly Cys Cys Thr Pro Pro Lys Lys Cy #s Lys Asp Arg Ala Cys 1               5    #                10   #                15 Lys Pro Ala Arg Cys Cys Gly Pro             20 <210> SEQ ID NO 511 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus parius <400> SEQUENCE: 511 Arg Gly Cys Cys Thr Pro Pro Arg Lys Cys Ly #s Asp Arg Ala Cys Lys 1               5    #                10   #                15 Pro Ala Arg Cys Cys Gly Pro             20 <210> SEQ ID NO 512 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(24) <223> OTHER INFORMATION: Xaa is Hyp <400> SEQUENCE: 512 Leu Xaa Ser Cys Cys Ser Leu Asn Leu Arg Le #u Cys Xaa Val Xaa Ala 1               5    #                10   #                15 Cys Lys Arg Asn Xaa Cys Cys Thr             20 <210> SEQ ID NO 513 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(24) <223> OTHER INFORMATION: Xaa is Hyp <400> SEQUENCE: 513 Glx Gln Arg Cys Cys Thr Val Lys Arg Ile Cy #s Xaa Val Xaa Ala Cys 1               5    #                10   #                15 Arg Ser Lys Xaa Cys Cys Lys Ser             20 <210> SEQ ID NO 514 <211> LENGTH: 24 <212> TYPE: PRT <213> ORGANISM: Conus radiatus <400> SEQUENCE: 514 Arg Gly Gly Cys Cys Thr Pro Pro Arg Lys Cy #s Lys Asp Arg Ala Cys 1               5    #                10   #                15 Lys Pro Ala Arg Cys Cys Gly Pro             20 <210> SEQ ID NO 515 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus stercusmuscarum <400> SEQUENCE: 515 Glx Lys Cys Cys Thr Gly Lys Lys Gly Ser Cy #s Ser Gly Lys Ala Cys 1               5    #                10   #                15 Lys Asn Leu Lys Cys Cys Ser             20 <210> SEQ ID NO 516 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Conus tulipa <220> FEATURE: <221> NAME/KEY: PEPTIDE <222> LOCATION: (1)..(21) <223> OTHER INFORMATION: Xaa is Hyp <400> SEQUENCE: 516 His Gly Cys Cys Lys Gly Xaa Glu Gly Cys Se #r Ser Arg Glu Cys Arg 1               5    #                10   #                15 Xaa Gln His Cys Cys             20 <210> SEQ ID NO 517 <211> LENGTH: 21 <212> TYPE: PRT <213> ORGANISM: Conus tulipa <400> SEQUENCE: 517 His Gly Cys Cys Glu Gly Pro Lys Gly Cys Se #r Ser Arg Glu Cys Arg 1               5    #                10   #                15 Pro Gln His Cys Cys             20 <210> SEQ ID NO 518 <211> LENGTH: 23 <212> TYPE: PRT <213> ORGANISM: Conus wittigi <400> SEQUENCE: 518 Leu Pro Ser Cys Cys Asp Phe Glu Arg Leu Cy #s Val Val Pro Ala Cys 1               5    #                10   #                15 Ile Arg His Gln Cys Cys Thr             20 <210> SEQ ID NO 519 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 519 Cys Cys Lys Tyr Gly Trp Thr Cys Leu Leu Gl #y Cys Thr Pro Cys Asp 1               5    #                10   #                15 Cys <210> SEQ ID NO 520 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Conus omaria <400> SEQUENCE: 520 Cys Cys Arg Tyr Gly Trp Thr Cys Trp Leu Gl #y Cys Thr Pro Cys Gly 1               5    #                10   #                15 Cys 

What is claimed is:
 1. An isolated peptide comprising the amino acid sequence Xaa—Asn—Cys—Cys—Asn—Gly—Gly—Cys—Ser—Ser—Lys—Xaa—Cys—Arg—Asp—His—Ala—Arg—Cys—Cys (SEQ ID NO:211), wherein Xaa at position 1 is Gln or pyro-Glu and Xaa at position 12 is Trp or bromo-Trp.
 2. The isolated peptide of claim 1, wherein Xaa at position 1 is pyro-Glu and Xaa at position 12 is Trp.
 3. An isolated μ-conopeptide propeptide comprising the amino acid sequence Gly-Ser-Met-Met-Ser-Lys-Leu-Gly-Val-Leu-Leu-Thr-Val-Cys-Leu-Leu- Leu-Phe-Pro-Leu-Thr-Ala-Leu-Pro-Leu-Asp-Gly-Asp-Gln-Pro-Ala-Asp-Arg-Pro-Ala-Glu-Arg-Met- Gln-Asp-ASp-Ile-Ser-Ser-Asp-Glu-His-Pro-Leu-Phe-Asp-Lys-Arg-Gln-Asn-Cys-Cys-Asn-Gly-Gly- Cys-Ser-Ser-Lys-Trp-Cys-Arg-Asp-His-Ala-Arg-Cys-Cys-Gly-Arg (SEQ ID NO:210).
 4. A method for treating or preventing disorders associated with voltage gated neuronal sodium channel disorders in which comprises administering to a patient in need thereof a therapeutically effective amount of a peptide of claim 1 or a pharmaceutically acceptable salt thereof.
 5. The method of claim 4, wherein said disorder is a neurologic disorder.
 6. The method of claim 5, wherein said neurologic disorder is Amytrophic Lateral Sclerosis.
 7. The method of claim 5, wherein said neurologic disorder is head trauma.
 8. The method of claim 5, wherein said neurologic disorder is epilepsy.
 9. The method of claim 5, wherein said neurologic disorder is a neurotoxic injury associated with conditions of hypoxia, anoxia or ischemia.
 10. The method of claim 9, wherein said neurotoxic injury is associated with stroke, cerebrovascular accident, brain or spinal cord trauma, myocardial infarct, physical trauma, drownings, suffocation, perinatal asphyxia, or hypoglycemic events.
 11. The method of claim 4, wherein said disorder is pain.
 12. The method of claim 11, wherein said pain is migraine, acute pain, persistent pain, chronic pain, neuropathic pain or nociceptive pain.
 13. The method of claim 12, wherein the pain is phantom limb pain, neuroma pain or pain associated with trigeminal neuralgia, diabetic neuropathy, and post-herpetic neuralgia.
 14. The method of claim 11, wherein said pain is burn pain.
 15. The method of claim 4, wherein said disorder is myofacial pain syndrome, chronic muscle spasm, or spasticity.
 16. A method of alleviating pain which comprises administering to a mammal that is either exhibiting pain or is about to be subjected to a pain-causing event a pain-alleviating amount of a peptide of claim 1 or a pharmaceutically acceptable salt thereof.
 17. The method of claim 16, wherein the peptide is administered as a local anesthetic.
 18. The method of claim 16, wherein the peptide is administered as an occular anesthetic. 